In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands Book Chapter

Houghten, RA, Dooley, CT, Appel, JR. (2008). In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands . 433-453. 10.1007/978-0-387-76678-2_26

cited authors

  • Houghten, RA; Dooley, CT; Appel, JR

authors

abstract

  • The use of combinatorial libraries for the identification of novel opiate and related ligands in opioid receptor assays is reviewed. Case studies involving opioid assays used to demonstrate the viability of combinatorial libraries are described. The identification of new opioid peptides composed of L-amino acids, D-amino acids, or L-, D-, and unnatural amino acids is reviewed. New opioid compounds have also been identified from peptidomimetic libraries, such as peptoids and alkylated dipeptides, and those identified from acyclic (eg, polyamine, urea) and heterocyclic (eg, bicyclic guanidine) libraries are reviewed. © American Association of Pharmaceutical Scientists 2008.

publication date

  • December 1, 2008

Digital Object Identifier (DOI)

International Standard Book Number (ISBN) 13

start page

  • 433

end page

  • 453