Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinones via β-lactam intermediates on the solid-phase Article

Pei, Y, Houghten, RA, Kiely, JS. (1997). Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinones via β-lactam intermediates on the solid-phase . TETRAHEDRON LETTERS, 38(19), 3349-3352. 10.1016/S0040-4039(97)00655-2

cited authors

  • Pei, Y; Houghten, RA; Kiely, JS

authors

abstract

  • The synthesis of 3,4-dihydro-2(1H)-quinolinones has been accomplished through the rearrangement of p-lactam intermediates on the solid-phase. The β-lactam intermediates were constructed through [2+2] cycloadditions between ketenes and imines on the solid-phase. A library of 4,140 dihydroquinolinones has been produced using this synthetic process.

publication date

  • May 12, 1997

published in

Digital Object Identifier (DOI)

start page

  • 3349

end page

  • 3352

volume

  • 38

issue

  • 19