A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation
Article
Shao, J, Houghten, RA, Dooley, CT et al. (2017). A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation
. ORGANIC & BIOMOLECULAR CHEMISTRY, 15(37), 7796-7801. 10.1039/c7ob01924f
Shao, J, Houghten, RA, Dooley, CT et al. (2017). A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation
. ORGANIC & BIOMOLECULAR CHEMISTRY, 15(37), 7796-7801. 10.1039/c7ob01924f
A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.