Synthesis of cyclic peptides through direct aminolysis of peptide thioesters catalyzed by imidazole in aqueous organic solutions Article

Li, Y, Yongye, A, Giulianotti, M et al. (2009). Synthesis of cyclic peptides through direct aminolysis of peptide thioesters catalyzed by imidazole in aqueous organic solutions . 11(6), 1066-1072. 10.1021/cc900100z

cited authors

  • Li, Y; Yongye, A; Giulianotti, M; Martinez-Mayorga, K; Yu, Y; Houghten, RA

authors

abstract

  • A promising method for the synthesis of cyclic peptides through the direct aminolysis of peptide thioesters is presented. The cyclization step was carried out in a mixture of acetonitrile and 1.5 M aqueous imidazole solution with no observable oligomers. Studies on the N- and C-terminal residues show that the choice of C-terminal residue has a more significant effect on the success rate of cyclization than the choice at the N-terminal residue. © 2009 American Chemical Society.

publication date

  • November 9, 2009

Digital Object Identifier (DOI)

start page

  • 1066

end page

  • 1072

volume

  • 11

issue

  • 6