Novel α-glucosidase inhibitors identified using multiple cyclic peptide combinatorial libraries Article

Eichler, J, Lucka, AW, Pinilla, C et al. (1996). Novel α-glucosidase inhibitors identified using multiple cyclic peptide combinatorial libraries . Molecular Diversity, 1(4), 233-240. 10.1007/BF01715527

cited authors

  • Eichler, J; Lucka, AW; Pinilla, C; Houghten, RA

abstract

  • Twenty-six cyclic synthetic peptide combinatorial libraries (disulfides and lactams) of varying size and composition, representing 6.8×103 to 4.7×107 individual peptides, were synthesized along with their respective linear analogs. One of the hexapeptide lactam libraries (cyclo[xXxXxN]) was found to have significant a-glucosidase inhibitory activity. This library was carried through an iterative process of synthesis and screening, during which all of the five mixture positions (x and X) were successively defined. As the result of this process, potent and selective α-glucosidase inhibitors were identified. © 1996 ESCOM Science Publishers B.V.

authors

publication date

  • January 1, 1996

published in

Digital Object Identifier (DOI)

start page

  • 233

end page

  • 240

volume

  • 1

issue

  • 4