Scholarly & Creative Works
selected scholarly works & creative activities
-
Article
-
2021CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope. JOURNAL OF EXPERIMENTAL MEDICINE. 218.Full Text via DOI: 10.1084/jem.20210785 Web of Science: 000702150000004
-
2021Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist. JOURNAL OF MEDICINAL CHEMISTRY. 64:14860-14875.Full Text via DOI: 10.1021/acs.jmedchem.1c01417 Web of Science: 000709633100049
-
2021Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4(+) T cell repertoire. PLOS PATHOGENS. 17.Full Text via DOI: 10.1371/journal.ppat.1009602 Web of Science: 000664722500001
-
2021Beryllium-specific CD4(+)T cells induced by chemokine neoantigens perpetuate inflammationFull Text via DOI: 10.1172/JCI144864 Web of Science: 000647672600001
-
2021Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. JOURNAL OF MEDICINAL CHEMISTRY. 64:5577-5592.Full Text via DOI: 10.1021/acs.jmedchem.0c02041 Web of Science: 000651785800020
-
2020Identification of T cell epitopes in sarcoidosis. JOURNAL OF IMMUNOLOGY. 204:224.26-224.26.Full Text via DOI: 10.4049/jimmunol.204.supp.224.26
-
2019A randomized double-blind placebo-controlled phase II trial of dendritic cell vaccine ICT-107 in newly diagnosed patients with glioblastoma. CLINICAL CANCER RESEARCH. 25:5799-5807.Full Text via DOI: 10.1158/1078-0432.CCR-19-0261
-
2019CD4+ T cell antigen discovery in sarcoidosis. JOURNAL OF IMMUNOLOGY. 202:182.57-182.57.Full Text via DOI: 10.4049/jimmunol.202.supp.182.57
-
2019Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μm MC4R Partial Agonist. JOURNAL OF MEDICINAL CHEMISTRY. 62:2738-2749.Full Text via DOI: 10.1021/acs.jmedchem.9b00053
-
2017Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH
2 . JOURNAL OF MEDICINAL CHEMISTRY. 60:4342-4357.Full Text via DOI: 10.1021/acs.jmedchem.7b00301 -
2016ATIM-19. CATEGORIZING IMMUNE RESPONDERS WITH FUSION METRICS AND SIMULATION FOR ASSOCIATION TO SURVIVAL AND PROGRESSION FREE SURVIVAL WITH IMMUNE RESPONSE IN HLA-A2+ PATIENTS WITH GBM FROM A PHASE 2 TRIAL OF DENDRITIC CELL (DC) IMMUNOTHERAPY (ICT-107). NEURO-ONCOLOGY. 18:vi22-vi22.Full Text via DOI: 10.1093/neuonc/now212.084
-
2016Identifying T cell antigens in sarcoidosis. JOURNAL OF IMMUNOLOGY. 196:54.20-54.20.Full Text via DOI: 10.4049/jimmunol.196.supp.54.20
-
2016Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice. MUCOSAL IMMUNOLOGY. 9:218-228.Full Text via DOI: 10.1038/mi.2015.54
-
2015IMCT-17STATISTICALLY SIGNIFICANT ASSOCIATION OF GLIOBLASTOMA IMMUNOTHERAPY PHASE II CLINICAL STUDY (ICT-107) TREATMENT AND SURVIVAL TO IMMUNE RESPONSE USING A NOVEL COMPREHENSIVE ELISPOT ANALYSIS. NEURO-ONCOLOGY. 17:v111-v111.Full Text via DOI: 10.1093/neuonc/nov218.17
-
2015IMCT-20ASSOCIATION OF SURVIVAL AND PROGRESSION-FREE SURVIVAL WITH IMMUNE RESPONSE IN HLA-A2+ NEWLY-DIAGNOSED GBM PATIENTS IN RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED PHASE 2 TRIAL OF DENDRITIC CELL (DC) IMMUNOTHERAPY WITH ICT-107. NEURO-ONCOLOGY. 17:v112-v112.Full Text via DOI: 10.1093/neuonc/nov218.20
-
2014Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs). JOURNAL OF MEDICINAL CHEMISTRY. 57:4615-4628.Full Text via DOI: 10.1021/jm500064t
-
2014Generation and characterization of immune-complex specific T cells (BA8P.121). JOURNAL OF IMMUNOLOGY. 192:113.4-113.4.Full Text via DOI: 10.4049/jimmunol.192.supp.113.4
-
2013Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease. JOURNAL OF EXPERIMENTAL MEDICINE. 210:1403-1418.Full Text via DOI: 10.1084/jem.20122426
-
2013Rapid scanning structure-activity relationships in combinatorial data sets: Identification of activity switches. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 53:1475-1485.Full Text via DOI: 10.1021/ci400192y
-
2013HTS by NMR of combinatorial libraries: A fragment-based approach to ligand discovery. CHEMISTRY & BIOLOGY. 20:19-33.Full Text via DOI: 10.1016/j.chembiol.2012.10.015
-
2012Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis. JOURNAL OF IMMUNOLOGY. 189:2897-2908.Full Text via DOI: 10.4049/jimmunol.1103087
-
2011Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymesFull Text via DOI: 10.1007/s11030-011-9333-2 Web of Science: 000300364700017
-
2011Integrating computational and mixture-based screening of combinatorial libraries. JOURNAL OF MOLECULAR MODELING. 17:1473-1482.Full Text via DOI: 10.1007/s00894-010-0850-1 Web of Science: 000291041800025
-
2011A high-content screening (HCS) assay for the identification of chemical inducers of PML oncogenic domains (PODs). JOURNAL OF BIOMOLECULAR SCREENING. 16:251-258.Full Text via DOI: 10.1177/1087057110394181
-
2010Small molecule functional analogs of peptides that inhibit lambda site-specific recombination and bind Holliday junctions. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 20:4531-4534.Full Text via DOI: 10.1016/j.bmcl.2010.06.029 Web of Science: 000279866300053
-
2010The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype. IMMUNOGENETICS. 62:451-464.Full Text via DOI: 10.1007/s00251-010-0450-3
-
2010Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML. BLOOD. 115:306-314.Full Text via DOI: 10.1182/blood-2009-03-212563
-
2010A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC. BRITISH JOURNAL OF CANCER. 102:97-103.Full Text via DOI: 10.1038/sj.bjc.6605418
-
2009Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries Small Molecule Repository. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 49:1010-1024.Full Text via DOI: 10.1021/ci800426u
-
2009Characterization of activity landscapes using 2D and 3D similarity methods: Consensus activity cliffs. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 49:477-491.Full Text via DOI: 10.1021/ci800379q
-
2008Simultaneous Activation of p53 and Inhibition of XIAP Enhance the Activation of Apoptosis Signaling Pathways in AML.. BLOOD. 112:1941.Full Text via DOI: 10.1182/blood.v112.11.1941.1941
-
2008Monkeypox virus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate T cell activation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 105:14567-14572.Full Text via DOI: 10.1073/pnas.0800589105
-
2008Characterization of Melan-A reactive memory CD8+ T cells in a healthy donorFull Text via DOI: 10.1093/intimm/dxn066
-
2008Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis. BIOORGANIC & MEDICINAL CHEMISTRY. 16:5932-5938.Full Text via DOI: 10.1016/j.bmc.2008.04.061
-
2008Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. BLOOD. 111:3742-3750.Full Text via DOI: 10.1182/blood-2007-05-091504
-
2008Small-molecule XIAP antagonist restores caspase-9-mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. BLOOD. 111:369-375.Full Text via DOI: 10.1182/blood-2007-04-085480
-
2008Thyroglobulin peptides associate in vivo to HLA-DR in autoimmune thyroid glands. JOURNAL OF IMMUNOLOGY. 181:795-807.Full Text via DOI: 10.4049/jimmunol.181.1.795
-
2007Small-Molecule XIAP Antagonist Restores Caspase-9-Mediated Apoptosis in XIAP-Positive Diffuse Large B-Cell Lymphoma Cells.. BLOOD. 110:803.Full Text via DOI: 10.1182/blood.v110.11.803.803
-
2007Characterization of the peptide-binding specificity of the chimpanzee class I alleles A*0301 and A*0401 using a combinatorial peptide library. IMMUNOGENETICS. 59:745-751.Full Text via DOI: 10.1007/s00251-007-0243-5
-
2007Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein. MOLECULAR CANCER THERAPEUTICS. 6:957-966.Full Text via DOI: 10.1158/1535-7163.MCT-06-0634
-
2007Cerebrospinal fluid-infiltrating CD4+ T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early lyme encephalitis. INFECTION AND IMMUNITY. 75:243-251.Full Text via DOI: 10.1128/IAI.01110-06
-
2006AML Progenitor/Stem Cells Overexpress XIAP and Are Sensitive to the Small Molecular XIAP Inhibitor 1396-11.. BLOOD. 108:2586.Full Text via DOI: 10.1182/blood.v108.11.2586.2586
-
2006Triptolide Sensitizes Leukemic Cells to TRAIL Induced Apoptosis Via Decrease of XIAP and p53-Mediated Increase of DR5.. BLOOD. 108:528.Full Text via DOI: 10.1182/blood.v108.11.528.528
-
2006New Peptide Inhibitors of Type IB Topoisomerases: Similarities and Differences Vis-a-vis Inhibitors of Tyrosine Recombinases. JOURNAL OF MOLECULAR BIOLOGY. 363:891-907.Full Text via DOI: 10.1016/j.jmb.2006.08.052
-
2006491 POSTER Trageting XIAP in paediatric cancersFull Text via DOI: 10.1016/s1359-6349(06)70496-7
-
2006Synthesis of platinum(II) chiral tetraamine coordination complexesFull Text via DOI: 10.1021/cc060045h Web of Science: 000240403200020
-
2006Identification of cross-reactive peptides using combinatorial libraries circumvents tolerance against Her-2/neu-immunodominant epitope. JOURNAL OF IMMUNOLOGY. 176:1796-1805.Full Text via DOI: 10.4049/jimmunol.176.3.1796
-
2006Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype. JOURNAL OF IMMUNOLOGY. 176:1951-1961.Full Text via DOI: 10.4049/jimmunol.176.3.1951
-
2006297 IDENTIFICATION OF NOVEL ALTERED PEPTIDE LIGANDS RECOGNIZED BY HUMAN TUMOR-REACTIVE T CELLS.. JOURNAL OF INVESTIGATIVE MEDICINE. 54:s131.Full Text via DOI: 10.2310/6650.2005.x0004.296
-
200650 IDENTIFICATION OF NOVEL ALTERED PEPTIDE LIGANDS RECOGNIZED BY HUMAN TUMOR-REACTIVE T CELLS.. JOURNAL OF INVESTIGATIVE MEDICINE. 54:s88.Full Text via DOI: 10.2310/6650.2005.x0004.49
-
2006Identification of Novel Altered Peptide Ligands Recognized by Human Tumor-Reactive T Cells. JOURNAL OF INVESTIGATIVE MEDICINE. 54:131-131.Full Text via DOI: 10.1177/108155890605401s180
-
2005High level of cross-reactivity in influenza virus hemagglutinin-specific CD4+ T-cell response: Implications for the initiation of autoimmune response in multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY. 169:31-38.Full Text via DOI: 10.1016/j.jneuroim.2005.07.014
-
2005Recognition of conserved amino acid motifs of common viruses and its role in autoimmunity. PLOS PATHOGENS. 1:0335-0348.Full Text via DOI: 10.1371/journal.ppat.0010041
-
2005Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis. BLOOD. 106:1742-1748.Full Text via DOI: 10.1182/blood-2005-02-0695 Web of Science: 000231495000040
-
2005How the T cell repertoire becomes peptide and MHC specificFull Text via DOI: 10.1016/j.cell.2005.05.013
-
2005Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells. BLOOD. 105:4043-4050.Full Text via DOI: 10.1182/blood-2004-08-3168 Web of Science: 000229009000050
-
2005Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells. CANCER RESEARCH. 65:2378-2386.Full Text via DOI: 10.1158/0008-5472.CAN-04-2649
-
2004Inhibition of XIAP Renders Newly CD40-Activated Chronic Lymphocytic Leukemia Cells Sensitive to Fas (CD95) Mediated Apoptosis.. BLOOD. 104:3474.Full Text via DOI: 10.1182/blood.v104.11.3474.3474
-
2004Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples.. BLOOD. 104:759.Full Text via DOI: 10.1182/blood.v104.11.759.759
-
2004Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors. JOURNAL OF BIOLOGICAL CHEMISTRY. 279:48168-48176.Full Text via DOI: 10.1074/jbc.M405022200
-
2004Reversible Inhibitors of λ Integrase-mediated Recombination Efficiently Trap Holliday Junction Intermediates and Form the Basis of a Novel Assay for Junction Resolution. JOURNAL OF BIOLOGICAL CHEMISTRY. 279:3472-3483.Full Text via DOI: 10.1074/jbc.M309361200
-
2004A powerful combination: The use of positional scanning libraries and biometrical analysis to identify cross-reactive T cell epitopes. MOLECULAR IMMUNOLOGY. 40:1063-1074.Full Text via DOI: 10.1016/j.molimm.2003.11.005
-
2004Peptidic complex mixtures as therapeutic agents in CNS autoimmunity. MOLECULAR IMMUNOLOGY. 40:1075-1087.Full Text via DOI: 10.1016/j.molimm.2003.11.006
-
2004Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activityFull Text via DOI: 10.1016/S1535-6108(03)00332-5 Web of Science: 000188400300007
-
2004Specificity and degeneracy of T cells. MOLECULAR IMMUNOLOGY. 40:1047-1055.Full Text via DOI: 10.1016/j.molimm.2003.11.022
-
2004Strong attraction may be dangerous: Parameters for the development of long term commitment. MOLECULAR IMMUNOLOGY. 40:1109-1112.Full Text via DOI: 10.1016/j.molimm.2003.11.036
-
2004The initiation of the autoimmune response in multiple sclerosis. CLINICAL NEUROLOGY AND NEUROSURGERY. 106:218-222.Full Text via DOI: 10.1016/j.clineuro.2004.02.018
-
2003Identification of novel small-molecule Ulex europaeus I mimetics for targeted drug delivery. BIOORGANIC & MEDICINAL CHEMISTRY. 11:4991-4997.Full Text via DOI: 10.1016/j.bmc.2003.09.002
-
2003Application of support vector machines for T-cell epitopes prediction. BIOINFORMATICS. 19:1978-1984.Full Text via DOI: 10.1093/bioinformatics/btg255
-
2003Toward targeted oral vaccine delivery systems: Selection of lectin mimetics from combinatorial libraries. PHARMACEUTICAL RESEARCH. 20:1258-1266.Full Text via DOI: 10.1023/A:1025061317400
-
2003Detection and characterization of T cells specific for BDC2.5 T cell-stimulating peptides. JOURNAL OF IMMUNOLOGY. 170:4011-4020.Full Text via DOI: 10.4049/jimmunol.170.8.4011
-
2003Use of combinatorial peptide libraries for T-cell epitope mappingFull Text via DOI: 10.1016/S1046-2023(02)00346-8
-
2003Synthetic Combinatorial Libraries as an Alternative Strategy for the Development of Novel Treatments for Infectious Diseases. METHODS IN ENZYMOLOGY. 369:322-344.Full Text via DOI: 10.1016/S0076-6879(03)69018-X
-
2002Positional scanning-synthetic peptide library-based analysis of self- and pathogen-derived peptide cross-reactivity with tumor-reactive Melan-A-specific CTL. JOURNAL OF IMMUNOLOGY. 169:5696-5707.Full Text via DOI: 10.4049/jimmunol.169.10.5696
-
2002Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-A peptide multimer+ CD8+ T cells in humans. JOURNAL OF EXPERIMENTAL MEDICINE. 196:207-216.Full Text via DOI: 10.1084/jem.20020242
-
2001Combinatorial peptide libraries and biometric score matrices permit the quantitative analysis of specific and degenerate interactions between clonotypic TCR and MHC peptide ligands. JOURNAL OF IMMUNOLOGY. 167:2130-2141.Full Text via DOI: 10.4049/jimmunol.167.4.2130
-
2001
-
2001Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries. BLOOD. 97:1776-1786.Full Text via DOI: 10.1182/blood.V97.6.1776
-
2001Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice. JOURNAL OF IMMUNOLOGY. 166:908-917.Full Text via DOI: 10.4049/jimmunol.166.2.908
-
2000Dissection of bacteriophage λ site-specific recombination using synthetic peptide. JOURNAL OF MOLECULAR BIOLOGY. 299:1193-1202.Full Text via DOI: 10.1006/jmbi.2000.3828
-
2000Contribution of individual amino acids within MHC molecule or antigenic peptide to TCR ligand potency. JOURNAL OF IMMUNOLOGY. 164:861-871.Full Text via DOI: 10.4049/jimmunol.164.2.861
-
1999Immunogenicity. I. Use of peptide libraries to identify epitopes that activate clonotypic CD4+ T cells and induce T cell responses to native peptide ligands. JOURNAL OF IMMUNOLOGY. 163:6424-6434.
-
1999ChemInform Abstract: Mixture‐Based Synthetic Combinatorial LibrariesFull Text via DOI: 10.1002/chin.199949239
-
1998All-D peptides recognized by an anti-carbohydrate antibody identified from a positional scanning library. JOURNAL OF MOLECULAR BIOLOGY. 283:1013-1025.Full Text via DOI: 10.1006/jmbi.1998.2137
-
1998From specificity to degeneracy to molecular mimicry: Antigen recognition of human autoreactive and pathogen-specific CD4+ T cells. JOURNAL OF NEUROIMMUNOLOGY. 90:34.Full Text via DOI: 10.1016/s0165-5728(98)91382-0
-
1998Cutting edge: Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology. JOURNAL OF IMMUNOLOGY. 160:3631-3636.
-
1998Activation of human class-II restricted T cell clones by short peptides. FASEB JOURNAL. 12.
-
1998
-
1998
-
1998Mapping the prion protein using recombinant antibodiesFull Text via DOI: 10.1128/jvi.72.11.9413-9418.1998
-
1997A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform. JOURNAL OF MOLECULAR BIOLOGY. 273:614-622.Full Text via DOI: 10.1006/jmbi.1997.1328
-
1996Exploring antibody polyspecificity using synthetic combinatorial librariesFull Text via DOI: 10.1007/BF01718697
-
1995ChemInform Abstract: Utility of Soluble Peptide Combinatorial LibrariesFull Text via DOI: 10.1002/chin.199543292
-
1995Activation of bee venom phospholipase A
2 through a peptide-enzyme complex. FEBS LETTERS. 372:131-134.Full Text via DOI: 10.1016/0014-5793(95)00964-B -
1995A review of the utility of soluble peptide combinatorial libraries. BIOPOLYMERS. 37:221-240.Full Text via DOI: 10.1002/bip.360370306
-
1995Soluble combinatorial libraries of organic, peptidomimetic and peptide diversities. TRAC-TRENDS IN ANALYTICAL CHEMISTRY. 14:83-92.Full Text via DOI: 10.1016/0165-9936(95)91476-9
-
1994Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9: Comparison of two different antibodies bound to the same peptide antigen. JOURNAL OF MOLECULAR BIOLOGY. 241:534-556.Full Text via DOI: 10.1006/jmbi.1994.1530
-
1994Investigation of antigen-antibody interactions using a soluble, non-support-bound synthetic decapeptide library composed of four trillion (4 x 1012) sequences. BIOCHEMICAL JOURNAL. 301:847-853.Full Text via DOI: 10.1042/bj3010847
-
1993Functional importance of amino acid residues making up peptide antigenic determinants. MOLECULAR IMMUNOLOGY. 30:577-585.Full Text via DOI: 10.1016/0161-5890(93)90032-7
-
1992Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries. BIOTECHNIQUES. 13:901-902+904.
-
1992Anomalous reversed-phase high-performacne liquid chromatographic behavior of synthetic peptides related to antigenic helper T cell sites. JOURNAL OF CHROMATOGRAPHY. 625:191-198.Full Text via DOI: 10.1016/0021-9673(92)85202-5
-
1992The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides. BIOTECHNIQUES. 13:412-421.
-
1991Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. NATURE. 354:84-86.Full Text via DOI: 10.1038/354084a0
-
1990Elucidation of discontinuous linear determinants in peptides. JOURNAL OF IMMUNOLOGY. 144:976-983.
-
Book Chapter
-
2018High-throughput flow cytometry screening of multidrug efflux systems. 293-318.Full Text via DOI: 10.1007/978-1-4939-7454-2_16
-
2013Use of Positional Scanning Libraries to Identify Immunologically Relevant Peptides. 617-624.Full Text via DOI: 10.1016/B978-0-12-385095-9.00084-1
-
2013Chapter 84 Use of Positional Scanning Libraries to Identify Immunologically Relevant Peptides. 617-624.Full Text via DOI: 10.1016/b978-0-12-385095-9.00084-1
-
2013Soluble synthetic combinatorial libraries: The use of molecular diversities for drug discovery. 1-26.Full Text via DOI: 10.1515/9783110808902.1
-
2007The versatility of nonsupport-bound combinatorial libraries. 139-171.Full Text via DOI: 10.1002/9783527614912.ch05
-
2001Characterization of Highly Stimulatory T Cell Ligands Identified Using Positional Scanning Libraries. 1051-1052.Full Text via DOI: 10.1007/978-94-010-0464-0_492
-
2001Identification and Optimization of HIV-Specific CTL Antigens for Vaccine Design. 1023-1024.Full Text via DOI: 10.1007/978-94-010-0464-0_478
-
2001The Integration of Positional Scanning Libraries with Bioinformatics and Proteomics. 194-195.Full Text via DOI: 10.1007/978-94-010-0464-0_86
-
2000Peptide Mimicry of Streptococcal Group A Carbohydrate. 83-94.Full Text via DOI: 10.1128/9781555818074.ch7
-
19961 Soluble Synthetic Combinatorial Libraries: The Use of Molecular Diversities for Drug Discovery. 1-26.Full Text via DOI: 10.1515/9783110808902.1
-
1996The generation of peptide combinatorial libraries using tea-bag synthesis. 835-845.Full Text via DOI: 10.1016/b978-012442710-5.50085-x
-
1995Detailed studies of antibody specificity using synthetic peptide combinatorial libraries. 113-114.Full Text via DOI: 10.1007/978-94-011-1468-4_42
-
1995Study of peptide-antibody interactions using a decapeptide positional scanning library. 815-816.Full Text via DOI: 10.1007/978-94-011-1468-4_374
-
1994Identification of an antigenic determinant for the surface antigen of hepatitis B virus using peptide libraries. 1016-1017.Full Text via DOI: 10.1007/978-94-011-0683-2_343
-
1994Optimal peptide length determination using synthetic peptide combinatorial libraries. 971-974.Full Text via DOI: 10.1007/978-94-011-0683-2_327
-
1993Positional scanning synthetic peptide combinatorial libraries. 65-66.Full Text via DOI: 10.1007/978-94-011-1470-7_19
-
1992Comparison of structural and functional approaches for the study of peptide-mAb interactions. 867-868.Full Text via DOI: 10.1007/978-94-011-2264-1_351
-
1992The use of a peptide library composed of 34 012 224 hexamers for basic research and drug discovery. 560-561.Full Text via DOI: 10.1007/978-94-011-2264-1_218
-
Conference
-
2012Abstract 510: Identification and characterization of immunogenic epitopes from CD133 and their potential for use to immunologically target cancer stem cells. CANCER RESEARCH. 510-510.Full Text via DOI: 10.1158/1538-7445.am2012-510
-
2001Molecular mimicry and antigen-specific T cell responses in multiple sclerosis and chronic CNS lyme disease. 187-192.Full Text via DOI: 10.1006/jaut.2000.0501
-
-
Other Scholarly Work
-
2023Erratum: Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput 'Unbiased' Screening Campaign (J. Med. Chem. (2021) 64:9 (5577−5592) DOI: 10.1021/acs.jmedchem.0c02041). JOURNAL OF MEDICINAL CHEMISTRY. 7063-7065.Full Text via DOI: 10.1021/acs.jmedchem.3c00588
-
1999Mixture-based synthetic combinatorial libraries. JOURNAL OF MEDICINAL CHEMISTRY. 3743-3778.Full Text via DOI: 10.1021/jm990174v Web of Science: 000082783200001
-
-
Preprint
-
Review
-
2023Restoring susceptibility to aminoglycosides: identifying small molecule inhibitors of enzymatic inactivation. 1591-1602.Full Text via DOI: 10.1039/d3md00226h Web of Science: 001040556100001
-
2020The value of antimicrobial peptides in the age of resistance. e216-e230.Full Text via DOI: 10.1016/S1473-3099(20)30327-3
-
2008Visualization of the chemical space in drug discovery. 322-333.Full Text via DOI: 10.2174/157340908786786010
-
2007Polyspecificity of T cell and B cell receptor recognition. 216-224.Full Text via DOI: 10.1016/j.smim.2007.02.012
-
2007Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools. JOURNAL OF MOLECULAR RECOGNITION. 75-82.Full Text via DOI: 10.1002/jmr.815
-
2003Successful identification of novel agents to control infectious diseases from screening mixture-based peptide combinatorial libraries in complex cell-based bioassays. BIOPOLYMERS. 103-116.Full Text via DOI: 10.1002/bip.10398
-
2003Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries. 118-122.Full Text via DOI: 10.1038/nm0103-118
-
2002Targeting approaches to oral drug delivery. EXPERT OPINION ON BIOLOGICAL THERAPY. 67-73.Full Text via DOI: 10.1517/14712598.2.1.67
-
2000Drug discovery and vaccine development using mixture-based synthetic combinatorial libraries. DRUG DISCOVERY TODAY. 276-285.Full Text via DOI: 10.1016/S1359-6446(00)01513-0
-
1995Peptide, peptidomimetic, and organic synthetic combinatorial libraries. 481-496.Full Text via DOI: 10.1002/med.2610150603
-
Research
principal investigator on
- Discovery of small molecule glucagon receptor agonists and ketogenic compounds awarded by Aarhus University 2021 - 2023
- T cell in sarcodiosis awarded by National Heart, Lung, & Blood Institute 2020 - 2023
- Immunoregulatory effect of microparticle delivered STING agonist in the control of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS) awarded by Allergy and Infectious Diseases 2021 - 2023
