Use of heterocyclic positional scanning synthetic combinatorial libraries for the discovery of highly active small molecules
Article
Houghten, RA. (1998). Use of heterocyclic positional scanning synthetic combinatorial libraries for the discovery of highly active small molecules
. FASEB JOURNAL, 12(5),
Houghten, RA. (1998). Use of heterocyclic positional scanning synthetic combinatorial libraries for the discovery of highly active small molecules
. FASEB JOURNAL, 12(5),
There is a clear division in the field of combinatorial chemistry as to whether all compounds in a library should be examined individually, as small mixtures (5 to 50 compounds) or as large mixtures (100 to 10,000 compounds). The majority of laboratories carrying out screening assays are currently not capable of screening hundreds of thousands of individual compounds in a timely and cost efficient manner. The practical considerations in the use of mixtures versus individual compounds and iterative deconvolution versus positional scanning will be discussed. The use of heterocyclic positional scanning synthetic combinatorial libraries to identify highly active individual compounds will also be illustrated.
