FIU Discovery

The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands

Identification of B Cell and T Cell Epitopes Using Synthetic Peptide Combinatorial Libraries

Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist.  JOURNAL OF MEDICINAL CHEMISTRY.  64:14860-14875.

Novel Cyclic Lipopeptides Fusaricidin Analogs for Treating Wound Infections

Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.  JOURNAL OF MEDICINAL CHEMISTRY.  64:5577-5592.

Peripheral kappa opioid receptor activation drives cold hypersensitivity in mice

A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A

A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation

Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μm MC4R Partial Agonist.  JOURNAL OF MEDICINAL CHEMISTRY.  62:2738-2749.

A novel probe for spliceosomal proteins that induces autophagy and death of melanoma cells reveals new targets for melanoma drug discovery.  CELLULAR PHYSIOLOGY AND BIOCHEMISTRY.  53:656-686.

Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency.  ACS MEDICINAL CHEMISTRY LETTERS.  9:1057-1062.

Identification of a novel polyamine scaffold with potent efflux pump inhibition activity toward multi-drug resistant bacterial pathogens

Exploring the chemical space of peptides for drug discovery: a focus on linear and cyclic penta-peptides

Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats.  JOURNAL OF MEDICINAL CHEMISTRY.  60:10092-10104.

Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries

Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa¹-Arg-(pI)DPhe-Xaa⁴-NH2.  JOURNAL OF MEDICINAL CHEMISTRY.  60:4342-4357.

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation.  ORGANIC & BIOMOLECULAR CHEMISTRY.  15:7796-7801.

Characterization of potent SMAC mimetics that sensitize cancer cells to TNF family-induced apoptosis

Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents.  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY.  60:4028-4036.

Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[ d -Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.  JOURNAL OF MEDICINAL CHEMISTRY.  59:1239-1245.

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines

Identification of 5,6-dihydroimidazo[2,1-b]thiazoles as a new class of antimicrobial agents.  BIOORGANIC & MEDICINAL CHEMISTRY.  24:5633-5638.

Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT).  CHEMICAL RESEARCH IN TOXICOLOGY.  28:2419-2425.

SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.  JOURNAL OF MEDICINAL CHEMISTRY.  58:5808-5824.

Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.  JOURNAL OF MEDICINAL CHEMISTRY.  58:4905-4917.

Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens.  JOURNAL OF MEDICINAL CHEMISTRY.  58:3340-3355.

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.  92:270-281.

Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs).  JOURNAL OF MEDICINAL CHEMISTRY.  57:4615-4628.

Discovery of a potent and selective α3β4 nicotinic acetylcholine receptor antagonist from an α-conotoxin synthetic combinatorial library.  JOURNAL OF MEDICINAL CHEMISTRY.  57:3511-3521.

Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition.  ANALYTICAL BIOCHEMISTRY.  449:68-75.

Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis.  JOURNAL OF MEDICINAL CHEMISTRY.  57:1599-1608.

Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies.  JOURNAL OF MEDICINAL CHEMISTRY.  56:10103-10117.

Dissociation of antimicrobial and hemolytic activities of gramicidin S through N-methylation modification.  CHEMMEDCHEM.  8:1865-1872.

Conditional probabilistic analysis for prediction of the activity landscape and relative compound activities.  JOURNAL OF CHEMICAL INFORMATION AND MODELING.  53:2613-2625.

Selective agonists and antagonists of formylpeptide receptors: Duplex flow cytometry and mixture-based positional scanning libraries

Libraries from libraries: A series of sulfonamide linked heterocycles derived from the same scaffold.  TETRAHEDRON LETTERS.  54:4296-4299.

Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates.  JOURNAL OF BIOLOGICAL CHEMISTRY.  288:22871-22879.

Parallel synthesis of 1,6-disubstituted-1,2,4-triazin-3-ones on solid-phase

Rapid scanning structure-activity relationships in combinatorial data sets: Identification of activity switches.  JOURNAL OF CHEMICAL INFORMATION AND MODELING.  53:1475-1485.

The mathematics of a successful deconvolution: A quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors

The role of imidazole in peptide cyclization by transesterification: Parallels to the catalytic triads of serine proteases.  ORGANIC & BIOMOLECULAR CHEMISTRY.  11:2979-2987.

ChemInform Abstract: Palladium‐Catalyzed C—H Functionalization Using Guanidine as a Directing Group: ortho‐Arylation and Olefination of Arylguanidines.

Discovery of novel antinociceptive α-conotoxin analogues from the direct in vivo screening of a synthetic mixture-based combinatorial library

A traceless approach to amide and peptide construction from thioacids and dithiocarbamate-terminal amines.  CHEMICAL SCIENCE.  4:970-976.

Identification of a Small Molecule That Selectively Inhibits Mouse PC2 over Mouse PC1/3: A Computational and Experimental Study

HTS by NMR of combinatorial libraries: A fragment-based approach to ligand discovery.  CHEMISTRY & BIOLOGY.  20:19-33.

Ligand/kappa-opioid receptor interactions: Insights from the X-ray crystal structure.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.  66:114-121.

The multi-leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.  JOURNAL OF MEDICINAL CHEMISTRY.  55:10501-10511.

Fluorescent Mu selective opioid ligands from a mixture based cyclic peptide library

A large scale classification of molecular fingerprints for the chemical space representation and SAR analysis

Activity-difference maps and consensus similarity measure characterize structure-activity relationships

Identification of B cell and T cell epitopes using synthetic peptide combinatorial libraries

Palladium-catalyzed C-H functionalization using guanidine as a directing group: Ortho arylation and olefination of arylguanidines.  ORGANIC LETTERS.  14:5452-5455.

Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.  JOURNAL OF BIOLOGICAL CHEMISTRY.  287:36473-36487.

A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries

ChemInform Abstract: Solid‐Phase Synthesis of Heterocycles from Peptides and Amino Acids.

Multitarget structure-activity relationships characterized by activity-difference maps and consensus similarity measure.  JOURNAL OF CHEMICAL INFORMATION AND MODELING.  51:2427-2439.

Solid-phase synthesis of 2,3,5,6-tetrahydro-1H-imidazo[1,2-a]benzo[d]- [1,3]diazepines via Pd(OAc)2/Cu(OAc)2-cocatalyzed cyclization.  SYNLETT.  2259-2261.

Solid-phase synthesis of 2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine derivatives.  TETRAHEDRON LETTERS.  52:4112-4113.

Integrating Virtual Screening and Combinatorial Chemistry for Accelerated Drug Discovery

Integrating computational and mixture-based screening of combinatorial libraries.  JOURNAL OF MOLECULAR MODELING.  17:1473-1482.

Solid-phase synthesis of N-substituted 3,4-dihydroquinazolinone derivatives.  TETRAHEDRON LETTERS.  52:2627-2628.

Use and implications of the harmonic mean model on mixtures for basic research and drug discovery

Increased Diversity of Libraries from Libraries: Chemoinformatic Analysis of Bis-Diazacyclic Libraries

Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization.  TETRAHEDRON LETTERS.  52:1456-1458.

High throughput synthesis of 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b] thiazole derivatives.  TETRAHEDRON LETTERS.  52:696-698.

A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a 'volatilizable' support.  TETRAHEDRON LETTERS.  51:5637-5639.

Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library

ChemInform Abstract: Traceless Approach for the Synthesis of 3,5‐Disubstituted Thiohydantoins on Functionalized Ionic‐Liquid Support.

Macrolactonization of peptide thioesters catalyzed by imidazole and its application in the synthesis of kahalalide B and analogues.  ORGANIC LETTERS.  12:2250-2253.

Conformational landscape of platinum(II)-tetraamine complexes: DFT and NBO studies

A synthetic combinatorial strategy for developing α-conotoxin analogs as potent α7 nicotinic acetylcholine receptor antagonists.  JOURNAL OF BIOLOGICAL CHEMISTRY.  285:1809-1821.

A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC.  BRITISH JOURNAL OF CANCER.  102:97-103.

Traceless approach for the synthesis of 3,5-disubstituted thiohydantoins on functionalized ionic-liquid support

Traceless solid-phase synthesis of N-substituted 3,5-bis(substituted-idene) piperidin-4-one derivatives.  TETRAHEDRON LETTERS.  51:5003-5004.

Synthesis of cyclic peptides through direct aminolysis of peptide thioesters catalyzed by imidazole in aqueous organic solutions

Solid-phase synthesis of 2-alkylidene-6-alkyl-imidazo[2,1-b]thiazole-3,5[2H,6H]-dione derivatives.  TETRAHEDRON LETTERS.  50:5857-5859.

Parallel synthesis of chiral pentaamines and pyrrolidine containing bis-heterocyclic libraries. Multiple scaffolds with multiple building blocks: A double diversity for the identification of new antitubercular compounds.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  19:5169-5175.

Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.  BIOORGANIC & MEDICINAL CHEMISTRY.  17:5583-5597.

Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries Small Molecule Repository.  JOURNAL OF CHEMICAL INFORMATION AND MODELING.  49:1010-1024.

One-pot high-throughput synthesis of β-turn cyclic peptidomimetics-via "volatilizable" supports.  JOURNAL OF ORGANIC CHEMISTRY.  74:2183-2185.

Synthetic Small-Molecule Prohormone Convertase 2 Inhibitors

Characterization of activity landscapes using 2D and 3D similarity methods: Consensus activity cliffs.  JOURNAL OF CHEMICAL INFORMATION AND MODELING.  49:477-491.

The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries.  EUROPEAN JOURNAL OF PHARMACOLOGY.  602:194-202.

Modeling of peptides containing D-amino acids: Implications on cyclization

Solid-phase synthesis of 4,8-disubstituted-8,9-dihydropyrazino[2,3-g]quinazolin-7(6H)-ones.  BIOPOLYMERS.  90:439-443.

High throughput synthesis of peptide α-thioesters through the use of "volatilizable" support

Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.  BIOORGANIC & MEDICINAL CHEMISTRY.  16:5932-5938.

High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on 'volatilizable' supports.  TETRAHEDRON LETTERS.  49:3632-3633.

ChemInform Abstract: Strategies for the Use of Mixture‐Based Synthetic Combinatorial Libraries: Scaffold Ranking, Direct Testing in vivo, and Enhanced Deconvolution by Computational Methods.

Novel d-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral κ-opioid receptors^,.  EUROPEAN JOURNAL OF PHARMACOLOGY.  583:62-72.

Small-molecule XIAP antagonist restores caspase-9-mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells.  BLOOD.  111:369-375.

A similarity-based data-fusion approach to the visual characterization and comparison of compound databases

Solid-phase synthesis of 3-alkyl-8-arylamino-1H-imidazo[4,5-g]quinazolin-2(3H)-thiones and 3-alkyl-8-arylamino-1H-imidazo[4,5-g]quinazolin-2(3H)-ones.  TETRAHEDRON LETTERS.  48:7042-7045.

A traceless approach for the solid-phase parallel synthesis of trisubstituted oxindoles

Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: Use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences

Scaffold approach for solid-phase synthesis of 2,3-disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines

427 POSTER Preclinical development of xiapuradamib therapy for lung cancer

491 POSTER Trageting XIAP in paediatric cancers

Synthesis of platinum(II) chiral tetraamine coordination complexes

Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: An example of lead optimization using mixture-based libraries.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  16:4331-4338.

The central effect of MCH system studied using a specific MCH 1R antagonist isolated from combinatorial libraries.  FASEB JOURNAL.  20:a686-a686.

Solid phase synthesis of 3,4,7-trisubstituted 4,5,8,9-tetrahydro-3H-imidazo[1,2-a][1,3,5]triazepin-2(7H)-thiones and N-alkyl-4,5,7,8-tetrahydro-3H-imidazo[1,2-a][1,3,5]triazepin-2-amines

Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis.  BLOOD.  106:1742-1748.

"Volatilizable" supports for high-throughput organic synthesis.  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY.  127:8582-8583.

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.  BLOOD.  105:4043-4050.

Mixture‐Based Combinatorial Libraries: from Peptides and Peptidomimetics to Small Molecule Acyclic and Heterocyclic Compounds

Inhibition of XIAP Enhances Specific Cytotoxic T Lymphocyte (CTL) Killing and CD20-Directed Antibody-Dependent Cellular Cytotoxicity of Chronic Lymphocytic Leukemia B Cells..  BLOOD.  104:3475.

Inhibition of XIAP Renders Newly CD40-Activated Chronic Lymphocytic Leukemia Cells Sensitive to Fas (CD95) Mediated Apoptosis..  BLOOD.  104:3474.

Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples..  BLOOD.  104:759.

Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors.  JOURNAL OF BIOLOGICAL CHEMISTRY.  279:48168-48176.

Solid-phase synthesis of 5-aminotetrazoles.  TETRAHEDRON LETTERS.  45:7787-7789.

Combinatorial Chemistry: Libraries from Libraries, the Art of the Diversity‐Oriented Transformation of Resin‐Bound Peptides and Chiral Polyamides to Low Molecular Weight Acyclic and Heterocyclic Compounds

Inhibition of furin by polyarginine-containing peptides: Nanomolar inhibition by nona-D-arginine.  JOURNAL OF BIOLOGICAL CHEMISTRY.  279:36788-36794.

Combinatorial chemistry: Libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds.  JOURNAL OF ORGANIC CHEMISTRY.  69:3603-3609.

De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  14:1947-1951.

Halogenoalkyl isocyanates as bifunctional reagents in an Aza-Wittig/heterocyclization reaction on the solid phase: Efficient entry into new tetracyclic benzimidazole systems

A Traceless Approach for the Solid-Phase Synthesis of 6-Amino-1,3,5- triazine-2,4-diones

Peptidic complex mixtures as therapeutic agents in CNS autoimmunity.  MOLECULAR IMMUNOLOGY.  40:1075-1087.

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

Specificity and degeneracy of T cells.  MOLECULAR IMMUNOLOGY.  40:1047-1055.

Identification of novel small-molecule Ulex europaeus I mimetics for targeted drug delivery.  BIOORGANIC & MEDICINAL CHEMISTRY.  11:4991-4997.

Combinatorial Chemistry: Mixture‐Based Combinatorial Libraries of Acyclic and Heterocyclic Compounds from Amino Acids and Short Peptides

Solid-phase synthesis of 3-amino-1,2,4-triazoles.  TETRAHEDRON LETTERS.  44:7841-7843.

Toward targeted oral vaccine delivery systems: Selection of lectin mimetics from combinatorial libraries.  PHARMACEUTICAL RESEARCH.  20:1258-1266.

Advances in the Use of Synthetic Combinatorial Chemistry: Mixture‐Based Libraries

Abnormal aza-Wittig reaction on the solid-phase: chemoselectivity studies towards the parallel synthesis of 3-aryl-2,4-dioxo-1,3,5-triazino[1,2-a]benzimidazoles.  TETRAHEDRON LETTERS.  44:3705-3708.

Solid-phase synthesis of indolines via palladium-catalyzed cyclization.  TETRAHEDRON LETTERS.  44:2569-2572.

Parallel solid-phase synthesis of 2-imino-4-oxo-1,3,5-triazino[1,2-a]benzimidazoles via tandem Aza-Wittig/heterocumulene-mediated annulation reaction

The combined solid/solution-phase synthesis of nitrosamines: The evolution of the "libraries from libraries" concept.  JOURNAL OF ORGANIC CHEMISTRY.  68:183-186.

Positional scanning-synthetic peptide library-based analysis of self- and pathogen-derived peptide cross-reactivity with tumor-reactive Melan-A-specific CTL.  JOURNAL OF IMMUNOLOGY.  169:5696-5707.

Opioid activity of 4-imidazolidinone positional analogues of Leu-enkephalin.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  12:3175-3178.

Parallel solid-phase synthesis of disubstituted 1,6-piperazine-2-ones

Determination of isokinetic ratios necessary for equimolar incorporation of carboxylic acids in the solid-phase synthesis of mixture-based combinatorial libraries.  BIOPOLYMERS.  65:32-39.

Efficient solid-phase synthesis of 1,3,5-trisubstituted 1,3,5-triazine-2,4,6-triones

Findings on T cell specificity revealed by synthetic combinatorial libraries

Use of vilsmeier reagent for the solid-phase synthesis of 1,5-disubstituted 4,5-dihydro-1H-imidazoles and disubstituted 4,5-dihydro-1H-imidazolylbenzimidazoles

A traceless approach for the parallel solid-phase synthesis of 2-(arylamino)quinazolinones.  JOURNAL OF ORGANIC CHEMISTRY.  67:5831-5834.

Combinatorial peptide library-based identification of peptide ligands for tumor-reactive cytolytic T lymphocytes of unknown specificity

Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-A peptide multimer⁺ CD8⁺ T cells in humans.  JOURNAL OF EXPERIMENTAL MEDICINE.  196:207-216.

Parallel solid-phase synthesis of trisubstituted triazinobenzimidazolediones

ChemInform Abstract: Solid‐Phase Synthesis of Mixture‐Based Acyclic and Heterocyclic Small Molecule Combinatorial Libraries from Resin‐Bound Polyamides.

An expedient method for the solid-phase synthesis of alpha-aminoalkyl phosphonopeptides.  TETRAHEDRON LETTERS.  43:4103-4106.

Solid-phase synthesis of 1,5-disubstituted 2-aryliminoimidazolidines.  JOURNAL OF ORGANIC CHEMISTRY.  67:3138-3141.

Novel approaches for the solid-phase synthesis of biheterocyclic dihydroimidazole analogues

Solid-phase parallel synthesis of 2-aminoimidazolidin-4-ones.  TETRAHEDRON.  58:3349-3353.

An efficient approach for solid-phase synthesis of peptidomimetics based on 4-imidazolidinones.  TETRAHEDRON LETTERS.  43:2343-2346.

Toward synthetic combinatorial peptide libraries in positional scanning format (PS-SCL)-based identification of CD8⁺tumor-reactive T-cell ligands: A comparative analysis of PS-SCL recognition by a single tumor-reactive CD8⁺cytolytic T-lymphocyte clone.  CANCER RESEARCH.  62:2058-2063.

Solid-phase parallel synthesis of substituted dihydroimidazolyl dihydrobenzimidazol-2-ones.  TETRAHEDRON.  58:2095-2100.

Solid-phase parallel synthesis of substituted dihydroimidazolylbutyl dihydroimidazol-3-ium salts.  TETRAHEDRON LETTERS.  43:1157-1160.

Solid-phase parallel synthesis of trisubstituted dihydroimidazolyl dihydroquinoxalin-2(1H)-ones.  TETRAHEDRON.  58:221-225.

A novel approach for solid-phase synthesis of substituted imidazolines and bis-imidazolines.  JOURNAL OF ORGANIC CHEMISTRY.  66:8673-8676.

Solid-phase synthesis of bis-cyclic guanidines from tripeptides.  TETRAHEDRON.  57:9911-9914.

Solid-phase synthesis of alpha,alpha-difluoro-beta-amino acids via the Reformatsky reaction.  JOURNAL OF ORGANIC CHEMISTRY.  66:8268-8272.

ChemInform Abstract: Solid‐Phase Synthesis of Heterocyclic Compounds from Amino Acids and Linear Peptides

A novel approach for the solid-phase synthesis of substituted cyclic guanidines, their respective bis analogues, and N-acylated guanidines from N-acylated amino acid amides

Identification of B cell and T cell epitopes using synthetic peptide combinatorial libraries.

Solid-phase synthesis of 2,3,5-trisubstituted 4H-imidazolones

Solid-phase synthesis of substituted imidazoline-tethered 2,3-diketopiperazines, cyclic ureas, and cyclic thioureas

Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones.  ORGANIC LETTERS.  3:2797-2799.

ChemInform Abstract: Synthesis and Screening of Positional Scanning Synthetic Combinatorial Libraries

Parallel synthesis of 4,5-dihydro-1H-1,4-benzodiazepine-2,3-diones.  TETRAHEDRON LETTERS.  42:5141-5143.

Combinatorial peptide libraries as an alternative approach to the identification of ligands for tumor-reactive cytolytic T lymphocytes.  CANCER RESEARCH.  61:5153-5160.

Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries.  BLOOD.  97:1776-1786.

An N-methyl-D-aspartate receptor channel blocker with neuroprotective activity.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  98:3519-3524.

Tethered libraries: Solid-phase synthesis of substituted urea-linked bicyclic guanidines

Solid phase synthesis of [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-ones.  TETRAHEDRON LETTERS.  42:623-625.

Solid phase synthesis of mixture-based acyclic and heterocyclic small molecule combinatorial libraries from resin-bound polyamides.  BIOPOLYMERS.  60:212-219.

Solid-phase synthesis of bis-heterocyclic compounds from resin-bound orthogonally protected lysine

Polyarginines are potent furin inhibitors.  JOURNAL OF BIOLOGICAL CHEMISTRY.  275:36741-36749.

ChemInform Abstract: Manual Multiple Synthesis Methods

Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides.  ORGANIC LETTERS.  2:3349-3350.

ChemInform Abstract: Parallel Array and Mixture‐Based Synthetic Combinatorial Chemistry: Tools for the Next Millennium

An efficient two-step synthesis of mono-, di- and triureas from resin-bound amides.  TETRAHEDRON LETTERS.  41:5441-5446.

Solid-phase synthesis of substituted 2,3-diketopiperazines from reduced polyamides.  TETRAHEDRON.  56:3319-3326.

Solid-phase synthesis of branched thiohydantoin benzimidazolinethiones and branched thiohydantoin tetrahydroquinoxalinediones.  TETRAHEDRON LETTERS.  41:2283-2287.

Solid phase synthesis of styrylquinazolinones.  TETRAHEDRON LETTERS.  41:2051-2054.

Solid phase synthesis of 1-substituted pyroglutamates.  TETRAHEDRON LETTERS.  41:851-854.

Solid phase synthesis of 1,3-disubstituted succinimides.  TETRAHEDRON LETTERS.  41:609-612.

Contribution of individual amino acids within MHC molecule or antigenic peptide to TCR ligand potency.  JOURNAL OF IMMUNOLOGY.  164:861-871.

Inhibition of β-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library.  JOURNAL OF STRUCTURAL BIOLOGY.  130:247-258.

Minimal peptide length requirements for CD4⁺ T cell clones - implications for molecular mimicry and T cell survival

Orphanin FQ/Nociceptin receptor binding studies.  PEPTIDES.  21:949-960.

Immunogenicity. I. Use of peptide libraries to identify epitopes that activate clonotypic CD4⁺ T cells and induce T cell responses to native peptide ligands.  JOURNAL OF IMMUNOLOGY.  163:6424-6434.

ChemInform Abstract: Mixture‐Based Synthetic Combinatorial Libraries

Solid phase synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids.  TETRAHEDRON LETTERS.  40:8539-8542.

Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease

New opioid peptides, peptidomimetics, and heterocyclic compounds from combinatorial libraries.  BIOPOLYMERS.  51:379-390.

Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library

Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives.  TETRAHEDRON LETTERS.  40:4939-4942.

ChemInform Abstract: Soluble Combinatorial Libraries of Peptides, Peptidomimetics, and Organics: Fundamental Tools for Basic Research and Drug Discovery

Parallel solid phase synthesis of tetrasubstituted diethylenetriamines via selective amide alklylation and exhaustive reduction of N-acylated dipeptides.  TETRAHEDRON.  55:335-344.

Exploring immunological specificity using synthetic peptide combinatorial libraries

Mixture-based heterocyclic combinatorial positional scanning libraries: Discovery of bicyclic guanidines having potent antifungal activities against Candida albicans and Cryptococcus neoformans.  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY.  43:106-114.

ChemInform Abstract: Synthesis and Screening of Positional Scanning Combinatorial Libraries

ChemInform Abstract: Peralkylation. “Libraries from Libraries”: Chemical Transformation of Synthetic Combinatorial Libraries

Tetrakis(pyridine)silver(2+)peroxydisulfate 2AgNO3 + 8C 5H5N + 3K2S2S8 → 2[Ag(C5H5N)4]S2O8 + 2K2SO4 + 2KNO3

Efficient solid phase synthesis of 3,5-disubstituted hydantoins.  TETRAHEDRON LETTERS.  39:8199-8202.

Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library.  JOURNAL OF BIOLOGICAL CHEMISTRY.  273:26589-26595.

Combinatorial chemistry: From peptides and peptidomimetics to small organic and heterocyclic compounds.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  8:2273-2278.

From specificity to degeneracy to molecular mimicry: Antigen recognition of human autoreactive and pathogen-specific CD4+ T cells.  JOURNAL OF NEUROIMMUNOLOGY.  90:34.

Selective ligands for the μ, δ, and κ opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library.  JOURNAL OF BIOLOGICAL CHEMISTRY.  273:18848-18856.

Solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones.  TETRAHEDRON LETTERS.  39:3671-3674.

Cutting edge: Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.  JOURNAL OF IMMUNOLOGY.  160:3631-3636.

Probing degeneracy in T-cell recognition using peptide combinatorial libraries

Selected peptides targeted to the NMDA receptor channel protect neurons from excitotoxic death.  NATURE BIOTECHNOLOGY.  16:286-291.

Activation of human class-II restricted T cell clones by short peptides.  FASEB JOURNAL.  12.

Precise prediction of class II T-cell epitopes using a combinatorial peptide library approach.  FASEB JOURNAL.  12.

Use of heterocyclic positional scanning synthetic combinatorial libraries for the discovery of highly active small molecules.  FASEB JOURNAL.  12.

ChemInform Abstract: Rapidly Expanding Molecular Diversity: Libraries from Libraries

A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats

Characterization of antigen-antibody interactions using single substitution analogs and mixture-based synthetic combinatorial libraries

Comparison of the binding of α-helical and β-sheet peptides to a hydrophobic surface

Identification of novel antitumor agents from mixture-based synthetic combinatorial libraries using cell-based assays

Mapping the prion protein using recombinant antibodies

Synthesis and screening of positional scanning combinatorial libraries.

The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells

Use of combinatorial library screening to identify inhibitors of a bacterial two-component signal transduction kinase

Synthesis of cyclic disulfide peptides: Comparison of oxidation methods.  PROTEIN AND PEPTIDE LETTERS.  4:157-164.

Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS.  283:735-741.

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.  JOURNAL OF MOLECULAR BIOLOGY.  273:614-622.

Immune activation in cervical neoplasia: Cross-sectional association between plasma soluble interleukin 2 receptor levels and disease.  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION.  6:807-813.

Solid phase synthesis of 1,3,4,7-tetrasubstituted perhydro-1,4-diazepine-2,5-diones.  TETRAHEDRON LETTERS.  38:4943-4946.

Polyalanine-based peptides as models for self-associated β-pleated- sheet complexes.  BIOCHEMISTRY.  36:8393-8400.

ChemInform Abstract: The Current Status of Heterocyclic Combinatorial Libraries

Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinones via β-lactam intermediates on the solid-phase.  TETRAHEDRON LETTERS.  38:3349-3352.

ChemInform Abstract: Generation of Peralkylated Peptidomimetic Combinatorial Libraries

First Japanese Conference on Combinatorial Chemistry and High Throughput Screening

Solid phase synthesis of heterocyclic compounds from linear peptides: Cyclic ureas and thioureas.  TETRAHEDRON LETTERS.  38:931-934.

Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.  INFECTION AND IMMUNITY.  65:3430-3437.

Secondary structure induction in aqueous vs membrane-like environments.  BIOPOLYMERS.  42:489-498.

Induction of neonatal tolerance by plasmid DNA vaccination of mice

Evidence of conformational equilibria during the RP-HPLC elution process of peptides

Interleukin 2 production in vitro by peripheral lymphocytes in response to human papillomavirus-derived peptides: Correlation with cervical pathology.  CANCER RESEARCH.  56:3967-3974.

Highly specific, cross-reactive sequences recognized by an anti-HBsAg antibody identified from a positional scanning synthetic combinatorial library

Orphanin FQ: Receptor binding and analog structure activity relationships in rat brain.  LIFE SCIENCES.  59.

ChemInform Abstract: Peptide, Peptidomimetic, and Organic Synthetic Combinatorial Libraries

Functionalized protein-like structures from conformationally defined synthetic combinatorial libraries.  JOURNAL OF BIOLOGICAL CHEMISTRY.  271:4120-4126.

Identification of inhibitors of melittin using nonsupport-bound combinatorial libraries.  JOURNAL OF BIOLOGICAL CHEMISTRY.  271:4093-4099.

A study of human T-cell lines generated from multiple sclerosis patients and controls by stimulation with peptides of myelin basic protein.  JOURNAL OF NEUROIMMUNOLOGY.  70:65-74.

Exploring antibody polyspecificity using synthetic combinatorial libraries

Generation of peralkylated peptidomimetic combinatorial libraries

Inclusion volume solid-phase synthesis.  JOURNAL OF PEPTIDE SCIENCE.  2:240-244.

Novel α-glucosidase inhibitors identified using multiple cyclic peptide combinatorial libraries

Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial libraries.  BIOCHEMICAL JOURNAL.  313:141-147.

Structural Characterization and 5′-mononucleotide Binding of Polyalanine β-sheet Complexes.  JOURNAL OF MOLECULAR RECOGNITION.  9:488-493.

Tea bag synthesis of positional scanning synthetic combinatorial libraries and their use for mapping antigenic determinants.

Use of nonsupport-bound synthetic combinatorial libraries in cell-based bioassay systems

Inhibition of a plant virus infection by analogs of melittin.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  92:12466-12469.

Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  92:11456-11460.

Irradiated sporozoite vaccine induces HLA-B8-restricted cytotoxic T lymphocyte responses against two overlapping epitopes of the Plasmodium falciparum sporozoite surface protein 2.  JOURNAL OF EXPERIMENTAL MEDICINE.  182:1435-1445.

Synthetic peptides from P.falciparum sexual stage 25-kDa protein induce antibodies that react with the native protein: The role of IL-2 and conformational structure on immunogenicity of Pfs25

ChemInform Abstract: Utility of Soluble Peptide Combinatorial Libraries

Activation of bee venom phospholipase A2 through a peptide-enzyme complex.  FEBS LETTERS.  372:131-134.

Elucidation of monoclonal antibody polyspecificity using a synthetic combinatorial library

Mapping the detailed specificity of a calcium-dependent monoclonal antibody through the use of soluble positional scanning combinatorial libraries: Identification of potent calcium-independent antigens

Six highly active mu-selective opioid peptides identified from two synthetic combinatorial libraries

A comparison of combinatorial library approaches for the study of opioid compounds

The role of amphipathicity in the folding, self-association and biological activity of multiple subunit small proteins.  JOURNAL OF BIOLOGICAL CHEMISTRY.  270:1048-1056.

A review of the utility of soluble peptide combinatorial libraries.  BIOPOLYMERS.  37:221-240.

Formation of an extremely stable polyalanine β-sheet macromolecule.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.  211:7-13.

HLA-A2-restricted cytotoxic T lymphocyte responses to multiple Plasmodium falciparum sporozoite surface protein 2 epitopes in sporozoite-immunized volunteers.  JOURNAL OF IMMUNOLOGY.  155:766-775.

IDENTIFICATION OF MU-SELECTIVE POLYAMINE ANTAGONISTS FROM A SYNTHETIC COMBINATORIAL LIBRARY

Identification of a nonameric H-2K(k)-restricted CD8⁺ cytotoxic T lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein.  INFECTION AND IMMUNITY.  63:1955-1959.

Induced conformational states of amphipathic peptides in aqueous/lipid environments.  BIOPHYSICAL JOURNAL.  68:351-359.

Peptide binding domains determined through chemical modification of the side-chain functional groups.  BIOPHYSICAL JOURNAL.  69:604-611.

Soluble combinatorial libraries of organic, peptidomimetic and peptide diversities.  TRAC-TRENDS IN ANALYTICAL CHEMISTRY.  14:83-92.

The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries

Two antipeptide monoclonal antibodies that recognize adhesive sequences in fibrinogen: identification of antigenic determinants and unrelated sequences using synthetic combinatorial libraries.

'Libraries from libraries': Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  91:11138-11142.

Rapid identification of novel opioid peptides from an N-acetylated synthetic combinatorial library.  REGULATORY PEPTIDES.  54:87-88.

Cyclic peptide template combinatorial libraries: Synthesis and identification of chymotrypsin inhibitors

Synthetic peptides as binding-step based catalytic mimics

Analysis of human T cell clones specific for conserved peptide sequences within malaria proteins: Paucity of clones responsive to intact parasites.  JOURNAL OF IMMUNOLOGY.  153:2082-2092.

Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9: Comparison of two different antibodies bound to the same peptide antigen.  JOURNAL OF MOLECULAR BIOLOGY.  241:534-556.

Synthetic compound peptide simulating antigenicity of conformation-dependent autoepitope.  JOURNAL OF BIOLOGICAL CHEMISTRY.  269:18529-18534.

Peptides that inhibit von willebrand factor binding to the platelet SPIB receptor

An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library.  SCIENCE.  266:2019-2022.

An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans

Crystal structure of deltakephalin: a γ‐selective opioid peptide with a novel β‐bend‐like conformation

Determination of the secondary structure of selected melittin analogues with different haemolytic activities.  BIOCHEMICAL JOURNAL.  299:587-591.

Identification of antimicrobial peptides by using combinatorial libraries made up of unnatural amino acids.  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY.  38:2280-2286.

Induction of murine cytotoxic T lymphocytes against Plasmodium falciparum sporozoite surface protein 2

Investigation of antigen-antibody interactions using a soluble, non-support-bound synthetic decapeptide library composed of four trillion (4 x 10¹²) sequences.  BIOCHEMICAL JOURNAL.  301:847-853.

Peptide libraries: Determination of relative reaction rates of protected amino acids in competitive couplings.  BIOPOLYMERS.  34:1681-1689.

Soluble Combinatorial Libraries: Extending the Range and Repertoire of Chemical Diversity

Tools of the Trade Combinatorial Libraries: Finding the needle in the haystack.  CURRENT BIOLOGY.  4:564-567.

Versatility of positional scanning synthetic combinatorial libraries for the identification of individual compounds

The broad utility of soluble peptide libraries for drug discovery.  GENE.  137:7-11.

Acetalins: Opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  90:10811-10815.

Influence of tryptophan residues on melittin's hemolytic activity

ChemInform Abstract: Modified Solid‐Phase Methods for the Rapid Synthesis of Opioid Peptides

Synthetic peptide combinatorial libraries (SPCLs): identification of the antigenic determinant of β-endorphin recognized by monoclonal antibody 3E7.  GENE.  128:71-76.

Analysis of the epitopes of proliferating cell nuclear antigen recognized by monoclonal antibodies.  LABORATORY INVESTIGATION.  68:204-210.

Comparison of 55% TFA/CH2Cl2 and 100% TFA for Boc group removal during solid‐phase peptide synthesis

Cytotoxic t lymphocyte (Ctl) low-responsiveness to the plasmodium falciparum circumsporozoite protein in naturally-exposed endemic populations: Analysis of human ctl response to most known variants

Functional importance of amino acid residues making up peptide antigenic determinants.  MOLECULAR IMMUNOLOGY.  30:577-585.

Identification of Substrate-Analog Trypsin Inhibitors through the Screening of Synthetic Peptide Combinatorial Libraries.  BIOCHEMISTRY.  32:11035-11041.

Peptide libraries: criteria and trends

The Importance of Dominant Negative Effects of Amino Acid Side Chain Substitution in Peptide-MHC Molecule Interactions and T Cell Recognition.  JOURNAL OF IMMUNOLOGY.  150:331341.

The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands.  LIFE SCIENCES.  52:1509-1517.

The use of synthetic peptide combinatorial libraries for the determination of peptide ligands in radio-receptor assays: Opioid peptides.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  3:405-412.

Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.  BIOTECHNIQUES.  13:901-902+904.

Anomalous reversed-phase high-performacne liquid chromatographic behavior of synthetic peptides related to antigenic helper T cell sites.  JOURNAL OF CHROMATOGRAPHY.  625:191-198.

Evaluation of peptidepeptide interactions using reversed-phase high-performance liquid chromatography.  JOURNAL OF CHROMATOGRAPHY.  625:199-206.

Conserved T and B cell epitopes on the M protein of group A streptococci: Induction of bactericidal antibodies.  JOURNAL OF IMMUNOLOGY.  149:2729-2735.

A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei.  JOURNAL OF IMMUNOLOGY.  149:2103-2109.

Immunization with soluble protein-pulsed spleen cells induces class I-restricted cytotoxic T lymphocytes that recognize immunodominant epitopic peptides from Plasmodium falciparum and HIV-1.  JOURNAL OF IMMUNOLOGY.  149:1311-1318.

Conformation and Dynamics of an Fab'-Bound Peptide by Isotope-Edited NMR Spectroscopy.  BIOCHEMISTRY.  31:3862-3871.

Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis.  JOURNAL OF IMMUNOLOGY.  148:1835-1840.

Design of Model Amphipathic Peptides Having Potent Antimicrobial Activities.  BIOCHEMISTRY.  31:12688-12694.

Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant.  SCIENCE.  255:333-336.

High frequency of malaria‐specific T cells in non‐exposed humans

Identification of related peptides recognized by a monoclonal antibody using a synthetic peptide combinatorial library

Induction of cytotoxic T cells to a cross-reactive epitope in the hepatitis C virus nonstructural RNA polymerase-like protein

Perturbation of peptide conformations induced in anisotropic environments.  BIOPOLYMERS.  32:575-583.

Recombinant pseudorabies virus carrying a plasmodium gene: herpesvirus as a new live viral vector for inducing T- and B-cell immunity.  VACCINE.  10:578-584.

The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides.  BIOTECHNIQUES.  13:412-421.

Toleration of amino acid substitutions within hepatitis B virus envelope protein epitopes established by peptide replacement set analysis. II. Region S(122-136).

Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity.  JOURNAL OF BIOLOGICAL CHEMISTRY.  266:24514-24519.

Autoantibody production in hepatitis B e antigen transgenic mice elicited with a self T-cell peptide and inhibited with nonself peptides.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  88:4348-4352.

Hemolytic and Antimicrobial Activities of the Twenty-Four Individual Omission Analogues of Melittin.  BIOCHEMISTRY.  30:4671-4678.

Assessment of human cytotoxic T cell activity using synthetic peptides: potential for field application.

Development of cross-reactive antibodies to plasminogen during the immune response to dengue virus infection.  JOURNAL OF INFECTIOUS DISEASES.  164:294-301.

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery.  NATURE.  354:84-86.

Human cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  88:3300-3304.

Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans: Correlation with a cytotoxic T cell epitope.  JOURNAL OF INFECTIOUS DISEASES.  164:1058-1065.

Location of human cytotoxic T cell epitopes within a polymorphic domain of the Plasmodium falciparum circumsporozoite protein

Probing the relationships between the structure and hemolytic activity of melittin with a complete set of leucine substitution analogs.

The use of synthetic peptides in the formation of biophysically and biologically active pulmonary surfactants.  PEDIATRIC RESEARCH.  29:460-465.

Major population differences in T cell response to a malaria sporozite vaccine candidate

Insights into native epitopes of proliferating cell nuclear antigen using recombinant DNA protein products.  JOURNAL OF EXPERIMENTAL MEDICINE.  172:419-429.

Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes.  JOURNAL OF EXPERIMENTAL MEDICINE.  171:763-773.

Elucidation of discontinuous linear determinants in peptides.  JOURNAL OF IMMUNOLOGY.  144:976-983.

Identification of a site in the α chain of platelet glycoprotein Ib that participates in von Willebrand factor binding.  JOURNAL OF BIOLOGICAL CHEMISTRY.  265:274-280.

A murine monoclonal anti-factor VIII inhibitory antibody and two human factor VIII inhibitors bind to different areas within a twenty amino acid segment of the acidic region of factor VIII heavy chain..  BLOOD COAGULATION & FIBRINOLYSIS.  1:9-15.

A synthetic factor VIII peptide of eight amino acid residues (1677-1684) contains the binding region of an anti-factor VIII antibody which inhibits the binding of factor VIII to von Willebrand factor

An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  87:2344-2348.

An evaluation of the advantages and effectiveness of picric acid monitoring during solid phase peptide synthesis.

Characterization of a helper T cell epitope recognized by mice of a low responder major histocompatibility type.  MOLECULAR IMMUNOLOGY.  27:941-946.

Peptide immunization can elicit malaria protein-specific memory helper but not proliferative T cells.

Structural requirements for class i mhc molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein.  JOURNAL OF EXPERIMENTAL MEDICINE.  170:2023-2035.

Degradation of [³H]β-endorphin in rat plasma is increased with chronic stress.  EUROPEAN JOURNAL OF PHARMACOLOGY.  167:229-236.

Identification of an epitope in the major envelope protein of Epstein-Barr virus that mediates viral binding to the B lymphocyte EBV receptor (CR2)

A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160.  SCIENCE.  246:118-121.

Analysis of a subclass-restricted HIV-1 gp41 epitope by omission Peptides

Determination of antigenic binding sites in antibodies directed against a mycobacterial peptide by deletion and substitution of single amino acids.

Distinction between immunogenicity and tolerogenicity among HBcAg T cell determinants. Influence of peptide-MHC interaction.  JOURNAL OF IMMUNOLOGY.  143:3148-3156.

Elucidation of a Protease-Sensitive Site Involved in the Binding of Calcium to C-Reactive Protein.  BIOCHEMISTRY.  28:9840-9848.

Functional identification of agretopic and epitopic residues within an HBcAg T cell determinant.  JOURNAL OF IMMUNOLOGY.  143:3141-3147.

Immunochemistry of the dominating antigenic region Ala⁵⁸² to Cys⁶⁰⁴ in the transmembranous protein of simian and human immunodeficiency virus.  JOURNAL OF IMMUNOLOGY.  143:3602-3608.

Induction of human B cell differentiation by Fc region activators. I. Identification of an active tetrapeptide

RGDV peptide selectively inhibits platelet-dependent thrombus formation in vivo. Studies using a baboon model

T and B cell responses of Plasmodium falciparum malaria-immune individuals to synthetic peptides corresponding to sequences in different regions of the P. falciparum antigen Pf155/RESA.  JOURNAL OF IMMUNOLOGY.  143:3043-3048.

T cell multideterminant regions in the human immunodeficiency virus envelope: Toward overcoming the problem of major histocompatibility complex restriction

The Chemistry of Site-Directed Serology for HIV Infections.  AIDS RESEARCH AND HUMAN RETROVIRUSES.  5:487-493.

Human and murine CD4 T cell epitopes map to the same region of the malaria circumsporozoite protein: limited immunogenicity of sporozoites and circumsporozoite protein

Structure of the von Willebrand factor domain interacting with glycoprotein Ib.  JOURNAL OF BIOLOGICAL CHEMISTRY.  263:17901-17904.

Folding of immunogenic peptide fragments of proteins in water solution. I. Sequence requirements for the formation of a reverse turn.  JOURNAL OF MOLECULAR BIOLOGY.  201:161-200.

Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix.  JOURNAL OF MOLECULAR BIOLOGY.  201:201-217.

An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility comples molecule-restricted murine cytotoxic T lymphocytes.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  85:3105-3109.

An immunogenic region within residues Val¹⁶⁷⁰-Glu¹⁶⁸⁴ of the factor VIII light chain induces antibodies which inhibit binding of factor VIII to von Willebrand factor.  JOURNAL OF BIOLOGICAL CHEMISTRY.  263:5230-5234.

Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum.  NATURE.  334:258-260.

Epitopes of the Mycobacterium tuberculosis 65-kilodalton protein antigen as recognized by human T cells.  JOURNAL OF IMMUNOLOGY.  141:2749-2754.

Generation and characterization of peptide-specific antibodies that inhibit Von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro¹⁷⁴³ and other amino acid residues adjacent to the sequence Arg¹⁷⁴⁴-Gly¹7.  JOURNAL OF BIOLOGICAL CHEMISTRY.  263:7500-7505.

Generation of rabbit antipeptide antibodies to HLA-class II antigens by the use of synthetic peptides.  CLINICAL AND EXPERIMENTAL IMMUNOLOGY.  73:76-81.

Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: Immunodominant T-cell domains map to the polymorphic regions of the molecule.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  85:1199-1203.

Localization of the binding regions of a murine monoclonal anti-factor VIII antibody and a human anti-factor VIII alloantibody, both of which inhibit factor VIII procoagulant activity, to amino acid residues Threonine³⁵¹-Serine³⁶⁵ of the factor VIII heavy chain

Localization of the binding site for a factor VIII activity neutralizing antibody to amino acid residues Asp¹⁶⁶³-Ser¹⁶⁶⁹.  JOURNAL OF BIOLOGICAL CHEMISTRY.  263:10198-10203.

Mapping of functional and antigenic domains of the α4 protein of herpes simplex virus 1

Opiate binding in calf thalamic membranes: A selective μ1 binding assay

The Magainins: sequence factors relevant to increased antimicrobial activity and decreased hemolytic activity.

Topology of the 32-kd liver gap junction protein determined by site-directed antibody localizations.

ChemInform Abstract: Simultaneous Multiple Peptide Synthesis: The Rapid Preparation of Large Numbers of Discrete Peptides for Biological, Immunological, and Methodological Studies

Recognition of HLA class II molecules by antipeptide antibodies elicited by synthetic peptides selected from regions of HLA-DP antigens

Immune response to uncoupled peptides of foot and mouth disease virus

Identification of a lymphocyte-activating pentapeptide sequence in the Fc region of human IgG1.  JOURNAL OF IMMUNOLOGY.  138:2581-2586.

A chemically synthesized peptide with mycobacterial characteristics

Effect of positional environmental domains on the variation of high-performance liquid chromatographic peptide retention coefficients.  JOURNAL OF CHROMATOGRAPHY.  386:223-228.

Identification of Linear HLA Class II Amino Acid Sequences Recognized by Rabbit Antisera against Native Molecules

Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helix..  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  84:8568-8572.

Is automated peptide synthesis slowing the advance of biomedical research?.  TRENDS IN BIOTECHNOLOGY.  5:322-324.

Localization of neutralizing regions of the envelope gene of feline leukemia virus by using anti-synthetic peptide antibodies

Site-directed serology with synthetic peptides representing the large glycoprotein G of respiratory syncytial virus..  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  84:6572-6576.

Synthetic peptide derived from the epstein‐barr virus encoded early diffuse antigen (ea‐d) reactive with human antibodies

The degradation of dynorphin A in brain tissue in vivo and in vitro.  PEPTIDES.  8:701-707.

Use of a synthetic peptide antigen to generate antisera reactive with a proteolytic processing site in native human proinsulin: Demonstration of cleavage within clathrin-coated (pro)secretory vesicles.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  84:6184-6188.

Antipeptide Antibodies: Do They Distinguish HLA-Alloantigens?

Specificity of Rabbit Antibodies Elicited by Related Synthetic Peptides

Enzyme Linked Immunosorbent Assay (ELISA) for β-endorphin and its antibodies.  LIFE SCIENCES.  38:1723-1732.

[³H]dynorphin a binding and κ selectivity of prodynorphin peptides in rat, guinea-pig and monkey brain.  EUROPEAN JOURNAL OF PHARMACOLOGY.  121:355-365.

IMMUNISATION OF VOLUNTEERS WITH A SYNTHETIC PEPTIDE VACCINE FOR ENTEROTOXIGENIC ESCHERICHIA COLI.  LANCET.  327:471-473.

A chemically synthesized peptide which elicits humoral and cellular immune responses to mycobacterial antigens.  INFECTION AND IMMUNITY.  53:560-564.

Effect of chronic exercise on beta-endorphin receptor levels in rats.

Inhibition of platelet function with synthetic peptides designed to be high-affinity antagonists of fibrinogen binding to platelets.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  83:5708-5712.

Opioid peptide immunoreactivity in spinal and trigeminal dorsal horn neurons projecting to the parabranchial nucleus in the rat.  JOURNAL OF NEUROSCIENCE.  6:1220-1226.

Simplified procedure for carrying out simultaneous multiple hydrogen fluoride cleavages of protected peptide resins

Simultaneous multiple peptide synthesis: The rapid preparation of large numbers of discrete peptides for biological, immunological, and methodological studies.  BIOTECHNIQUES.  4:522-528.

Site-directed antisera to the chromophore binding site of phytochrome: Characterization and cross-reactivity.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS.  248:35-42.

The genome-linked proteins of aphthoviruses: Specific immunoprecipitation of the three species detected on virus RNA and identification of possible precursors

Use of 10% sulfuric acid/dioxane for removal of N‐α‐tertiary‐butyloxycarbonyl group during solid phase peptide synthesis

Anti-peptide antibodies detect oncogene-related proteins in urine.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  82:7924-7928.

The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn.  NATURE.  318:480-483.

Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides.  JOURNAL OF EXPERIMENTAL MEDICINE.  162:487-500.

Human major histocompatibility complex class I antigens: Residues 61-83 of the HLA-B7 heavy chain specify an alloreactive site.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  82:539-542.

Human immune responses to synthetic peptides from the Epstein-Barr nuclear antigen.  JOURNAL OF IMMUNOLOGY.  134:211-216.

Characterization of an epibody: An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF.  JOURNAL OF EXPERIMENTAL MEDICINE.  161:323-331.

A completely synthetic toxoid vaccine containing Escherichia coli heat-stable toxin and antigenic determinants of the heat-labile toxin B subunit.  INFECTION AND IMMUNITY.  48:735-740.

Affinity purification of β-endorphin-like material from NG108CC15 hybrid cells by means of the monoclonal β-endorphin antibody 3-E7.  NEUROCHEMISTRY INTERNATIONAL.  7:247-253.

Antibodies to human interleukin-2 induced by synthetic peptides

General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  82:5131-5135.

Immunological priming with synthetic peptides of foot-and-mouth disease virus

Mobility and evolutionary variability factors in protein antigenicity.  NATURE.  317:90.

Mucosal antitoxin response in volunteers to immunization with a synthetic peptide of Escherichia coli heat-stable enterotoxin.  INFECTION AND IMMUNITY.  50:328-332.

Prodynorphin peptide immunocytochemistry in rhesus monkey brain.  PEPTIDES.  6:155-166.

T cell responses to cleaved rabies virus glycooprotein and to synthetic peptides.  JOURNAL OF IMMUNOLOGY.  133:2748-2752.

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein.  NATURE.  312:127-134.

Rabbit antipeptide antibodies against restricted domains of the histocompatibility complex

Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide.  JOURNAL OF EXPERIMENTAL MEDICINE.  159:1502-1511.

Binding of [³H]dynorphin a to apparent κ opioid receptors in deep layers of guinea pig cerebral cortex.  EUROPEAN JOURNAL OF PHARMACOLOGY.  98:149-150.

Anti-hypervariable region antibody induced by a defined peptide: An approach for studying the structural correlates of idiotypes.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  81:1784-1788.

Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  81:2176-2180.

Chemical synthesis of an octadecapeptide with the biological and immunological properties of human heat‐stable Escherichia coli enterotoxin

Detection of high molecular weight forms of platelet-derived growth factor by sequence-specific antisera.  SCIENCE.  226:701-703.

Differences in cross-protection in rats immunized with the B subunits of cholera toxin and Escherichia coli heat-labile toxin.  INFECTION AND IMMUNITY.  43:811-816.

Enzyme-linked immunosorbent assay for Escherichia coli heat-stable enterotoxin

Immunologic and functional characterization of anti-HLA-DR rabbit antibodies induced by synthetic peptides.  MOLECULAR IMMUNOLOGY.  21:847-852.

Properties of cross-linked toxoid vaccines made with hyperantigenic forms of synthetic Escherichia coli heat-stable toxin.  INFECTION AND IMMUNITY.  44:268-273.

The immune response to Epstein-Barr nuclear antigen: Conformational and structural features of antibody binding to synthetic peptides.  MOLECULAR IMMUNOLOGY.  21:1047-1054.

The structure of an antigenic determinant in a protein

[³H]-β-endorphin binding in rat brain.  JOURNAL OF NEUROSCIENCE.  4:2460-2465.

Autoradiography of [³H]β-endorphin binding in brain.  BRAIN RESEARCH.  288:334-337.

Chemical basis of antigenic variation in foot-and-mouth disease virus.  NATURE.  306:694-697.

α-Neo-endorphin: Receptor binding properties of the tritiated ligand.  LIFE SCIENCES.  33:1811-1820.

[³H]Dynorphin a binds selectively to guinea pig brain.  EUROPEAN JOURNAL OF PHARMACOLOGY.  91:327-328.

Synthetic peptides mimic subtype specificity of foot-and-mouth disease virus.  FEBS LETTERS.  157:261-264.

Anti-HLA antibodies of predetermined specificity: A chemically synthesized peptide induces antibodies specific for HLA-A,B heavy chain.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  80:255-258.

Antibodies of predetermined specificity detect two retroviral oncogene products and inhibit their kinase activities.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  80:1246-1250.

Biochemical and pharmacological evidence for opioid receptor multiplicity in the central nervous system.  LIFE SCIENCES.  33:167-173.

Enzyme linked immunosorbent assay (ELISA) for β-endorphin and its antibodies.  LIFE SCIENCES.  33:129-132.

Generation of protein-reactive antibodies by short peptides is an event of high frequency: Implications for the structural basis of immune recognition.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  80:4949-4953.

Immunological properties of purified Klebsiella pneumoniae heat-stable enterotoxin.  INFECTION AND IMMUNITY.  42:838-841.

Properties of synthetically produced Escherichia coli heat-stable enterotoxin.  INFECTION AND IMMUNITY.  39:117-121.

Protection against human and porcine enterotoxigenic strains of Escherichia coli in rats immunized with a cross-linked toxoid vaccine.  INFECTION AND IMMUNITY.  40:924-929.

Protection in rabbits immunized with a vaccine of Escherichia coli heat-stable toxin cross-linked to the heat-labile toxin B subunit.  INFECTION AND IMMUNITY.  40:888-893.

Reduction of Sulfoxides in Peptides and Proteins.  METHODS IN ENZYMOLOGY.  91:549-559.

Synthetic idiotypes: The third hypervariable region of murine anti-dextran antibodies

Vaccine for enterotoxigenic Escherichia coli based on synthetic heat-stable toxin crossed-linked to the B subunit of heat-labile toxin.  JOURNAL OF INFECTIOUS DISEASES.  147:318-326.

[³H] dynorphin binding to guinea pig and rat brain.  LIFE SCIENCES.  33:287-290.

Identification of a β-endorphin-like peptide in cultured human placental cells.  NATURE.  295:593-595.

Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence.  NATURE.  298:30-33.

Binding of ³H-β-endorphin in rat brain.  LIFE SCIENCES.  31:1381-1384.

Tritiated porcine dynorphin (1-17): Synthesis and characterization.  LIFE SCIENCES.  31:1805-1808.

ISOLATION OF α‐MELANOTROPIN AND N, O‐DIACETYLSERINE¹‐α‐MELANOTROPIN FROM PORCINE PITUITARY EXTRACTS

HUMAN β‐ENDORPHIN: SYNTHESIS AND CHARACTERIZATION OF ANALOGS IODINATED AND TRITIATED AT TRYOSINE RESIDUES 1 AND 27

β-Endorphin: Stability, clearance behavior, and entry into the central nervous system after intravenous injection of the tritiated peptide in rats and rabbits.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  77:4588-4591.

Studies on the reaction between human growth hormone and oleic acid using polyacrylamide gel electrophoresis.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS.  197:163-169.

Reduction of sulfoxides in peptides and proteins.  ANALYTICAL BIOCHEMISTRY.  98:36-46.

β-Endorphin: Characteristics of binding sites in the rat brain.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.  89:786-792.

Bicyclic Guanidino Ketones.  JOURNAL OF ORGANIC CHEMISTRY.  44:4536-4543.

Tritiated β(h)-endorphin: Preparation and clearance rates of radioactivity in rats and rabbits.  FEDERATION PROCEEDINGS.  38.

Cyclopeptide Alkaloids. Synthesis of the Ring System and Its Ion Affinity.  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY.  100:8202-8209.

ISOLATION AND PROPERTIES OF TWO FRAGMENTS FROM PLASMIN DIGESTS OF HUMAN CHORIOMAMMOTROPIN

PREPARATION AND PROPERTIES OF TRITIATED HUMANβ‐ENDORPHIN WITH HIGH SPECIFIC RADIOACTIVITY

REACTION OF OVINE PROLACTIN WITH 2‐(2‐NITROPHENYLSULFENYL)‐3‐METHYL‐3‘‐BROMOINDOLEMINE*

SELECTIVE CLEAVAGE AT THE SINGLE TRYPTOPHAN RESIDUE IN BOVINE SOMATOTROPIN BY 2‐(2‐NITROPHENYLSULFENYL)‐3‐METHYL‐3‘‐BROMOINDOLEMINE

Human somatotropin. Reaction with hydrogen peroxide.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS.  178:350-355.

Preparative isotachophoresis on polyacrylamide gels: Resolution as a function of time and wattage.  ANALYTICAL BIOCHEMISTRY.  77:303-309.

Reaction of Human Choriomammotropin with Hydrogen Peroxide

Separation of inorganic isomers by thin-layer chromatography. VI. Isomers of the non-metals boron, phosphorus and silica.  JOURNAL OF CHROMATOGRAPHY.  123:448-453.

Studies on pituitary prolactin 39. Reaction of the ovine hormone with hydrogen peroxide

Synthesis of Pure p-Chlorophenyl-L-alanine form L-Phenylalanine.  JOURNAL OF MEDICINAL CHEMISTRY.  17:556-558.

Solid-Phase Synthesis of trisubstituted 2-imidazolidones and 2-imidazolidinethiones

Solid-phase synthesis of 1,2,5-trisubstituted 4-imidazolidinones

Solid-phase synthesis of linear ureas tethered to hydantoins and thiohydantoins

Strategies for the use of mixture-based synthetic combinatorial libraries: Scaffold ranking, direct testing, in vivo, and enhanced deconvolution by computational methods

PEPTIDE SYNTHESIS.

Reversed-phase chromatography: The effect of induced conformations on peptide retention.  633-642.

Soluble synthetic combinatorial libraries: The use of molecular diversities for drug discovery.  1-26.

Solid-phase synthesis of heterocycles from peptides and amino acids.  269-318.

In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands.  433-453.

The versatility of nonsupport-bound combinatorial libraries.  139-171.

Mixture-Based Combinatorial Libraries.  1487-1494.

CHAPTER 208 Mixture-Based Combinatorial Libraries.  1487-1494.

From Tens to Trillions - Advances in Synthetic Combinatorial Chemistry of Peptides, Peptidomimetics and Heterocyclic Compounds Derived from Peptides.  3-12.

Combinatorial chemistry: Mixture-based combinatorial libraries of acyclic and heterocyclic compounds from amino acids and short peptides.  109-123.

Combinatorial libraries: Equimolar incorporation of benzaldehyde mixtures in reductive alkylation reactions.  57-58.

Identification and optimization of antigens for T cell clones of clinical relevance using positional scanning combinatorial libraries.  683-684.

Novel D-amino acid hexapeptide calmodulin antagonists identified from synthetic combinatorial libraries.  605-606.

Rapid parallel synthesis of 584 betides, peptides composed largely of beta-amino acids with side-chains not found in natural peptides.  174-175.

Synthesis of cyclic ureas and cyclic thioureas from acyl dipeptides.  264-266.

Synthetic combinatorial libraries for the study of molecular mimicry: Identification of an all D-amino acid peptide recognized by an anti-carbohydrate antibody.  761-762.

Identification of Novel Ligands for Vasopressin V2 Receptor from Positional Scanning Libraries.  921-922.

New Antiproliferative Agents from a Peptidomimetic Library.  640-641.

Polyamines as Intermediates for the Synthesis of Heterocyclic Compounds and Oligomeric Heterocyclic Compounds from Resin-Bound Polyamides.  252-254.

Solid Phase Synthesis of 1,2,4-Triazinan-3-ones.  259-260.

Solid Phase Synthesis of 1,2,5-Substituted Derivatives of 4-Imidazolidinone.  257-258.

Solid-Phase Synthesis of Substituted Dihydroimidazoles and Their Bis Analogs.  255-256.

Solid-Phase Synthesis of α-Difluoro-β-amino Acids by a Reformatsky Reaction.  261-262.

Solid-Phase Synthesis of Heterocyclic Compounds from Amino Acids and Linear Peptides.  639-670.

Combinatorial chemistry: Solid-phase synthesis of heterocyclic compounds from C-alpha-functionalized amino acids.  189-190.

Solid phase synthesis of heterocyclic combinatorial libraries derived from peptides.  192-197.

Synthetic Combinatorial Libraries: A New Tool for Antimicrobial Agent Discovery.  311-319.

Manual multiple synthesis methods

From specificity to degeneracy to molecular mimicry: antigen recognition of human autoreactive and pathogen-specific CD4+ T cells.  21-28.

Peptides as precursors in the synthesis of heterocyclic positional scanning combinatorial libraries.  25-27.

Preparation of heterocyclic positional scanning combinatorial libraries from peptides.  123-127.

Peralkylation. "Libraries from libraries": chemical transformation of synthetic combinatorial libraries..  41-49.

Synthesis and Screening of Positional Scanning Combinatorial Libraries.  13-24.

Tetrakis(Pyridine)Silver(2+)Peroxydisulfate.  177-181.

Peptidomimetic synthetic combinatorial libraries.  109-125.

1 Soluble Synthetic Combinatorial Libraries: The Use of Molecular Diversities for Drug Discovery.  1-26.

The design of self-assembling peptide complexes using conformationally defined libraries.  65-71.

Generation and use of nonsupport-bound peptide and peptidomimetic combinatorial libraries.  220-226.

Tea Bag Synthesis of Positional Scanning Synthetic Combinatorial Libraries and Their Use for Mapping Antigenic Determinants.  171-179.

The generation of peptide combinatorial libraries using tea-bag synthesis.  835-845.

10 Soluble Chemical Combinatorial Libraries Current Capabilities and Future Possibilities.  395-417.

Cyclic peptide template synthetic combinatorial libraries.  461-462.

Design of conformationally defined combinatorial libraries.  85-86.

Detailed studies of antibody specificity using synthetic peptide combinatorial libraries.  113-114.

Direct determination of the extent of racemization during post peptide synthesis reactions.  416-417.

Extending the range of molecular diversity through amide alkylation of peptide libraries.  463-464.

Identification of tetrameric opioid peptides from a combinatorial library composed of L-, D- and non-proteinogenic amino acids.  805-806.

Libraries from libraries: The generation of peptidomimetic combinatorial diversities.  459-460.

Polyalkylamine chemical combinatorial libraries.  465-466.

Study of peptide-antibody interactions using a decapeptide positional scanning library.  815-816.

Identification of an antigenic determinant for the surface antigen of hepatitis B virus using peptide libraries.  1016-1017.

Membrane Protecting Sequences and New Antimicrobial Peptides Identified through the Screening of Synthetic Peptide Combinatorial Libraries.  509-516.

New, potent N-acetylated all D-amino acid opioid peptides.  984-985.

Optimal peptide length determination using synthetic peptide combinatorial libraries.  971-974.

A priori determination of peptide ligands for opiate receptors using synthetic peptide combinatorial libraries.  649-650.

Determination of multiple binding specificities of a monoclonal antibody using a synthetic peptide combinatorial library.  903-904.

Inhibition of melittin’s hemolytic activity using synthetic peptide combinatorial libraries.  761-762.

Novel N-acetylated opioid peptides determined through the use of synthetic peptide combinatorial libraries.  11-13.

Positional scanning synthetic peptide combinatorial libraries.  65-66.

The Systematic Development of Peptides Having Potent Antimicrobial Activity Against E. coli Through the Use of Synthetic Peptide Combinatorial Libraries.  249-256.

Chapter 17. Progress in Antimicrobial Peptides.  159-168.

Comparison of structural and functional approaches for the study of peptide-mAb interactions.  867-868.

The relationship between potential induced conformation of melittin and its hemolytic activity.  433-434.

The use of a peptide library composed of 34 012 224 hexamers for basic research and drug discovery.  560-561.

Multiple epitope specificity of monoclonal antibodies to a single synthetic peptide: Use in the characterization of the GP IIb-IIIa binding domain of von Willebrand factor.  133-144.

Induced conformations of peptides during RPHPLC: Positional dependence of methionine oxidation.  478-480.

Peptide-monoclonal antibody interactions defined at the amino acid level: Advantages of competitive ELISA techniques.  860-861.

The effect of induced conformation on antimicrobial and hemolytic activity of amphipathic peptides.  738-739.

Simultaneous multiple peptide synthesis: The rapid preparation of large numbers of discrete peptides for biological, immunological, and methodological studies.  166-172.

The determination of the precise amino acids involved, and their relative importance, in peptide antigen/monoclonal antibody interactions.  543-546.

IDENTIFICATION OF FOLDED STRUCTURES IN IMMUNOGENIC PEPTIDES BY 2D NMR SPECTROSCOPY.  477-480.

Simultaneous Multiple Peptide Synthesis: The Rapid Preparation of Large Numbers of Peptides.  463-470.

Selection by site-directed antibodies of small regions of peptides which are ordered in water..  58-75.

The Antigenic Structure of the Rabies Virus Glycoprotein.  3-12.

CHARACTERIZATION OF A HIGH AFFINITY 3H-βh-ENDORPHIN RECEPTOR IN RAT BRAIN CRUDE SYNAPTOSOMAL FRACTION.  225-228.

TNFα-Based Peptides as Bioprobes for Exosites of ADAM Proteases

Exploring structural scaffolds as a strategy to design selective ligands.  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

Structure activity relation study of small-molecule antagonists of apoptosis suppressor XIAP.  CANCER RESEARCH.

Efficient synthesis of fused tetracyclic benzimidazole systems.  39-40.

Parallel solid-phase synthesis of difluorinated dipeptide analogs.  63-64.

Highly regioselective parallel solid phase synthesis of new tetracyclic 1,3,5-triazino[1,2-A]benzimidazoles.  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U306-U306.

One-pot Aza-Wittig/heterocyclization/substitution reaction for the parallel solid phase synthesis of new tetracyclic 1,3,5-triazino[1,2-a]benzimidazolium derivatives.  BIOPOLYMERS. 353-354.

Solid-phase synthesis of alpha,alpha-difluorinated beta-amino acids by Reformatsky reaction.  BIOPOLYMERS. 353-353.

Parallel solid phase synthesis of 1,3,5-triazino[1,2-a]benzimidazoles via tandem Aza-Wittig/heterocumulene-mediated annulation..  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. B208-B209.

Solid phase synthesis of alpha,alpha-difluoro-beta-amino acid derivatives by Reformatsky reaction..  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U556-U556.

Solid phase synthesis of alpha,alpha-difluoro-beta-amino acid derivatives by reformatsky reaction..  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. B209-B209.

Synthesis of cyclic ureas and cyclic thioureas from acyl dipeptides.  265-266.

SYNTHETIC PEPTIDE PROBES OF FACTOR VIII IMMUNOLOGY AND FUNCTION.  536-536.

Editorial.  330.

Molecular diversity comes of age !.  1-3.

The theory and practice of combinatorial chemistry.  249.

Solid-phase synthesis of trisubstituted bicyclic guanidines via cyclization of reduced N-acylated dipeptides.  JOURNAL OF ORGANIC CHEMISTRY. 8622-8623.

Isolation of populations of antipeptide antibodies directed against different epitopes of the same fragment.  148-150.

Erratum: Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput 'Unbiased' Screening Campaign (J. Med. Chem. (2021) 64:9 (5577−5592) DOI: 10.1021/acs.jmedchem.0c02041).  JOURNAL OF MEDICINAL CHEMISTRY. 7063-7065.

A traceless approach for the solid-phase parallel synthesis of trisubstituted oxindoles (J. Comb. Chem.) 2007;9:566-568.  752.

In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands..  E371-E382.

Combinatorial chemistry: Libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds. (vol 69,3603, 2004).  JOURNAL OF ORGANIC CHEMISTRY. 5516-5516.

Erratum: Combinatorial chemistry: Libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds (Journal of Organic Chemistry (2004) 69 (3603)).  JOURNAL OF ORGANIC CHEMISTRY. 5516.

Mixture-based synthetic combinatorial libraries.  JOURNAL OF MEDICINAL CHEMISTRY. 3743-3778.

Erratum: A study of human T-cell lines generated from multiple sclerosis patients and controls by stimulation with peptides of myelin basic protein (J. Neuroimmunol. 70, 65-74 (1996)).  JOURNAL OF NEUROIMMUNOLOGY. 213.

Peripheral kappa opioid receptor activation drives noxious cold hypersensitivity in mice

All D-amino acid hexapeptide inhibitors of melittin's cytolytic activity derived from synthetic combinatorial libraries.  JOURNAL OF MOLECULAR RECOGNITION. 163-168.

The synthesis of peptidomimetic combinatorial libraries through successive amide alkylations.  BIOORGANIC & MEDICINAL CHEMISTRY. 709-715.

Modified solid-phase methods for the rapid synthesis of opioid peptides.  239-255.

A CTL epitope on the circumsporozoite protein of P. yoelii.  99-103.

The value of antimicrobial peptides in the age of resistance.  e216-e230.

Mu-Opioid receptor biased ligands: A safer and painless discovery of analgesics?.  DRUG DISCOVERY TODAY. 1719-1729.

Shifting from the single to the multitarget paradigm in drug discovery.  DRUG DISCOVERY TODAY. 495-501.

Expanding the medicinally relevant chemical space with compound libraries.  DRUG DISCOVERY TODAY. 718-726.

Visualization of the chemical space in drug discovery.  322-333.

In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands

Improved, high yield synthesis of 3H-quinazolin-4-ones, the key intermediates of recently developed drugs.  CURRENT MEDICINAL CHEMISTRY. 2549-2553.

Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries.  118-122.

Combinatorial chemistry: mixture-based combinatorial libraries of acyclic and heterocyclic compounds from amino acids and short peptides..  109-123.

Mixture-based combinatorial libraries: From peptides and peptidomimetics to small molecule acyclic and heterocyclic compounds.  METHODS IN ENZYMOLOGY. 496-517.

Drug discovery and vaccine development using mixture-based synthetic combinatorial libraries.  DRUG DISCOVERY TODAY. 276-285.

Parallel array and mixture-based synthetic combinatorial chemistry: Tools for the next millennium.  273-282.

Libraries from libraries: Generation and comparison of screening profiles.  41-45.

Novel antimicrobial compounds identified using synthetic combinatorial library technology.  TRENDS IN BIOTECHNOLOGY. 60-65.

Generation and utilization of synthetic combinatorial libraries.  174-180.

Peptide, peptidomimetic, and organic synthetic combinatorial libraries.  481-496.

Synthetic peptide combinatorial libraries may be used to determine peptide ligands for opioid receptors.  66-74.

Analyses of human rheumatoid factors with anti-idiotypes induced by synthetic peptides..  12-23.

The current status of heterocyclic combinatorial libraries.  CHEMICAL REVIEWS. 449-472.