The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries Article

Blondelle, SE, Takahashi, E, Dinh, KT et al. (1995). The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries . 78(1), 39-46. 10.1111/j.1365-2672.1995.tb01671.x

cited authors

  • Blondelle, SE; Takahashi, E; Dinh, KT; Houghten, RA

authors

abstract

  • S.E. BLONDELLE, E. TAKAHASHI, K.T. DINH AND R.A. HOUGHTEN. 1995. A series of peptides identified through the use of synthetic hexapeptide combinatorial libraries (represented by the formula Ac‐RRWWCO‐NH2) were examined for their antimicrobial activity against five different micro‐organisms. Their toxicity was also evaluated in an in vitro haemolytic assay. The peptides showed activity against the five micro‐organisms, although higher activities were found against Gram‐positive bacteria. Both growth inhibition and cell viability assays were carried out to demonstrate the bactericidal activities of these peptides against two of the micro‐organisms tested. The dimeric cystine forms of these peptides were shown to have biological activities identical to the monomeric forms. Copyright © 1995, Wiley Blackwell. All rights reserved

publication date

  • January 1, 1995

Digital Object Identifier (DOI)

start page

  • 39

end page

  • 46

volume

  • 78

issue

  • 1