[3H] dynorphin binding to guinea pig and rat brain Article

Young, E, Walker, JM, Houghten, R et al. (1983). [3H] dynorphin binding to guinea pig and rat brain . LIFE SCIENCES, 33(SUPPL. 1), 287-290. 10.1016/0024-3205(83)90499-X

cited authors

  • Young, E; Walker, JM; Houghten, R; Akil, H

authors

abstract

  • [3H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types supports the kappa selectivity of dynorphin in guinea pig. However, in rat brain, a substantial proportion of the [3H] dynorphin binding is displaced by morphine, suggesting a mu as well as kappa component. Consequently, in rat, dynorphin may show effects at both mu and kappa receptors in vivo. © 1983.

publication date

  • January 1, 1983

published in

Digital Object Identifier (DOI)

start page

  • 287

end page

  • 290

volume

  • 33

issue

  • SUPPL. 1