Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization Article

Chen, W, Li, Z, Ou, L et al. (2011). Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization . TETRAHEDRON LETTERS, 52(13), 1456-1458. 10.1016/j.tetlet.2011.01.055

cited authors

  • Chen, W; Li, Z; Ou, L; Giulianott, MA; Houghten, RA; Yu, Y

authors

abstract

  • The solid-phase synthesis of sultams from resin-bound amino acids is described. The sulfonylation of the resin-bound primary amines afforded the requisite secondary amines, after which the intramolecular Buchwald-Hartwig-type coupling forms the C-S bond. A final alkylation on the sulfonamides followed by cleavage provided the corresponding seven-membered sultams. © 2011 Elsevier Ltd. All rights reserved.

publication date

  • March 30, 2011

published in

Digital Object Identifier (DOI)

start page

  • 1456

end page

  • 1458

volume

  • 52

issue

  • 13