A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries Article

Giulianotti, MA, Debevec, G, Santos, RG et al. (2012). A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries . 14(9), 503-512. 10.1021/co300060s

cited authors

  • Giulianotti, MA; Debevec, G; Santos, RG; Maida, LE; Chen, W; Ou, L; Yu, Y; Dooley, CT; Houghten, RA

authors

abstract

  • A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed. © 2012 American Chemical Society.

publication date

  • September 10, 2012

Digital Object Identifier (DOI)

start page

  • 503

end page

  • 512

volume

  • 14

issue

  • 9