Tritiated porcine dynorphin (1-17): Synthesis and characterization Article

Houghten, RA. (1982). Tritiated porcine dynorphin (1-17): Synthesis and characterization . LIFE SCIENCES, 31(16-17), 1805-1808. 10.1016/0024-3205(82)90215-6

cited authors

  • Houghten, RA

authors

abstract

  • Tritiated porcine dynorphin (1-17) has been prepared from its corresponding iodinated analog. The iodinated analog (diiodotyrosine at position 1) was syntesized, along with its non-iodinated counterpart, by the solid-phase method. Catalytic exchange of this iodinated analog in the presence of tritium yielded tritiated porcine dynorphin having a specific activity of 42 Ci/mmole. Both the native, iodinated and tritiated dynorphin analogs were shown to be homogenous by chromatography on carboxymethylcellulose, paper chromatography, amino acid analysis, electrophoresis, high performance liquid chromatography and isoelectric focusing on polyacrylamide. © 1982.

publication date

  • January 1, 1982

published in

Digital Object Identifier (DOI)

start page

  • 1805

end page

  • 1808

volume

  • 31

issue

  • 16-17