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The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein Article

Tainer, JA, Getzoff, ED, Alexander, H et al. (1984). The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein . NATURE, 312(5990), 127-134. 10.1038/312127a0

cited authors

  • Tainer, JA; Getzoff, ED; Alexander, H; Houghten, RA; Olson, AJ; Lerner, RA; Hendrickson, WA

authors

abstract

  • To study the nature of antigenic recognition, antibodies have been prepared against a set of peptide sequences representing both highly mobile and well-ordered regions of myohaemerythrin, based on X-ray crystallographic temperature factors. Anti-peptide antibodies against highly mobile regions react strongly with the native protein; anti-peptide antibodies from well-ordered regions do not. Mobility is a major factor in the recognition of the native protein by anti-peptide antibodies; this may be of general significance in protein-protein interactions. © 1984 Nature Publishing Group.

publication date

  • December 1, 1984

published in

Digital Object Identifier (DOI)

start page

  • 127

end page

  • 134

volume

  • 312

issue

  • 5990