Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries Article

Giulianotti, MA, Vesely, BA, Azhari, A et al. (2017). Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries . 8(8), 802-807. 10.1021/acsmedchemlett.7b00045

cited authors

  • Giulianotti, MA; Vesely, BA; Azhari, A; Souza, A; Lavoi, T; Houghten, RA; Kyle, DE; Leahy, JW

abstract

  • From a screening campaign that included mixture-based libraries containing more than 6 million compounds, a lead series of bis-cyclic guanidines was identified as the most promising. Lead optimization resulted in the identification of potent (IC50 < 500 nM) and selective compounds within this series as well as potent and selective monoguanidines.

publication date

  • August 10, 2017

Digital Object Identifier (DOI)

start page

  • 802

end page

  • 807

volume

  • 8

issue

  • 8