Solid-phase synthesis of 5-aminotetrazoles Article

Yu, Y, Ostresh, JM, Houghten, RA. (2004). Solid-phase synthesis of 5-aminotetrazoles . TETRAHEDRON LETTERS, 45(41), 7787-7789. 10.1016/j.tetlet.2004.07.160

cited authors

  • Yu, Y; Ostresh, JM; Houghten, RA

authors

abstract

  • A solid-phase synthesis of 5-aminotetrazoles is described. Resin-bound thioureas were displaced by sodium azide in the presence of HgCl 2 and following nucleophilic cyclization produced the resin-bound products. The desired 5-aminotetrazoles were cleaved from the resin using 95% trifluoroacetic acid in dichloromethane in good yield and purity. © 2004 Elsevier Ltd. All rights reserved.

publication date

  • October 4, 2004

published in

Digital Object Identifier (DOI)

start page

  • 7787

end page

  • 7789

volume

  • 45

issue

  • 41