Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells Article

Berezovskaya, O, Schimmer, AD, Glinskii, AB et al. (2005). Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells . CANCER RESEARCH, 65(6), 2378-2386. 10.1158/0008-5472.CAN-04-2649

cited authors

  • Berezovskaya, O; Schimmer, AD; Glinskii, AB; Pinilla, C; Hoffman, RM; Reed, JC; Glinsky, GV

authors

abstract

  • Survival in lymph or blood is an essential prerequisite for metastasis of carcinoma cells to distant organs. Recently, we reported isolation and initial biological characterization of circulating metastatic cells in a fluorescent, orthotopic, metastatic nude-mouse model of human prostate cancer. Here we show that the metastatic human prostate carcinoma cells selected for survival in the circulation have increased resistance to anoikis, which is apoptosis induced by cell detachment. Using gene silencing and gene transfer techniques, we show that increased expression of the apoptosis-inhibitory protein XIAP contributes to anoikis resistance of the circulating metastatic human prostate carcinoma cells. We also provide initial preclinical data on the antimetastatic efficacy of recently discovered small-molecule antagonists of XIAP. ©2005 American Association for Cancer Research.

publication date

  • March 15, 2005

published in

Digital Object Identifier (DOI)

start page

  • 2378

end page

  • 2386

volume

  • 65

issue

  • 6