Synthetic idiotypes: The third hypervariable region of murine anti-dextran antibodies Article

McMillan, S, Seiden, MV, Houghten, RA et al. (1983). Synthetic idiotypes: The third hypervariable region of murine anti-dextran antibodies . 35(3 PART 2), 859-863. 10.1016/0092-8674(83)90118-6

cited authors

  • McMillan, S; Seiden, MV; Houghten, RA; Clevinger, B; Davie, JM; Lerner, RA

authors

abstract

  • Synthetic peptides with the sequence of the third hypervariable region of either M104 or J558 murine myeloma proteins have been used to immunize rabbits. Most of the resulting antisera distinguished the two proteins in a specific manner corresponding to the sequence of the immunizing peptide. Thus synthetic peptides have been used to elicit antisera specific for particular idiotypes. These studies have significant implications for our understanding of the molecular basis of idiotypy. © 1983.

publication date

  • January 1, 1983

Digital Object Identifier (DOI)

start page

  • 859

end page

  • 863

volume

  • 35

issue

  • 3 PART 2