High throughput synthesis of 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b] thiazole derivatives Article

Li, Y, Giulianotti, M, Houghten, RA. (2011). High throughput synthesis of 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b] thiazole derivatives . TETRAHEDRON LETTERS, 52(6), 696-698. 10.1016/j.tetlet.2010.12.006

cited authors

  • Li, Y; Giulianotti, M; Houghten, RA

abstract

  • A facile approach to the synthesis of 2,3,6-trisubstituted-5,6- dihydroimidazo[2,1-b]thiazole was reported. A resin bound cyclic thiourea was formed by the treatment of a resin bound diamine with 1,1′- thiocarbonyldiimidazole, and then reacted with a α-haloketone to generate a resin bound isothiourea. HF treatment of the resin bound isothiourea resulted in the cleavage of the product and simultaneous formation of an enamine bond. This led to the formation of the 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b] thiazole in high yield and purity. © 2010 Elsevier Ltd. All rights reserved.

publication date

  • January 1, 2011

published in

Digital Object Identifier (DOI)

start page

  • 696

end page

  • 698

volume

  • 52

issue

  • 6