Anti-peptide antibodies detect oncogene-related proteins in urine
Article
Niman, HL, Thompson, AMH, Yu, A et al. (1985). Anti-peptide antibodies detect oncogene-related proteins in urine
. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 82(23), 7924-7928. 10.1073/pnas.82.23.7924
Niman, HL, Thompson, AMH, Yu, A et al. (1985). Anti-peptide antibodies detect oncogene-related proteins in urine
. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 82(23), 7924-7928. 10.1073/pnas.82.23.7924
Antisera to a number of synthetic peptides predicted from nucleic acid sequences of oncogenes have been used to screen 483 urine samples of cancer patients, pregnant women, and normal controls for the presence of immunologically related proteins. Increased levels of oncogene-related proteins are found during neoplasia and pregnancy. The differential detection of these oncogene-related proteins indicates that panels of monoclonal antibodies may provide a convenient noninvasive means of detecting, classifying, and staging a wide variety of malignancies and may be useful in following fetal development during pregnancy.
