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Pinilla, Clemencia
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Research
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Scholarly & Creative Works
selected scholarly works & creative activities
Article
2023
The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands
Full Text via DOI:
10.3390/ijms241210145
Web of Science:
001014623600001
2022
Identification of B Cell and T Cell Epitopes Using Synthetic Peptide Combinatorial Libraries
Full Text via DOI:
10.1002/cpz1.378
2021
Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist
.
JOURNAL OF MEDICINAL CHEMISTRY
. 64:14860-14875.
Full Text via DOI:
10.1021/acs.jmedchem.1c01417
Web of Science:
000709633100049
2021
CD4
+
T cells in the lungs of acute sarcoidosis patients recognize an
Aspergillus nidulans
epitope
.
JOURNAL OF EXPERIMENTAL MEDICINE
. 218.
Full Text via DOI:
10.1084/jem.20210785
Web of Science:
000702150000004
2021
Inhibition of Aminoglycoside 6′-
N
-acetyltransferase Type Ib (AAC(6′)-Ib): Structure-Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors
Full Text via DOI:
10.3390/biomedicines9091218
Web of Science:
000699202200001
2021
Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4
+
T cell repertoire
.
PLOS PATHOGENS
. 17.
Full Text via DOI:
10.1371/journal.ppat.1009602
Web of Science:
000664722500001
2021
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign
.
JOURNAL OF MEDICINAL CHEMISTRY
. 64:5577-5592.
Full Text via DOI:
10.1021/acs.jmedchem.0c02041
Web of Science:
000651785800020
2021
Beryllium-specific CD4
+
T cells induced by chemokine neoantigens perpetuate inflammation
Full Text via DOI:
10.1172/JCI144864
Web of Science:
000647672600001
2020
Identification of T cell epitopes in sarcoidosis
.
JOURNAL OF IMMUNOLOGY
. 204:224.26-224.26.
Full Text via DOI:
10.4049/jimmunol.204.supp.224.26
2019
A randomized double-blind placebo-controlled phase II trial of dendritic cell vaccine ICT-107 in newly diagnosed patients with glioblastoma
.
CLINICAL CANCER RESEARCH
. 25:5799-5807.
Full Text via DOI:
10.1158/1078-0432.CCR-19-0261
2019
CD4+ T cell antigen discovery in sarcoidosis
.
JOURNAL OF IMMUNOLOGY
. 202:182.57-182.57.
Full Text via DOI:
10.4049/jimmunol.202.supp.182.57
2019
Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μm MC4R Partial Agonist
.
JOURNAL OF MEDICINAL CHEMISTRY
. 62:2738-2749.
Full Text via DOI:
10.1021/acs.jmedchem.9b00053
2018
GDP-l-fucose synthase is a CD4+ T cell-specific autoantigen in DRB3∗02:02 patients with multiple sclerosis
Full Text via DOI:
10.1126/scitranslmed.aat4301
2018
Memory B Cells Activate Brain-Homing, Autoreactive CD4
+
T Cells in Multiple Sclerosis
Full Text via DOI:
10.1016/j.cell.2018.08.011
2018
Identification of a small molecule inhibitor of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] using mixture-based combinatorial libraries
Full Text via DOI:
10.1016/j.ijantimicag.2018.01.019
2017
Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa
1
-Arg-(pI)DPhe-Xaa
4
-NH
2
.
JOURNAL OF MEDICINAL CHEMISTRY
. 60:4342-4357.
Full Text via DOI:
10.1021/acs.jmedchem.7b00301
2017
Methodological approach to the ex vivo expansion and detection of T. cruzi-specific T cells from chronic Chagas disease patients
Full Text via DOI:
10.1371/journal.pone.0178380
2016
ATIM-19. CATEGORIZING IMMUNE RESPONDERS WITH FUSION METRICS AND SIMULATION FOR ASSOCIATION TO SURVIVAL AND PROGRESSION FREE SURVIVAL WITH IMMUNE RESPONSE IN HLA-A2+ PATIENTS WITH GBM FROM A PHASE 2 TRIAL OF DENDRITIC CELL (DC) IMMUNOTHERAPY (ICT-107)
.
NEURO-ONCOLOGY
. 18:vi22-vi22.
Full Text via DOI:
10.1093/neuonc/now212.084
2016
Characterization of potent SMAC mimetics that sensitize cancer cells to TNF family-induced apoptosis
Full Text via DOI:
10.1371/journal.pone.0161952
2016
Identifying T cell antigens in sarcoidosis
.
JOURNAL OF IMMUNOLOGY
. 196:54.20-54.20.
Full Text via DOI:
10.4049/jimmunol.196.supp.54.20
2016
Metal-specific CD4
+
T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice
.
MUCOSAL IMMUNOLOGY
. 9:218-228.
Full Text via DOI:
10.1038/mi.2015.54
2015
IMCT-17STATISTICALLY SIGNIFICANT ASSOCIATION OF GLIOBLASTOMA IMMUNOTHERAPY PHASE II CLINICAL STUDY (ICT-107) TREATMENT AND SURVIVAL TO IMMUNE RESPONSE USING A NOVEL COMPREHENSIVE ELISPOT ANALYSIS
.
NEURO-ONCOLOGY
. 17:v111-v111.
Full Text via DOI:
10.1093/neuonc/nov218.17
2015
IMCT-20ASSOCIATION OF SURVIVAL AND PROGRESSION-FREE SURVIVAL WITH IMMUNE RESPONSE IN HLA-A2+ NEWLY-DIAGNOSED GBM PATIENTS IN RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED PHASE 2 TRIAL OF DENDRITIC CELL (DC) IMMUNOTHERAPY WITH ICT-107
.
NEURO-ONCOLOGY
. 17:v112-v112.
Full Text via DOI:
10.1093/neuonc/nov218.20
2015
Investigating the role of the host multidrug resistance associated protein transporter family in burkholderia cepacia complex pathogenicity using a caenorhabditis elegans infection model
Full Text via DOI:
10.1371/journal.pone.0142883
2015
Antigen Discovery for the Identification of Vaccine Candidates and Biomarkers Using a T Cell Driven Approach in Combination with Positional Scanning Peptide Libraries
Full Text via DOI:
10.1016/j.provac.2015.05.013
2015
Improvement of IFNγ ELISPOT performance following overnight resting of frozen PBMC samples confirmed through rigorous statistical analysis
Full Text via DOI:
10.3390/cells4010001
2014
Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs)
.
JOURNAL OF MEDICINAL CHEMISTRY
. 57:4615-4628.
Full Text via DOI:
10.1021/jm500064t
2014
Generation and characterization of immune-complex specific T cells (BA8P.121)
.
JOURNAL OF IMMUNOLOGY
. 192:113.4-113.4.
Full Text via DOI:
10.4049/jimmunol.192.supp.113.4
2014
Cytokine Production but Lack of Proliferation in Peripheral Blood Mononuclear Cells from Chronic Chagas' Disease Cardiomyopathy Patients in Response to T. cruzi Ribosomal P Proteins
Full Text via DOI:
10.1371/journal.pntd.0002906
2014
Identification of novel human leukocyte antigen-A*0201-restricted, Cytotoxic T lymphocyte epitopes on CD133 for cancer stem cell immunotherapy
Full Text via DOI:
10.5966/sctm.2013-0135
2013
Selective agonists and antagonists of formylpeptide receptors: Duplex flow cytometry and mixture-based positional scanning libraries
Full Text via DOI:
10.1124/mol.113.086595
2013
Measurement of MHC/peptide interactions by gel filtration or monoclonal antibody capture
Full Text via DOI:
10.1002/0471142735.im1803s100
2013
Identification of beryllium-dependent peptides recognized by CD4
+
T cells in chronic beryllium disease
.
JOURNAL OF EXPERIMENTAL MEDICINE
. 210:1403-1418.
Full Text via DOI:
10.1084/jem.20122426
2013
Rapid scanning structure-activity relationships in combinatorial data sets: Identification of activity switches
.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
. 53:1475-1485.
Full Text via DOI:
10.1021/ci400192y
2013
The mathematics of a successful deconvolution: A quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors
Full Text via DOI:
10.3390/molecules18066408
2013
HTS by NMR of combinatorial libraries: A fragment-based approach to ligand discovery
.
CHEMISTRY & BIOLOGY
. 20:19-33.
Full Text via DOI:
10.1016/j.chembiol.2012.10.015
2012
Identification of B cell and T cell epitopes using synthetic peptide combinatorial libraries
Full Text via DOI:
10.1002/0471142735.im0905s99
2012
Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis
.
JOURNAL OF IMMUNOLOGY
. 189:2897-2908.
Full Text via DOI:
10.4049/jimmunol.1103087
2012
Novel T cell driven approach leads to the identification of immunoprevalent antigens
Full Text via DOI:
10.1016/j.provac.2012.04.004
2011
Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes
Full Text via DOI:
10.1007/s11030-011-9333-2
Web of Science:
000300364700017
2011
GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4+ T cells following smallpox vaccination
Full Text via DOI:
10.1371/journal.pone.0024091
2011
A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers
Full Text via DOI:
10.1016/j.immuni.2011.04.017
2011
Integrating computational and mixture-based screening of combinatorial libraries
.
JOURNAL OF MOLECULAR MODELING
. 17:1473-1482.
Full Text via DOI:
10.1007/s00894-010-0850-1
Web of Science:
000291041800025
2011
Use and implications of the harmonic mean model on mixtures for basic research and drug discovery
Full Text via DOI:
10.1021/co100065a
2011
A high-content screening (HCS) assay for the identification of chemical inducers of PML oncogenic domains (PODs)
.
JOURNAL OF BIOMOLECULAR SCREENING
. 16:251-258.
Full Text via DOI:
10.1177/1087057110394181
2010
Small molecule functional analogs of peptides that inhibit λ site-specific recombination and bind Holliday junctions
.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
. 20:4531-4534.
Full Text via DOI:
10.1016/j.bmcl.2010.06.029
Web of Science:
000279866300053
2010
The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype
.
IMMUNOGENETICS
. 62:451-464.
Full Text via DOI:
10.1007/s00251-010-0450-3
2010
Combining positional scanning peptide libraries, HLA-DR transfectants and bioinformatics to dissect the epitope spectrum of HLA class II cross-restricted CD4+ T cell clones
Full Text via DOI:
10.1016/j.jim.2009.12.006
2010
Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML
.
BLOOD
. 115:306-314.
Full Text via DOI:
10.1182/blood-2009-03-212563
2010
A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC
.
BRITISH JOURNAL OF CANCER
. 102:97-103.
Full Text via DOI:
10.1038/sj.bjc.6605418
2009
Derivation of an amino acid similarity matrix for peptide:MHC binding and its application as a Bayesian prior
Full Text via DOI:
10.1186/1471-2105-10-394
2009
Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries Small Molecule Repository
.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
. 49:1010-1024.
Full Text via DOI:
10.1021/ci800426u
2009
Characterization of activity landscapes using 2D and 3D similarity methods: Consensus activity cliffs
.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
. 49:477-491.
Full Text via DOI:
10.1021/ci800379q
2008
Simultaneous Activation of p53 and Inhibition of XIAP Enhance the Activation of Apoptosis Signaling Pathways in AML.
.
BLOOD
. 112:1941.
Full Text via DOI:
10.1182/blood.v112.11.1941.1941
2008
Monkeypox virus evades antiviral CD4
+
and CD8
+
T cell responses by suppressing cognate T cell activation
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
. 105:14567-14572.
Full Text via DOI:
10.1073/pnas.0800589105
2008
Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor
Full Text via DOI:
10.1093/intimm/dxn066
2008
Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis
.
BIOORGANIC & MEDICINAL CHEMISTRY
. 16:5932-5938.
Full Text via DOI:
10.1016/j.bmc.2008.04.061
2008
Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: Implications for the initiation of the autoimmune response in multiple sclerosis
Full Text via DOI:
10.1002/eji.200737519
2008
Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5
.
BLOOD
. 111:3742-3750.
Full Text via DOI:
10.1182/blood-2007-05-091504
2008
Quantitative peptide binding motifs for 19 human and mouse MHC class i molecules derived using positional scanning combinatorial peptide libraries
Full Text via DOI:
10.1186/1745-7580-4-2
2008
Small-molecule XIAP antagonist restores caspase-9-mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells
.
BLOOD
. 111:369-375.
Full Text via DOI:
10.1182/blood-2007-04-085480
2008
Thyroglobulin peptides associate in vivo to HLA-DR in autoimmune thyroid glands
.
JOURNAL OF IMMUNOLOGY
. 181:795-807.
Full Text via DOI:
10.4049/jimmunol.181.1.795
2007
Small-Molecule XIAP Antagonist Restores Caspase-9-Mediated Apoptosis in XIAP-Positive Diffuse Large B-Cell Lymphoma Cells.
.
BLOOD
. 110:803.
Full Text via DOI:
10.1182/blood.v110.11.803.803
2007
A similarity-based data-fusion approach to the visual characterization and comparison of compound databases
Full Text via DOI:
10.1111/j.1747-0285.2007.00579.x
2007
Characterization of the peptide-binding specificity of the chimpanzee class I alleles A*0301 and A*0401 using a combinatorial peptide library
.
IMMUNOGENETICS
. 59:745-751.
Full Text via DOI:
10.1007/s00251-007-0243-5
2007
Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein
.
MOLECULAR CANCER THERAPEUTICS
. 6:957-966.
Full Text via DOI:
10.1158/1535-7163.MCT-06-0634
2007
Cerebrospinal fluid-infiltrating CD4
+
T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early lyme encephalitis
.
INFECTION AND IMMUNITY
. 75:243-251.
Full Text via DOI:
10.1128/IAI.01110-06
2006
AML Progenitor/Stem Cells Overexpress XIAP and Are Sensitive to the Small Molecular XIAP Inhibitor 1396-11.
.
BLOOD
. 108:2586.
Full Text via DOI:
10.1182/blood.v108.11.2586.2586
2006
Triptolide Sensitizes Leukemic Cells to TRAIL Induced Apoptosis Via Decrease of XIAP and p53-Mediated Increase of DR5.
.
BLOOD
. 108:528.
Full Text via DOI:
10.1182/blood.v108.11.528.528
2006
New Peptide Inhibitors of Type IB Topoisomerases: Similarities and Differences Vis-a-vis Inhibitors of Tyrosine Recombinases
.
JOURNAL OF MOLECULAR BIOLOGY
. 363:891-907.
Full Text via DOI:
10.1016/j.jmb.2006.08.052
2006
427 POSTER Preclinical development of xiapuradamib therapy for lung cancer
Full Text via DOI:
10.1016/s1359-6349(06)70432-3
2006
491 POSTER Trageting XIAP in paediatric cancers
Full Text via DOI:
10.1016/s1359-6349(06)70496-7
2006
Synthesis of platinum(II) chiral tetraamine coordination complexes
Full Text via DOI:
10.1021/cc060045h
Web of Science:
000240403200020
2006
Decreased specific CD8
+
T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptide
Full Text via DOI:
10.1002/eji.200535805
2006
Identification of cross-reactive peptides using combinatorial libraries circumvents tolerance against Her-2/neu-immunodominant epitope
.
JOURNAL OF IMMUNOLOGY
. 176:1796-1805.
Full Text via DOI:
10.4049/jimmunol.176.3.1796
2006
Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype
.
JOURNAL OF IMMUNOLOGY
. 176:1951-1961.
Full Text via DOI:
10.4049/jimmunol.176.3.1951
2006
297 IDENTIFICATION OF NOVEL ALTERED PEPTIDE LIGANDS RECOGNIZED BY HUMAN TUMOR-REACTIVE T CELLS.
.
JOURNAL OF INVESTIGATIVE MEDICINE
. 54:s131.
Full Text via DOI:
10.2310/6650.2005.x0004.296
2006
50 IDENTIFICATION OF NOVEL ALTERED PEPTIDE LIGANDS RECOGNIZED BY HUMAN TUMOR-REACTIVE T CELLS.
.
JOURNAL OF INVESTIGATIVE MEDICINE
. 54:s88.
Full Text via DOI:
10.2310/6650.2005.x0004.49
2006
Identification of Novel Altered Peptide Ligands Recognized by Human Tumor-Reactive T Cells
.
JOURNAL OF INVESTIGATIVE MEDICINE
. 54:131-131.
Full Text via DOI:
10.1177/108155890605401s180
2006
Identification of peptides from human pathogens able to cross-activate an HIV-1-gag-specific CD4
+
T cell clone
Full Text via DOI:
10.1002/eji.200425767
2006
Sa.5. The Range of Potential Targets in Antigen-Specific Therapy Are Expanded with Degenerate Autoantigen Recognition By T-Cells
Full Text via DOI:
10.1016/j.clim.2006.04.237
2005
High level of cross-reactivity in influenza virus hemagglutinin-specific CD4+ T-cell response: Implications for the initiation of autoimmune response in multiple sclerosis
.
JOURNAL OF NEUROIMMUNOLOGY
. 169:31-38.
Full Text via DOI:
10.1016/j.jneuroim.2005.07.014
2005
Recognition of conserved amino acid motifs of common viruses and its role in autoimmunity
.
PLOS PATHOGENS
. 1:0335-0348.
Full Text via DOI:
10.1371/journal.ppat.0010041
2005
Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis
.
BLOOD
. 106:1742-1748.
Full Text via DOI:
10.1182/blood-2005-02-0695
Web of Science:
000231495000040
2005
How the T cell repertoire becomes peptide and MHC specific
Full Text via DOI:
10.1016/j.cell.2005.05.013
2005
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells
.
BLOOD
. 105:4043-4050.
Full Text via DOI:
10.1182/blood-2004-08-3168
Web of Science:
000229009000050
2005
Discovery and characterization of highly immunogenic and broadly recognized mimics of the HIV-1 CTL epitope Gag
77-85
Full Text via DOI:
10.1002/eji.200425903
2005
Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells
.
CANCER RESEARCH
. 65:2378-2386.
Full Text via DOI:
10.1158/0008-5472.CAN-04-2649
2004
Inhibition of XIAP Enhances Specific Cytotoxic T Lymphocyte (CTL) Killing and CD20-Directed Antibody-Dependent Cellular Cytotoxicity of Chronic Lymphocytic Leukemia B Cells.
.
BLOOD
. 104:3475.
Full Text via DOI:
10.1182/blood.v104.11.3475.3475
2004
Inhibition of XIAP Renders Newly CD40-Activated Chronic Lymphocytic Leukemia Cells Sensitive to Fas (CD95) Mediated Apoptosis.
.
BLOOD
. 104:3474.
Full Text via DOI:
10.1182/blood.v104.11.3474.3474
2004
Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples.
.
BLOOD
. 104:759.
Full Text via DOI:
10.1182/blood.v104.11.759.759
2004
Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors
.
JOURNAL OF BIOLOGICAL CHEMISTRY
. 279:48168-48176.
Full Text via DOI:
10.1074/jbc.M405022200
2004
Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes
Full Text via DOI:
10.1016/j.clim.2004.03.007
2004
Peptides from common viral and bacterial pathogens can efficiently activate diabetogenic T-cells
Full Text via DOI:
10.2337/diabetes.53.9.2301
2004
Reversible Inhibitors of λ Integrase-mediated Recombination Efficiently Trap Holliday Junction Intermediates and Form the Basis of a Novel Assay for Junction Resolution
.
JOURNAL OF BIOLOGICAL CHEMISTRY
. 279:3472-3483.
Full Text via DOI:
10.1074/jbc.M309361200
2004
A powerful combination: The use of positional scanning libraries and biometrical analysis to identify cross-reactive T cell epitopes
.
MOLECULAR IMMUNOLOGY
. 40:1063-1074.
Full Text via DOI:
10.1016/j.molimm.2003.11.005
2004
Peptidic complex mixtures as therapeutic agents in CNS autoimmunity
.
MOLECULAR IMMUNOLOGY
. 40:1075-1087.
Full Text via DOI:
10.1016/j.molimm.2003.11.006
2004
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
Full Text via DOI:
10.1016/S1535-6108(03)00332-5
Web of Science:
000188400300007
2004
Specificity and degeneracy of T cells
.
MOLECULAR IMMUNOLOGY
. 40:1047-1055.
Full Text via DOI:
10.1016/j.molimm.2003.11.022
2004
Strong attraction may be dangerous: Parameters for the development of long term commitment
.
MOLECULAR IMMUNOLOGY
. 40:1109-1112.
Full Text via DOI:
10.1016/j.molimm.2003.11.036
2004
The initiation of the autoimmune response in multiple sclerosis
.
CLINICAL NEUROLOGY AND NEUROSURGERY
. 106:218-222.
Full Text via DOI:
10.1016/j.clineuro.2004.02.018
2003
A Time-Resolved Fluorescence Immunoassay (DELFIA) Increases the Sensitivity of Antigen-Driven Cytokine Detection
Full Text via DOI:
10.1081/IAS-120025772
2003
Identification of novel small-molecule Ulex europaeus I mimetics for targeted drug delivery
.
BIOORGANIC & MEDICINAL CHEMISTRY
. 11:4991-4997.
Full Text via DOI:
10.1016/j.bmc.2003.09.002
2003
Application of support vector machines for T-cell epitopes prediction
.
BIOINFORMATICS
. 19:1978-1984.
Full Text via DOI:
10.1093/bioinformatics/btg255
2003
Toward targeted oral vaccine delivery systems: Selection of lectin mimetics from combinatorial libraries
.
PHARMACEUTICAL RESEARCH
. 20:1258-1266.
Full Text via DOI:
10.1023/A:1025061317400
2003
Advances in the Use of Synthetic Combinatorial Chemistry: Mixture‐Based Libraries
Full Text via DOI:
10.1002/chin.200329235
2003
Detection and characterization of T cells specific for BDC2.5 T cell-stimulating peptides
.
JOURNAL OF IMMUNOLOGY
. 170:4011-4020.
Full Text via DOI:
10.4049/jimmunol.170.8.4011
2003
Use of combinatorial peptide libraries for T-cell epitope mapping
Full Text via DOI:
10.1016/S1046-2023(02)00346-8
2003
Synthetic Combinatorial Libraries as an Alternative Strategy for the Development of Novel Treatments for Infectious Diseases
.
METHODS IN ENZYMOLOGY
. 369:322-344.
Full Text via DOI:
10.1016/S0076-6879(03)69018-X
2002
Positional scanning-synthetic peptide library-based analysis of self- and pathogen-derived peptide cross-reactivity with tumor-reactive Melan-A-specific CTL
.
JOURNAL OF IMMUNOLOGY
. 169:5696-5707.
Full Text via DOI:
10.4049/jimmunol.169.10.5696
2002
Findings on T cell specificity revealed by synthetic combinatorial libraries
Full Text via DOI:
10.1016/S0022-1759(02)00142-4
2002
Combinatorial peptide library-based identification of peptide ligands for tumor-reactive cytolytic T lymphocytes of unknown specificity
Full Text via DOI:
10.1002/1521-4141(200208)32:8<2292::AID-IMMU2292>3.0.CO;2-K
2002
Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-A peptide multimer
+
CD8
+
T cells in humans
.
JOURNAL OF EXPERIMENTAL MEDICINE
. 196:207-216.
Full Text via DOI:
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Research
principal investigator on
Discovery of small molecule glucagon receptor agonists and ketogenic compounds
awarded by
Aarhus University
2021 - 2023
T cell in sarcodiosis
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National Heart, Lung, & Blood Institute
2020 - 2023
Immunoregulatory effect of microparticle delivered STING agonist in the control of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS)
awarded by
Allergy and Infectious Diseases
2021 - 2023
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