Giulianotti, Marcello

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Giulianotti, Marcello

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Patents issued

Bacterial Topoisomerase Inhibitors and Use Thereof Patent

selected scholarly works & creative activities

Article
- 2022
  
  Identification of B Cell and T Cell Epitopes Using Synthetic Peptide Combinatorial Libraries
  Full Text via DOI: 10.1002/cpz1.378
- 2022
  
  Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity
  Full Text via DOI: 10.3390/v14030531
- 2021
  
  Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist. JOURNAL OF MEDICINAL CHEMISTRY. 64:14860-14875.
  Full Text via DOI: 10.1021/acs.jmedchem.1c01417 Web of Science: 000709633100049
- 2021
  
  Inhibition of Aminoglycoside 6′-N-acetyltransferase Type Ib (AAC(6′)-Ib): Structure-Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors
  Full Text via DOI: 10.3390/biomedicines9091218 Web of Science: 000699202200001
- 2021
  
  Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. JOURNAL OF MEDICINAL CHEMISTRY. 64:5577-5592.
  Full Text via DOI: 10.1021/acs.jmedchem.0c02041 Web of Science: 000651785800020
- 2020
  
  A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A
  Full Text via DOI: 10.1177/2472555220926146
- 2020
  
  Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 527:317-323.
  Full Text via DOI: 10.1016/j.bbrc.2020.04.037
- 2020
  
  Tissue Chips in Space: Modeling Human Diseases in Microgravity. PHARMACEUTICAL RESEARCH. 37.
  Full Text via DOI: 10.1007/s11095-019-2742-0
- 2019
  
  A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation
  Full Text via DOI: 10.1021/acschembio.9b00093
- 2019
  
  Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μm MC4R Partial Agonist. JOURNAL OF MEDICINAL CHEMISTRY. 62:2738-2749.
  Full Text via DOI: 10.1021/acs.jmedchem.9b00053
- 2019
  
  A novel probe for spliceosomal proteins that induces autophagy and death of melanoma cells reveals new targets for melanoma drug discovery. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 53:656-686.
  Full Text via DOI: 10.33594/000000164
- 2018
  
  Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency. ACS MEDICINAL CHEMISTRY LETTERS. 9:1057-1062.
  Full Text via DOI: 10.1021/acsmedchemlett.8b00425 Web of Science: 000447471800021
- 2018
  
  Identification of a novel polyamine scaffold with potent efflux pump inhibition activity toward multi-drug resistant bacterial pathogens
  Full Text via DOI: 10.3389/fmicb.2018.01301
- 2018
  
  Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs. PSYCHOPHARMACOLOGY. 235:1745-1757.
  Full Text via DOI: 10.1007/s00213-018-4883-y
- 2018
  
  Identification of a small molecule inhibitor of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] using mixture-based combinatorial libraries
  Full Text via DOI: 10.1016/j.ijantimicag.2018.01.019
- 2017
  
  Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats. JOURNAL OF MEDICINAL CHEMISTRY. 60:10092-10104.
  Full Text via DOI: 10.1021/acs.jmedchem.7b01250
- 2017
  
  Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries
  Full Text via DOI: 10.1021/acsmedchemlett.7b00045
- 2017
  
  Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa¹-Arg-(pI)DPhe-Xaa⁴-NH2. JOURNAL OF MEDICINAL CHEMISTRY. 60:4342-4357.
  Full Text via DOI: 10.1021/acs.jmedchem.7b00301
- 2017
  
  A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation. ORGANIC & BIOMOLECULAR CHEMISTRY. 15:7796-7801.
  Full Text via DOI: 10.1039/c7ob01924f
- 2016
  
  Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 60:4028-4036.
  Full Text via DOI: 10.1128/AAC.00288-16 Web of Science: 000378094400020
- 2016
  
  Identification of protein palmitoylation inhibitors from a scaffold ranking library
  Full Text via DOI: 10.2174/1386207319666160324123844
- 2016
  
  Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines
  Full Text via DOI: 10.1021/acscombsci.5b00126 Web of Science: 000368048100006
- 2015
  
  Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT). CHEMICAL RESEARCH IN TOXICOLOGY. 28:2419-2425.
  Full Text via DOI: 10.1021/acs.chemrestox.5b00432 Web of Science: 000367118000019
- 2015
  
  SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. JOURNAL OF MEDICINAL CHEMISTRY. 58:5808-5824.
  Full Text via DOI: 10.1021/acs.jmedchem.5b00354
- 2015
  
  Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens. JOURNAL OF MEDICINAL CHEMISTRY. 58:3340-3355.
  Full Text via DOI: 10.1021/jm501628s Web of Science: 000353602200006
- 2015
  
  Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 92:270-281.
  Full Text via DOI: 10.1016/j.ejmech.2014.12.049
- 2015
  
  Antigen Discovery for the Identification of Vaccine Candidates and Biomarkers Using a T Cell Driven Approach in Combination with Positional Scanning Peptide Libraries
  Full Text via DOI: 10.1016/j.provac.2015.05.013
- 2015
  
  Interaction fingerprints and their applications to identify hot spots
  Full Text via DOI: 10.1007/978-1-4939-2914-6_20
- 2014
  
  Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs). JOURNAL OF MEDICINAL CHEMISTRY. 57:4615-4628.
  Full Text via DOI: 10.1021/jm500064t
- 2014
  
  Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition. ANALYTICAL BIOCHEMISTRY. 449:68-75.
  Full Text via DOI: 10.1016/j.ab.2013.12.018
- 2014
  
  Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis. JOURNAL OF MEDICINAL CHEMISTRY. 57:1599-1608.
  Full Text via DOI: 10.1021/jm4019542
- 2013
  
  Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies. JOURNAL OF MEDICINAL CHEMISTRY. 56:10103-10117.
  Full Text via DOI: 10.1021/jm401543h Web of Science: 000329331600020
- 2013
  
  Conditional probabilistic analysis for prediction of the activity landscape and relative compound activities. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 53:2613-2625.
  Full Text via DOI: 10.1021/ci400243e
- 2013
  
  Selective agonists and antagonists of formylpeptide receptors: Duplex flow cytometry and mixture-based positional scanning libraries
  Full Text via DOI: 10.1124/mol.113.086595
- 2013
  
  Libraries from libraries: A series of sulfonamide linked heterocycles derived from the same scaffold. TETRAHEDRON LETTERS. 54:4296-4299.
  Full Text via DOI: 10.1016/j.tetlet.2013.06.003
- 2013
  
  Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:22871-22879.
  Full Text via DOI: 10.1074/jbc.M113.462267
- 2013
  
  Parallel synthesis of 1,6-disubstituted-1,2,4-triazin-3-ones on solid-phase
  Full Text via DOI: 10.1021/co400064d
- 2013
  
  Identification of beryllium-dependent peptides recognized by CD4⁺ T cells in chronic beryllium disease. JOURNAL OF EXPERIMENTAL MEDICINE. 210:1403-1418.
  Full Text via DOI: 10.1084/jem.20122426
- 2013
  
  Rapid scanning structure-activity relationships in combinatorial data sets: Identification of activity switches. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 53:1475-1485.
  Full Text via DOI: 10.1021/ci400192y
- 2013
  
  The mathematics of a successful deconvolution: A quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors
  Full Text via DOI: 10.3390/molecules18066408
- 2013
  
  ChemInform Abstract: Palladium‐Catalyzed C—H Functionalization Using Guanidine as a Directing Group: ortho‐Arylation and Olefination of Arylguanidines.
  Full Text via DOI: 10.1002/chin.201311079
- 2013
  
  A traceless approach to amide and peptide construction from thioacids and dithiocarbamate-terminal amines. CHEMICAL SCIENCE. 4:970-976.
  Full Text via DOI: 10.1039/c2sc21317f
- 2013
  
  HTS by NMR of combinatorial libraries: A fragment-based approach to ligand discovery. CHEMISTRY & BIOLOGY. 20:19-33.
  Full Text via DOI: 10.1016/j.chembiol.2012.10.015
- 2013
  
  Ligand/kappa-opioid receptor interactions: Insights from the X-ray crystal structure. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 66:114-121.
  Full Text via DOI: 10.1016/j.ejmech.2013.05.021
- 2012
  
  Fluorescent Mu selective opioid ligands from a mixture based cyclic peptide library
  Full Text via DOI: 10.1021/co300110t
- 2012
  
  Palladium-catalyzed C-H functionalization using guanidine as a directing group: Ortho arylation and olefination of arylguanidines. ORGANIC LETTERS. 14:5452-5455.
  Full Text via DOI: 10.1021/ol302533w
- 2012
  
  Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:36473-36487.
  Full Text via DOI: 10.1074/jbc.M112.389114
- 2012
  
  A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries
  Full Text via DOI: 10.1021/co300060s
- 2012
  
  ChemInform Abstract: Solid‐Phase Synthesis of Heterocycles from Peptides and Amino Acids.
  Full Text via DOI: 10.1002/chin.201226242
- 2012
  
  Novel T cell driven approach leads to the identification of immunoprevalent antigens
  Full Text via DOI: 10.1016/j.provac.2012.04.004
- 2012
  
  Synthesis of 2,3,4-trisubstituted pyrroles via a facile reaction of vinyl azides and tosylmethyl isocyanide. CANADIAN JOURNAL OF CHEMISTRY. 90:214-221.
  Full Text via DOI: 10.1139/v11-150
- 2011
  
  Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 46:5970-5977.
  Full Text via DOI: 10.1016/j.ejmech.2011.10.009
- 2011
  
  Parallel synthesis of novel antitumor agents: 1, 2, 3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR
  Full Text via DOI: 10.1007/s11030-011-9324-3
- 2011
  
  Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes
  Full Text via DOI: 10.1007/s11030-011-9333-2 Web of Science: 000300364700017
- 2011
  
  GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4+ T cells following smallpox vaccination
  Full Text via DOI: 10.1371/journal.pone.0024091
- 2011
  
  Solid-phase synthesis of 2,3,5,6-tetrahydro-1H-imidazo[1,2-a]benzo[d]- [1,3]diazepines via Pd(OAc)2/Cu(OAc)2-cocatalyzed cyclization. SYNLETT. 2259-2261.
  Full Text via DOI: 10.1055/s-0030-1261186
- 2011
  
  Solid-phase synthesis of 2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine derivatives. TETRAHEDRON LETTERS. 52:4112-4113.
  Full Text via DOI: 10.1016/j.tetlet.2011.05.138
- 2011
  
  A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and vinyl azides. TETRAHEDRON. 67:4887-4891.
  Full Text via DOI: 10.1016/j.tet.2011.04.103
- 2011
  
  Integrating Virtual Screening and Combinatorial Chemistry for Accelerated Drug Discovery
  Full Text via DOI: 10.2174/138620711795767866 Web of Science: 000292772100004
- 2011
  
  Integrating computational and mixture-based screening of combinatorial libraries. JOURNAL OF MOLECULAR MODELING. 17:1473-1482.
  Full Text via DOI: 10.1007/s00894-010-0850-1 Web of Science: 000291041800025
- 2011
  
  Solid-phase synthesis of N-substituted 3,4-dihydroquinazolinone derivatives. TETRAHEDRON LETTERS. 52:2627-2628.
  Full Text via DOI: 10.1016/j.tetlet.2011.03.034
- 2011
  
  Use and implications of the harmonic mean model on mixtures for basic research and drug discovery
  Full Text via DOI: 10.1021/co100065a
- 2011
  
  High throughput synthesis of 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b] thiazole derivatives. TETRAHEDRON LETTERS. 52:696-698.
  Full Text via DOI: 10.1016/j.tetlet.2010.12.006
- 2011
  
  Structure-activity relationships of benzimidazole derivatives as antiparasitic agents: Dual activity-difference (DAD) maps. MEDCHEMCOMM. 2:44-49.
  Full Text via DOI: 10.1039/c0md00159g
- 2010
  
  Towards a systematic characterization of the antiprotozoal activity landscape of benzimidazole derivatives. BIOORGANIC & MEDICINAL CHEMISTRY. 18:7380-7391.
  Full Text via DOI: 10.1016/j.bmc.2010.09.019
- 2010
  
  A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a 'volatilizable' support. TETRAHEDRON LETTERS. 51:5637-5639.
  Full Text via DOI: 10.1016/j.tetlet.2010.08.026
- 2010
  
  Docking of protein kinase B inhibitors: implications in the structure-based optimization of a novel scaffold
  Full Text via DOI: 10.1111/j.1747-0285.2010.01002.x
- 2010
  
  Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library
  Full Text via DOI: 10.1208/s12248-010-9191-3 Web of Science: 000288425000008
- 2010
  
  Conformational landscape of platinum(II)-tetraamine complexes: DFT and NBO studies
  Full Text via DOI: 10.1007/s10822-010-9328-6 Web of Science: 000276965100005
- 2010
  
  Combining positional scanning peptide libraries, HLA-DR transfectants and bioinformatics to dissect the epitope spectrum of HLA class II cross-restricted CD4+ T cell clones
  Full Text via DOI: 10.1016/j.jim.2009.12.006
- 2010
  
  Traceless solid-phase synthesis of N-substituted 3,5-bis(substituted-idene) piperidin-4-one derivatives. TETRAHEDRON LETTERS. 51:5003-5004.
  Full Text via DOI: 10.1016/j.tetlet.2010.07.072
- 2009
  
  Synthesis of cyclic peptides through direct aminolysis of peptide thioesters catalyzed by imidazole in aqueous organic solutions
  Full Text via DOI: 10.1021/cc900100z
- 2009
  
  Solid-phase synthesis of 2-alkylidene-6-alkyl-imidazo[2,1-b]thiazole-3,5[2H,6H]-dione derivatives. TETRAHEDRON LETTERS. 50:5857-5859.
  Full Text via DOI: 10.1016/j.tetlet.2009.08.009
- 2009
  
  Discovery of a novel protein kinase B inhibitor by structure-based virtual screening. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 19:4634-4638.
  Full Text via DOI: 10.1016/j.bmcl.2009.06.078
- 2009
  
  Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands. BIOORGANIC & MEDICINAL CHEMISTRY. 17:5583-5597.
  Full Text via DOI: 10.1016/j.bmc.2009.06.026 Web of Science: 000268099700026
- 2009
  
  Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries Small Molecule Repository. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 49:1010-1024.
  Full Text via DOI: 10.1021/ci800426u
- 2009
  
  One-pot high-throughput synthesis of β-turn cyclic peptidomimetics-via "volatilizable" supports. JOURNAL OF ORGANIC CHEMISTRY. 74:2183-2185.
  Full Text via DOI: 10.1021/jo802583t
- 2009
  
  Characterization of activity landscapes using 2D and 3D similarity methods: Consensus activity cliffs. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 49:477-491.
  Full Text via DOI: 10.1021/ci800379q
- 2009
  
  Modeling of peptides containing D-amino acids: Implications on cyclization
  Full Text via DOI: 10.1007/s10822-009-9295-y
- 2008
  
  High throughput synthesis of peptide α-thioesters through the use of "volatilizable" support
  Full Text via DOI: 10.1021/cc800076b
- 2008
  
  Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis. BIOORGANIC & MEDICINAL CHEMISTRY. 16:5932-5938.
  Full Text via DOI: 10.1016/j.bmc.2008.04.061
- 2008
  
  High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on 'volatilizable' supports. TETRAHEDRON LETTERS. 49:3632-3633.
  Full Text via DOI: 10.1016/j.tetlet.2008.03.156
- 2007
  
  A similarity-based data-fusion approach to the visual characterization and comparison of compound databases
  Full Text via DOI: 10.1111/j.1747-0285.2007.00579.x
- 2006
  
  Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype. JOURNAL OF IMMUNOLOGY. 176:1951-1961.
  Full Text via DOI: 10.4049/jimmunol.176.3.1951
- 2003
  
  Efficient approach for the diversity-oriented synthesis of macro-heterocycles on solid-support. TETRAHEDRON LETTERS. 44:5307-5309.
  Full Text via DOI: 10.1016/S0040-4039(03)01219-X Web of Science: 000183780300037
- 2001
  
  Solid-phase synthesis of bis-heterocyclic compounds from resin-bound orthogonally protected lysine
  Full Text via DOI: 10.1021/cc000061t Web of Science: 000167935000010
- 2000
  
  Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides. ORGANIC LETTERS. 2:3349-3350.
  Full Text via DOI: 10.1021/ol000225e Web of Science: 000089831900026
- 2000
  
  Solid-phase synthesis of substituted 2,3-diketopiperazines from reduced polyamides. TETRAHEDRON. 56:3319-3326.
  Full Text via DOI: 10.1016/S0040-4020(00)00253-2 Web of Science: 000087032100006
- 2000
  
  Solid-phase synthesis of branched thiohydantoin benzimidazolinethiones and branched thiohydantoin tetrahydroquinoxalinediones. TETRAHEDRON LETTERS. 41:2283-2287.
  Full Text via DOI: 10.1016/S0040-4039(00)00162-3 Web of Science: 000086681100004
- 1999
  
  Solid phase synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids. TETRAHEDRON LETTERS. 40:8539-8542.
  Full Text via DOI: 10.1016/S0040-4039(99)01823-7 Web of Science: 000083665600010
- 1999
  
  Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives. TETRAHEDRON LETTERS. 40:4939-4942.
  Full Text via DOI: 10.1016/S0040-4039(99)00964-8 Web of Science: 000081122400006
- 1998
  
  Efficient solid phase synthesis of 3,5-disubstituted hydantoins. TETRAHEDRON LETTERS. 39:8199-8202.
  Full Text via DOI: 10.1016/S0040-4039(98)01874-7 Web of Science: 000076524100004
- 1998
  
  Solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones. TETRAHEDRON LETTERS. 39:3671-3674.
  Full Text via DOI: 10.1016/S0040-4039(98)00645-5 Web of Science: 000073724300014
- Solid-Phase Synthesis of trisubstituted 2-imidazolidones and 2-imidazolidinethiones
  Full Text via DOI: 10.1021/cc980019m Web of Science: 000081948200005
- Solid-phase synthesis of linear ureas tethered to hydantoins and thiohydantoins
  Full Text via DOI: 10.1021/cc010064l Web of Science: 000174633500013
- Strategies for the use of mixture-based synthetic combinatorial libraries: Scaffold ranking, direct testing, in vivo, and enhanced deconvolution by computational methods
  Full Text via DOI: 10.1021/cc7001205 Web of Science: 000252409800002
Book Chapter
- 2011
  
  Solid-phase synthesis of heterocycles from peptides and amino acids. 269-318.
  Full Text via DOI: 10.1002/9781118141649.ch9
- 2002
  
  Combinatorial libraries: Equimolar incorporation of benzaldehyde mixtures in reductive alkylation reactions. 57-58.
  Full Text via DOI: 10.1007/0-306-46862-x_18
- 2002
  
  Synthesis of cyclic ureas and cyclic thioureas from acyl dipeptides. 264-266.
  Full Text via DOI: 10.1007/0-306-46862-x_109
- 2000
  
  Combinatorial chemistry: Solid-phase synthesis of heterocyclic compounds from C-alpha-functionalized amino acids. 189-190.
  Web of Science: 000166856900077
- 2000
  
  Solid phase synthesis of heterocyclic combinatorial libraries derived from peptides. 192-197.
  Web of Science: 000166933900049
- 1999
  
  Peptides as precursors in the synthesis of heterocyclic positional scanning combinatorial libraries. 25-27.
  Web of Science: 000085202200005
Conference
- 2022
  
  Discovery and Characterization of the First Biased Beta-Agonist That Favors Gs-Coupling vs Beta-Arrestin Mediated Desensitization: A New Class of Structurally Distinct Beta-Agonists for Treating Obstructive Lung Diseases. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000792480403126
- 2019
  
  The international space station U.S. National Lab - Tissue engineering and regenerative medicine
- 2019
  
  Tissue chips in space
- 2013
  
  TNFα-Based Peptides as Bioprobes for Exosites of ADAM Proteases
  Full Text via DOI: 10.17952/23aps.2013.136
Note
- 2020
  
  Pharmaceutical Research Enabled Through Microgravity: Perspectives on the Use of the International Space Station U.S. National Laboratory. PHARMACEUTICAL RESEARCH.
  Full Text via DOI: 10.1007/s11095-019-2719-z
Other Scholarly Work
- 2015
  
  Identification of novel chemotherapies targeting mitochondrial-cell communication. FASEB JOURNAL.
  Web of Science: 000361722705237
Review
- 2020
  
  The value of antimicrobial peptides in the age of resistance. e216-e230.
  Full Text via DOI: 10.1016/S1473-3099(20)30327-3
- 2013
  
  Shifting from the single to the multitarget paradigm in drug discovery. DRUG DISCOVERY TODAY. 495-501.
  Full Text via DOI: 10.1016/j.drudis.2013.01.008
- 2012
  
  Expanding the medicinally relevant chemical space with compound libraries. DRUG DISCOVERY TODAY. 718-726.
  Full Text via DOI: 10.1016/j.drudis.2012.04.001
- 2008
  
  Visualization of the chemical space in drug discovery. 322-333.
  Full Text via DOI: 10.2174/157340908786786010

principal investigator on

Melanocortin Receptor Selective Ligands awarded by University of Minnesota 2021 - 2023
Dealing with antibiotic resistance: antisense technology - novel compound synthesis awarded by California State University - Fullerton 2022 - 2023
Synthesis of Select Compounds awarded by BTB Japan Inc 2021 - 2022
Novel and potent compounds that promote axon growth awarded by Craig H. Neilsen Foundation 2020 - 2022
Dealing with antibiotic resistance: antisense technology - novel compound synthesis awarded by California State University - Fullerton 2021
Synthesis of Compounds 2155-14 and 2155-18 awarded by Nova Southeastern University 2020 - 2021
Synthesis of Select Compounds awarded by BTB Japan Inc 2020
NPQ/SPEXIN THE ENDOGENOUS LIGAND FOR THE GALANIN RECEPTOR 3 awarded by National Institute on Drug Abuse 2020

visualizations

Co-author Network

Co-investigator Network