The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands Article

Ericson, Mark D, Freeman, Katie T, LaVoi, Travis M et al. (2023). The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands . 24(12), 10.3390/ijms241210145

Open Access

cited authors

  • Ericson, Mark D; Freeman, Katie T; LaVoi, Travis M; Donow, Haley M; Santos, Radleigh G; Giulianotti, Marc A; Pinilla, Clemencia; Houghten, Richard A; Haskell-Luevano, Carrie

sustainable development goals

authors

publication date

  • June 1, 2023

keywords

  • AGOUTI
  • ANTAGONIST
  • Biochemistry & Molecular Biology
  • CLONING
  • Chemistry
  • Chemistry, Multidisciplinary
  • EXPRESSION
  • FRAMESHIFT MUTATION
  • IN-VIVO
  • Life Sciences & Biomedicine
  • MELANOCYTE-STIMULATING-HORMONE
  • OBESITY
  • PROTEIN
  • Physical Sciences
  • SOLID-PHASE SYNTHESIS
  • Science & Technology
  • mMC3R small-molecule ligands
  • mMC5R fragments
  • parallel structure-activity relationship studies

Digital Object Identifier (DOI)

publisher

  • MDPI

volume

  • 24

issue

  • 12