Houghten, Richard
- Research Professor, Center for Translational Science , Office of Research and Economic Development
Scholarly & Creative Works
Patents issued
selected scholarly works & creative activities
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Article
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2021Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist. JOURNAL OF MEDICINAL CHEMISTRY. 64:14860-14875.Full Text via DOI: 10.1021/acs.jmedchem.1c01417 Web of Science: 000709633100049
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2021Novel Cyclic Lipopeptides Fusaricidin Analogs for Treating Wound InfectionsFull Text via DOI: 10.3389/fmicb.2021.708904
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2021Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. JOURNAL OF MEDICINAL CHEMISTRY. 64:5577-5592.Full Text via DOI: 10.1021/acs.jmedchem.0c02041 Web of Science: 000651785800020
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2019Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μm MC4R Partial Agonist. JOURNAL OF MEDICINAL CHEMISTRY. 62:2738-2749.Full Text via DOI: 10.1021/acs.jmedchem.9b00053
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2019A novel probe for spliceosomal proteins that induces autophagy and death of melanoma cells reveals new targets for melanoma drug discovery. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 53:656-686.Full Text via DOI: 10.33594/000000164
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2018Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency. ACS MEDICINAL CHEMISTRY LETTERS. 9:1057-1062.Full Text via DOI: 10.1021/acsmedchemlett.8b00425 Web of Science: 000447471800021
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2017Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats. JOURNAL OF MEDICINAL CHEMISTRY. 60:10092-10104.Full Text via DOI: 10.1021/acs.jmedchem.7b01250
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2017Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH
2 . JOURNAL OF MEDICINAL CHEMISTRY. 60:4342-4357.Full Text via DOI: 10.1021/acs.jmedchem.7b00301 -
2017A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation. ORGANIC & BIOMOLECULAR CHEMISTRY. 15:7796-7801.Full Text via DOI: 10.1039/c7ob01924f
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2016Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 60:4028-4036.Full Text via DOI: 10.1128/AAC.00288-16 Web of Science: 000378094400020
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2016Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[ d -Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation. JOURNAL OF MEDICINAL CHEMISTRY. 59:1239-1245.Full Text via DOI: 10.1021/acs.jmedchem.5b01899
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2016Identification of 5,6-dihydroimidazo[2,1-b]thiazoles as a new class of antimicrobial agents. BIOORGANIC & MEDICINAL CHEMISTRY. 24:5633-5638.Full Text via DOI: 10.1016/j.bmc.2016.09.027
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2015Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT). CHEMICAL RESEARCH IN TOXICOLOGY. 28:2419-2425.Full Text via DOI: 10.1021/acs.chemrestox.5b00432 Web of Science: 000367118000019
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2015SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. JOURNAL OF MEDICINAL CHEMISTRY. 58:5808-5824.Full Text via DOI: 10.1021/acs.jmedchem.5b00354
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2015Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at mu (MOR), delta (DOR), and kappa (KOR) Opioid Receptors. JOURNAL OF MEDICINAL CHEMISTRY. 58:4905-4917.Full Text via DOI: 10.1021/jm501637c Web of Science: 000357139000005
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2015Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens. JOURNAL OF MEDICINAL CHEMISTRY. 58:3340-3355.Full Text via DOI: 10.1021/jm501628s Web of Science: 000353602200006
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2015Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 92:270-281.Full Text via DOI: 10.1016/j.ejmech.2014.12.049
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2014Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs). JOURNAL OF MEDICINAL CHEMISTRY. 57:4615-4628.Full Text via DOI: 10.1021/jm500064t
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2014Discovery of a potent and selective α3β4 nicotinic acetylcholine receptor antagonist from an α-conotoxin synthetic combinatorial library. JOURNAL OF MEDICINAL CHEMISTRY. 57:3511-3521.Full Text via DOI: 10.1021/jm500183r
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2014Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition. ANALYTICAL BIOCHEMISTRY. 449:68-75.Full Text via DOI: 10.1016/j.ab.2013.12.018
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2014Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis. JOURNAL OF MEDICINAL CHEMISTRY. 57:1599-1608.Full Text via DOI: 10.1021/jm4019542
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2013Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies. JOURNAL OF MEDICINAL CHEMISTRY. 56:10103-10117.Full Text via DOI: 10.1021/jm401543h Web of Science: 000329331600020
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2013Dissociation of antimicrobial and hemolytic activities of gramicidin S through N-methylation modification. CHEMMEDCHEM. 8:1865-1872.Full Text via DOI: 10.1002/cmdc.201300232
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2013Conditional probabilistic analysis for prediction of the activity landscape and relative compound activities. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 53:2613-2625.Full Text via DOI: 10.1021/ci400243e
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2013Libraries from libraries: A series of sulfonamide linked heterocycles derived from the same scaffold. TETRAHEDRON LETTERS. 54:4296-4299.Full Text via DOI: 10.1016/j.tetlet.2013.06.003
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2013Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:22871-22879.Full Text via DOI: 10.1074/jbc.M113.462267
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2013Parallel synthesis of 1,6-disubstituted-1,2,4-triazin-3-ones on solid-phaseFull Text via DOI: 10.1021/co400064d
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2013Rapid scanning structure-activity relationships in combinatorial data sets: Identification of activity switches. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 53:1475-1485.Full Text via DOI: 10.1021/ci400192y
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2013The role of imidazole in peptide cyclization by transesterification: Parallels to the catalytic triads of serine proteases. ORGANIC & BIOMOLECULAR CHEMISTRY. 11:2979-2987.Full Text via DOI: 10.1039/c3ob27464k
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2013A traceless approach to amide and peptide construction from thioacids and dithiocarbamate-terminal amines. CHEMICAL SCIENCE. 4:970-976.Full Text via DOI: 10.1039/c2sc21317f
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2013HTS by NMR of combinatorial libraries: A fragment-based approach to ligand discovery. CHEMISTRY & BIOLOGY. 20:19-33.Full Text via DOI: 10.1016/j.chembiol.2012.10.015
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2013Ligand/kappa-opioid receptor interactions: Insights from the X-ray crystal structure. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 66:114-121.Full Text via DOI: 10.1016/j.ejmech.2013.05.021
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2012The multi-leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells. JOURNAL OF MEDICINAL CHEMISTRY. 55:10501-10511.Full Text via DOI: 10.1021/jm3011178
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2012Fluorescent Mu selective opioid ligands from a mixture based cyclic peptide libraryFull Text via DOI: 10.1021/co300110t
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2012Palladium-catalyzed C-H functionalization using guanidine as a directing group: Ortho arylation and olefination of arylguanidines. ORGANIC LETTERS. 14:5452-5455.Full Text via DOI: 10.1021/ol302533w
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2012Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:36473-36487.Full Text via DOI: 10.1074/jbc.M112.389114
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2011Multitarget structure-activity relationships characterized by activity-difference maps and consensus similarity measure. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 51:2427-2439.Full Text via DOI: 10.1021/ci200281v
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2011Solid-phase synthesis of 2,3,5,6-tetrahydro-1H-imidazo[1,2-a]benzo[d]- [1,3]diazepines via Pd(OAc)
2 /Cu(OAc)2 -cocatalyzed cyclization. SYNLETT. 2259-2261.Full Text via DOI: 10.1055/s-0030-1261186 -
2011Solid-phase synthesis of 2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine derivatives. TETRAHEDRON LETTERS. 52:4112-4113.Full Text via DOI: 10.1016/j.tetlet.2011.05.138
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2011Integrating Virtual Screening and Combinatorial Chemistry for Accelerated Drug DiscoveryFull Text via DOI: 10.2174/138620711795767866 Web of Science: 000292772100004
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2011Integrating computational and mixture-based screening of combinatorial libraries. JOURNAL OF MOLECULAR MODELING. 17:1473-1482.Full Text via DOI: 10.1007/s00894-010-0850-1 Web of Science: 000291041800025
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2011Solid-phase synthesis of N-substituted 3,4-dihydroquinazolinone derivatives. TETRAHEDRON LETTERS. 52:2627-2628.Full Text via DOI: 10.1016/j.tetlet.2011.03.034
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2011Increased Diversity of Libraries from Libraries: Chemoinformatic Analysis of Bis-Diazacyclic LibrariesFull Text via DOI: 10.1111/j.1747-0285.2011.01100.x Web of Science: 000289474100004
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2011Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization. TETRAHEDRON LETTERS. 52:1456-1458.Full Text via DOI: 10.1016/j.tetlet.2011.01.055
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2011High throughput synthesis of 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b] thiazole derivatives. TETRAHEDRON LETTERS. 52:696-698.Full Text via DOI: 10.1016/j.tetlet.2010.12.006
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2010A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a 'volatilizable' support. TETRAHEDRON LETTERS. 51:5637-5639.Full Text via DOI: 10.1016/j.tetlet.2010.08.026
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2010ChemInform Abstract: Utility of Soluble Peptide Combinatorial LibrariesFull Text via DOI: 10.1002/chin.199543292
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2010ChemInform Abstract: Mixture‐Based Synthetic Combinatorial LibrariesFull Text via DOI: 10.1002/chin.199949239
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2010ChemInform Abstract: Manual Multiple Synthesis MethodsFull Text via DOI: 10.1002/chin.200045266
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2010Macrolactonization of peptide thioesters catalyzed by imidazole and its application in the synthesis of kahalalide B and analogues. ORGANIC LETTERS. 12:2250-2253.Full Text via DOI: 10.1021/ol100596p
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2010Conformational landscape of platinum(II)-tetraamine complexes: DFT and NBO studiesFull Text via DOI: 10.1007/s10822-010-9328-6 Web of Science: 000276965100005
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2010A synthetic combinatorial strategy for developing α-conotoxin analogs as potent α
7 nicotinic acetylcholine receptor antagonists. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:1809-1821.Full Text via DOI: 10.1074/jbc.M109.071183 -
2010A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC. BRITISH JOURNAL OF CANCER. 102:97-103.Full Text via DOI: 10.1038/sj.bjc.6605418
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2010Traceless solid-phase synthesis of N-substituted 3,5-bis(substituted-idene) piperidin-4-one derivatives. TETRAHEDRON LETTERS. 51:5003-5004.Full Text via DOI: 10.1016/j.tetlet.2010.07.072
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2009Solid-phase synthesis of 2-alkylidene-6-alkyl-imidazo[2,1-b]thiazole-3,5[2H,6H]-dione derivatives. TETRAHEDRON LETTERS. 50:5857-5859.Full Text via DOI: 10.1016/j.tetlet.2009.08.009
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2009Parallel synthesis of chiral pentaamines and pyrrolidine containing bis-heterocyclic libraries. Multiple scaffolds with multiple building blocks: A double diversity for the identification of new antitubercular compounds. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 19:5169-5175.Full Text via DOI: 10.1016/j.bmcl.2009.07.010 Web of Science: 000268863800063
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2009Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands. BIOORGANIC & MEDICINAL CHEMISTRY. 17:5583-5597.Full Text via DOI: 10.1016/j.bmc.2009.06.026 Web of Science: 000268099700026
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2009Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries Small Molecule Repository. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 49:1010-1024.Full Text via DOI: 10.1021/ci800426u
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2009One-pot high-throughput synthesis of β-turn cyclic peptidomimetics-via "volatilizable" supports. JOURNAL OF ORGANIC CHEMISTRY. 74:2183-2185.Full Text via DOI: 10.1021/jo802583t
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2009Synthetic Small-Molecule Prohormone Convertase 2 InhibitorsFull Text via DOI: 10.1124/mol.108.051334 Web of Science: 000263559500019
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2009Characterization of activity landscapes using 2D and 3D similarity methods: Consensus activity cliffs. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 49:477-491.Full Text via DOI: 10.1021/ci800379q
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2009The pharmacological properties of a novel MCH
1 receptor antagonist isolated from combinatorial libraries. EUROPEAN JOURNAL OF PHARMACOLOGY. 602:194-202.Full Text via DOI: 10.1016/j.ejphar.2008.10.068 -
2009Modeling of peptides containing D-amino acids: Implications on cyclizationFull Text via DOI: 10.1007/s10822-009-9295-y
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2008Solid-phase synthesis of 4,8-disubstituted-8,9-dihydropyrazino[2,3-g]quinazolin-7(6H)-ones. BIOPOLYMERS. 90:439-443.Full Text via DOI: 10.1002/bip.20842
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2008Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis. BIOORGANIC & MEDICINAL CHEMISTRY. 16:5932-5938.Full Text via DOI: 10.1016/j.bmc.2008.04.061
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2008High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on 'volatilizable' supports. TETRAHEDRON LETTERS. 49:3632-3633.Full Text via DOI: 10.1016/j.tetlet.2008.03.156
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2008Novel d-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral κ-opioid receptors,. EUROPEAN JOURNAL OF PHARMACOLOGY. 583:62-72.Full Text via DOI: 10.1016/j.ejphar.2008.01.011
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2008Small-molecule XIAP antagonist restores caspase-9-mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. BLOOD. 111:369-375.Full Text via DOI: 10.1182/blood-2007-04-085480
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2007Solid-phase synthesis of 3-alkyl-8-arylamino-1H-imidazo[4,5-g]quinazolin-2(3H)-thiones and 3-alkyl-8-arylamino-1H-imidazo[4,5-g]quinazolin-2(3H)-ones. TETRAHEDRON LETTERS. 48:7042-7045.Full Text via DOI: 10.1016/j.tetlet.2007.07.134
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2006491 POSTER Trageting XIAP in paediatric cancersFull Text via DOI: 10.1016/s1359-6349(06)70496-7
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2006Synthesis of platinum(II) chiral tetraamine coordination complexesFull Text via DOI: 10.1021/cc060045h Web of Science: 000240403200020
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2006Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: An example of lead optimization using mixture-based libraries. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 16:4331-4338.Full Text via DOI: 10.1016/j.bmcl.2006.05.053 Web of Science: 000239349000035
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2006The central effect of MCH system studied using a specific MCH 1R antagonist isolated from combinatorial libraries. FASEB JOURNAL. 20:a686-a686.Full Text via DOI: 10.1096/fasebj.20.4.a686-a
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2005Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis. BLOOD. 106:1742-1748.Full Text via DOI: 10.1182/blood-2005-02-0695 Web of Science: 000231495000040
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2005"Volatilizable" supports for high-throughput organic synthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 127:8582-8583.Full Text via DOI: 10.1021/ja0402396
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2005Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells. BLOOD. 105:4043-4050.Full Text via DOI: 10.1182/blood-2004-08-3168 Web of Science: 000229009000050
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2004Inhibition of XIAP Renders Newly CD40-Activated Chronic Lymphocytic Leukemia Cells Sensitive to Fas (CD95) Mediated Apoptosis.. BLOOD. 104:3474-3474.Full Text via DOI: 10.1182/blood.v104.11.3474.3474
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2004Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples.. BLOOD. 104:759-759.Full Text via DOI: 10.1182/blood.v104.11.759.759
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2004Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors. JOURNAL OF BIOLOGICAL CHEMISTRY. 279:48168-48176.Full Text via DOI: 10.1074/jbc.M405022200
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2004Solid-phase synthesis of 5-aminotetrazoles. TETRAHEDRON LETTERS. 45:7787-7789.Full Text via DOI: 10.1016/j.tetlet.2004.07.160
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2004Inhibition of furin by polyarginine-containing peptides: Nanomolar inhibition by nona-D-arginine. JOURNAL OF BIOLOGICAL CHEMISTRY. 279:36788-36794.Full Text via DOI: 10.1074/jbc.M400484200
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2004Combinatorial chemistry: Libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds. JOURNAL OF ORGANIC CHEMISTRY. 69:3603-3609.Full Text via DOI: 10.1021/jo040114j Web of Science: 000221624900001
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2004De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 14:1947-1951.Full Text via DOI: 10.1016/j.bmcl.2004.01.090
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2004Peptidic complex mixtures as therapeutic agents in CNS autoimmunity. MOLECULAR IMMUNOLOGY. 40:1075-1087.Full Text via DOI: 10.1016/j.molimm.2003.11.006
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2004Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activityFull Text via DOI: 10.1016/S1535-6108(03)00332-5 Web of Science: 000188400300007
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2004Specificity and degeneracy of T cells. MOLECULAR IMMUNOLOGY. 40:1047-1055.Full Text via DOI: 10.1016/j.molimm.2003.11.022
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2003Identification of novel small-molecule Ulex europaeus I mimetics for targeted drug delivery. BIOORGANIC & MEDICINAL CHEMISTRY. 11:4991-4997.Full Text via DOI: 10.1016/j.bmc.2003.09.002
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2003Solid-phase synthesis of 3-amino-1,2,4-triazoles. TETRAHEDRON LETTERS. 44:7841-7843.Full Text via DOI: 10.1016/j.tetlet.2003.08.074
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2003Toward targeted oral vaccine delivery systems: Selection of lectin mimetics from combinatorial libraries. PHARMACEUTICAL RESEARCH. 20:1258-1266.Full Text via DOI: 10.1023/A:1025061317400
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2003Abnormal aza-Wittig reaction on the solid-phase: chemoselectivity studies towards the parallel synthesis of 3-aryl-2,4-dioxo-1,3,5-triazino[1,2-a]benzimidazoles. TETRAHEDRON LETTERS. 44:3705-3708.Full Text via DOI: 10.1016/S0040-4039(03)00633-6 Web of Science: 000182496400027
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2003Solid-phase synthesis of indolines via palladium-catalyzed cyclization. TETRAHEDRON LETTERS. 44:2569-2572.Full Text via DOI: 10.1016/S0040-4039(03)00317-4
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2003The combined solid/solution-phase synthesis of nitrosamines: The evolution of the "libraries from libraries" concept. JOURNAL OF ORGANIC CHEMISTRY. 68:183-186.Full Text via DOI: 10.1021/jo0204909
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2002Positional scanning-synthetic peptide library-based analysis of self- and pathogen-derived peptide cross-reactivity with tumor-reactive Melan-A-specific CTL. JOURNAL OF IMMUNOLOGY. 169:5696-5707.Full Text via DOI: 10.4049/jimmunol.169.10.5696
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2002Opioid activity of 4-imidazolidinone positional analogues of Leu-enkephalin. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 12:3175-3178.Full Text via DOI: 10.1016/S0960-894X(02)00678-9 Web of Science: 000178693100034
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2002Parallel solid-phase synthesis of disubstituted 1,6-piperazine-2-onesFull Text via DOI: 10.1021/cc0200235 Web of Science: 000179254700002
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2002Determination of isokinetic ratios necessary for equimolar incorporation of carboxylic acids in the solid-phase synthesis of mixture-based combinatorial libraries. BIOPOLYMERS. 65:32-39.Full Text via DOI: 10.1002/bip.10206
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2002A traceless approach for the parallel solid-phase synthesis of 2-(arylamino)quinazolinones. JOURNAL OF ORGANIC CHEMISTRY. 67:5831-5834.Full Text via DOI: 10.1021/jo020236g
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2002Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-A peptide multimer+ CD8+ T cells in humans. JOURNAL OF EXPERIMENTAL MEDICINE. 196:207-216.Full Text via DOI: 10.1084/jem.20020242
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2002Parallel solid-phase synthesis of trisubstituted triazinobenzimidazoledionesFull Text via DOI: 10.1021/cc010089k
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2002An expedient method for the solid-phase synthesis of alpha-aminoalkyl phosphonopeptides. TETRAHEDRON LETTERS. 43:4103-4106.Full Text via DOI: 10.1016/S0040-4039(02)00695-0 Web of Science: 000175894400034
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2002Solid-phase synthesis of 1,5-disubstituted 2-aryliminoimidazolidines. JOURNAL OF ORGANIC CHEMISTRY. 67:3138-3141.Full Text via DOI: 10.1021/jo0109366
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2002Solid-phase synthesis of 1,2,5-trisubstituted 4-imidazolidinonesFull Text via DOI: 10.1021/cc0100565 Web of Science: 000175658100006
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2002Solid-phase parallel synthesis of 2-aminoimidazolidin-4-ones. TETRAHEDRON. 58:3349-3353.Full Text via DOI: 10.1016/S0040-4020(02)00299-5
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2002An efficient approach for solid-phase synthesis of peptidomimetics based on 4-imidazolidinones. TETRAHEDRON LETTERS. 43:2343-2346.Full Text via DOI: 10.1016/S0040-4039(02)00263-0 Web of Science: 000174765600006
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2002Solid-phase parallel synthesis of substituted dihydroimidazolyl dihydrobenzimidazol-2-ones. TETRAHEDRON. 58:2095-2100.Full Text via DOI: 10.1016/S0040-4020(02)00104-7
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2002Solid-phase synthesis of linear ureas tethered to hydantoins and thiohydantoinsFull Text via DOI: 10.1021/cc010064l Web of Science: 000174633500013
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2002Solid-phase parallel synthesis of substituted dihydroimidazolylbutyl dihydroimidazol-3-ium salts. TETRAHEDRON LETTERS. 43:1157-1160.Full Text via DOI: 10.1016/S0040-4039(01)02385-1
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2002Solid-phase parallel synthesis of trisubstituted dihydroimidazolyl dihydroquinoxalin-2(1H)-ones. TETRAHEDRON. 58:221-225.Full Text via DOI: 10.1016/S0040-4020(01)01155-3
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2001A novel approach for solid-phase synthesis of substituted imidazolines and bis-imidazolines. JOURNAL OF ORGANIC CHEMISTRY. 66:8673-8676.Full Text via DOI: 10.1021/jo010814d
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2001Solid-phase synthesis of bis-cyclic guanidines from tripeptides. TETRAHEDRON. 57:9911-9914.Full Text via DOI: 10.1016/S0040-4020(01)01010-9
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2001Solid-phase synthesis of alpha,alpha-difluoro-beta-amino acids via the Reformatsky reaction. JOURNAL OF ORGANIC CHEMISTRY. 66:8268-8272.Full Text via DOI: 10.1021/jo010872z Web of Science: 000172489500053
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2001Solid-phase synthesis of 2,3,5-trisubstituted 4H-imidazolonesFull Text via DOI: 10.1021/cc010022x
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2001Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones. ORGANIC LETTERS. 3:2797-2799.Full Text via DOI: 10.1021/ol010102+
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2001Parallel synthesis of 4,5-dihydro-1H-1,4-benzodiazepine-2,3-diones. TETRAHEDRON LETTERS. 42:5141-5143.Full Text via DOI: 10.1016/S0040-4039(01)00939-X Web of Science: 000170062400003
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2001
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2001Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries. BLOOD. 97:1776-1786.Full Text via DOI: 10.1182/blood.V97.6.1776
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2001An N-methyl-D-aspartate receptor channel blocker with neuroprotective activity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 98:3519-3524.Full Text via DOI: 10.1073/pnas.061449498
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2001Tethered libraries: Solid-phase synthesis of substituted urea-linked bicyclic guanidinesFull Text via DOI: 10.1021/cc0000803 Web of Science: 000169606600009
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2001Solid phase synthesis of [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-ones. TETRAHEDRON LETTERS. 42:623-625.Full Text via DOI: 10.1016/S0040-4039(00)02022-0
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2001Solid phase synthesis of mixture-based acyclic and heterocyclic small molecule combinatorial libraries from resin-bound polyamides. BIOPOLYMERS. 60:212-219.Full Text via DOI: 10.1002/1097-0282(2001)60:3<212::AID-BIP10033>3.0.CO;2-D Web of Science: 000173078000005
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2001Solid-phase synthesis of bis-heterocyclic compounds from resin-bound orthogonally protected lysineFull Text via DOI: 10.1021/cc000061t Web of Science: 000167935000010
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2000Polyarginines are potent furin inhibitors. JOURNAL OF BIOLOGICAL CHEMISTRY. 275:36741-36749.Full Text via DOI: 10.1074/jbc.M003848200
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2000Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides. ORGANIC LETTERS. 2:3349-3350.Full Text via DOI: 10.1021/ol000225e Web of Science: 000089831900026
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2000An efficient two-step synthesis of mono-, di- and triureas from resin-bound amides. TETRAHEDRON LETTERS. 41:5441-5446.Full Text via DOI: 10.1016/S0040-4039(00)00845-5 Web of Science: 000088200200003
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2000Solid-phase synthesis of substituted 2,3-diketopiperazines from reduced polyamides. TETRAHEDRON. 56:3319-3326.Full Text via DOI: 10.1016/S0040-4020(00)00253-2 Web of Science: 000087032100006
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2000Solid-phase synthesis of branched thiohydantoin benzimidazolinethiones and branched thiohydantoin tetrahydroquinoxalinediones. TETRAHEDRON LETTERS. 41:2283-2287.Full Text via DOI: 10.1016/S0040-4039(00)00162-3 Web of Science: 000086681100004
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2000Solid phase synthesis of styrylquinazolinones. TETRAHEDRON LETTERS. 41:2051-2054.Full Text via DOI: 10.1016/S0040-4039(00)00112-X
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2000Solid phase synthesis of 1-substituted pyroglutamates. TETRAHEDRON LETTERS. 41:851-854.Full Text via DOI: 10.1016/S0040-4039(99)02208-X Web of Science: 000085305600017
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2000Solid phase synthesis of 1,3-disubstituted succinimides. TETRAHEDRON LETTERS. 41:609-612.Full Text via DOI: 10.1016/S0040-4039(99)02166-8 Web of Science: 000085038700008
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2000Contribution of individual amino acids within MHC molecule or antigenic peptide to TCR ligand potency. JOURNAL OF IMMUNOLOGY. 164:861-871.Full Text via DOI: 10.4049/jimmunol.164.2.861
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2000Inhibition of β-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library. JOURNAL OF STRUCTURAL BIOLOGY. 130:247-258.Full Text via DOI: 10.1006/jsbi.2000.4245
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2000Orphanin FQ/Nociceptin receptor binding studies. PEPTIDES. 21:949-960.Full Text via DOI: 10.1016/S0196-9781(00)00231-X
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1999Immunogenicity. I. Use of peptide libraries to identify epitopes that activate clonotypic CD4+ T cells and induce T cell responses to native peptide ligands. JOURNAL OF IMMUNOLOGY. 163:6424-6434.
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1999Solid phase synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids. TETRAHEDRON LETTERS. 40:8539-8542.Full Text via DOI: 10.1016/S0040-4039(99)01823-7 Web of Science: 000083665600010
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1999New opioid peptides, peptidomimetics, and heterocyclic compounds from combinatorial libraries. BIOPOLYMERS. 51:379-390.Full Text via DOI: 10.1002/(SICI)1097-0282(1999)51:6<379::AID-BIP2>3.0.CO;2-E
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1999Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives. TETRAHEDRON LETTERS. 40:4939-4942.Full Text via DOI: 10.1016/S0040-4039(99)00964-8 Web of Science: 000081122400006
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1999Solid-Phase Synthesis of trisubstituted 2-imidazolidones and 2-imidazolidinethionesFull Text via DOI: 10.1021/cc980019m Web of Science: 000081948200005
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1999Parallel solid phase synthesis of tetrasubstituted diethylenetriamines via selective amide alklylation and exhaustive reduction of N-acylated dipeptides. TETRAHEDRON. 55:335-344.Full Text via DOI: 10.1016/S0040-4020(98)01043-6 Web of Science: 000077791900003
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1999Mixture-based heterocyclic combinatorial positional scanning libraries: Discovery of bicyclic guanidines having potent antifungal activities against Candida albicans and Cryptococcus neoformans. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 43:106-114.Full Text via DOI: 10.1128/aac.43.1.106
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1998Efficient solid phase synthesis of 3,5-disubstituted hydantoins. TETRAHEDRON LETTERS. 39:8199-8202.Full Text via DOI: 10.1016/S0040-4039(98)01874-7 Web of Science: 000076524100004
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1998Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library. JOURNAL OF BIOLOGICAL CHEMISTRY. 273:26589-26595.Full Text via DOI: 10.1074/jbc.273.41.26589
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1998Combinatorial chemistry: From peptides and peptidomimetics to small organic and heterocyclic compounds. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 8:2273-2278.Full Text via DOI: 10.1016/S0960-894X(98)00412-0 Web of Science: 000075976300002
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1998From specificity to degeneracy to molecular mimicry: Antigen recognition of human autoreactive and pathogen-specific CD4+ T cells. JOURNAL OF NEUROIMMUNOLOGY. 90:34.Full Text via DOI: 10.1016/s0165-5728(98)91382-0
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1998Selective ligands for the μ, δ, and κ opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library. JOURNAL OF BIOLOGICAL CHEMISTRY. 273:18848-18856.Full Text via DOI: 10.1074/jbc.273.30.18848
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1998Solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones. TETRAHEDRON LETTERS. 39:3671-3674.Full Text via DOI: 10.1016/S0040-4039(98)00645-5 Web of Science: 000073724300014
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1998Cutting edge: Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology. JOURNAL OF IMMUNOLOGY. 160:3631-3636.
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1998Selected peptides targeted to the NMDA receptor channel protect neurons from excitotoxic death. NATURE BIOTECHNOLOGY. 16:286-291.Full Text via DOI: 10.1038/nbt0398-286
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1998Activation of human class-II restricted T cell clones by short peptides. FASEB JOURNAL. 12.
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1998
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1998Mapping the prion protein using recombinant antibodiesFull Text via DOI: 10.1128/jvi.72.11.9413-9418.1998
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1997Synthesis of cyclic disulfide peptides: Comparison of oxidation methods. PROTEIN AND PEPTIDE LETTERS. 4:157-164.
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1997Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 283:735-741.
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1997A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform. JOURNAL OF MOLECULAR BIOLOGY. 273:614-622.Full Text via DOI: 10.1006/jmbi.1997.1328
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1997Immune activation in cervical neoplasia: Cross-sectional association between plasma soluble interleukin 2 receptor levels and disease. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 6:807-813.
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1997Solid phase synthesis of 1,3,4,7-tetrasubstituted perhydro-1,4-diazepine-2,5-diones. TETRAHEDRON LETTERS. 38:4943-4946.Full Text via DOI: 10.1016/S0040-4039(97)01086-1 Web of Science: A1997XK06100007
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1997Polyalanine-based peptides as models for self-associated β-pleated- sheet complexes. BIOCHEMISTRY. 36:8393-8400.Full Text via DOI: 10.1021/bi963015b
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1997Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinones via β-lactam intermediates on the solid-phase. TETRAHEDRON LETTERS. 38:3349-3352.Full Text via DOI: 10.1016/S0040-4039(97)00655-2
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1997First Japanese Conference on Combinatorial Chemistry and High Throughput ScreeningFull Text via DOI: 10.1007/bf01715632
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1997Solid phase synthesis of heterocyclic compounds from linear peptides: Cyclic ureas and thioureas. TETRAHEDRON LETTERS. 38:931-934.Full Text via DOI: 10.1016/S0040-4039(96)02516-6 Web of Science: A1997WG34800010
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1997Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes. INFECTION AND IMMUNITY. 65:3430-3437.Full Text via DOI: 10.1128/iai.65.8.3430-3437.1997
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1997Secondary structure induction in aqueous vs membrane-like environments. BIOPOLYMERS. 42:489-498.Full Text via DOI: 10.1002/(sici)1097-0282(19971005)42:4<489::aid-bip11>3.0.co;2-b
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1996Induction of neonatal tolerance by plasmid DNA vaccination of miceFull Text via DOI: 10.1172/JCI119094
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1996Orphanin FQ: Receptor binding and analog structure activity relationships in rat brain. LIFE SCIENCES. 59.Full Text via DOI: 10.1016/0024-3205(96)00261-5
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1996Functionalized protein-like structures from conformationally defined synthetic combinatorial libraries. JOURNAL OF BIOLOGICAL CHEMISTRY. 271:4120-4126.Full Text via DOI: 10.1074/jbc.271.8.4120
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1996Identification of inhibitors of melittin using nonsupport-bound combinatorial libraries. JOURNAL OF BIOLOGICAL CHEMISTRY. 271:4093-4099.Full Text via DOI: 10.1074/jbc.271.8.4093
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1996A study of human T-cell lines generated from multiple sclerosis patients and controls by stimulation with peptides of myelin basic protein. JOURNAL OF NEUROIMMUNOLOGY. 70:65-74.Full Text via DOI: 10.1016/S0165-5728(96)00105-1
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1996Exploring antibody polyspecificity using synthetic combinatorial librariesFull Text via DOI: 10.1007/BF01718697
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1996Inclusion volume solid-phase synthesis. JOURNAL OF PEPTIDE SCIENCE. 2:240-244.Full Text via DOI: 10.1002/psc.310020402
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1996Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial libraries. BIOCHEMICAL JOURNAL. 313:141-147.Full Text via DOI: 10.1042/bj3130141
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1996Structural Characterization and 5′-mononucleotide Binding of Polyalanine β-sheet Complexes. JOURNAL OF MOLECULAR RECOGNITION. 9:488-493.Full Text via DOI: 10.1002/(SICI)1099-1352(199634/12)9:5/6<488::AID-JMR289>3.0.CO;2-F
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1995Inhibition of a plant virus infection by analogs of melittin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 92:12466-12469.Full Text via DOI: 10.1073/pnas.92.26.12466
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1995Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 92:11456-11460.Full Text via DOI: 10.1073/pnas.92.25.11456
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1995Irradiated sporozoite vaccine induces HLA-B8-restricted cytotoxic T lymphocyte responses against two overlapping epitopes of the plasmodiumfalciparum sporozoite surface protein 2. JOURNAL OF EXPERIMENTAL MEDICINE. 182:1435-1445.Full Text via DOI: 10.1084/jem.182.5.1435
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1995Activation of bee venom phospholipase A
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1995
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1995A comparison of combinatorial library approaches for the study of opioid compoundsFull Text via DOI: 10.1007/BF02172068
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1995A review of the utility of soluble peptide combinatorial libraries. BIOPOLYMERS. 37:221-240.Full Text via DOI: 10.1002/bip.360370306
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1995Formation of an extremely stable polyalanine β-sheet macromolecule. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 211:7-13.Full Text via DOI: 10.1006/bbrc.1995.1770
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1995Identification of a nonameric H-2K(k)-restricted CD8+ cytotoxic T lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein. INFECTION AND IMMUNITY. 63:1955-1959.Full Text via DOI: 10.1128/iai.63.5.1955-1959.1995
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1995Induced conformational states of amphipathic peptides in aqueous/lipid environments. BIOPHYSICAL JOURNAL. 68:351-359.Full Text via DOI: 10.1016/S0006-3495(95)80194-3
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1995Peptide binding domains determined through chemical modification of the side-chain functional groups. BIOPHYSICAL JOURNAL. 69:604-611.Full Text via DOI: 10.1016/S0006-3495(95)79934-9
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1995Soluble combinatorial libraries of organic, peptidomimetic and peptide diversities. TRAC-TRENDS IN ANALYTICAL CHEMISTRY. 14:83-92.Full Text via DOI: 10.1016/0165-9936(95)91476-9
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1995The role of amphipathicity in the folding, self-association and biological activity of multiple subunit small proteins. JOURNAL OF BIOLOGICAL CHEMISTRY. 270:1048-1056.Full Text via DOI: 10.1074/jbc.270.3.1048
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1994'Libraries from libraries': Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 91:11138-11142.Full Text via DOI: 10.1073/pnas.91.23.11138
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1994Rapid identification of novel opioid peptides from an N-acetylated synthetic combinatorial library. REGULATORY PEPTIDES. 54:87-88.Full Text via DOI: 10.1016/0167-0115(94)90402-2
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1994Analysis of human T cell clones specific for conserved peptide sequences within malaria proteins: Paucity of clones responsive to intact parasites. JOURNAL OF IMMUNOLOGY. 153:2082-2092.
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1994Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9: Comparison of two different antibodies bound to the same peptide antigen. JOURNAL OF MOLECULAR BIOLOGY. 241:534-556.Full Text via DOI: 10.1006/jmbi.1994.1530
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1994An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library. SCIENCE. 266:2019-2022.Full Text via DOI: 10.1126/science.7801131
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1994Determination of the secondary structure of selected melittin analogues with different haemolytic activities. BIOCHEMICAL JOURNAL. 299:587-591.Full Text via DOI: 10.1042/bj2990587
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1994Identification of antimicrobial peptides by using combinatorial libraries made up of unnatural amino acids. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 38:2280-2286.Full Text via DOI: 10.1128/AAC.38.10.2280
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1994Investigation of antigen-antibody interactions using a soluble, non-support-bound synthetic decapeptide library composed of four trillion (4 x 1012) sequences. BIOCHEMICAL JOURNAL. 301:847-853.Full Text via DOI: 10.1042/bj3010847
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1994Peptide libraries: Determination of relative reaction rates of protected amino acids in competitive couplings. BIOPOLYMERS. 34:1681-1689.Full Text via DOI: 10.1002/bip.360341212
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1994Synthetic compound peptide simulating antigenicity of conformation- dependent autoepitope. JOURNAL OF BIOLOGICAL CHEMISTRY. 269:18529-18534.
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1994Tools of the Trade Combinatorial Libraries: Finding the needle in the haystack. CURRENT BIOLOGY. 4:564-567.Full Text via DOI: 10.1016/S0960-9822(00)00127-5
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1993The broad utility of soluble peptide libraries for drug discovery. GENE. 137:7-11.Full Text via DOI: 10.1016/0378-1119(93)90244-W
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1993Acetalins: Opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 90:10811-10815.Full Text via DOI: 10.1073/pnas.90.22.10811
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1993Influence of tryptophan residues on melittin's hemolytic activityFull Text via DOI: 10.1016/0167-4838(93)90024-L
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1993Analysis of the epitopes of proliferating cell nuclear antigen recognized by monoclonal antibodies. LABORATORY INVESTIGATION. 68:204-210.
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1993Functional importance of amino acid residues making up peptide antigenic determinants. MOLECULAR IMMUNOLOGY. 30:577-585.Full Text via DOI: 10.1016/0161-5890(93)90032-7
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1993Identification of Substrate-Analog Trypsin Inhibitors through the Screening of Synthetic Peptide Combinatorial Libraries. BIOCHEMISTRY. 32:11035-11041.Full Text via DOI: 10.1021/bi00092a013
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1993The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition. JOURNAL OF IMMUNOLOGY. 150:331-341.
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1993The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands. LIFE SCIENCES. 52:1509-1517.Full Text via DOI: 10.1016/0024-3205(93)90113-H
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1993The use of synthetic peptide combinatorial libraries for the determination of peptide ligands in radio-receptor assays: Opioid peptides. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 3:405-412.Full Text via DOI: 10.1016/S0960-894X(01)80222-5
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1992Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries. BIOTECHNIQUES. 13:901-902+904.
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1992Anomalous reversed-phase high-performacne liquid chromatographic behavior of synthetic peptides related to antigenic helper T cell sites. JOURNAL OF CHROMATOGRAPHY. 625:191-198.Full Text via DOI: 10.1016/0021-9673(92)85202-5
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1992Evaluation of peptidepeptide interactions using reversed-phase high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY. 625:199-206.Full Text via DOI: 10.1016/0021-9673(92)85203-6
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1992Conformation and Dynamics of an Fab'-Bound Peptide by Isotope-Edited NMR Spectroscopy. BIOCHEMISTRY. 31:3862-3871.Full Text via DOI: 10.1021/bi00130a018
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1992Design of Model Amphipathic Peptides Having Potent Antimicrobial Activities. BIOCHEMISTRY. 31:12688-12694.Full Text via DOI: 10.1021/bi00165a020
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1992A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei. JOURNAL OF IMMUNOLOGY. 149:2103-2109.
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1992Conserved T and B cell epitopes on the M protein of group A streptococci: Induction of bactericidal antibodies. JOURNAL OF IMMUNOLOGY. 149:2729-2735.
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1992High frequency of malaria‐specific T cells in non‐exposed humansFull Text via DOI: 10.1002/eji.1830220311
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1992Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis. JOURNAL OF IMMUNOLOGY. 148:1835-1840.
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1992Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant. SCIENCE. 255:333-336.Full Text via DOI: 10.1126/science.1372448
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1992Perturbation of peptide conformations induced in anisotropic environments. BIOPOLYMERS. 32:575-583.Full Text via DOI: 10.1002/bip.360320602
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1992Recombinant pseudorabies virus carrying a plasmodium gene: herpesvirus as a new live viral vector for inducing T- and B-cell immunity. VACCINE. 10:578-584.Full Text via DOI: 10.1016/0264-410X(92)90436-N
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1992The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides. BIOTECHNIQUES. 13:412-421.
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1991Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 266:24514-24519.
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1991Autoantibody production in hepatitis B e antigen transgenic mice elicited with a self T-cell peptide and inhibited with nonself peptides. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 88:4348-4352.Full Text via DOI: 10.1073/pnas.88.10.4348
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1991Hemolytic and Antimicrobial Activities of the Twenty-Four Individual Omission Analogues of Melittin. BIOCHEMISTRY. 30:4671-4678.Full Text via DOI: 10.1021/bi00233a006
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1991Development of cross-reactive antibodies to plasminogen during the immune response to dengue virus infection. JOURNAL OF INFECTIOUS DISEASES. 164:294-301.Full Text via DOI: 10.1093/infdis/164.2.294
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1991Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. NATURE. 354:84-86.Full Text via DOI: 10.1038/354084a0
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1991Human cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 88:3300-3304.Full Text via DOI: 10.1073/pnas.88.8.3300
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1991Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans: Correlation with a cytotoxic T cell epitope. JOURNAL OF INFECTIOUS DISEASES. 164:1058-1065.Full Text via DOI: 10.1093/infdis/164.6.1058
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1991The use of synthetic peptides in the formation of biophysically and biologically active pulmonary surfactants. PEDIATRIC RESEARCH. 29:460-465.Full Text via DOI: 10.1203/00006450-199105010-00010
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1990Insights into native epitopes of proliferating cell nuclear antigen using recombinant DNA protein products. JOURNAL OF EXPERIMENTAL MEDICINE. 172:419-429.Full Text via DOI: 10.1084/jem.172.2.419
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1990Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes. JOURNAL OF EXPERIMENTAL MEDICINE. 171:763-773.Full Text via DOI: 10.1084/jem.171.3.763
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1990Identification of a site in the α chain of platelet glycoprotein Ib that participates in von Willebrand factor binding. JOURNAL OF BIOLOGICAL CHEMISTRY. 265:274-280.
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1990A murine monoclonal anti-factor VIII inhibitory antibody and two human factor VIII inhibitors bind to different areas within a twenty amino acid segment of the acidic region of factor VIII heavy chain.. BLOOD COAGULATION & FIBRINOLYSIS. 1:9-15.Full Text via DOI: 10.1097/00001721-199003000-00003
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1990An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 87:2344-2348.Full Text via DOI: 10.1073/pnas.87.6.2344
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1990Characterization of a helper T cell epitope recognized by mice of a low responder major histocompatibility type. MOLECULAR IMMUNOLOGY. 27:941-946.Full Text via DOI: 10.1016/0161-5890(90)90116-H
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1990Elucidation of discontinuous linear determinants in peptides. JOURNAL OF IMMUNOLOGY. 144:976-983.
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1989Structural requirements for class i mhc molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein. JOURNAL OF EXPERIMENTAL MEDICINE. 170:2023-2035.Full Text via DOI: 10.1084/jem.170.6.2023
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1989Degradation of [3H]β-endorphin in rat plasma is increased with chronic stress. EUROPEAN JOURNAL OF PHARMACOLOGY. 167:229-236.Full Text via DOI: 10.1016/0014-2999(89)90583-9
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1989A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160. SCIENCE. 246:118-121.Full Text via DOI: 10.1126/science.2789433
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1989Distinction between immunogenicity and tolerogenicity among HBcAg T cell determinants. Influence of peptide-MHC interaction. JOURNAL OF IMMUNOLOGY. 143:3148-3156.
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1989Elucidation of a Protease-Sensitive Site Involved in the Binding of Calcium to C-Reactive Protein. BIOCHEMISTRY. 28:9840-9848.Full Text via DOI: 10.1021/bi00451a044
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1989Functional identification of agretopic and epitopic residues within an HBcAg T cell determinant. JOURNAL OF IMMUNOLOGY. 143:3141-3147.
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1989Immunochemistry of the dominating antigenic region Ala582 to Cys604 in the transmembranous protein of simian and human immunodeficiency virus. JOURNAL OF IMMUNOLOGY. 143:3602-3608.
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1989The Chemistry of Site-Directed Serology for HIV Infections. AIDS RESEARCH AND HUMAN RETROVIRUSES. 5:487-493.Full Text via DOI: 10.1089/aid.1989.5.487
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1988Structure of the von Willebrand factor domain interacting with glycoprotein Ib. JOURNAL OF BIOLOGICAL CHEMISTRY. 263:17901-17904.
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1988Folding of immunogenic peptide fragments of proteins in water solution. I. Sequence requirements for the formation of a reverse turn. JOURNAL OF MOLECULAR BIOLOGY. 201:161-200.Full Text via DOI: 10.1016/0022-2836(88)90446-9
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1988Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix. JOURNAL OF MOLECULAR BIOLOGY. 201:201-217.Full Text via DOI: 10.1016/0022-2836(88)90447-0
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1988An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility comples molecule-restricted murine cytotoxic T lymphocytes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 85:3105-3109.Full Text via DOI: 10.1073/pnas.85.9.3105
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1988An immunogenic region within residues Val1670-Glu1684 of the factor VIII light chain induces antibodies which inhibit binding of factor VIII to von Willebrand factor. JOURNAL OF BIOLOGICAL CHEMISTRY. 263:5230-5234.
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1988Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum. NATURE. 334:258-260.Full Text via DOI: 10.1038/334258a0
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1988Epitopes of the Mycobacterium tuberculosis 65-kilodalton protein antigen as recognized by human T cells. JOURNAL OF IMMUNOLOGY. 141:2749-2754.
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1988Generation and characterization of peptide-specific antibodies that inhibit Von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro1743 and other amino acid residues adjacent to the sequence Arg1744-Gly17. JOURNAL OF BIOLOGICAL CHEMISTRY. 263:7500-7505.
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1988Generation of rabbit antipeptide antibodies to HLA-class II antigens by the use of synthetic peptides. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 73:76-81.
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1988Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: Immunodominant T-cell domains map to the polymorphic regions of the molecule. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 85:1199-1203.Full Text via DOI: 10.1073/pnas.85.4.1199
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1988Localization of the binding regions of a murine monoclonal anti-factor VIII antibody and a human anti-factor VIII alloantibody, both of which inhibit factor VIII procoagulant activity, to amino acid residues Threonine351-Serine365 of the factor VIII heavy chainFull Text via DOI: 10.1172/JCI113559
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1988Localization of the binding site for a factor VIII activity neutralizing antibody to amino acid residues Asp1663-Ser1669. JOURNAL OF BIOLOGICAL CHEMISTRY. 263:10198-10203.
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1987Identification of a lymphocyte-activating pentapeptide sequence in the Fc region of human IgG1. JOURNAL OF IMMUNOLOGY. 138:2581-2586.
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1987A chemically synthesized peptide with mycobacterial characteristicsFull Text via DOI: 10.1002/jcla.1860010308
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1987Effect of positional environmental domains on the variation of high-performance liquid chromatographic peptide retention coefficients. JOURNAL OF CHROMATOGRAPHY. 386:223-228.Full Text via DOI: 10.1016/S0021-9673(01)94599-6
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1987Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helix.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 84:8568-8572.Full Text via DOI: 10.1073/pnas.84.23.8568
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1987Is automated peptide synthesis slowing the advance of biomedical research?. TRENDS IN BIOTECHNOLOGY. 5:322-324.Full Text via DOI: 10.1016/0167-7799(87)90014-X
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1987Site-directed serology with synthetic peptides representing the large glycoprotein G of respiratory syncytial virus.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 84:6572-6576.Full Text via DOI: 10.1073/pnas.84.18.6572
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1987The degradation of dynorphin A in brain tissue in vivo and in vitro. PEPTIDES. 8:701-707.Full Text via DOI: 10.1016/0196-9781(87)90046-5
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1986Antipeptide Antibodies: Do They Distinguish HLA-Alloantigens?Full Text via DOI: 10.1515/znc-1986-5-627
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1986Specificity of Rabbit Antibodies Elicited by Related Synthetic PeptidesFull Text via DOI: 10.1515/znc-1986-5-620
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1986Enzyme Linked Immunosorbent Assay (ELISA) for β-endorphin and its antibodies. LIFE SCIENCES. 38:1723-1732.Full Text via DOI: 10.1016/0024-3205(86)90122-0
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1986[3H]dynorphin a binding and κ selectivity of prodynorphin peptides in rat, guinea-pig and monkey brain. EUROPEAN JOURNAL OF PHARMACOLOGY. 121:355-365.Full Text via DOI: 10.1016/0014-2999(86)90256-6
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1986IMMUNISATION OF VOLUNTEERS WITH A SYNTHETIC PEPTIDE VACCINE FOR ENTEROTOXIGENIC ESCHERICHIA COLI. LANCET. 327:471-473.Full Text via DOI: 10.1016/S0140-6736(86)92930-2
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1986A chemically synthesized peptide which elicits humoral and cellular immune responses to mycobacterial antigens. INFECTION AND IMMUNITY. 53:560-564.Full Text via DOI: 10.1128/iai.53.3.560-564.1986
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1986Inhibition of platelet function with synthetic peptides designed to be high-affinity antagonists of fibrinogen binding to platelets. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 83:5708-5712.Full Text via DOI: 10.1073/pnas.83.15.5708
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1986Site-directed antisera to the chromophore binding site of phytochrome: Characterization and cross-reactivity. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 248:35-42.Full Text via DOI: 10.1016/0003-9861(86)90398-X
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1985Anti-peptide antibodies detect oncogene-related proteins in urine. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 82:7924-7928.Full Text via DOI: 10.1073/pnas.82.23.7924
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1985The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn. NATURE. 318:480-483.Full Text via DOI: 10.1038/318480a0
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1985Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides. JOURNAL OF EXPERIMENTAL MEDICINE. 162:487-500.Full Text via DOI: 10.1084/jem.162.2.487
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1985Human major histocompatibility complex class I antigens: Residues 61-83 of the HLA-B7 heavy chain specify an alloreactive site. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 82:539-542.Full Text via DOI: 10.1073/pnas.82.2.539
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1985Human immune responses to synthetic peptides from the Epstein-Barr nuclear antigen. JOURNAL OF IMMUNOLOGY. 134:211-216.
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1985Characterization of an epibody: An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF. JOURNAL OF EXPERIMENTAL MEDICINE. 161:323-331.Full Text via DOI: 10.1084/jem.161.2.323
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1985A completely synthetic toxoid vaccine containing Escherichia coli heat-stable toxin and antigenic determinants of the heat-labile toxin B subunit. INFECTION AND IMMUNITY. 48:735-740.Full Text via DOI: 10.1128/iai.48.3.735-740.1985
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1985Affinity purification of β-endorphin-like material from NG108CC15 hybrid cells by means of the monoclonal β-endorphin antibody 3-E7. NEUROCHEMISTRY INTERNATIONAL. 7:247-253.Full Text via DOI: 10.1016/0197-0186(85)90112-3
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1985General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 82:5131-5135.Full Text via DOI: 10.1073/pnas.82.15.5131
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1985Mobility and evolutionary variability factors in protein antigenicity. NATURE. 317:90.Full Text via DOI: 10.1038/317090b0
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1985Mucosal antitoxin response in volunteers to immunization with a synthetic peptide of Escherichia coli heat-stable enterotoxin. INFECTION AND IMMUNITY. 50:328-332.Full Text via DOI: 10.1128/iai.50.1.328-332.1985
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1985Prodynorphin peptide immunocytochemistry in rhesus monkey brain. PEPTIDES. 6:155-166.Full Text via DOI: 10.1016/0196-9781(85)90149-4
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1984T cell responses to cleaved rabies virus glycooprotein and to synthetic peptides. JOURNAL OF IMMUNOLOGY. 133:2748-2752.
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1984The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. NATURE. 312:127-134.Full Text via DOI: 10.1038/312127a0
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1984Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide. JOURNAL OF EXPERIMENTAL MEDICINE. 159:1502-1511.Full Text via DOI: 10.1084/jem.159.5.1502
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1984Binding of [3H]dynorphin a to apparent κ opioid receptors in deep layers of guinea pig cerebral cortex. EUROPEAN JOURNAL OF PHARMACOLOGY. 98:149-150.Full Text via DOI: 10.1016/0014-2999(84)90124-9
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1984Anti-hypervariable region antibody induced by a defined peptide: An approach for studying the structural correlates of idiotypes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 81:1784-1788.Full Text via DOI: 10.1073/pnas.81.6.1784
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1984Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 81:2176-2180.Full Text via DOI: 10.1073/pnas.81.7.2176
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1984Detection of high molecular weight forms of platelet-derived growth factor by sequence-specific antisera. SCIENCE. 226:701-703.Full Text via DOI: 10.1126/science.6494905
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1984Differences in cross-protection in rats immunized with the B subunits of cholera toxin and Escherichia coli heat-labile toxin. INFECTION AND IMMUNITY. 43:811-816.Full Text via DOI: 10.1128/iai.43.3.811-816.1984
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1984Immunologic and functional characterization of anti-HLA-DR rabbit antibodies induced by synthetic peptides. MOLECULAR IMMUNOLOGY. 21:847-852.Full Text via DOI: 10.1016/0161-5890(84)90138-X
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1984Properties of cross-linked toxoid vaccines made with hyperantigenic forms of synthetic Escherichia coli heat-stable toxin. INFECTION AND IMMUNITY. 44:268-273.Full Text via DOI: 10.1128/iai.44.2.268-273.1984
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1984The immune response to Epstein-Barr nuclear antigen: Conformational and structural features of antibody binding to synthetic peptides. MOLECULAR IMMUNOLOGY. 21:1047-1054.Full Text via DOI: 10.1016/0161-5890(84)90114-7
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1984The structure of an antigenic determinant in a proteinFull Text via DOI: 10.1016/0092-8674(84)90412-4
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1984[3H]-β-endorphin binding in rat brain. JOURNAL OF NEUROSCIENCE. 4:2460-2465.Full Text via DOI: 10.1523/jneurosci.04-10-02460.1984
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1983Autoradiography of [3H]β-endorphin binding in brain. BRAIN RESEARCH. 288:334-337.Full Text via DOI: 10.1016/0006-8993(83)90113-0
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1983Chemical basis of antigenic variation in foot-and-mouth disease virus. NATURE. 306:694-697.Full Text via DOI: 10.1038/306694a0
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1983α-Neo-endorphin: Receptor binding properties of the tritiated ligand. LIFE SCIENCES. 33:1811-1820.Full Text via DOI: 10.1016/0024-3205(83)90689-6
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1983[3H]Dynorphin a binds selectively to guinea pig brain. EUROPEAN JOURNAL OF PHARMACOLOGY. 91:327-328.Full Text via DOI: 10.1016/0014-2999(83)90489-2
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1983Synthetic peptides mimic subtype specificity of foot-and-mouth disease virus. FEBS LETTERS. 157:261-264.Full Text via DOI: 10.1016/0014-5793(83)80558-4
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1983Anti-HLA antibodies of predetermined specificity: A chemically synthesized peptide induces antibodies specific for HLA-A,B heavy chain. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 80:255-258.Full Text via DOI: 10.1073/pnas.80.1.255
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1983Antibodies of predetermined specificity detect two retroviral oncogene products and inhibit their kinase activities. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 80:1246-1250.Full Text via DOI: 10.1073/pnas.80.5.1246
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1983Biochemical and pharmacological evidence for opioid receptor multiplicity in the central nervous system. LIFE SCIENCES. 33:167-173.Full Text via DOI: 10.1016/0024-3205(83)90470-8
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1983Enzyme linked immunosorbent assay (ELISA) for β-endorphin and its antibodies. LIFE SCIENCES. 33:129-132.Full Text via DOI: 10.1016/0024-3205(83)90461-7
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1983Generation of protein-reactive antibodies by short peptides is an event of high frequency: Implications for the structural basis of immune recognition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 80:4949-4953.Full Text via DOI: 10.1073/pnas.80.16.4949
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1983Immunological properties of purified Klebsiella pneumoniae heat-stable enterotoxin. INFECTION AND IMMUNITY. 42:838-841.Full Text via DOI: 10.1128/iai.42.2.838-841.1983
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1983Properties of synthetically produced Escherichia coli heat-stable enterotoxin. INFECTION AND IMMUNITY. 39:117-121.Full Text via DOI: 10.1128/iai.39.1.117-121.1983
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1983Protection against human and porcine enterotoxigenic strains of Escherichia coli in rats immunized with a cross-linked toxoid vaccine. INFECTION AND IMMUNITY. 40:924-929.Full Text via DOI: 10.1128/iai.40.3.924-929.1983
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1983Protection in rabbits immunized with a vaccine of Escherichia coli heat-stable toxin cross-linked to the heat-labile toxin B subunit. INFECTION AND IMMUNITY. 40:888-893.Full Text via DOI: 10.1128/iai.40.3.888-893.1983
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1983Reduction of Sulfoxides in Peptides and Proteins. METHODS IN ENZYMOLOGY. 91:549-559.Full Text via DOI: 10.1016/S0076-6879(83)91050-9
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1983Vaccine for enterotoxigenic Escherichia coli based on synthetic heat-stable toxin crossed-linked to the B subunit of heat-labile toxin. JOURNAL OF INFECTIOUS DISEASES. 147:318-326.Full Text via DOI: 10.1093/infdis/147.2.318
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1983[3H] dynorphin binding to guinea pig and rat brain. LIFE SCIENCES. 33:287-290.Full Text via DOI: 10.1016/0024-3205(83)90499-X
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1982Identification of a β-endorphin-like peptide in cultured human placental cells. NATURE. 295:593-595.Full Text via DOI: 10.1038/295593a0
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1982Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. NATURE. 298:30-33.Full Text via DOI: 10.1038/298030a0
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1982Binding of 3H-β-endorphin in rat brain. LIFE SCIENCES. 31:1381-1384.Full Text via DOI: 10.1016/0024-3205(82)90386-1
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1982Tritiated porcine dynorphin (1-17): Synthesis and characterization. LIFE SCIENCES. 31:1805-1808.Full Text via DOI: 10.1016/0024-3205(82)90215-6
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1980β-Endorphin: Stability, clearance behavior, and entry into the central nervous system after intravenous injection of the tritiated peptide in rats and rabbits. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 77:4588-4591.Full Text via DOI: 10.1073/pnas.77.8.4588
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1979Studies on the reaction between human growth hormone and oleic acid using polyacrylamide gel electrophoresis. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 197:163-169.Full Text via DOI: 10.1016/0003-9861(79)90232-7
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1979Reduction of sulfoxides in peptides and proteins. ANALYTICAL BIOCHEMISTRY. 98:36-46.Full Text via DOI: 10.1016/0003-2697(79)90702-4
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1979β-Endorphin: Characteristics of binding sites in the rat brain. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 89:786-792.Full Text via DOI: 10.1016/0006-291X(79)91847-3
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1979Bicyclic Guanidino Ketones. JOURNAL OF ORGANIC CHEMISTRY. 44:4536-4543.Full Text via DOI: 10.1021/jo00393a017
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1979Tritiated β(h)-endorphin: Preparation and clearance rates of radioactivity in rats and rabbits. FEDERATION PROCEEDINGS. 38.
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1978Cyclopeptide Alkaloids. Synthesis of the Ring System and Its Ion Affinity. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 100:8202-8209.Full Text via DOI: 10.1021/ja00494a030
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1977Human somatotropin. Reaction with hydrogen peroxide. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 178:350-355.Full Text via DOI: 10.1016/0003-9861(77)90203-X
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1977Preparative isotachophoresis on polyacrylamide gels: Resolution as a function of time and wattage. ANALYTICAL BIOCHEMISTRY. 77:303-309.Full Text via DOI: 10.1016/0003-2697(77)90319-0
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1977Reaction of Human Choriomammotropin with Hydrogen PeroxideFull Text via DOI: 10.1111/j.1432-1033.1977.tb11649.x
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1976Separation of inorganic isomers by thin-layer chromatography. VI. Isomers of the non-metals boron, phosphorus and silica. JOURNAL OF CHROMATOGRAPHY. 123:448-453.Full Text via DOI: 10.1016/S0021-9673(00)82219-0
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1974Synthesis of Pure p-Chlorophenyl-L-alanine form L-Phenylalanine. JOURNAL OF MEDICINAL CHEMISTRY. 17:556-558.Full Text via DOI: 10.1021/jm00251a025
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Book
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1985
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Book Chapter
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2017Reversed-phase chromatography: The effect of induced conformations on peptide retention. 633-642.Full Text via DOI: 10.1201/9780203751947
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2013Soluble synthetic combinatorial libraries: The use of molecular diversities for drug discovery. 1-26.Full Text via DOI: 10.1515/9783110808902.1
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2011Solid-phase synthesis of heterocycles from peptides and amino acids. 269-318.Full Text via DOI: 10.1002/9781118141649.ch9
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2007The versatility of nonsupport-bound combinatorial libraries. 139-171.Full Text via DOI: 10.1002/9783527614912.ch05
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2006Mixture-Based Combinatorial Libraries. 1487-1494.Full Text via DOI: 10.1016/B978-012369442-3/50211-7
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2006CHAPTER 208 Mixture-Based Combinatorial Libraries. 1487-1494.Full Text via DOI: 10.1016/b978-012369442-3/50211-7
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2002Combinatorial libraries: Equimolar incorporation of benzaldehyde mixtures in reductive alkylation reactions. 57-58.Full Text via DOI: 10.1007/0-306-46862-x_18
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2002Novel D-amino acid hexapeptide calmodulin antagonists identified from synthetic combinatorial libraries. 605-606.Full Text via DOI: 10.1007/0-306-46862-x_263
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2002Synthesis of cyclic ureas and cyclic thioureas from acyl dipeptides. 264-266.Full Text via DOI: 10.1007/0-306-46862-x_109
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2001Identification of Novel Ligands for Vasopressin V2 Receptor from Positional Scanning Libraries. 921-922.Full Text via DOI: 10.1007/978-94-010-0464-0_430
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2001New Antiproliferative Agents from a Peptidomimetic Library. 640-641.Full Text via DOI: 10.1007/978-94-010-0464-0_298
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2001Solid Phase Synthesis of 1,2,4-Triazinan-3-ones. 259-260.Full Text via DOI: 10.1007/978-94-010-0464-0_117
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2001Solid Phase Synthesis of 1,2,5-Substituted Derivatives of 4-Imidazolidinone. 257-258.Full Text via DOI: 10.1007/978-94-010-0464-0_116
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2001Solid-Phase Synthesis of Substituted Dihydroimidazoles and Their Bis Analogs. 255-256.Full Text via DOI: 10.1007/978-94-010-0464-0_115
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2001Solid-Phase Synthesis of α-Difluoro-β-amino Acids by a Reformatsky Reaction. 261-262.Full Text via DOI: 10.1007/978-94-010-0464-0_118
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2000
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2000Solid phase synthesis of heterocyclic combinatorial libraries derived from peptides. 192-197.Web of Science: 000166933900049
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2000Synthetic Combinatorial Libraries: A New Tool for Antimicrobial Agent Discovery. 311-319.Full Text via DOI: 10.1007/978-3-642-60250-4_17
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1999
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1999Preparation of heterocyclic positional scanning combinatorial libraries from peptides. 123-127.Web of Science: 000081131800040
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1998Synthesis and Screening of Positional Scanning Combinatorial Libraries. 13-24.Full Text via DOI: 10.1385/0-89603-392-9:13
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1998Tetrakis(Pyridine)Silver(2+)Peroxydisulfate. 177-181.Full Text via DOI: 10.1002/9780470132630.ch30
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1997Peptidomimetic synthetic combinatorial libraries. 109-125.Full Text via DOI: 10.1016/s1874-5113(97)80006-8
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19961 Soluble Synthetic Combinatorial Libraries: The Use of Molecular Diversities for Drug Discovery. 1-26.Full Text via DOI: 10.1515/9783110808902.1
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1996The design of self-assembling peptide complexes using conformationally defined libraries. 65-71.Full Text via DOI: 10.1016/S1080-8914(96)80010-X
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1996Generation and use of nonsupport-bound peptide and peptidomimetic combinatorial libraries. 220-226.Full Text via DOI: 10.1016/s0076-6879(96)67015-3
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1996The generation of peptide combinatorial libraries using tea-bag synthesis. 835-845.Full Text via DOI: 10.1016/b978-012442710-5.50085-x
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199510 Soluble Chemical Combinatorial Libraries Current Capabilities and Future Possibilities. 395-417.Full Text via DOI: 10.1016/b978-012310920-0/50011-5
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1995Cyclic peptide template synthetic combinatorial libraries. 461-462.Full Text via DOI: 10.1007/978-94-011-1468-4_207
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1995Design of conformationally defined combinatorial libraries. 85-86.Full Text via DOI: 10.1007/978-94-011-1468-4_30
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1995Detailed studies of antibody specificity using synthetic peptide combinatorial libraries. 113-114.Full Text via DOI: 10.1007/978-94-011-1468-4_42
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1995Direct determination of the extent of racemization during post peptide synthesis reactions. 416-417.Full Text via DOI: 10.1007/978-94-011-1468-4_187
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1995Extending the range of molecular diversity through amide alkylation of peptide libraries. 463-464.Full Text via DOI: 10.1007/978-94-011-1468-4_208
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1995Libraries from libraries: The generation of peptidomimetic combinatorial diversities. 459-460.Full Text via DOI: 10.1007/978-94-011-1468-4_206
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1995Polyalkylamine chemical combinatorial libraries. 465-466.Full Text via DOI: 10.1007/978-94-011-1468-4_209
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1995Study of peptide-antibody interactions using a decapeptide positional scanning library. 815-816.Full Text via DOI: 10.1007/978-94-011-1468-4_374
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1994Identification of an antigenic determinant for the surface antigen of hepatitis B virus using peptide libraries. 1016-1017.Full Text via DOI: 10.1007/978-94-011-0683-2_343
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1994New, potent N-acetylated all D-amino acid opioid peptides. 984-985.Full Text via DOI: 10.1007/978-94-011-0683-2_331
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1994Optimal peptide length determination using synthetic peptide combinatorial libraries. 971-974.Full Text via DOI: 10.1007/978-94-011-0683-2_327
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1993A priori determination of peptide ligands for opiate receptors using synthetic peptide combinatorial libraries. 649-650.Full Text via DOI: 10.1007/978-94-011-1470-7_294
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1993Inhibition of melittin’s hemolytic activity using synthetic peptide combinatorial libraries. 761-762.Full Text via DOI: 10.1007/978-94-011-1470-7_349
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1993Positional scanning synthetic peptide combinatorial libraries. 65-66.Full Text via DOI: 10.1007/978-94-011-1470-7_19
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1992Chapter 17. Progress in Antimicrobial Peptides. 159-168.Full Text via DOI: 10.1016/S0065-7743(08)60415-7
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1992Comparison of structural and functional approaches for the study of peptide-mAb interactions. 867-868.Full Text via DOI: 10.1007/978-94-011-2264-1_351
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1992The relationship between potential induced conformation of melittin and its hemolytic activity. 433-434.Full Text via DOI: 10.1007/978-94-011-2264-1_162
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1992The use of a peptide library composed of 34 012 224 hexamers for basic research and drug discovery. 560-561.Full Text via DOI: 10.1007/978-94-011-2264-1_218
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1991Induced conformations of peptides during RPHPLC: Positional dependence of methionine oxidation. 478-480.Full Text via DOI: 10.1007/978-94-011-3034-9_200
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1991The effect of induced conformation on antimicrobial and hemolytic activity of amphipathic peptides. 738-739.Full Text via DOI: 10.1007/978-94-011-3034-9_306
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1987IDENTIFICATION OF FOLDED STRUCTURES IN IMMUNOGENIC PEPTIDES BY 2D NMR SPECTROSCOPY. 477-480.Full Text via DOI: 10.1016/b978-0-08-035588-7.50109-6
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1987Simultaneous Multiple Peptide Synthesis: The Rapid Preparation of Large Numbers of Peptides. 463-470.Full Text via DOI: 10.1007/978-1-4613-1787-6_46
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1985The Antigenic Structure of the Rabies Virus Glycoprotein. 3-12.Full Text via DOI: 10.1007/978-3-642-70060-6_1
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1980CHARACTERIZATION OF A HIGH AFFINITY 3H-βh-ENDORPHIN RECEPTOR IN RAT BRAIN CRUDE SYNAPTOSOMAL FRACTION. 225-228.Full Text via DOI: 10.1016/b978-0-08-025488-3.50061-1
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Conference
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2013TNFα-Based Peptides as Bioprobes for Exosites of ADAM ProteasesFull Text via DOI: 10.17952/23aps.2013.136
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2010Exploring structural scaffolds as a strategy to design selective ligands. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000208164704108
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2006Structure activity relation study of small-molecule antagonists of apoptosis suppressor XIAP. CANCER RESEARCH.Web of Science: 000454606201447
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2004Efficient synthesis of fused tetracyclic benzimidazole systems. 39-40.Web of Science: 000238911100013
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2004Parallel solid-phase synthesis of difluorinated dipeptide analogs. 63-64.Web of Science: 000238911100025
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2003Highly regioselective parallel solid phase synthesis of new tetracyclic 1,3,5-triazino[1,2-A]benzimidazoles. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U306-U306.Web of Science: 000187918001570
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2003
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2003Solid-phase synthesis of alpha,alpha-difluorinated beta-amino acids by Reformatsky reaction. BIOPOLYMERS. 353-353.Web of Science: 000183878800350
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2002Parallel solid phase synthesis of 1,3,5-triazino[1,2-a]benzimidazoles via tandem Aza-Wittig/heterocumulene-mediated annulation.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. B208-B209.Web of Science: 000176296801155
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2002Solid phase synthesis of alpha,alpha-difluoro-beta-amino acid derivatives by Reformatsky reaction.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U556-U556.Web of Science: 000176296703054
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2002Solid phase synthesis of alpha,alpha-difluoro-beta-amino acid derivatives by reformatsky reaction.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. B209-B209.Web of Science: 000176296801157
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1999Synthesis of cyclic ureas and cyclic thioureas from acyl dipeptides. 265-266.Web of Science: 000085202200109
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1987SYNTHETIC PEPTIDE PROBES OF FACTOR VIII IMMUNOLOGY AND FUNCTION. 536-536.Full Text via DOI: 10.1055/s-0038-1644768
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Editorial Material
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Letter
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1998Solid-phase synthesis of trisubstituted bicyclic guanidines via cyclization of reduced N-acylated dipeptides. JOURNAL OF ORGANIC CHEMISTRY. 8622-8623.Full Text via DOI: 10.1021/jo9810617 Web of Science: 000077376200001
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Note
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1985Isolation of populations of antipeptide antibodies directed against different epitopes of the same fragment. 148-150.Full Text via DOI: 10.1515/znc-1985-1-230
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Other Scholarly Work
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2023Erratum: Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput ‘Unbiased’ Screening Campaign (J. Med. Chem. (2021) 64:9 (5577−5592) DOI: 10.1021/acs.jmedchem.0c02041). JOURNAL OF MEDICINAL CHEMISTRY.Full Text via DOI: 10.1021/acs.jmedchem.3c00588
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2004Combinatorial chemistry: Libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds. (vol 69,3603, 2004). JOURNAL OF ORGANIC CHEMISTRY. 5516-5516.Full Text via DOI: 10.1021/jo040002s Web of Science: 000223008100057
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2004
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1999Mixture-based synthetic combinatorial libraries. JOURNAL OF MEDICINAL CHEMISTRY. 3743-3778.Full Text via DOI: 10.1021/jm990174v Web of Science: 000082783200001
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1997Erratum: A study of human T-cell lines generated from multiple sclerosis patients and controls by stimulation with peptides of myelin basic protein (J. Neuroimmunol. 70, 65-74 (1996)). JOURNAL OF NEUROIMMUNOLOGY. 213.Full Text via DOI: 10.1016/S0165-5728(96)00222-6
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1986Opioid peptide immunoreactivity in spinal and trigeminal dorsal horn neurons projecting to the parabrachial nucleus in the rat.. JOURNAL OF NEUROSCIENCE. 1220-1226.Full Text via DOI: 10.1523/jneurosci.06-05-01220.1986
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Preprint
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Proceedings Paper
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1996All D-amino acid hexapeptide inhibitors of melittin's cytolytic activity derived from synthetic combinatorial libraries. JOURNAL OF MOLECULAR RECOGNITION. 163-168.Full Text via DOI: 10.1002/(SICI)1099-1352(199603)9:2<163::AID-JMR255>3.0.CO;2-6
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1996The synthesis of peptidomimetic combinatorial libraries through successive amide alkylations. BIOORGANIC & MEDICINAL CHEMISTRY. 709-715.Full Text via DOI: 10.1016/0968-0896(96)00067-3
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Review
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2020The value of antimicrobial peptides in the age of resistance. e216-e230.Full Text via DOI: 10.1016/S1473-3099(20)30327-3
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2017Mu-Opioid receptor biased ligands: A safer and painless discovery of analgesics?. DRUG DISCOVERY TODAY. 1719-1729.Full Text via DOI: 10.1016/j.drudis.2017.07.002
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2013Shifting from the single to the multitarget paradigm in drug discovery. DRUG DISCOVERY TODAY. 495-501.Full Text via DOI: 10.1016/j.drudis.2013.01.008
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2012Expanding the medicinally relevant chemical space with compound libraries. DRUG DISCOVERY TODAY. 718-726.Full Text via DOI: 10.1016/j.drudis.2012.04.001
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2008Visualization of the chemical space in drug discovery. 322-333.Full Text via DOI: 10.2174/157340908786786010
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2004Improved, high yield synthesis of 3H-quinazolin-4-ones, the key intermediates of recently developed drugs. CURRENT MEDICINAL CHEMISTRY. 2549-2553.Full Text via DOI: 10.2174/0929867043364423
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2003Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries. 118-122.Full Text via DOI: 10.1038/nm0103-118
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2003Mixture-based combinatorial libraries: From peptides and peptidomimetics to small molecule acyclic and heterocyclic compounds. METHODS IN ENZYMOLOGY. 496-517.Web of Science: 000188282700025
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2000Drug discovery and vaccine development using mixture-based synthetic combinatorial libraries. DRUG DISCOVERY TODAY. 276-285.Full Text via DOI: 10.1016/S1359-6446(00)01513-0
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2000Parallel array and mixture-based synthetic combinatorial chemistry: Tools for the next millennium. 273-282.Full Text via DOI: 10.1146/annurev.pharmtox.40.1.273
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1997The current status of heterocyclic combinatorial libraries. CHEMICAL REVIEWS. 449-472.Full Text via DOI: 10.1021/cr960010b Web of Science: A1997WR43100006
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1996Libraries from libraries: Generation and comparison of screening profiles. 41-45.Full Text via DOI: 10.1007/BF01718699
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1996Novel antimicrobial compounds identified using synthetic combinatorial library technology. TRENDS IN BIOTECHNOLOGY. 60-65.Full Text via DOI: 10.1016/0167-7799(96)80922-X
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1995Peptide, peptidomimetic, and organic synthetic combinatorial libraries. 481-496.Full Text via DOI: 10.1002/med.2610150603
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1995Generation and utilization of synthetic combinatorial libraries. 174-180.Full Text via DOI: 10.1016/S1357-4310(95)91867-1
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Research
principal investigator on
- FIU Drug Discovery Project awarded by Alzheimer's and Aging Research Center 2021 - 2023
- A High-Throughput Chemical Screen to Identify Inhibitors of the Fungal Azole Transporter Cdr1p awarded by Allergy and Infectious Diseases 2020 - 2021
Contact
full name
- Richard Houghten
