Solid-phase synthesis of 3-amino-1,2,4-triazoles Article

Yu, Y, Ostresh, JM, Houghten, RA. (2003). Solid-phase synthesis of 3-amino-1,2,4-triazoles . TETRAHEDRON LETTERS, 44(42), 7841-7843. 10.1016/j.tetlet.2003.08.074

cited authors

  • Yu, Y; Ostresh, JM; Houghten, RA

authors

abstract

  • A solid-phase synthesis of 3-amino-1,2,4-triazoles is described. Reaction of resin bound S-methylisothiourea 2 with carboxylic acids yielded resin-bound S-methyl-N-acylisothioureas 3, which reacted with hydrazines under mild conditions to afford the corresponding resin-bound 3-amino-1,2,4-triazoles 4 with regioselectivity. Following cleavage, the desired products 5 were obtained in good yields and purities. © 2003 Elsevier Ltd. All rights reserved.

publication date

  • October 13, 2003

published in

Digital Object Identifier (DOI)

start page

  • 7841

end page

  • 7843

volume

  • 44

issue

  • 42