"Volatilizable" supports for high-throughput organic synthesis Article

Houghten, RA, Yu, Y. (2005). "Volatilizable" supports for high-throughput organic synthesis . JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(24), 8582-8583. 10.1021/ja0402396

cited authors

  • Houghten, RA; Yu, Y

authors

abstract

  • The concepts and use of "volatilizable" solid supports are presented. Such supports, which are completely removed by volatilization following decomposition, improve the efficiency of the solid-phase synthesis of both individual and mixtures of low-molecular weight acyclic and heterocyclic compounds as well as peptides, peptidomimetics, and protected peptide fragments. The "volatilizable" silica-based solid supports and linkers used to illustrate this concept were found to be completely removed by their decomposition and ultimate "volatilization" during the final cleavage step of synthetic process to yield solely the desired synthetic product(s) in the final reaction vessel. Copyright © 2005 American Chemical Society.

publication date

  • June 22, 2005

published in

Digital Object Identifier (DOI)

start page

  • 8582

end page

  • 8583

volume

  • 127

issue

  • 24