Identification of peptides from human pathogens able to cross-activate an HIV-1-gag-specific CD4+ T cell clone Article

Venturini, S, Allicotti, G, Zhao, Y et al. (2006). Identification of peptides from human pathogens able to cross-activate an HIV-1-gag-specific CD4+ T cell clone . 36(1), 27-36. 10.1002/eji.200425767

cited authors

  • Venturini, S; Allicotti, G; Zhao, Y; Simon, R; Burton, DR; Pinilla, C; Poignard, P

authors

abstract

  • Antigen recognition by T cells is degenerate both at the MHC and the TCR level. In this study, we analyzed the cross-reactivity of a human HIV-1 gag p24-specific CD4+ T cell clone obtained from an HIV-1-seronegative donor using a positional scanning synthetic combinatorial peptide library (PS-SCL)-based biometrical analysis. A number of decapeptides able to activate the HIV-1 gag-specific clone were identified and shown to correspond to sequences found in other human pathogens. Two of these peptides activated the T cell done with the same stimulatory potency as the original HIV-1 gag p24 peptide. These findings show that an HIV-1-specific human T helper clone can react efficiently with peptides from other pathogens and suggest that cellular immune responses identified as being specific for one human pathogen (HIV-1) could arise from exposure to other pathogens. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

publication date

  • January 1, 2006

Digital Object Identifier (DOI)

start page

  • 27

end page

  • 36

volume

  • 36

issue

  • 1