Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist Article

Ericson, Mark D, Doering, Skye R, Larson, Courtney M et al. (2021). Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist . JOURNAL OF MEDICINAL CHEMISTRY, 64(19), 14860-14875. 10.1021/acs.jmedchem.1c01417

Open Access

cited authors

  • Ericson, Mark D; Doering, Skye R; Larson, Courtney M; Freeman, Katie T; LaVoi, Travis M; Donow, Haley M; Santos, Radleigh G; Cho, Rachel H; Koerperich, Zoe M; Giulianotti, Marc A; Pinilla, Clemencia; Houghten, Richard A; Haskell-Luevano, Carrie

sustainable development goals

authors

publication date

  • October 14, 2021

published in

keywords

  • AGONIST AC-HIS-DPHE-ARG-TRP-NH2
  • AGOUTI-RELATED PROTEIN
  • ALPHA-MELANOTROPIN
  • AMINO-ACIDS
  • Chemistry, Medicinal
  • FRAMESHIFT MUTATION
  • IN-VIVO
  • Life Sciences & Biomedicine
  • MELANOTROPIN ANALOGS
  • MOLECULAR-CLONING
  • Pharmacology & Pharmacy
  • SELECTIVE AGONISTS
  • SOLID-PHASE SYNTHESIS
  • Science & Technology

Digital Object Identifier (DOI)

publisher

  • AMER CHEMICAL SOC

start page

  • 14860

end page

  • 14875

volume

  • 64

issue

  • 19