Traceless solid-phase synthesis of N-substituted 3,5-bis(substituted-idene) piperidin-4-one derivatives Article

Liu, Z, Medina-Franco, JL, Houghten, RA et al. (2010). Traceless solid-phase synthesis of N-substituted 3,5-bis(substituted-idene) piperidin-4-one derivatives . TETRAHEDRON LETTERS, 51(38), 5003-5004. 10.1016/j.tetlet.2010.07.072

cited authors

  • Liu, Z; Medina-Franco, JL; Houghten, RA; Giulianotti, MA

abstract

  • A series of N-substituted 3,5-bis(substituted-idene)piperidin-4-ones have been prepared using solidphase organic synthesis. The synthesis starts with a Michael addition with piperidin-4-one serving as the donor and REM resin as the acceptor. Various aldehydes were then utilized through a Knoevenagel condensation to afford the 3,5-bis(substituted-idene)piperidin-4-ones on the solid support. The final products were removed from the support and a second diversity position was introduced through a Hofmann elimination using different alkyl bromides. © 2010 Elsevier Ltd. All rights reserved.

publication date

  • January 1, 2010

published in

Digital Object Identifier (DOI)

start page

  • 5003

end page

  • 5004

volume

  • 51

issue

  • 38