A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation Article

Shao, J, Houghten, RA, Dooley, CT et al. (2017). A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation . ORGANIC & BIOMOLECULAR CHEMISTRY, 15(37), 7796-7801. 10.1039/c7ob01924f

cited authors

  • Shao, J; Houghten, RA; Dooley, CT; Cazares, M; McLaughlin, JP; Eans, SO; Ganno, ML; Hoot, MR; Giulianotti, MA; Yu, Y

authors

abstract

  • A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.

publication date

  • January 1, 2017

published in

Digital Object Identifier (DOI)

start page

  • 7796

end page

  • 7801

volume

  • 15

issue

  • 37