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Houghten, Richard
Positions
Research Professor
,
Center for Translational Science
,
Office of Research and Economic Development
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Scholarly & Creative Works
Research
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Scholarly & Creative Works
Patents issued
Bacterial Topoisomerase Inhibitors and Use Thereof
Patent
selected scholarly works & creative activities
Article
2023
The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands
Full Text via DOI:
10.3390/ijms241210145
Web of Science:
001014623600001
2022
Identification of B Cell and T Cell Epitopes Using Synthetic Peptide Combinatorial Libraries
Full Text via DOI:
10.1002/cpz1.378
2021
Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist
.
JOURNAL OF MEDICINAL CHEMISTRY
. 64:14860-14875.
Full Text via DOI:
10.1021/acs.jmedchem.1c01417
Web of Science:
000709633100049
2021
Novel Cyclic Lipopeptides Fusaricidin Analogs for Treating Wound Infections
Full Text via DOI:
10.3389/fmicb.2021.708904
2021
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign
.
JOURNAL OF MEDICINAL CHEMISTRY
. 64:5577-5592.
Full Text via DOI:
10.1021/acs.jmedchem.0c02041
Web of Science:
000651785800020
2021
Peripheral kappa opioid receptor activation drives cold hypersensitivity in mice
.
JOURNAL OF PAIN
. 22:582.
Full Text via DOI:
10.1016/j.jpain.2021.03.020
2020
A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A
Full Text via DOI:
10.1177/2472555220926146
2019
A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation
Full Text via DOI:
10.1021/acschembio.9b00093
2019
Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μm MC4R Partial Agonist
.
JOURNAL OF MEDICINAL CHEMISTRY
. 62:2738-2749.
Full Text via DOI:
10.1021/acs.jmedchem.9b00053
2019
A novel probe for spliceosomal proteins that induces autophagy and death of melanoma cells reveals new targets for melanoma drug discovery
.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
. 53:656-686.
Full Text via DOI:
10.33594/000000164
2018
Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency
.
ACS MEDICINAL CHEMISTRY LETTERS
. 9:1057-1062.
Full Text via DOI:
10.1021/acsmedchemlett.8b00425
Web of Science:
000447471800021
2018
Identification of a novel polyamine scaffold with potent efflux pump inhibition activity toward multi-drug resistant bacterial pathogens
Full Text via DOI:
10.3389/fmicb.2018.01301
2018
Exploring the chemical space of peptides for drug discovery: a focus on linear and cyclic penta-peptides
Full Text via DOI:
10.1007/s11030-018-9812-9
2017
Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats
.
JOURNAL OF MEDICINAL CHEMISTRY
. 60:10092-10104.
Full Text via DOI:
10.1021/acs.jmedchem.7b01250
2017
Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries
Full Text via DOI:
10.1021/acsmedchemlett.7b00045
2017
Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa
1
-Arg-(pI)DPhe-Xaa
4
-NH
2
.
JOURNAL OF MEDICINAL CHEMISTRY
. 60:4342-4357.
Full Text via DOI:
10.1021/acs.jmedchem.7b00301
2017
A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation
.
ORGANIC & BIOMOLECULAR CHEMISTRY
. 15:7796-7801.
Full Text via DOI:
10.1039/c7ob01924f
2016
Characterization of potent SMAC mimetics that sensitize cancer cells to TNF family-induced apoptosis
Full Text via DOI:
10.1371/journal.pone.0161952
2016
Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
. 60:4028-4036.
Full Text via DOI:
10.1128/AAC.00288-16
Web of Science:
000378094400020
2016
Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[ d -Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation
.
JOURNAL OF MEDICINAL CHEMISTRY
. 59:1239-1245.
Full Text via DOI:
10.1021/acs.jmedchem.5b01899
2016
Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines
Full Text via DOI:
10.1021/acscombsci.5b00126
Web of Science:
000368048100006
2016
Identification of 5,6-dihydroimidazo[2,1-b]thiazoles as a new class of antimicrobial agents
.
BIOORGANIC & MEDICINAL CHEMISTRY
. 24:5633-5638.
Full Text via DOI:
10.1016/j.bmc.2016.09.027
2015
Identification of Small Molecule Inhibitors of Human As(III)
S
-Adenosylmethionine Methyltransferase (AS3MT)
.
CHEMICAL RESEARCH IN TOXICOLOGY
. 28:2419-2425.
Full Text via DOI:
10.1021/acs.chemrestox.5b00432
Web of Science:
000367118000019
2015
SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes
.
JOURNAL OF MEDICINAL CHEMISTRY
. 58:5808-5824.
Full Text via DOI:
10.1021/acs.jmedchem.5b00354
2015
Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors
.
JOURNAL OF MEDICINAL CHEMISTRY
. 58:4905-4917.
Full Text via DOI:
10.1021/jm501637c
Web of Science:
000357139000005
2015
Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens
.
JOURNAL OF MEDICINAL CHEMISTRY
. 58:3340-3355.
Full Text via DOI:
10.1021/jm501628s
Web of Science:
000353602200006
2015
Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities
.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
. 92:270-281.
Full Text via DOI:
10.1016/j.ejmech.2014.12.049
2014
Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs)
.
JOURNAL OF MEDICINAL CHEMISTRY
. 57:4615-4628.
Full Text via DOI:
10.1021/jm500064t
2014
Discovery of a potent and selective α3β4 nicotinic acetylcholine receptor antagonist from an α-conotoxin synthetic combinatorial library
.
JOURNAL OF MEDICINAL CHEMISTRY
. 57:3511-3521.
Full Text via DOI:
10.1021/jm500183r
2014
Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition
.
ANALYTICAL BIOCHEMISTRY
. 449:68-75.
Full Text via DOI:
10.1016/j.ab.2013.12.018
2014
Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis
.
JOURNAL OF MEDICINAL CHEMISTRY
. 57:1599-1608.
Full Text via DOI:
10.1021/jm4019542
2013
Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies
.
JOURNAL OF MEDICINAL CHEMISTRY
. 56:10103-10117.
Full Text via DOI:
10.1021/jm401543h
Web of Science:
000329331600020
2013
Dissociation of antimicrobial and hemolytic activities of gramicidin S through N-methylation modification
.
CHEMMEDCHEM
. 8:1865-1872.
Full Text via DOI:
10.1002/cmdc.201300232
2013
Conditional probabilistic analysis for prediction of the activity landscape and relative compound activities
.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
. 53:2613-2625.
Full Text via DOI:
10.1021/ci400243e
2013
Selective agonists and antagonists of formylpeptide receptors: Duplex flow cytometry and mixture-based positional scanning libraries
Full Text via DOI:
10.1124/mol.113.086595
2013
Libraries from libraries: A series of sulfonamide linked heterocycles derived from the same scaffold
.
TETRAHEDRON LETTERS
. 54:4296-4299.
Full Text via DOI:
10.1016/j.tetlet.2013.06.003
2013
Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates
.
JOURNAL OF BIOLOGICAL CHEMISTRY
. 288:22871-22879.
Full Text via DOI:
10.1074/jbc.M113.462267
2013
Parallel synthesis of 1,6-disubstituted-1,2,4-triazin-3-ones on solid-phase
Full Text via DOI:
10.1021/co400064d
2013
Rapid scanning structure-activity relationships in combinatorial data sets: Identification of activity switches
.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
. 53:1475-1485.
Full Text via DOI:
10.1021/ci400192y
2013
The mathematics of a successful deconvolution: A quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors
Full Text via DOI:
10.3390/molecules18066408
2013
The role of imidazole in peptide cyclization by transesterification: Parallels to the catalytic triads of serine proteases
.
ORGANIC & BIOMOLECULAR CHEMISTRY
. 11:2979-2987.
Full Text via DOI:
10.1039/c3ob27464k
2013
ChemInform Abstract: Palladium‐Catalyzed C—H Functionalization Using Guanidine as a Directing Group: ortho‐Arylation and Olefination of Arylguanidines.
Full Text via DOI:
10.1002/chin.201311079
2013
Discovery of novel antinociceptive α-conotoxin analogues from the direct in vivo screening of a synthetic mixture-based combinatorial library
Full Text via DOI:
10.1021/co300152x
2013
A traceless approach to amide and peptide construction from thioacids and dithiocarbamate-terminal amines
.
CHEMICAL SCIENCE
. 4:970-976.
Full Text via DOI:
10.1039/c2sc21317f
2013
Identification of a Small Molecule That Selectively Inhibits Mouse PC2 over Mouse PC1/3: A Computational and Experimental Study
Full Text via DOI:
10.1371/journal.pone.0056957
2013
HTS by NMR of combinatorial libraries: A fragment-based approach to ligand discovery
.
CHEMISTRY & BIOLOGY
. 20:19-33.
Full Text via DOI:
10.1016/j.chembiol.2012.10.015
2013
Ligand/kappa-opioid receptor interactions: Insights from the X-ray crystal structure
.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
. 66:114-121.
Full Text via DOI:
10.1016/j.ejmech.2013.05.021
2012
The multi-leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells
.
JOURNAL OF MEDICINAL CHEMISTRY
. 55:10501-10511.
Full Text via DOI:
10.1021/jm3011178
2012
Fluorescent Mu selective opioid ligands from a mixture based cyclic peptide library
Full Text via DOI:
10.1021/co300110t
2012
A large scale classification of molecular fingerprints for the chemical space representation and SAR analysis
Full Text via DOI:
10.1186/1758-2946-4-s1-p26
2012
Activity-difference maps and consensus similarity measure characterize structure-activity relationships
Full Text via DOI:
10.1186/1758-2946-4-s1-p24
2012
Identification of B cell and T cell epitopes using synthetic peptide combinatorial libraries
Full Text via DOI:
10.1002/0471142735.im0905s99
2012
Palladium-catalyzed C-H functionalization using guanidine as a directing group: Ortho arylation and olefination of arylguanidines
.
ORGANIC LETTERS
. 14:5452-5455.
Full Text via DOI:
10.1021/ol302533w
2012
Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates
.
JOURNAL OF BIOLOGICAL CHEMISTRY
. 287:36473-36487.
Full Text via DOI:
10.1074/jbc.M112.389114
2012
A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries
Full Text via DOI:
10.1021/co300060s
2012
ChemInform Abstract: Solid‐Phase Synthesis of Heterocycles from Peptides and Amino Acids.
Full Text via DOI:
10.1002/chin.201226242
2011
Multitarget structure-activity relationships characterized by activity-difference maps and consensus similarity measure
.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
. 51:2427-2439.
Full Text via DOI:
10.1021/ci200281v
2011
Solid-phase synthesis of 2,3,5,6-tetrahydro-1H-imidazo[1,2-a]benzo[d]- [1,3]diazepines via Pd(OAc)
2
/Cu(OAc)
2
-cocatalyzed cyclization
.
SYNLETT
. 2259-2261.
Full Text via DOI:
10.1055/s-0030-1261186
2011
Solid-phase synthesis of 2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine derivatives
.
TETRAHEDRON LETTERS
. 52:4112-4113.
Full Text via DOI:
10.1016/j.tetlet.2011.05.138
2011
Integrating Virtual Screening and Combinatorial Chemistry for Accelerated Drug Discovery
Full Text via DOI:
10.2174/138620711795767866
Web of Science:
000292772100004
2011
Integrating computational and mixture-based screening of combinatorial libraries
.
JOURNAL OF MOLECULAR MODELING
. 17:1473-1482.
Full Text via DOI:
10.1007/s00894-010-0850-1
Web of Science:
000291041800025
2011
Solid-phase synthesis of N-substituted 3,4-dihydroquinazolinone derivatives
.
TETRAHEDRON LETTERS
. 52:2627-2628.
Full Text via DOI:
10.1016/j.tetlet.2011.03.034
2011
Use and implications of the harmonic mean model on mixtures for basic research and drug discovery
Full Text via DOI:
10.1021/co100065a
2011
Increased Diversity of Libraries from Libraries: Chemoinformatic Analysis of Bis-Diazacyclic Libraries
Full Text via DOI:
10.1111/j.1747-0285.2011.01100.x
Web of Science:
000289474100004
2011
Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization
.
TETRAHEDRON LETTERS
. 52:1456-1458.
Full Text via DOI:
10.1016/j.tetlet.2011.01.055
2011
High throughput synthesis of 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b] thiazole derivatives
.
TETRAHEDRON LETTERS
. 52:696-698.
Full Text via DOI:
10.1016/j.tetlet.2010.12.006
2010
A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a 'volatilizable' support
.
TETRAHEDRON LETTERS
. 51:5637-5639.
Full Text via DOI:
10.1016/j.tetlet.2010.08.026
2010
Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct
In Vivo
Screening of a Large Mixture-Based Combinatorial Library
Full Text via DOI:
10.1208/s12248-010-9191-3
Web of Science:
000288425000008
2010
ChemInform Abstract: Traceless Approach for the Synthesis of 3,5‐Disubstituted Thiohydantoins on Functionalized Ionic‐Liquid Support.
Full Text via DOI:
10.1002/chin.201030131
2010
Macrolactonization of peptide thioesters catalyzed by imidazole and its application in the synthesis of kahalalide B and analogues
.
ORGANIC LETTERS
. 12:2250-2253.
Full Text via DOI:
10.1021/ol100596p
2010
Conformational landscape of platinum(II)-tetraamine complexes: DFT and NBO studies
Full Text via DOI:
10.1007/s10822-010-9328-6
Web of Science:
000276965100005
2010
A synthetic combinatorial strategy for developing α-conotoxin analogs as potent α
7
nicotinic acetylcholine receptor antagonists
.
JOURNAL OF BIOLOGICAL CHEMISTRY
. 285:1809-1821.
Full Text via DOI:
10.1074/jbc.M109.071183
2010
A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC
.
BRITISH JOURNAL OF CANCER
. 102:97-103.
Full Text via DOI:
10.1038/sj.bjc.6605418
2010
Traceless approach for the synthesis of 3,5-disubstituted thiohydantoins on functionalized ionic-liquid support
Full Text via DOI:
10.1080/00397910903013697
2010
Traceless solid-phase synthesis of N-substituted 3,5-bis(substituted-idene) piperidin-4-one derivatives
.
TETRAHEDRON LETTERS
. 51:5003-5004.
Full Text via DOI:
10.1016/j.tetlet.2010.07.072
2009
Synthesis of cyclic peptides through direct aminolysis of peptide thioesters catalyzed by imidazole in aqueous organic solutions
Full Text via DOI:
10.1021/cc900100z
2009
Solid-phase synthesis of 2-alkylidene-6-alkyl-imidazo[2,1-b]thiazole-3,5[2H,6H]-dione derivatives
.
TETRAHEDRON LETTERS
. 50:5857-5859.
Full Text via DOI:
10.1016/j.tetlet.2009.08.009
2009
Parallel synthesis of chiral pentaamines and pyrrolidine containing bis-heterocyclic libraries. Multiple scaffolds with multiple building blocks: A double diversity for the identification of new antitubercular compounds
.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
. 19:5169-5175.
Full Text via DOI:
10.1016/j.bmcl.2009.07.010
Web of Science:
000268863800063
2009
Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands
.
BIOORGANIC & MEDICINAL CHEMISTRY
. 17:5583-5597.
Full Text via DOI:
10.1016/j.bmc.2009.06.026
Web of Science:
000268099700026
2009
Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries Small Molecule Repository
.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
. 49:1010-1024.
Full Text via DOI:
10.1021/ci800426u
2009
One-pot high-throughput synthesis of β-turn cyclic peptidomimetics-via "volatilizable" supports
.
JOURNAL OF ORGANIC CHEMISTRY
. 74:2183-2185.
Full Text via DOI:
10.1021/jo802583t
2009
Synthetic Small-Molecule Prohormone Convertase 2 Inhibitors
Full Text via DOI:
10.1124/mol.108.051334
Web of Science:
000263559500019
2009
Characterization of activity landscapes using 2D and 3D similarity methods: Consensus activity cliffs
.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
. 49:477-491.
Full Text via DOI:
10.1021/ci800379q
2009
The pharmacological properties of a novel MCH
1
receptor antagonist isolated from combinatorial libraries
.
EUROPEAN JOURNAL OF PHARMACOLOGY
. 602:194-202.
Full Text via DOI:
10.1016/j.ejphar.2008.10.068
2009
Modeling of peptides containing D-amino acids: Implications on cyclization
Full Text via DOI:
10.1007/s10822-009-9295-y
2008
Solid-phase synthesis of 4,8-disubstituted-8,9-dihydropyrazino[2,3-g]quinazolin-7(6H)-ones
.
BIOPOLYMERS
. 90:439-443.
Full Text via DOI:
10.1002/bip.20842
2008
High throughput synthesis of peptide α-thioesters through the use of "volatilizable" support
Full Text via DOI:
10.1021/cc800076b
2008
Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis
.
BIOORGANIC & MEDICINAL CHEMISTRY
. 16:5932-5938.
Full Text via DOI:
10.1016/j.bmc.2008.04.061
2008
High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on 'volatilizable' supports
.
TETRAHEDRON LETTERS
. 49:3632-3633.
Full Text via DOI:
10.1016/j.tetlet.2008.03.156
2008
ChemInform Abstract: Strategies for the Use of Mixture‐Based Synthetic Combinatorial Libraries: Scaffold Ranking, Direct Testing in vivo, and Enhanced Deconvolution by Computational Methods.
Full Text via DOI:
10.1002/chin.200818222
2008
Novel d-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral κ-opioid receptors
,
.
EUROPEAN JOURNAL OF PHARMACOLOGY
. 583:62-72.
Full Text via DOI:
10.1016/j.ejphar.2008.01.011
2008
Small-molecule XIAP antagonist restores caspase-9-mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells
.
BLOOD
. 111:369-375.
Full Text via DOI:
10.1182/blood-2007-04-085480
2007
A similarity-based data-fusion approach to the visual characterization and comparison of compound databases
Full Text via DOI:
10.1111/j.1747-0285.2007.00579.x
2007
Solid-phase synthesis of 3-alkyl-8-arylamino-1H-imidazo[4,5-g]quinazolin-2(3H)-thiones and 3-alkyl-8-arylamino-1H-imidazo[4,5-g]quinazolin-2(3H)-ones
.
TETRAHEDRON LETTERS
. 48:7042-7045.
Full Text via DOI:
10.1016/j.tetlet.2007.07.134
2007
A traceless approach for the solid-phase parallel synthesis of trisubstituted oxindoles
Full Text via DOI:
10.1021/cc070010x
2007
Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: Use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences
Full Text via DOI:
10.1124/mol.106.027946
2007
Scaffold approach for solid-phase synthesis of 2,3-disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines
Full Text via DOI:
10.1021/cc0601231
2006
427 POSTER Preclinical development of xiapuradamib therapy for lung cancer
Full Text via DOI:
10.1016/s1359-6349(06)70432-3
2006
491 POSTER Trageting XIAP in paediatric cancers
Full Text via DOI:
10.1016/s1359-6349(06)70496-7
2006
Synthesis of platinum(II) chiral tetraamine coordination complexes
Full Text via DOI:
10.1021/cc060045h
Web of Science:
000240403200020
2006
Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: An example of lead optimization using mixture-based libraries
.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
. 16:4331-4338.
Full Text via DOI:
10.1016/j.bmcl.2006.05.053
Web of Science:
000239349000035
2006
The central effect of MCH system studied using a specific MCH 1R antagonist isolated from combinatorial libraries
.
FASEB JOURNAL
. 20:a686-a686.
Full Text via DOI:
10.1096/fasebj.20.4.a686-a
2006
Solid phase synthesis of 3,4,7-trisubstituted 4,5,8,9-tetrahydro-3H-imidazo[1,2-a][1,3,5]triazepin-2(7H)-thiones and N-alkyl-4,5,7,8-tetrahydro-3H-imidazo[1,2-a][1,3,5]triazepin-2-amines
Full Text via DOI:
10.1021/cc050094e
Web of Science:
000234608500020
2005
Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis
.
BLOOD
. 106:1742-1748.
Full Text via DOI:
10.1182/blood-2005-02-0695
Web of Science:
000231495000040
2005
"Volatilizable" supports for high-throughput organic synthesis
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
. 127:8582-8583.
Full Text via DOI:
10.1021/ja0402396
2005
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells
.
BLOOD
. 105:4043-4050.
Full Text via DOI:
10.1182/blood-2004-08-3168
Web of Science:
000229009000050
2005
Mixture‐Based Combinatorial Libraries: from Peptides and Peptidomimetics to Small Molecule Acyclic and Heterocyclic Compounds
Full Text via DOI:
10.1002/chin.200501270
2004
Inhibition of XIAP Enhances Specific Cytotoxic T Lymphocyte (CTL) Killing and CD20-Directed Antibody-Dependent Cellular Cytotoxicity of Chronic Lymphocytic Leukemia B Cells.
.
BLOOD
. 104:3475.
Full Text via DOI:
10.1182/blood.v104.11.3475.3475
2004
Inhibition of XIAP Renders Newly CD40-Activated Chronic Lymphocytic Leukemia Cells Sensitive to Fas (CD95) Mediated Apoptosis.
.
BLOOD
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Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples.
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BLOOD
. 104:759.
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Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors
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JOURNAL OF BIOLOGICAL CHEMISTRY
. 279:48168-48176.
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10.1074/jbc.M405022200
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Solid-phase synthesis of 5-aminotetrazoles
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TETRAHEDRON LETTERS
. 45:7787-7789.
Full Text via DOI:
10.1016/j.tetlet.2004.07.160
2004
Combinatorial Chemistry: Libraries from Libraries, the Art of the Diversity‐Oriented Transformation of Resin‐Bound Peptides and Chiral Polyamides to Low Molecular Weight Acyclic and Heterocyclic Compounds
Full Text via DOI:
10.1002/chin.200436237
2004
Inhibition of furin by polyarginine-containing peptides: Nanomolar inhibition by nona-D-arginine
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JOURNAL OF BIOLOGICAL CHEMISTRY
. 279:36788-36794.
Full Text via DOI:
10.1074/jbc.M400484200
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Combinatorial chemistry: Libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds
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JOURNAL OF ORGANIC CHEMISTRY
. 69:3603-3609.
Full Text via DOI:
10.1021/jo040114j
Web of Science:
000221624900001
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De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
. 14:1947-1951.
Full Text via DOI:
10.1016/j.bmcl.2004.01.090
2004
Halogenoalkyl isocyanates as bifunctional reagents in an Aza-Wittig/heterocyclization reaction on the solid phase: Efficient entry into new tetracyclic benzimidazole systems
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10.1021/cc030036y
Web of Science:
000220187800009
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A Traceless Approach for the Solid-Phase Synthesis of 6-Amino-1,3,5- triazine-2,4-diones
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10.1021/cc030017o
2004
Peptidic complex mixtures as therapeutic agents in CNS autoimmunity
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MOLECULAR IMMUNOLOGY
. 40:1075-1087.
Full Text via DOI:
10.1016/j.molimm.2003.11.006
2004
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
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10.1016/S1535-6108(03)00332-5
Web of Science:
000188400300007
2004
Specificity and degeneracy of T cells
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MOLECULAR IMMUNOLOGY
. 40:1047-1055.
Full Text via DOI:
10.1016/j.molimm.2003.11.022
2003
Identification of novel small-molecule Ulex europaeus I mimetics for targeted drug delivery
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BIOORGANIC & MEDICINAL CHEMISTRY
. 11:4991-4997.
Full Text via DOI:
10.1016/j.bmc.2003.09.002
2003
Combinatorial Chemistry: Mixture‐Based Combinatorial Libraries of Acyclic and Heterocyclic Compounds from Amino Acids and Short Peptides
Full Text via DOI:
10.1002/chin.200344239
2003
Solid-phase synthesis of 3-amino-1,2,4-triazoles
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TETRAHEDRON LETTERS
. 44:7841-7843.
Full Text via DOI:
10.1016/j.tetlet.2003.08.074
2003
Toward targeted oral vaccine delivery systems: Selection of lectin mimetics from combinatorial libraries
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PHARMACEUTICAL RESEARCH
. 20:1258-1266.
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10.1023/A:1025061317400
2003
Advances in the Use of Synthetic Combinatorial Chemistry: Mixture‐Based Libraries
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10.1002/chin.200329235
2003
Abnormal aza-Wittig reaction on the solid-phase: chemoselectivity studies towards the parallel synthesis of 3-aryl-2,4-dioxo-1,3,5-triazino[1,2-a]benzimidazoles
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TETRAHEDRON LETTERS
. 44:3705-3708.
Full Text via DOI:
10.1016/S0040-4039(03)00633-6
Web of Science:
000182496400027
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Solid-phase synthesis of indolines via palladium-catalyzed cyclization
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TETRAHEDRON LETTERS
. 44:2569-2572.
Full Text via DOI:
10.1016/S0040-4039(03)00317-4
2003
Parallel solid-phase synthesis of 2-imino-4-oxo-1,3,5-triazino[1,2-a]benzimidazoles via tandem Aza-Wittig/heterocumulene-mediated annulation reaction
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10.1021/cc020077e
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The combined solid/solution-phase synthesis of nitrosamines: The evolution of the "libraries from libraries" concept
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JOURNAL OF ORGANIC CHEMISTRY
. 68:183-186.
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Positional scanning-synthetic peptide library-based analysis of self- and pathogen-derived peptide cross-reactivity with tumor-reactive Melan-A-specific CTL
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JOURNAL OF IMMUNOLOGY
. 169:5696-5707.
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10.4049/jimmunol.169.10.5696
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Opioid activity of 4-imidazolidinone positional analogues of Leu-enkephalin
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
. 12:3175-3178.
Full Text via DOI:
10.1016/S0960-894X(02)00678-9
Web of Science:
000178693100034
2002
Parallel solid-phase synthesis of disubstituted 1,6-piperazine-2-ones
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10.1021/cc0200235
Web of Science:
000179254700002
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Determination of isokinetic ratios necessary for equimolar incorporation of carboxylic acids in the solid-phase synthesis of mixture-based combinatorial libraries
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BIOPOLYMERS
. 65:32-39.
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10.1002/bip.10206
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Efficient solid-phase synthesis of 1,3,5-trisubstituted 1,3,5-triazine-2,4,6-triones
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10.1021/cc020004v
2002
Findings on T cell specificity revealed by synthetic combinatorial libraries
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10.1016/S0022-1759(02)00142-4
2002
Use of vilsmeier reagent for the solid-phase synthesis of 1,5-disubstituted 4,5-dihydro-1H-imidazoles and disubstituted 4,5-dihydro-1H-imidazolylbenzimidazoles
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10.1021/cc020020s
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A traceless approach for the parallel solid-phase synthesis of 2-(arylamino)quinazolinones
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JOURNAL OF ORGANIC CHEMISTRY
. 67:5831-5834.
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10.1021/jo020236g
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Combinatorial peptide library-based identification of peptide ligands for tumor-reactive cytolytic T lymphocytes of unknown specificity
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10.1002/1521-4141(200208)32:8<2292::AID-IMMU2292>3.0.CO;2-K
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Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-A peptide multimer
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CD8
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T cells in humans
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JOURNAL OF EXPERIMENTAL MEDICINE
. 196:207-216.
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10.1084/jem.20020242
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Parallel solid-phase synthesis of trisubstituted triazinobenzimidazolediones
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10.1021/cc010089k
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ChemInform Abstract: Solid‐Phase Synthesis of Mixture‐Based Acyclic and Heterocyclic Small Molecule Combinatorial Libraries from Resin‐Bound Polyamides.
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10.1002/chin.200225266
2002
An expedient method for the solid-phase synthesis of alpha-aminoalkyl phosphonopeptides
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TETRAHEDRON LETTERS
. 43:4103-4106.
Full Text via DOI:
10.1016/S0040-4039(02)00695-0
Web of Science:
000175894400034
2002
Solid-phase synthesis of 1,5-disubstituted 2-aryliminoimidazolidines
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JOURNAL OF ORGANIC CHEMISTRY
. 67:3138-3141.
Full Text via DOI:
10.1021/jo0109366
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Novel approaches for the solid-phase synthesis of biheterocyclic dihydroimidazole analogues
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10.1021/cc010067y
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Solid-phase parallel synthesis of 2-aminoimidazolidin-4-ones
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TETRAHEDRON
. 58:3349-3353.
Full Text via DOI:
10.1016/S0040-4020(02)00299-5
2002
An efficient approach for solid-phase synthesis of peptidomimetics based on 4-imidazolidinones
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TETRAHEDRON LETTERS
. 43:2343-2346.
Full Text via DOI:
10.1016/S0040-4039(02)00263-0
Web of Science:
000174765600006
2002
Toward synthetic combinatorial peptide libraries in positional scanning format (PS-SCL)-based identification of CD8
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tumor-reactive T-cell ligands: A comparative analysis of PS-SCL recognition by a single tumor-reactive CD8
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cytolytic T-lymphocyte clone
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CANCER RESEARCH
. 62:2058-2063.
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Solid-phase parallel synthesis of substituted dihydroimidazolyl dihydrobenzimidazol-2-ones
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TETRAHEDRON
. 58:2095-2100.
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10.1016/S0040-4020(02)00104-7
2002
Solid-phase parallel synthesis of substituted dihydroimidazolylbutyl dihydroimidazol-3-ium salts
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TETRAHEDRON LETTERS
. 43:1157-1160.
Full Text via DOI:
10.1016/S0040-4039(01)02385-1
2002
Solid-phase parallel synthesis of trisubstituted dihydroimidazolyl dihydroquinoxalin-2(1H)-ones
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TETRAHEDRON
. 58:221-225.
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10.1016/S0040-4020(01)01155-3
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A novel approach for solid-phase synthesis of substituted imidazolines and bis-imidazolines
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JOURNAL OF ORGANIC CHEMISTRY
. 66:8673-8676.
Full Text via DOI:
10.1021/jo010814d
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Solid-phase synthesis of bis-cyclic guanidines from tripeptides
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TETRAHEDRON
. 57:9911-9914.
Full Text via DOI:
10.1016/S0040-4020(01)01010-9
2001
Solid-phase synthesis of alpha,alpha-difluoro-beta-amino acids via the Reformatsky reaction
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JOURNAL OF ORGANIC CHEMISTRY
. 66:8268-8272.
Full Text via DOI:
10.1021/jo010872z
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000172489500053
2001
ChemInform Abstract: Solid‐Phase Synthesis of Heterocyclic Compounds from Amino Acids and Linear Peptides
Full Text via DOI:
10.1002/chin.200148274
2001
A novel approach for the solid-phase synthesis of substituted cyclic guanidines, their respective bis analogues, and N-acylated guanidines from N-acylated amino acid amides
Full Text via DOI:
10.1021/cc0100262
2001
Identification of B cell and T cell epitopes using synthetic peptide combinatorial libraries.
Full Text via DOI:
10.1002/0471142735.im0905s45
2001
Solid-phase synthesis of 2,3,5-trisubstituted 4H-imidazolones
Full Text via DOI:
10.1021/cc010022x
2001
Solid-phase synthesis of substituted imidazoline-tethered 2,3-diketopiperazines, cyclic ureas, and cyclic thioureas
Full Text via DOI:
10.1021/cc010030d
2001
Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones
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ORGANIC LETTERS
. 3:2797-2799.
Full Text via DOI:
10.1021/ol010102+
2001
ChemInform Abstract: Synthesis and Screening of Positional Scanning Synthetic Combinatorial Libraries
Full Text via DOI:
10.1002/chin.200132268
2001
Parallel synthesis of 4,5-dihydro-1H-1,4-benzodiazepine-2,3-diones
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TETRAHEDRON LETTERS
. 42:5141-5143.
Full Text via DOI:
10.1016/S0040-4039(01)00939-X
Web of Science:
000170062400003
2001
Combinatorial peptide libraries as an alternative approach to the identification of ligands for tumor-reactive cytolytic T lymphocytes
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CANCER RESEARCH
. 61:5153-5160.
2001
Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries
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BLOOD
. 97:1776-1786.
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An N-methyl-D-aspartate receptor channel blocker with neuroprotective activity
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
. 98:3519-3524.
Full Text via DOI:
10.1073/pnas.061449498
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Tethered libraries: Solid-phase synthesis of substituted urea-linked bicyclic guanidines
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10.1021/cc0000803
Web of Science:
000169606600009
2001
Solid phase synthesis of [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-ones
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TETRAHEDRON LETTERS
. 42:623-625.
Full Text via DOI:
10.1016/S0040-4039(00)02022-0
2001
Solid phase synthesis of mixture-based acyclic and heterocyclic small molecule combinatorial libraries from resin-bound polyamides
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BIOPOLYMERS
. 60:212-219.
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10.1002/1097-0282(2001)60:3<212::AID-BIP10033>3.0.CO;2-D
Web of Science:
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2001
Solid-phase synthesis of bis-heterocyclic compounds from resin-bound orthogonally protected lysine
Full Text via DOI:
10.1021/cc000061t
Web of Science:
000167935000010
2000
Polyarginines are potent furin inhibitors
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JOURNAL OF BIOLOGICAL CHEMISTRY
. 275:36741-36749.
Full Text via DOI:
10.1074/jbc.M003848200
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ChemInform Abstract: Manual Multiple Synthesis Methods
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10.1002/chin.200045266
2000
Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides
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ORGANIC LETTERS
. 2:3349-3350.
Full Text via DOI:
10.1021/ol000225e
Web of Science:
000089831900026
2000
ChemInform Abstract: Parallel Array and Mixture‐Based Synthetic Combinatorial Chemistry: Tools for the Next Millennium
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10.1002/chin.200042288
2000
An efficient two-step synthesis of mono-, di- and triureas from resin-bound amides
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TETRAHEDRON LETTERS
. 41:5441-5446.
Full Text via DOI:
10.1016/S0040-4039(00)00845-5
Web of Science:
000088200200003
2000
Solid-phase synthesis of substituted 2,3-diketopiperazines from reduced polyamides
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TETRAHEDRON
. 56:3319-3326.
Full Text via DOI:
10.1016/S0040-4020(00)00253-2
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2000
Solid-phase synthesis of branched thiohydantoin benzimidazolinethiones and branched thiohydantoin tetrahydroquinoxalinediones
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TETRAHEDRON LETTERS
. 41:2283-2287.
Full Text via DOI:
10.1016/S0040-4039(00)00162-3
Web of Science:
000086681100004
2000
Solid phase synthesis of styrylquinazolinones
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TETRAHEDRON LETTERS
. 41:2051-2054.
Full Text via DOI:
10.1016/S0040-4039(00)00112-X
2000
Solid phase synthesis of 1-substituted pyroglutamates
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TETRAHEDRON LETTERS
. 41:851-854.
Full Text via DOI:
10.1016/S0040-4039(99)02208-X
Web of Science:
000085305600017
2000
Solid phase synthesis of 1,3-disubstituted succinimides
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TETRAHEDRON LETTERS
. 41:609-612.
Full Text via DOI:
10.1016/S0040-4039(99)02166-8
Web of Science:
000085038700008
2000
Contribution of individual amino acids within MHC molecule or antigenic peptide to TCR ligand potency
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JOURNAL OF IMMUNOLOGY
. 164:861-871.
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10.4049/jimmunol.164.2.861
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Inhibition of β-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library
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JOURNAL OF STRUCTURAL BIOLOGY
. 130:247-258.
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10.1006/jsbi.2000.4245
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Minimal peptide length requirements for CD4
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T cell clones - implications for molecular mimicry and T cell survival
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10.1093/intimm/12.3.375
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Orphanin FQ/Nociceptin receptor binding studies
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PEPTIDES
. 21:949-960.
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Immunogenicity. I. Use of peptide libraries to identify epitopes that activate clonotypic CD4
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T cells and induce T cell responses to native peptide ligands
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JOURNAL OF IMMUNOLOGY
. 163:6424-6434.
1999
ChemInform Abstract: Mixture‐Based Synthetic Combinatorial Libraries
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10.1002/chin.199949239
1999
Solid phase synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids
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TETRAHEDRON LETTERS
. 40:8539-8542.
Full Text via DOI:
10.1016/S0040-4039(99)01823-7
Web of Science:
000083665600010
1999
Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease
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10.1038/70946
1999
New opioid peptides, peptidomimetics, and heterocyclic compounds from combinatorial libraries
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BIOPOLYMERS
. 51:379-390.
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10.1002/(SICI)1097-0282(1999)51:6<379::AID-BIP2>3.0.CO;2-E
1999
Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library
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10.1002/(SICI)1098-2396(19990901)33:3<239::AID-SYN8>3.0.CO;2-R
1999
Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives
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TETRAHEDRON LETTERS
. 40:4939-4942.
Full Text via DOI:
10.1016/S0040-4039(99)00964-8
Web of Science:
000081122400006
1999
ChemInform Abstract: Soluble Combinatorial Libraries of Peptides, Peptidomimetics, and Organics: Fundamental Tools for Basic Research and Drug Discovery
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10.1002/chin.199914325
1999
Parallel solid phase synthesis of tetrasubstituted diethylenetriamines via selective amide alklylation and exhaustive reduction of N-acylated dipeptides
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TETRAHEDRON
. 55:335-344.
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10.1016/S0040-4020(98)01043-6
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Exploring immunological specificity using synthetic peptide combinatorial libraries
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10.1016/S0952-7915(99)80033-8
1999
Mixture-based heterocyclic combinatorial positional scanning libraries: Discovery of bicyclic guanidines having potent antifungal activities against Candida albicans and Cryptococcus neoformans
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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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1998
ChemInform Abstract: Synthesis and Screening of Positional Scanning Combinatorial Libraries
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10.1002/chin.199849317
1998
ChemInform Abstract: Peralkylation. “Libraries from Libraries”: Chemical Transformation of Synthetic Combinatorial Libraries
Full Text via DOI:
10.1002/chin.199848334
1998
Tetrakis(pyridine)silver(2+)peroxydisulfate 2AgNO
3
+ 8C
5
H
5
N + 3K
2
S
2
S
8
→ 2[Ag(C
5
H
5
N)
4
]S
2
O
8
+ 2K
2
SO
4
+ 2KNO
3
1998
Efficient solid phase synthesis of 3,5-disubstituted hydantoins
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TETRAHEDRON LETTERS
. 39:8199-8202.
Full Text via DOI:
10.1016/S0040-4039(98)01874-7
Web of Science:
000076524100004
1998
Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library
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JOURNAL OF BIOLOGICAL CHEMISTRY
. 273:26589-26595.
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10.1074/jbc.273.41.26589
1998
Combinatorial chemistry: From peptides and peptidomimetics to small organic and heterocyclic compounds
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
. 8:2273-2278.
Full Text via DOI:
10.1016/S0960-894X(98)00412-0
Web of Science:
000075976300002
1998
From specificity to degeneracy to molecular mimicry: Antigen recognition of human autoreactive and pathogen-specific CD4+ T cells
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JOURNAL OF NEUROIMMUNOLOGY
. 90:34.
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10.1016/s0165-5728(98)91382-0
1998
Selective ligands for the μ, δ, and κ opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library
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JOURNAL OF BIOLOGICAL CHEMISTRY
. 273:18848-18856.
Full Text via DOI:
10.1074/jbc.273.30.18848
1998
Solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones
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TETRAHEDRON LETTERS
. 39:3671-3674.
Full Text via DOI:
10.1016/S0040-4039(98)00645-5
Web of Science:
000073724300014
1998
Cutting edge: Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology
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JOURNAL OF IMMUNOLOGY
. 160:3631-3636.
1998
Probing degeneracy in T-cell recognition using peptide combinatorial libraries
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10.1016/S0167-5699(97)01217-6
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Selected peptides targeted to the NMDA receptor channel protect neurons from excitotoxic death
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NATURE BIOTECHNOLOGY
. 16:286-291.
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Activation of human class-II restricted T cell clones by short peptides
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FASEB JOURNAL
. 12.
1998
Precise prediction of class II T-cell epitopes using a combinatorial peptide library approach
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FASEB JOURNAL
. 12.
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Use of heterocyclic positional scanning synthetic combinatorial libraries for the discovery of highly active small molecules
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FASEB JOURNAL
. 12.
1998
ChemInform Abstract: Rapidly Expanding Molecular Diversity: Libraries from Libraries
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10.1002/chin.199804275
1998
A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats
Full Text via DOI:
10.1124/mol.54.5.864
1998
Characterization of antigen-antibody interactions using single substitution analogs and mixture-based synthetic combinatorial libraries
Full Text via DOI:
10.1111/j.1399-3011.1998.tb00659.x
1998
Comparison of the binding of α-helical and β-sheet peptides to a hydrophobic surface
Full Text via DOI:
10.1111/j.1399-3011.1998.tb00638.x
1998
Identification of novel antitumor agents from mixture-based synthetic combinatorial libraries using cell-based assays
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10.1023/A:1026441400053
1998
Mapping the prion protein using recombinant antibodies
Full Text via DOI:
10.1128/jvi.72.11.9413-9418.1998
1998
Synthesis and screening of positional scanning combinatorial libraries.
1998
The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells
Full Text via DOI:
10.1111/j.1399-3011.1998.tb00658.x
1998
Use of combinatorial library screening to identify inhibitors of a bacterial two-component signal transduction kinase
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10.1023/A:1009695718427
1997
Synthesis of cyclic disulfide peptides: Comparison of oxidation methods
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PROTEIN AND PEPTIDE LETTERS
. 4:157-164.
1997
Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1
.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
. 283:735-741.
1997
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform
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JOURNAL OF MOLECULAR BIOLOGY
. 273:614-622.
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10.1006/jmbi.1997.1328
1997
Immune activation in cervical neoplasia: Cross-sectional association between plasma soluble interleukin 2 receptor levels and disease
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CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
. 6:807-813.
1997
Solid phase synthesis of 1,3,4,7-tetrasubstituted perhydro-1,4-diazepine-2,5-diones
.
TETRAHEDRON LETTERS
. 38:4943-4946.
Full Text via DOI:
10.1016/S0040-4039(97)01086-1
Web of Science:
A1997XK06100007
1997
Polyalanine-based peptides as models for self-associated β-pleated- sheet complexes
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BIOCHEMISTRY
. 36:8393-8400.
Full Text via DOI:
10.1021/bi963015b
1997
ChemInform Abstract: The Current Status of Heterocyclic Combinatorial Libraries
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10.1002/chin.199727304
1997
Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinones via β-lactam intermediates on the solid-phase
.
TETRAHEDRON LETTERS
. 38:3349-3352.
Full Text via DOI:
10.1016/S0040-4039(97)00655-2
1997
ChemInform Abstract: Generation of Peralkylated Peptidomimetic Combinatorial Libraries
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10.1002/chin.199715284
1997
First Japanese Conference on Combinatorial Chemistry and High Throughput Screening
Full Text via DOI:
10.1007/bf01715632
1997
Solid phase synthesis of heterocyclic compounds from linear peptides: Cyclic ureas and thioureas
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TETRAHEDRON LETTERS
. 38:931-934.
Full Text via DOI:
10.1016/S0040-4039(96)02516-6
Web of Science:
A1997WG34800010
1997
Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes
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INFECTION AND IMMUNITY
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Evidence of conformational equilibria during the RP-HPLC elution process of peptides
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Interleukin 2 production in vitro by peripheral lymphocytes in response to human papillomavirus-derived peptides: Correlation with cervical pathology
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CANCER RESEARCH
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Highly specific, cross-reactive sequences recognized by an anti-HBsAg antibody identified from a positional scanning synthetic combinatorial library
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Orphanin FQ: Receptor binding and analog structure activity relationships in rat brain
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LIFE SCIENCES
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ChemInform Abstract: Peptide, Peptidomimetic, and Organic Synthetic Combinatorial Libraries
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Functionalized protein-like structures from conformationally defined synthetic combinatorial libraries
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Identification of inhibitors of melittin using nonsupport-bound combinatorial libraries
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JOURNAL OF BIOLOGICAL CHEMISTRY
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A study of human T-cell lines generated from multiple sclerosis patients and controls by stimulation with peptides of myelin basic protein
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Generation of peralkylated peptidomimetic combinatorial libraries
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Novel α-glucosidase inhibitors identified using multiple cyclic peptide combinatorial libraries
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Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial libraries
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Structural Characterization and 5′-mononucleotide Binding of Polyalanine β-sheet Complexes
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Use of nonsupport-bound synthetic combinatorial libraries in cell-based bioassay systems
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Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library
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Synthetic peptides from P.falciparum sexual stage 25-kDa protein induce antibodies that react with the native protein: The role of IL-2 and conformational structure on immunogenicity of Pfs25
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ChemInform Abstract: Utility of Soluble Peptide Combinatorial Libraries
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Elucidation of monoclonal antibody polyspecificity using a synthetic combinatorial library
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Mapping the detailed specificity of a calcium-dependent monoclonal antibody through the use of soluble positional scanning combinatorial libraries: Identification of potent calcium-independent antigens
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Six highly active mu-selective opioid peptides identified from two synthetic combinatorial libraries
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A comparison of combinatorial library approaches for the study of opioid compounds
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The role of amphipathicity in the folding, self-association and biological activity of multiple subunit small proteins
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A review of the utility of soluble peptide combinatorial libraries
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IDENTIFICATION OF MU-SELECTIVE POLYAMINE ANTAGONISTS FROM A SYNTHETIC COMBINATORIAL LIBRARY
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Identification of a nonameric H-2K(k)-restricted CD8
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INFECTION AND IMMUNITY
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Induced conformational states of amphipathic peptides in aqueous/lipid environments
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Peptide binding domains determined through chemical modification of the side-chain functional groups
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The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries
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Two antipeptide monoclonal antibodies that recognize adhesive sequences in fibrinogen: identification of antigenic determinants and unrelated sequences using synthetic combinatorial libraries.
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'Libraries from libraries': Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity
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Rapid identification of novel opioid peptides from an N-acetylated synthetic combinatorial library
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Cyclic peptide template combinatorial libraries: Synthesis and identification of chymotrypsin inhibitors
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Synthetic peptides as binding-step based catalytic mimics
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Analysis of human T cell clones specific for conserved peptide sequences within malaria proteins: Paucity of clones responsive to intact parasites
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Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9: Comparison of two different antibodies bound to the same peptide antigen
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Peptides that inhibit von willebrand factor binding to the platelet SPIB receptor
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An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library
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An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans
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Crystal structure of deltakephalin: a γ‐selective opioid peptide with a novel β‐bend‐like conformation
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Determination of the secondary structure of selected melittin analogues with different haemolytic activities
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Identification of antimicrobial peptides by using combinatorial libraries made up of unnatural amino acids
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Induction of murine cytotoxic T lymphocytes against Plasmodium falciparum sporozoite surface protein 2
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Investigation of antigen-antibody interactions using a soluble, non-support-bound synthetic decapeptide library composed of four trillion (4 x 10
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Peptide libraries: Determination of relative reaction rates of protected amino acids in competitive couplings
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Soluble Combinatorial Libraries: Extending the Range and Repertoire of Chemical Diversity
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Versatility of positional scanning synthetic combinatorial libraries for the identification of individual compounds
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The broad utility of soluble peptide libraries for drug discovery
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Acetalins: Opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries
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Influence of tryptophan residues on melittin's hemolytic activity
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ChemInform Abstract: Modified Solid‐Phase Methods for the Rapid Synthesis of Opioid Peptides
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Synthetic peptide combinatorial libraries (SPCLs): identification of the antigenic determinant of β-endorphin recognized by monoclonal antibody 3E7
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Analysis of the epitopes of proliferating cell nuclear antigen recognized by monoclonal antibodies
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Comparison of 55% TFA/CH
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Cytotoxic t lymphocyte (Ctl) low-responsiveness to the plasmodium falciparum circumsporozoite protein in naturally-exposed endemic populations: Analysis of human ctl response to most known variants
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Functional importance of amino acid residues making up peptide antigenic determinants
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Identification of Substrate-Analog Trypsin Inhibitors through the Screening of Synthetic Peptide Combinatorial Libraries
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The Importance of Dominant Negative Effects of Amino Acid Side Chain Substitution in Peptide-MHC Molecule Interactions and T Cell Recognition
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The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands
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The use of synthetic peptide combinatorial libraries for the determination of peptide ligands in radio-receptor assays: Opioid peptides
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Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries
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Anomalous reversed-phase high-performacne liquid chromatographic behavior of synthetic peptides related to antigenic helper T cell sites
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Evaluation of peptidepeptide interactions using reversed-phase high-performance liquid chromatography
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Conserved T and B cell epitopes on the M protein of group A streptococci: Induction of bactericidal antibodies
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JOURNAL OF IMMUNOLOGY
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A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei
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Immunization with soluble protein-pulsed spleen cells induces class I-restricted cytotoxic T lymphocytes that recognize immunodominant epitopic peptides from Plasmodium falciparum and HIV-1
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JOURNAL OF IMMUNOLOGY
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Conformation and Dynamics of an Fab'-Bound Peptide by Isotope-Edited NMR Spectroscopy
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Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis
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Design of Model Amphipathic Peptides Having Potent Antimicrobial Activities
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Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant
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High frequency of malaria‐specific T cells in non‐exposed humans
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Identification of related peptides recognized by a monoclonal antibody using a synthetic peptide combinatorial library
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Induction of cytotoxic T cells to a cross-reactive epitope in the hepatitis C virus nonstructural RNA polymerase-like protein
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Perturbation of peptide conformations induced in anisotropic environments
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Recombinant pseudorabies virus carrying a plasmodium gene: herpesvirus as a new live viral vector for inducing T- and B-cell immunity
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The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides
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Toleration of amino acid substitutions within hepatitis B virus envelope protein epitopes established by peptide replacement set analysis. II. Region S(122-136).
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Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity
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JOURNAL OF BIOLOGICAL CHEMISTRY
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Autoantibody production in hepatitis B e antigen transgenic mice elicited with a self T-cell peptide and inhibited with nonself peptides
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Hemolytic and Antimicrobial Activities of the Twenty-Four Individual Omission Analogues of Melittin
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Assessment of human cytotoxic T cell activity using synthetic peptides: potential for field application.
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Development of cross-reactive antibodies to plasminogen during the immune response to dengue virus infection
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JOURNAL OF INFECTIOUS DISEASES
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Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
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Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans: Correlation with a cytotoxic T cell epitope
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JOURNAL OF INFECTIOUS DISEASES
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Location of human cytotoxic T cell epitopes within a polymorphic domain of the Plasmodium falciparum circumsporozoite protein
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1991
Probing the relationships between the structure and hemolytic activity of melittin with a complete set of leucine substitution analogs.
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The use of synthetic peptides in the formation of biophysically and biologically active pulmonary surfactants
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Major population differences in T cell response to a malaria sporozite vaccine candidate
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Insights into native epitopes of proliferating cell nuclear antigen using recombinant DNA protein products
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JOURNAL OF EXPERIMENTAL MEDICINE
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Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes
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JOURNAL OF EXPERIMENTAL MEDICINE
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Elucidation of discontinuous linear determinants in peptides
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JOURNAL OF IMMUNOLOGY
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Identification of a site in the α chain of platelet glycoprotein Ib that participates in von Willebrand factor binding
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JOURNAL OF BIOLOGICAL CHEMISTRY
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A murine monoclonal anti-factor VIII inhibitory antibody and two human factor VIII inhibitors bind to different areas within a twenty amino acid segment of the acidic region of factor VIII heavy chain.
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A synthetic factor VIII peptide of eight amino acid residues (1677-1684) contains the binding region of an anti-factor VIII antibody which inhibits the binding of factor VIII to von Willebrand factor
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1990
An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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An evaluation of the advantages and effectiveness of picric acid monitoring during solid phase peptide synthesis.
1990
Characterization of a helper T cell epitope recognized by mice of a low responder major histocompatibility type
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MOLECULAR IMMUNOLOGY
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Peptide immunization can elicit malaria protein-specific memory helper but not proliferative T cells.
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Structural requirements for class i mhc molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein
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JOURNAL OF EXPERIMENTAL MEDICINE
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Degradation of [
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EUROPEAN JOURNAL OF PHARMACOLOGY
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Identification of an epitope in the major envelope protein of Epstein-Barr virus that mediates viral binding to the B lymphocyte EBV receptor (CR2)
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A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160
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SCIENCE
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Analysis of a subclass-restricted HIV-1 gp41 epitope by omission Peptides
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Determination of antigenic binding sites in antibodies directed against a mycobacterial peptide by deletion and substitution of single amino acids.
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Distinction between immunogenicity and tolerogenicity among HBcAg T cell determinants. Influence of peptide-MHC interaction
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JOURNAL OF IMMUNOLOGY
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Elucidation of a Protease-Sensitive Site Involved in the Binding of Calcium to C-Reactive Protein
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Functional identification of agretopic and epitopic residues within an HBcAg T cell determinant
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JOURNAL OF IMMUNOLOGY
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Immunochemistry of the dominating antigenic region Ala
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JOURNAL OF IMMUNOLOGY
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Induction of human B cell differentiation by Fc region activators. I. Identification of an active tetrapeptide
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RGDV peptide selectively inhibits platelet-dependent thrombus formation in vivo. Studies using a baboon model
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1989
T and B cell responses of Plasmodium falciparum malaria-immune individuals to synthetic peptides corresponding to sequences in different regions of the P. falciparum antigen Pf155/RESA
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T cell multideterminant regions in the human immunodeficiency virus envelope: Toward overcoming the problem of major histocompatibility complex restriction
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The Chemistry of Site-Directed Serology for HIV Infections
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Human and murine CD4 T cell epitopes map to the same region of the malaria circumsporozoite protein: limited immunogenicity of sporozoites and circumsporozoite protein
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Structure of the von Willebrand factor domain interacting with glycoprotein Ib
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Folding of immunogenic peptide fragments of proteins in water solution. I. Sequence requirements for the formation of a reverse turn
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Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix
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An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility comples molecule-restricted murine cytotoxic T lymphocytes
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An immunogenic region within residues Val
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Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum
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Epitopes of the Mycobacterium tuberculosis 65-kilodalton protein antigen as recognized by human T cells
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Generation and characterization of peptide-specific antibodies that inhibit Von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro
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1
7
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JOURNAL OF BIOLOGICAL CHEMISTRY
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Generation of rabbit antipeptide antibodies to HLA-class II antigens by the use of synthetic peptides
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Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: Immunodominant T-cell domains map to the polymorphic regions of the molecule
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Localization of the binding regions of a murine monoclonal anti-factor VIII antibody and a human anti-factor VIII alloantibody, both of which inhibit factor VIII procoagulant activity, to amino acid residues Threonine
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Localization of the binding site for a factor VIII activity neutralizing antibody to amino acid residues Asp
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Mapping of functional and antigenic domains of the α4 protein of herpes simplex virus 1
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1988
Opiate binding in calf thalamic membranes: A selective μ
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1988
The Magainins: sequence factors relevant to increased antimicrobial activity and decreased hemolytic activity.
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ChemInform Abstract: Simultaneous Multiple Peptide Synthesis: The Rapid Preparation of Large Numbers of Discrete Peptides for Biological, Immunological, and Methodological Studies
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Recognition of HLA class II molecules by antipeptide antibodies elicited by synthetic peptides selected from regions of HLA-DP antigens
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Inhibition of platelet function with synthetic peptides designed to be high-affinity antagonists of fibrinogen binding to platelets
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The genome-linked proteins of aphthoviruses: Specific immunoprecipitation of the three species detected on virus RNA and identification of possible precursors
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Use of 10% sulfuric acid/dioxane for removal of N‐α‐tertiary‐butyloxycarbonyl group during solid phase peptide synthesis
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Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides
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Human major histocompatibility complex class I antigens: Residues 61-83 of the HLA-B7 heavy chain specify an alloreactive site
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Chemical synthesis of an octadecapeptide with the biological and immunological properties of human heat‐stable Escherichia coli enterotoxin
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Reduction of Sulfoxides in Peptides and Proteins
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Synthetic idiotypes: The third hypervariable region of murine anti-dextran antibodies
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ISOLATION OF α‐MELANOTROPIN AND N, O‐DIACETYLSERINE
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HUMAN β‐ENDORPHIN: SYNTHESIS AND CHARACTERIZATION OF ANALOGS IODINATED AND TRITIATED AT TRYOSINE RESIDUES 1 AND 27
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ISOLATION AND PROPERTIES OF TWO FRAGMENTS FROM PLASMIN DIGESTS OF HUMAN CHORIOMAMMOTROPIN
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PREPARATION AND PROPERTIES OF TRITIATED HUMANβ‐ENDORPHIN WITH HIGH SPECIFIC RADIOACTIVITY
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REACTION OF OVINE PROLACTIN WITH 2‐(2‐NITROPHENYLSULFENYL)‐3‐METHYL‐3‘‐BROMOINDOLEMINE*
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SELECTIVE CLEAVAGE AT THE SINGLE TRYPTOPHAN RESIDUE IN BOVINE SOMATOTROPIN BY 2‐(2‐NITROPHENYLSULFENYL)‐3‐METHYL‐3‘‐BROMOINDOLEMINE
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Human somatotropin. Reaction with hydrogen peroxide
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Reaction of Human Choriomammotropin with Hydrogen Peroxide
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CHAPTER 208 Mixture-Based Combinatorial Libraries
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From Tens to Trillions - Advances in Synthetic Combinatorial Chemistry of Peptides, Peptidomimetics and Heterocyclic Compounds Derived from Peptides
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Novel D-amino acid hexapeptide calmodulin antagonists identified from synthetic combinatorial libraries
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Identification of Novel Ligands for Vasopressin V2 Receptor from Positional Scanning Libraries
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