Use of vilsmeier reagent for the solid-phase synthesis of 1,5-disubstituted 4,5-dihydro-1H-imidazoles and disubstituted 4,5-dihydro-1H-imidazolylbenzimidazoles
Article
Acharya, AN, Thai, C, Ostresh, JM et al. (2002). Use of vilsmeier reagent for the solid-phase synthesis of 1,5-disubstituted 4,5-dihydro-1H-imidazoles and disubstituted 4,5-dihydro-1H-imidazolylbenzimidazoles
. 4(5), 496-500. 10.1021/cc020020s
Acharya, AN, Thai, C, Ostresh, JM et al. (2002). Use of vilsmeier reagent for the solid-phase synthesis of 1,5-disubstituted 4,5-dihydro-1H-imidazoles and disubstituted 4,5-dihydro-1H-imidazolylbenzimidazoles
. 4(5), 496-500. 10.1021/cc020020s
The solid-phase synthesis of novel imidazolines and dihydroimidazolylbenzimidazoles is described. Resinbound diamines, derived from resin-bound N-acylated amino acid amides, were cyclized using Vilsmeier reagent to yield imidazolines following cleavage. Similarly, cyclization of resin-bound tetraamines having two secondary amines and an o-dianiline yielded dihydroimidazolylbenzimidazoles following cleavage.
