Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign Article

Doering, Skye R, Freeman, Katie, Debevec, Ginamarie et al. (2021). Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign . JOURNAL OF MEDICINAL CHEMISTRY, 64(9), 5577-5592. 10.1021/acs.jmedchem.0c02041

Open Access

cited authors

  • Doering, Skye R; Freeman, Katie; Debevec, Ginamarie; Geer, Phaedra; Santos, Radleigh G; Lavoi, Travis M; Giulianotti, Marc A; Pinilla, Clemencia; Appel, Jon R; Houghten, Richard A; Ericson, Mark D; Haskell-Luevano, Carrie

sustainable development goals

authors

publication date

  • April 22, 2021

webpage

published in

keywords

  • ALPHA-MELANOTROPIN
  • COMBINATORIAL LIBRARIES
  • Chemistry, Medicinal
  • FOOD-INTAKE
  • FRAMESHIFT MUTATION
  • IN-VIVO
  • Life Sciences & Biomedicine
  • MC4R AGONIST
  • MELANOCYTE-STIMULATING HORMONE
  • MINIMAL ACTIVE SEQUENCE
  • POTENT
  • Pharmacology & Pharmacy
  • SOLID-PHASE SYNTHESIS
  • Science & Technology

Digital Object Identifier (DOI)

publisher

  • AMER CHEMICAL SOC

start page

  • 5577

end page

  • 5592

volume

  • 64

issue

  • 9