Use of vilsmeier reagent for the solid-phase synthesis of 1,5-disubstituted 4,5-dihydro-1H-imidazoles and disubstituted 4,5-dihydro-1H-imidazolylbenzimidazoles Article

Acharya, AN, Thai, C, Ostresh, JM et al. (2002). Use of vilsmeier reagent for the solid-phase synthesis of 1,5-disubstituted 4,5-dihydro-1H-imidazoles and disubstituted 4,5-dihydro-1H-imidazolylbenzimidazoles . 4(5), 496-500. 10.1021/cc020020s

cited authors

  • Acharya, AN; Thai, C; Ostresh, JM; Houghten, RA

abstract

  • The solid-phase synthesis of novel imidazolines and dihydroimidazolylbenzimidazoles is described. Resinbound diamines, derived from resin-bound N-acylated amino acid amides, were cyclized using Vilsmeier reagent to yield imidazolines following cleavage. Similarly, cyclization of resin-bound tetraamines having two secondary amines and an o-dianiline yielded dihydroimidazolylbenzimidazoles following cleavage.

publication date

  • September 1, 2002

Digital Object Identifier (DOI)

start page

  • 496

end page

  • 500

volume

  • 4

issue

  • 5