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Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence Article

Bittle, JL, Houghten, RA, Alexander, H et al. (1982). Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence . NATURE, 298(5869), 30-33. 10.1038/298030a0

cited authors

  • Bittle, JL; Houghten, RA; Alexander, H; Shinnick, TM; Sutcliffe, JG; Lerner, RA; Rowlands, DJ; Brown, F

authors

abstract

  • Chemically synthesized peptides corresponding to two different regions of the VP1 polypeptide of foot-and-mouth disease virus (FMDV) produced high levels of serotype-specific virus neutralizing antibody in cattle, guinea pigs and rabbits. A single inoculation of one of these peptides protected guinea pigs against subsequent challenge with the virulent virus. © 1982 Nature Publishing Group.

publication date

  • December 1, 1982

published in

Digital Object Identifier (DOI)

start page

  • 30

end page

  • 33

volume

  • 298

issue

  • 5869