Use and implications of the harmonic mean model on mixtures for basic research and drug discovery Article

Santos, RG, Giulianotti, MA, Dooley, CT et al. (2011). Use and implications of the harmonic mean model on mixtures for basic research and drug discovery . ACS Combinatorial Science, 13(3), 337-344. 10.1021/co100065a

cited authors

  • Santos, RG; Giulianotti, MA; Dooley, CT; Pinilla, C; Appel, JR; Houghten, RA

abstract

  • The use of the harmonic mean model for predicting the activities of a given mixture and its constituents has not previously been explored in the context of combinatorial libraries and drug discovery. Herein, the analyses of historical data confirm the harmonic mean as an accurate predictor of mixture activity. The implications of these results are discussed. © 2011 American Chemical Society.

authors

publication date

  • May 9, 2011

published in

Digital Object Identifier (DOI)

start page

  • 337

end page

  • 344

volume

  • 13

issue

  • 3