Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinones via β-lactam intermediates on the solid-phase
Article
Pei, Y, Houghten, RA, Kiely, JS. (1997). Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinones via β-lactam intermediates on the solid-phase
. TETRAHEDRON LETTERS, 38(19), 3349-3352. 10.1016/S0040-4039(97)00655-2
Pei, Y, Houghten, RA, Kiely, JS. (1997). Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinones via β-lactam intermediates on the solid-phase
. TETRAHEDRON LETTERS, 38(19), 3349-3352. 10.1016/S0040-4039(97)00655-2
The synthesis of 3,4-dihydro-2(1H)-quinolinones has been accomplished through the rearrangement of p-lactam intermediates on the solid-phase. The β-lactam intermediates were constructed through [2+2] cycloadditions between ketenes and imines on the solid-phase. A library of 4,140 dihydroquinolinones has been produced using this synthetic process.