Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries
Article
Giulianotti, MA, Vesely, BA, Azhari, A et al. (2017). Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries
. 8(8), 802-807. 10.1021/acsmedchemlett.7b00045
Giulianotti, MA, Vesely, BA, Azhari, A et al. (2017). Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries
. 8(8), 802-807. 10.1021/acsmedchemlett.7b00045
From a screening campaign that included mixture-based libraries containing more than 6 million compounds, a lead series of bis-cyclic guanidines was identified as the most promising. Lead optimization resulted in the identification of potent (IC50 < 500 nM) and selective compounds within this series as well as potent and selective monoguanidines.