Libraries from libraries: Generation and comparison of screening profiles Article

Houghten, RA, Blondelle, SE, Dooley, CT et al. (1996). Libraries from libraries: Generation and comparison of screening profiles . 2(1-2), 41-45. 10.1007/BF01718699

cited authors

  • Houghten, RA; Blondelle, SE; Dooley, CT; Dörner, B; Eichler, J; Ostresh, JM

abstract

  • A positional scanning tetrapeptide library was chemically modified through alkylation and/or reduction of the amide bonds, thus generating three new combinatorial libraries with physico-chemical properties very different from the parent peptide library ('libraries from libraries'). Specific results were obtained with each of these libraries upon screening in κ-opioid receptor binding and microdilution antimicrobial assays, illustrating the potential of the 'libraries from libraries' concept for the efficient generation of a variety of chemically diverse combinatorial libraries. © 1996 ESCOM Science Publishers B.V.

publication date

  • January 1, 1996

Digital Object Identifier (DOI)

start page

  • 41

end page

  • 45

volume

  • 2

issue

  • 1-2