Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans: Correlation with a cytotoxic T cell epitope
Article
De Groot, AS, Clerici, M, Hosmalin, A et al. (1991). Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans: Correlation with a cytotoxic T cell epitope
. JOURNAL OF INFECTIOUS DISEASES, 164(6), 1058-1065. 10.1093/infdis/164.6.1058
De Groot, AS, Clerici, M, Hosmalin, A et al. (1991). Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans: Correlation with a cytotoxic T cell epitope
. JOURNAL OF INFECTIOUS DISEASES, 164(6), 1058-1065. 10.1093/infdis/164.6.1058
T cell immunity may be critical to development of a vaccine for human immunodeficiency virus (HIV-1). T helper epitopes were identified in three predominantly conserved regions in the HIV-1 reverse transcriptase by using reverse transcriptase-immunized mice of five major histocompatibility complex haplotypes. One peptide (residues 38-52) that stimulated H-2k T cells also contained an epitope recognized by cytotoxic T cells from the same mice and from HIV-infected patients. Such concordance between helper and cytotoxic T lymphocyte epitopes, observed in four cases, may be important in vaccine development. Peptide 36-52 was recognized by interleukin-2-producing peripheral blood T cells from 9 of 17 HIV-seropositive humans studied, of multiple human leukocyte antigen-DR and -DQ types. The broad recognition of this peptide by both helper and cytotoxic T cells substantiates its potential importance in a vaccine.
