Solid-phase parallel synthesis of 2-aminoimidazolidin-4-ones Article

Yu, Y, Ostresh, JM, Houghten, RA. (2002). Solid-phase parallel synthesis of 2-aminoimidazolidin-4-ones . TETRAHEDRON, 58(17), 3349-3353. 10.1016/S0040-4020(02)00299-5

cited authors

  • Yu, Y; Ostresh, JM; Houghten, RA

authors

abstract

  • The solid phase synthesis of 2-aminoimidazolidin-4-ones from resin-bound amino acids is described. Resin-bound thioureas were treated with Mukaiyama's reagent (2-chloro-1-methypyridinium iodide) to form, via intramolecular cyclization, resin-bound 2-iminoimidazolidin-4-ones. Following alkylation and cleavage, the corresponding 1,5-disubstituted 2-aminoimidazolidin-4-ones were provided in good yield and purity. © 2002 Elsevier Science Ltd. All rights reserved.

publication date

  • April 22, 2002

published in

Digital Object Identifier (DOI)

start page

  • 3349

end page

  • 3353

volume

  • 58

issue

  • 17