A Traceless Approach for the Solid-Phase Synthesis of 6-Amino-1,3,5- triazine-2,4-diones
Article
Yu, Y, Ostresh, JM, Houghten, RA. (2004). A Traceless Approach for the Solid-Phase Synthesis of 6-Amino-1,3,5- triazine-2,4-diones
. 6(1), 83-85. 10.1021/cc030017o
Yu, Y, Ostresh, JM, Houghten, RA. (2004). A Traceless Approach for the Solid-Phase Synthesis of 6-Amino-1,3,5- triazine-2,4-diones
. 6(1), 83-85. 10.1021/cc030017o
A traceless approach for the solid-phase synthesis of 6-amino-1,3,5- triazine-2,4-diones is described. Reaction of resin-bound S-methylisothiourea with isocyanates yielded resin-bound iminoureas 3, which reacted with amines to afford the corresponding guanidines 4. Following intramolecular cyclizative cleavage of the resin-bound guanidines using potassium ethoxide as a base, the desired products 5 were obtained in good yields and high purities.
