Monkeypox virus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate T cell activation Article

Hammarlund, E, Dasgupta, A, Pinilla, C et al. (2008). Monkeypox virus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate T cell activation . PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(38), 14567-14572. 10.1073/pnas.0800589105

cited authors

  • Hammarlund, E; Dasgupta, A; Pinilla, C; Norori, P; Früh, K; Slifka, MK

authors

abstract

  • Monkeypox virus (MPV) is a virulent human pathogen that has gained increased attention because of its potential use as a bioterrorism agent and inadvertent introduction into North America in 2003. The US outbreak also provided an important opportunity to study MPV-specific T cell immunity. Although MPV-specific CD4+ and CD8+ T cells could recognize vaccinia virus (VV)-infected monocytes and produce inflammatory cytokines such as IFNγ and TNFα, they were largely incapable of responding to autologous MPV-infected cells. Further analysis revealed that, unlike cowpox virus (CPV), MPV did not interfere with MHC expression or intracellular transport of MHC molecules. Instead, MPV-infected cells were capable of preventing T cell receptor (TcR)-mediated T cell activation in trans. The ability to trigger a state of nonresponsiveness represents a unique MHC-independent mechanism for blocking antiviral T cell activation and inflammatory cytokine production and is likely an important attribute involved with viral dissemination in the infected host. © 2008 by The National Academy of Sciences of the USA.

publication date

  • September 23, 2008

published in

Digital Object Identifier (DOI)

start page

  • 14567

end page

  • 14572

volume

  • 105

issue

  • 38