Publications
Patents issued
selected scholarly works & creative activities
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Article
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2022Identification of B Cell and T Cell Epitopes Using Synthetic Peptide Combinatorial Libraries. Current Protocols. 2.Full Text via DOI: 10.1002/cpz1.378
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2022Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity. Viruses. 14.Full Text via DOI: 10.3390/v14030531
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2021Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist. Journal of Medicinal Chemistry. 64:14860-14875.Full Text via DOI: 10.1021/acs.jmedchem.1c01417 Web of Science: 000709633100049
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2021Inhibition of Aminoglycoside 6′-N-acetyltransferase Type Ib (AAC(6′)-Ib): Structure-Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors. Biomedicines. 9.Full Text via DOI: 10.3390/biomedicines9091218 Web of Science: 000699202200001
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2021Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. Journal of Medicinal Chemistry. 64:5577-5592.Full Text via DOI: 10.1021/acs.jmedchem.0c02041 Web of Science: 000651785800020
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2020A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A. SLAS Discovery. 25:1038-1046.Full Text via DOI: 10.1177/2472555220926146
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2020Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency. Biochemical and Biophysical Research Communications. 527:317-323.Full Text via DOI: 10.1016/j.bbrc.2020.04.037
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2020Tissue Chips in Space: Modeling Human Diseases in Microgravity. Pharmaceutical Research. 37.Full Text via DOI: 10.1007/s11095-019-2742-0
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2019A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation. ACS Chemical Biology. 14:1183-1194.Full Text via DOI: 10.1021/acschembio.9b00093
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2019Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μm MC4R Partial Agonist. Journal of Medicinal Chemistry. 62:2738-2749.Full Text via DOI: 10.1021/acs.jmedchem.9b00053
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2019A novel probe for spliceosomal proteins that induces autophagy and death of melanoma cells reveals new targets for melanoma drug discovery. Cellular Physiology and Biochemistry. 53:656-686.Full Text via DOI: 10.33594/000000164
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2018Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency. ACS Medicinal Chemistry Letters. 9:1057-1062.Full Text via DOI: 10.1021/acsmedchemlett.8b00425 Web of Science: 000447471800021
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2018Identification of a novel polyamine scaffold with potent efflux pump inhibition activity toward multi-drug resistant bacterial pathogens. Frontiers in Microbiology. 9.Full Text via DOI: 10.3389/fmicb.2018.01301
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2018Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs. Psychopharmacology. 235:1745-1757.Full Text via DOI: 10.1007/s00213-018-4883-y
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2018Identification of a small molecule inhibitor of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] using mixture-based combinatorial libraries. International Journal of Antimicrobial Agents. 51:752-761.Full Text via DOI: 10.1016/j.ijantimicag.2018.01.019
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2017Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats. Journal of Medicinal Chemistry. 60:10092-10104.Full Text via DOI: 10.1021/acs.jmedchem.7b01250
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2017Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries. ACS Medicinal Chemistry Letters. 8:802-807.Full Text via DOI: 10.1021/acsmedchemlett.7b00045
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2017Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2. Journal of Medicinal Chemistry. 60:4342-4357.Full Text via DOI: 10.1021/acs.jmedchem.7b00301
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2017A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation. Organic and Biomolecular Chemistry. 15:7796-7801.Full Text via DOI: 10.1039/c7ob01924f
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2016Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents. Antimicrobial Agents and Chemotherapy. 60:4028-4036.Full Text via DOI: 10.1128/AAC.00288-16 Web of Science: 000378094400020
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2016Identification of protein palmitoylation inhibitors from a scaffold ranking library. Combinatorial Chemistry and High Throughput Screening. 19:262-274.Full Text via DOI: 10.2174/1386207319666160324123844
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2016Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines. ACS Combinatorial Science. 18:51-64.Full Text via DOI: 10.1021/acscombsci.5b00126 Web of Science: 000368048100006
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2015Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT). Chemical Research in Toxicology. 28:2419-2425.Full Text via DOI: 10.1021/acs.chemrestox.5b00432 Web of Science: 000367118000019
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2015SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. Journal of Medicinal Chemistry. 58:5808-5824.Full Text via DOI: 10.1021/acs.jmedchem.5b00354
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2015Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens. Journal of Medicinal Chemistry. 58:3340-3355.Full Text via DOI: 10.1021/jm501628s Web of Science: 000353602200006
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2015Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities. European Journal of Medicinal Chemistry. 92:270-281.Full Text via DOI: 10.1016/j.ejmech.2014.12.049
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2015Antigen Discovery for the Identification of Vaccine Candidates and Biomarkers Using a T Cell Driven Approach in Combination with Positional Scanning Peptide Libraries. Procedia in Vaccinology. 9:91-95.Full Text via DOI: 10.1016/j.provac.2015.05.013
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2015Interaction fingerprints and their applications to identify hot spots. Methods in molecular biology (Clifton, N.J.). 1335:313-324.Full Text via DOI: 10.1007/978-1-4939-2914-6_20
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2014Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs). Journal of Medicinal Chemistry. 57:4615-4628.Full Text via DOI: 10.1021/jm500064t
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2014Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition. Analytical Biochemistry. 449:68-75.Full Text via DOI: 10.1016/j.ab.2013.12.018
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2014Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis. Journal of Medicinal Chemistry. 57:1599-1608.Full Text via DOI: 10.1021/jm4019542
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2013Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies. Journal of Medicinal Chemistry. 56:10103-10117.Full Text via DOI: 10.1021/jm401543h Web of Science: 000329331600020
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2013Conditional probabilistic analysis for prediction of the activity landscape and relative compound activities. Journal of Chemical Information and Modeling. 53:2613-2625.Full Text via DOI: 10.1021/ci400243e
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2013Selective agonists and antagonists of formylpeptide receptors: Duplex flow cytometry and mixture-based positional scanning libraries. Molecular Pharmacology. 84:314-324.Full Text via DOI: 10.1124/mol.113.086595
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2013Libraries from libraries: A series of sulfonamide linked heterocycles derived from the same scaffold. Tetrahedron Letters. 54:4296-4299.Full Text via DOI: 10.1016/j.tetlet.2013.06.003
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2013Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates. Journal of Biological Chemistry. 288:22871-22879.Full Text via DOI: 10.1074/jbc.M113.462267
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2013Parallel synthesis of 1,6-disubstituted-1,2,4-triazin-3-ones on solid-phase. ACS Combinatorial Science. 15:335-339.Full Text via DOI: 10.1021/co400064d
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2013Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease. Journal of Experimental Medicine (JEM). 210:1403-1418.Full Text via DOI: 10.1084/jem.20122426
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2013Rapid scanning structure-activity relationships in combinatorial data sets: Identification of activity switches. Journal of Chemical Information and Modeling. 53:1475-1485.Full Text via DOI: 10.1021/ci400192y
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2013The mathematics of a successful deconvolution: A quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors. Molecules. 18:6408-6424.Full Text via DOI: 10.3390/molecules18066408
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2013ChemInform Abstract: Palladium‐Catalyzed C—H Functionalization Using Guanidine as a Directing Group: ortho‐Arylation and Olefination of Arylguanidines.. ChemInform. 44:no-no.Full Text via DOI: 10.1002/chin.201311079
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2013A traceless approach to amide and peptide construction from thioacids and dithiocarbamate-terminal amines. Chemical Science. 4:970-976.Full Text via DOI: 10.1039/c2sc21317f
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2013HTS by NMR of combinatorial libraries: A fragment-based approach to ligand discovery. Chemistry and Biology. 20:19-33.Full Text via DOI: 10.1016/j.chembiol.2012.10.015
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2013Ligand/kappa-opioid receptor interactions: Insights from the X-ray crystal structure. European Journal of Medicinal Chemistry. 66:114-121.Full Text via DOI: 10.1016/j.ejmech.2013.05.021
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2012Fluorescent Mu selective opioid ligands from a mixture based cyclic peptide library. ACS Combinatorial Science. 14:673-679.Full Text via DOI: 10.1021/co300110t
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2012Palladium-catalyzed C-H functionalization using guanidine as a directing group: Ortho arylation and olefination of arylguanidines. Organic Letters. 14:5452-5455.Full Text via DOI: 10.1021/ol302533w
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2012Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates. Journal of Biological Chemistry. 287:36473-36487.Full Text via DOI: 10.1074/jbc.M112.389114
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2012A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries. ACS Combinatorial Science. 14:503-512.Full Text via DOI: 10.1021/co300060s
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2012ChemInform Abstract: Solid‐Phase Synthesis of Heterocycles from Peptides and Amino Acids.. ChemInform. 43:no-no.Full Text via DOI: 10.1002/chin.201226242
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2012Novel T cell driven approach leads to the identification of immunoprevalent antigens. Procedia in Vaccinology. 6:14-20.Full Text via DOI: 10.1016/j.provac.2012.04.004
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2012Synthesis of 2,3,4-trisubstituted pyrroles via a facile reaction of vinyl azides and tosylmethyl isocyanide. Canadian Journal of Chemistry. 90:214-221.Full Text via DOI: 10.1139/v11-150
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2011Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents. European Journal of Medicinal Chemistry. 46:5970-5977.Full Text via DOI: 10.1016/j.ejmech.2011.10.009
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2011Parallel synthesis of novel antitumor agents: 1, 2, 3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR. Molecular Diversity. 15:927-946.Full Text via DOI: 10.1007/s11030-011-9324-3
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2011Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes. Molecular Diversity. 15:989-1005.Full Text via DOI: 10.1007/s11030-011-9333-2 Web of Science: 000300364700017
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2011Solid-phase synthesis of 2,3,5,6-tetrahydro-1H-imidazo[1,2-a]benzo[d]- [1,3]diazepines via Pd(OAc)2/Cu(OAc)2-cocatalyzed cyclization. Synlett. 2259-2261.Full Text via DOI: 10.1055/s-0030-1261186
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2011Solid-phase synthesis of 2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine derivatives. Tetrahedron Letters. 52:4112-4113.Full Text via DOI: 10.1016/j.tetlet.2011.05.138
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2011A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and vinyl azides. Tetrahedron. 67:4887-4891.Full Text via DOI: 10.1016/j.tet.2011.04.103
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2011Integrating Virtual Screening and Combinatorial Chemistry for Accelerated Drug Discovery. Combinatorial Chemistry and High Throughput Screening. 14:475-487.Full Text via DOI: 10.2174/138620711795767866 Web of Science: 000292772100004
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2011Integrating computational and mixture-based screening of combinatorial libraries. Journal of Molecular Modeling. 17:1473-1482.Full Text via DOI: 10.1007/s00894-010-0850-1 Web of Science: 000291041800025
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2011Solid-phase synthesis of N-substituted 3,4-dihydroquinazolinone derivatives. Tetrahedron Letters. 52:2627-2628.Full Text via DOI: 10.1016/j.tetlet.2011.03.034
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2011Use and implications of the harmonic mean model on mixtures for basic research and drug discovery. ACS Combinatorial Science. 13:337-344.Full Text via DOI: 10.1021/co100065a
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2011High throughput synthesis of 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b] thiazole derivatives. Tetrahedron Letters. 52:696-698.Full Text via DOI: 10.1016/j.tetlet.2010.12.006
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2011Structure-activity relationships of benzimidazole derivatives as antiparasitic agents: Dual activity-difference (DAD) maps. RSC Medicinal Chemistry. 2:44-49.Full Text via DOI: 10.1039/c0md00159g
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2010Towards a systematic characterization of the antiprotozoal activity landscape of benzimidazole derivatives. Bioorganic and Medicinal Chemistry. 18:7380-7391.Full Text via DOI: 10.1016/j.bmc.2010.09.019
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2010A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a 'volatilizable' support. Tetrahedron Letters. 51:5637-5639.Full Text via DOI: 10.1016/j.tetlet.2010.08.026
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2010Docking of protein kinase B inhibitors: implications in the structure-based optimization of a novel scaffold. Chemical Biology and Drug Design. 76:269-276.Full Text via DOI: 10.1111/j.1747-0285.2010.01002.x
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2010Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library. AAPS Journal. 12:318-329.Full Text via DOI: 10.1208/s12248-010-9191-3 Web of Science: 000288425000008
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2010Conformational landscape of platinum(II)-tetraamine complexes: DFT and NBO studies. Journal of Computer-Aided Molecular Design. 24:225-235.Full Text via DOI: 10.1007/s10822-010-9328-6 Web of Science: 000276965100005
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2010Combining positional scanning peptide libraries, HLA-DR transfectants and bioinformatics to dissect the epitope spectrum of HLA class II cross-restricted CD4+ T cell clones. Journal of Immunological Methods. 353:93-101.Full Text via DOI: 10.1016/j.jim.2009.12.006
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2010Traceless solid-phase synthesis of N-substituted 3,5-bis(substituted-idene) piperidin-4-one derivatives. Tetrahedron Letters. 51:5003-5004.Full Text via DOI: 10.1016/j.tetlet.2010.07.072
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2009Synthesis of cyclic peptides through direct aminolysis of peptide thioesters catalyzed by imidazole in aqueous organic solutions. ACS Combinatorial Science. 11:1066-1072.Full Text via DOI: 10.1021/cc900100z
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2009Solid-phase synthesis of 2-alkylidene-6-alkyl-imidazo[2,1-b]thiazole-3,5[2H,6H]-dione derivatives. Tetrahedron Letters. 50:5857-5859.Full Text via DOI: 10.1016/j.tetlet.2009.08.009
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2009Discovery of a novel protein kinase B inhibitor by structure-based virtual screening. Bioorganic and Medicinal Chemistry Letters. 19:4634-4638.Full Text via DOI: 10.1016/j.bmcl.2009.06.078
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2009Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands. Bioorganic and Medicinal Chemistry. 17:5583-5597.Full Text via DOI: 10.1016/j.bmc.2009.06.026 Web of Science: 000268099700026
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2009Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries Small Molecule Repository. Journal of Chemical Information and Modeling. 49:1010-1024.Full Text via DOI: 10.1021/ci800426u
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2009One-pot high-throughput synthesis of β-turn cyclic peptidomimetics-via "volatilizable" supports. Journal of Organic Chemistry. 74:2183-2185.Full Text via DOI: 10.1021/jo802583t
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2009Characterization of activity landscapes using 2D and 3D similarity methods: Consensus activity cliffs. Journal of Chemical Information and Modeling. 49:477-491.Full Text via DOI: 10.1021/ci800379q
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2009Modeling of peptides containing D-amino acids: Implications on cyclization. Journal of Computer-Aided Molecular Design. 23:677-689.Full Text via DOI: 10.1007/s10822-009-9295-y
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2008High throughput synthesis of peptide α-thioesters through the use of "volatilizable" support. ACS Combinatorial Science. 10:613-616.Full Text via DOI: 10.1021/cc800076b
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2008Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis. Bioorganic and Medicinal Chemistry. 16:5932-5938.Full Text via DOI: 10.1016/j.bmc.2008.04.061
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2008High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on 'volatilizable' supports. Tetrahedron Letters. 49:3632-3633.Full Text via DOI: 10.1016/j.tetlet.2008.03.156
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2007A similarity-based data-fusion approach to the visual characterization and comparison of compound databases. Chemical Biology and Drug Design. 70:393-412.Full Text via DOI: 10.1111/j.1747-0285.2007.00579.x
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2006Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype. Journal of Immunology. 176:1951-1961.Full Text via DOI: 10.4049/jimmunol.176.3.1951
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2003Efficient approach for the diversity-oriented synthesis of macro-heterocycles on solid-support. Tetrahedron Letters. 44:5307-5309.Full Text via DOI: 10.1016/S0040-4039(03)01219-X Web of Science: 000183780300037
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2000Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides. Organic Letters. 2:3349-3350.Full Text via DOI: 10.1021/ol000225e Web of Science: 000089831900026
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2000Solid-phase synthesis of substituted 2,3-diketopiperazines from reduced polyamides. Tetrahedron. 56:3319-3326.Full Text via DOI: 10.1016/S0040-4020(00)00253-2 Web of Science: 000087032100006
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2000Solid-phase synthesis of branched thiohydantoin benzimidazolinethiones and branched thiohydantoin tetrahydroquinoxalinediones. Tetrahedron Letters. 41:2283-2287.Full Text via DOI: 10.1016/S0040-4039(00)00162-3 Web of Science: 000086681100004
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1999Solid phase synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids. Tetrahedron Letters. 40:8539-8542.Full Text via DOI: 10.1016/S0040-4039(99)01823-7 Web of Science: 000083665600010
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1999Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives. Tetrahedron Letters. 40:4939-4942.Full Text via DOI: 10.1016/S0040-4039(99)00964-8 Web of Science: 000081122400006
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1998Efficient solid phase synthesis of 3,5-disubstituted hydantoins. Tetrahedron Letters. 39:8199-8202.Full Text via DOI: 10.1016/S0040-4039(98)01874-7 Web of Science: 000076524100004
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1998Solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones. Tetrahedron Letters. 39:3671-3674.Full Text via DOI: 10.1016/S0040-4039(98)00645-5 Web of Science: 000073724300014
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Solid-Phase Synthesis of trisubstituted 2-imidazolidones and 2-imidazolidinethiones. ACS Combinatorial Science. 1:195-198.Full Text via DOI: 10.1021/cc980019m Web of Science: 000081948200005
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Solid-phase synthesis of bis-heterocyclic compounds from resin-bound orthogonally protected lysine. ACS Combinatorial Science. 3:68-70.Full Text via DOI: 10.1021/cc000061t Web of Science: 000167935000010
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Solid-phase synthesis of linear ureas tethered to hydantoins and thiohydantoins. ACS Combinatorial Science. 4:175-178.Full Text via DOI: 10.1021/cc010064l Web of Science: 000174633500013
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Strategies for the use of mixture-based synthetic combinatorial libraries: Scaffold ranking, direct testing, in vivo, and enhanced deconvolution by computational methods. ACS Combinatorial Science. 10:3-19.Full Text via DOI: 10.1021/cc7001205 Web of Science: 000252409800002
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Book Chapter
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2011Solid-phase synthesis of heterocycles from peptides and amino acids. 269-318.Full Text via DOI: 10.1002/9781118141649.ch9
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2002Combinatorial libraries: Equimolar incorporation of benzaldehyde mixtures in reductive alkylation reactions. 57-58.Full Text via DOI: 10.1007/0-306-46862-x_18
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2002Synthesis of cyclic ureas and cyclic thioureas from acyl dipeptides. 264-266.Full Text via DOI: 10.1007/0-306-46862-x_109
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2000
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2000Solid phase synthesis of heterocyclic combinatorial libraries derived from peptides. 192-197.Web of Science: 000166933900049
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1999
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Conference
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2022Discovery and Characterization of the First Biased Beta-Agonist That Favors Gs-Coupling vs Beta-Arrestin Mediated Desensitization: A New Class of Structurally Distinct Beta-Agonists for Treating Obstructive Lung Diseases. American Journal of Respiratory and Critical Care Medicine.Web of Science: 000792480403126
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2019The international space station U.S. National Lab - Tissue engineering and regenerative medicine. Proceedings of the International Astronautical Congress, IAC.
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2019Tissue chips in space. Proceedings of the International Astronautical Congress, IAC.
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2013TNFα-Based Peptides as Bioprobes for Exosites of ADAM ProteasesFull Text via DOI: 10.17952/23aps.2013.136
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Note
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2020Pharmaceutical Research Enabled Through Microgravity: Perspectives on the Use of the International Space Station U.S. National Laboratory. Pharmaceutical Research.Full Text via DOI: 10.1007/s11095-019-2719-z
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Other Scholarly Work
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2015Identification of novel chemotherapies targeting mitochondrial-cell communication. The FASEB Journal.Web of Science: 000361722705237
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Review
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2020The value of antimicrobial peptides in the age of resistance. The Lancet Infectious Diseases. e216-e230.Full Text via DOI: 10.1016/S1473-3099(20)30327-3
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2013Shifting from the single to the multitarget paradigm in drug discovery. Drug Discovery Today. 495-501.Full Text via DOI: 10.1016/j.drudis.2013.01.008
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2012Expanding the medicinally relevant chemical space with compound libraries. Drug Discovery Today. 718-726.Full Text via DOI: 10.1016/j.drudis.2012.04.001
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2008Visualization of the chemical space in drug discovery. Current Computer-Aided Drug Design. 322-333.Full Text via DOI: 10.2174/157340908786786010
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Research
principal investigator on
- Melanocortin Receptor Selective Ligands awarded by Diabetes & Digestive & Kidney Diseases 2021 - 2023
- Dealing with antibiotic resistance: antisense technology - novel compound synthesis awarded by California State University - Fullerton 2022 - 2023
- Synthesis of Select Compounds awarded by BTB Japan Inc 2021 - 2022
- Novel and potent compounds that promote axon growth awarded by Craig H. Neilsen Foundation 2020 - 2022
- Dealing with antibiotic resistance: antisense technology - novel compound synthesis awarded by California State University - Fullerton 2021
- Synthesis of Compounds 2155-14 and 2155-18 awarded by Nova Southeastern University 2020 - 2021
- Synthesis of Select Compounds awarded by BTB Japan Inc 2020
- NPQ/SPEXIN THE ENDOGENOUS LIGAND FOR THE GALANIN RECEPTOR 3 awarded by National Institute on Drug Abuse 2020
