Overview
biography
- Research involves invention of mechanism-based inhibitors of enzymes vital to cancer cell and/or virus proliferation, and collaborative biochemical evaluation. Another area focuses on new fluorination, radical desulfonylation, and Pd-catalyzed cross-coupling methodologies. Dr. Wnuk’s research group is also interested in the design and synthesis of 18F labeled nucleoside-based probes for Positron Emission Tomography Imaging.
research interests
- Organic Chemistry of Nucleosides and Nucleotides
Scholarly & Creative Works
Patents issued
- 2-Methylthiopyrrolidines and Their Use for Modulating Bacterial Quorum Sensing Patent
- 2-Methylthiopyrrolidines and Their Use for Modulating Bacterial Quorum Sensing Patent
- Synthesis of Haloindenes Patent
- Synthesis of the Organoarsenical Antibiotic Arsinothricin and Derivatives Thereof Patent
- Synthesis of the Organoarsenical Antibiotic Arsinothricin and Derivatives Thereof Patent
selected scholarly works & creative activities
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Article
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20246-azido and 6-azidomethyl uracil nucleosides. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 43:453-471.Full Text via DOI: 10.1080/15257770.2023.2271023 Web of Science: 001163001200001
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2023Gas-Phase Synthesis of Coronene through Stepwise Directed Ring Annulation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 145:15443-15455.Full Text via DOI: 10.1021/jacs.3c03816 Web of Science: 001022894800001
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2023Construction of quaternary stereocenters at carbon 2 ' of nucleosides. CARBOHYDRATE RESEARCH. 528.Full Text via DOI: 10.1016/j.carres.2023.108814 Web of Science: 000984673000001
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2023Gas phase synthesis of the C40 nano bowl C40H10Full Text via DOI: 10.1038/s41467-023-37058-y Web of Science: 000957141600006
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2023Pathways of the Dissociative Electron Attachment Observed in 5-and 6-Azidomethyluracil Nucleosides: Nitrogen (N2) Elimination vs Azide Anion (N3-) Elimination. JOURNAL OF PHYSICAL CHEMISTRY B.Full Text via DOI: 10.1021/acs.jpcb.2c08257 Web of Science: 000963497700001
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2023Exotic Reaction Dynamics in the Gas-Phase Preparation of Anthracene (C14H10) via Spiroaromatic Radical Transients in the Indenyl-Cyclopentadienyl Radical-Radical Reaction. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY.Full Text via DOI: 10.1021/jacs.2c12045 Web of Science: 000925728800001
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2021Chemical synthesis of the organoarsenical antibiotic arsinothricinFull Text via DOI: 10.1039/d1ra06770b Web of Science: 000714163200001
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2021A molecular beam and computational study on the barrierless gas phase formation of (iso)quinoline in low temperature extraterrestrial environments. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 23:18495-18505.Full Text via DOI: 10.1039/d1cp02169a Web of Science: 000687267600001
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2021Gas-phase synthesis of corannulene - a molecular building block of fullerenes. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 23:5740-5749.Full Text via DOI: 10.1039/d0cp06537d Web of Science: 000630207300060
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2021A small molecule inhibits pancreatic cancer stem cellsFull Text via DOI: 10.52756/ijerr.2021.v26.001
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2020Site of Azido Substitution in the Sugar Moiety of Azidopyrimidine Nucleosides Influences the Reactivity of Aminyl Radicals Formed by Dissociative Electron Attachment. JOURNAL OF PHYSICAL CHEMISTRY B. 124:11357-11370.Full Text via DOI: 10.1021/acs.jpcb.0c08201 Web of Science: 000608855200006
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2020Iodoindenes: Synthesis and application to cross-coupling. TETRAHEDRON LETTERS. 61.Full Text via DOI: 10.1016/j.tetlet.2020.152427 Web of Science: 000579003400003
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2020Gas phase formation of cyclopentanaphthalene (benzindene) isomers via reactions of 5-and 6-indenyl radicals with vinylacetylene. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 22:22493-22500.Full Text via DOI: 10.1039/d0cp03846f Web of Science: 000581179800031
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2020Semisynthesis of the Organoarsenical Antibiotic Arsinothricin. JOURNAL OF NATURAL PRODUCTS. 83:2809-2813.Full Text via DOI: 10.1021/acs.jnatprod.0c00522 Web of Science: 000575848000032
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2020Gas phase formation of phenalene via 10 Pi-aromatic, resonantly stabilized free radical intermediates. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 22:15381-15388.Full Text via DOI: 10.1039/d0cp02216k Web of Science: 000549894000021
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2019Molecular mass growth through ring expansion in polycyclic aromatic hydrocarbons via radical-radical reactionsFull Text via DOI: 10.1038/s41467-019-11652-5 Web of Science: 000480684500006
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2019How to add a five-membered ring to polycyclic aromatic hydrocarbons (PAHs) - molecular mass growth of the 2-naphthyl radical (C10H7) to benzindenes (C13H10) as a case study. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 21:16737-16750.Full Text via DOI: 10.1039/c9cp02930c Web of Science: 000477987200032
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2019Cover Feature: Reactivity of the Indenyl Radical (C9H7) with Acetylene (C2H2) and Vinylacetylene (C4H4) (ChemPhysChem 11/2019). CHEMPHYSCHEM. 20:1413-1413.Full Text via DOI: 10.1002/cphc.201900486
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2019Reactivity of the Indenyl Radical (C9H7) with Acetylene (C2H2) and Vinylacetylene (C4H4). CHEMPHYSCHEM. 20:1437-1447.Full Text via DOI: 10.1002/cphc.201900052 Web of Science: 000470785900004
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2019Gas phase synthesis of [4]-helicene. NATURE COMMUNICATIONS. 10.Full Text via DOI: 10.1038/s41467-019-09224-8 Web of Science: 000463170600009
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2019Front Cover: Gas‐Phase Synthesis of Triphenylene (C18H12) (ChemPhysChem 6/2019). CHEMPHYSCHEM. 20:785-785.Full Text via DOI: 10.1002/cphc.201900201
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2019Gas-Phase Synthesis of Triphenylene (C18H12). CHEMPHYSCHEM. 20:791-797.Full Text via DOI: 10.1002/cphc.201801154 Web of Science: 000461867600001
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2019Fluorescent 5-Pyrimidine and 8-Purine Nucleosides Modified with an N-Unsubstituted 1,2,3-Triazol-4-yl Moiety. JOURNAL OF ORGANIC CHEMISTRY. 84:3624-3631.Full Text via DOI: 10.1021/acs.joc.8b03135 Web of Science: 000461844000051
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2018Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells. ORGANIC LETTERS. 20:7400-7404.Full Text via DOI: 10.1021/acs.orglett.8b03035 Web of Science: 000452930100012
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20184-N-Alkanoyl and 4-N-alkyl gemcitabine analogues with NOTA chelators for 68-gallium labelling. BIOORGANIC & MEDICINAL CHEMISTRY. 26:5624-5630.Full Text via DOI: 10.1016/j.bmc.2018.10.007 Web of Science: 000450102200004
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2018VUV Photoionization Study of the Formation of the Simplest Polycyclic Aromatic Hydrocarbon: Naphthalene (C10H8). JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 9:2620-2626.Full Text via DOI: 10.1021/acs.jpclett.8b01020 Web of Science: 000432756600026
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2018Pyrimidine Nucleosides with a Reactive (ss-Chlorovinyl)sulfone or (ss-Keto)sulfone Group at the C5 Position, Their Reactions with Nucleophiles and Electrophiles, and Their Polymerase-Catalyzed Incorporation into DNA. ACS OMEGA. 3:4276-4288.Full Text via DOI: 10.1021/acsomega.8b00584 Web of Science: 000430200300070
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2018The 4-N-acyl and 4-N-alkyl gemcitabine analogues with silicon-fluoride-acceptor: Application to F-18-Radiolabeling. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 148:314-324.Full Text via DOI: 10.1016/j.ejmech.2018.02.017 Web of Science: 000428824700025
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2018Gemcitabine analogues with 4-N-alkyl chain modified with fluoromethyl ketone group. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 37:248-260.Full Text via DOI: 10.1080/15257770.2018.1465186 Web of Science: 000441057900004
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2017Prehydrated One-Electron Attachment to Azido-Modified Pentofuranoses: Aminyl Radical Formation, Rapid H-Atom Transfer, and Subsequent Ring Opening. JOURNAL OF PHYSICAL CHEMISTRY B. 121:4968-4980.Full Text via DOI: 10.1021/acs.jpcb.7b01838 Web of Science: 000402024000004
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2017Antiviral and Cytostatic Evaluation of 5-(1-Halo-2-sulfonylvinyl)- and 5-(2-Furyl)uracil Nucleosides. ARCHIV DER PHARMAZIE. 350.Full Text via DOI: 10.1002/ardp.201700023 Web of Science: 000398574600010
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2016Transition-Metal-Free Cross-Coupling of Aryl Halides with Arylstannanes. JOURNAL OF ORGANIC CHEMISTRY. 81:9422-9427.Full Text via DOI: 10.1021/acs.joc.6b01648 Web of Science: 000385054300073
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2016Synthesis of 8-(1,2,3-triazol-1-y1)-7-deazapurine nucleosides by azide-alkyne click reactions and direct C-H bond functionalization. TETRAHEDRON LETTERS. 57:4364-4367.Full Text via DOI: 10.1016/j.tetlet.2016.08.053 Web of Science: 000383939700010
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2016Reduction of sugar lactones to hemiacetals with lithium triethylborohydride. CARBOHYDRATE RESEARCH. 432:17-22.Full Text via DOI: 10.1016/j.carres.2016.06.002 Web of Science: 000380682800003
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2016S-Ribosylhomocysteine analogues modified at the ribosyl C-4 position. JOURNAL OF SULFUR CHEMISTRY. 37:307-327.Full Text via DOI: 10.1080/17415993.2015.1137921 Web of Science: 000375958600007
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2016Studies toward the oxidative and reductive activation of C-S bonds in 2 '-S-aryl-2 '-thiouridine derivatives. TETRAHEDRON. 72:1969-1977.Full Text via DOI: 10.1016/j.tet.2016.02.063 Web of Science: 000374198700010
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2016Uracil Nucleosides with Reactive Group at C5 Position: 5-(1-Halo-2-sulfonylvinyl)uridine Analogues. ORGANIC LETTERS. 18:1418-1421.Full Text via DOI: 10.1021/acs.orglett.6b00346 Web of Science: 000372664600051
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2015S-Ribosylhomocysteine analogs containing a [4-thio]ribose ring. CARBOHYDRATE RESEARCH. 415:39-47.Full Text via DOI: 10.1016/j.carres.2015.07.005 Web of Science: 000362889100006
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2015Strain Promoted Click Chemistry of 2-or 8-Azidopurine and 5-Azidopyrimidine Nucleosides and 8-Azidoadenosine Triphosphate with Cyclooctynes. Application to Living Cell Fluorescent Imaging. BIOCONJUGATE CHEMISTRY. 26:1519-1532.Full Text via DOI: 10.1021/acs.bioconjchem.5b00300 Web of Science: 000359962900017
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2014One-Electron Oxidation of Gemcitabine and Analogs: Mechanism of Formation of C3 ' and C2 ' Sugar Radicals. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 136:15646-15653.Full Text via DOI: 10.1021/ja5083156 Web of Science: 000344516600035
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2014Synthesis of Purine and 7-Deazapurine Nucleoside Analogues of 6-N-(4-Nitrobenzyl)adenosine; Inhibition of Nucleoside Transport and Proliferation of Cancer Cells. CHEMMEDCHEM. 9:2186-2192.Full Text via DOI: 10.1002/cmdc.201402047 Web of Science: 000341623300030
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2014Palladium-Catalyzed Direct Arylation of 5-Halouracils and 5-Halouracil Nucleosides with Arenes and Heteroarenes Promoted by TBAF. JOURNAL OF ORGANIC CHEMISTRY. 79:4094-4103.Full Text via DOI: 10.1021/jo500602p Web of Science: 000335490700039
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2014Synthesis of 1-Amino-5,6-diaryl-3-cyano-1H-pyridin-2-ones and 6,7-Diaryl-4-cyano-3-hydroxy-1H-[1,2]diazepines from Isoflavones. HELVETICA CHIMICA ACTA. 97:561-568.Full Text via DOI: 10.1002/hlca.201300246 Web of Science: 000333921600012
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2014Synthesis and Cytostatic Evaluation of 4-N-Alkanoyl and 4-N-Alkyl Gemcitabine Analogues. JOURNAL OF MEDICINAL CHEMISTRY. 57:191-203.Full Text via DOI: 10.1021/jm401586a Web of Science: 000329677800014
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2014A CoMSIA study to design antagonist ligands for the LuxS protein. NEW JOURNAL OF CHEMISTRY. 38:1235-1249.Full Text via DOI: 10.1039/c3nj01162c Web of Science: 000331805000048
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2013Synthesis of 5,6-Diarylpyridin-2(1H)-ones from Isoflavones. CHINESE JOURNAL OF CHEMISTRY. 31:1027-1032.Full Text via DOI: 10.1002/cjoc.201300279 Web of Science: 000327738500011
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2013Hydrogermylation of 5-Ethynyluracil Nucleosides: Formation of 5-(2-Germylvinyl)uracil and 5-(2-Germylacetyl)uracil Nucleosides. JOURNAL OF ORGANIC CHEMISTRY. 78:5761-5767.Full Text via DOI: 10.1021/jo400590z Web of Science: 000320298700069
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2013Hydroxyl Ion Addition to One-Electron Oxidized Thymine: Unimolecular Interconversion of C5 to C6 OH-Adducts. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 135:3121-3135.Full Text via DOI: 10.1021/ja310650n Web of Science: 000315618900045
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2012Investigation of reactions postulated to occur during inhibition of ribonucleotide reductases by 2 '-azido-2 '-deoxynucleotides. TETRAHEDRON. 68:5655-5667.Full Text via DOI: 10.1016/j.tet.2012.04.050 Web of Science: 000306350800042
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2012Bromination at C-5 of pyrimidine and C-8 of purine nucleosides with 1,3-dibromo-5,5-dimethylhydantoin. TETRAHEDRON LETTERS. 53:3333-3336.Full Text via DOI: 10.1016/j.tetlet.2012.04.081 Web of Science: 000304851500033
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2012S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: Potent inhibitory activity of 9-(2-deoxy-2-fluoro-beta,D-arabinofuranosyl)adenine. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 22:4203-4205.Full Text via DOI: 10.1016/j.bmcl.2012.03.087 Web of Science: 000304484600072
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2011Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring. BIOORGANIC & MEDICINAL CHEMISTRY. 19:5507-5519.Full Text via DOI: 10.1016/j.bmc.2011.07.043 Web of Science: 000294711100023
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2011Substituted lactam and cyclic azahemiacetals modulate Pseudomonas aeruginosa quorum sensing. BIOORGANIC & MEDICINAL CHEMISTRY. 19:5500-5506.Full Text via DOI: 10.1016/j.bmc.2011.07.044 Web of Science: 000294711100022
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2011Chemoselective Transfer of Allyl or Phenyl Group from Allyl(phenyl)germanes in Pd-catalyzed Reactions with Aryl Halides. CHEMISTRY LETTERS. 40:967-969.Full Text via DOI: 10.1246/cl.2011.967 Web of Science: 000295660400025
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2011ChemInform Abstract: Fluoride‐Promoted Cross‐Coupling of Chloro(mono‐, di‐, or triphenyl)germanes with Aryl Halides in “Moist” Toluene. Multiple Transfer of the Phenyl Group from Organogermane Substrates and Comparison of the Coupling Efficiencies of Chloro(phenyl)germanes with Their Corresponding Stannane and Silane Counterparts.Full Text via DOI: 10.1002/chin.201112080
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2011MODELING OF THE RIBONUCLEOTIDE REDUCTASES SUBSTRATE REACTION. HYDROGEN ATOM ABSTRACTION BY A THIYL FREE RADICAL AND DETECTION OF THE RIBOSYL-BASED CARBON RADICAL BY PULSE RADIOLYSIS. COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS. 76:1223-1238.Full Text via DOI: 10.1135/cccc2011085 Web of Science: 000298004400005
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2010AdoHcy hydrolase of Trichomonas vaginalis: Studies of the effects of 5 '-modified adenosine analogues and related 6-N-cyclopropyl derivatives. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 20:7466-7468.Full Text via DOI: 10.1016/j.bmcl.2010.10.014 Web of Science: 000284332900062
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2010Fluoride-Promoted Cross-Coupling of Chloro(mono-, di-, or triphenyl)germanes with Aryl Halides in "Moist" Toluene. Multiple Transfer of the Phenyl Group from Organogermane Substrates and Comparison of the Coupling Efficiencies of Chloro(phenyl)germanes with their Corresponding Stannane and Silane Counterparts. JOURNAL OF ORGANIC CHEMISTRY. 75:8199-8212.Full Text via DOI: 10.1021/jo101848f Web of Science: 000284519900022
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2010Arylchlorogermanes/TBAF/"Moist" Toluene: A Promising Combination for Pd-Catalyzed Germyl-Stille Cross-Coupling. ORGANIC LETTERS. 12:816-819.Full Text via DOI: 10.1021/ol9028918 Web of Science: 000274465900043
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2009Radical-mediated thiodesulfonylation of the vinyl sulfones: access to (alpha-fluoro)vinyl sulfides. TETRAHEDRON LETTERS. 50:5424-5427.Full Text via DOI: 10.1016/j.tetlet.2009.07.063 Web of Science: 000269383200036
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2009Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position. BIOORGANIC & MEDICINAL CHEMISTRY. 17:6699-6706.Full Text via DOI: 10.1016/j.bmc.2009.07.057 Web of Science: 000269399700024
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2009APPLICATION OF GERMYLDESULFONYLATION REACTIONS TO THE SYNTHESIS OF GERMANIUM-CONTAINING NUCLEOSIDE ANALOGUES. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 28:537-549.Full Text via DOI: 10.1080/15257770903054340 Web of Science: 000269443400015
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2009Isolation and characterization of an anticancer catechol compound from Semecarpus anacardium. JOURNAL OF ETHNOPHARMACOLOGY. 122:450-456.Full Text via DOI: 10.1016/j.jep.2009.02.001 Web of Science: 000265893900007
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2009Reactions of trimethylsilyl fluorosulfonyldifluoroacetate with purine and pyrimidine nucleosides. JOURNAL OF FLUORINE CHEMISTRY. 130:321-328.Full Text via DOI: 10.1016/j.jfluchem.2008.12.004 Web of Science: 000264650500006
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2009Probing the Catalytic Mechanism of S-Ribosylhomocysteinase (LuxS) with Catalytic Intermediates and Substrate Analogues. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 131:1243-1250.Full Text via DOI: 10.1021/ja808206w Web of Science: 000264791600065
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2009Structure of the Nucleotide Radical Formed during Reaction of CDP/TTP with the E441Q-alpha 2 beta 2 of E-coli Ribonucleotide Reductase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 131:200-211.Full Text via DOI: 10.1021/ja806693s Web of Science: 000262483100051
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2008Vinyl tris(trimethylsilyl)silanes: substrates for Hiyama coupling. TETRAHEDRON. 64:5322-5327.Full Text via DOI: 10.1016/j.tet.2008.03.024 Web of Science: 000256179700057
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2008Synthesis of 5 '-functionalized nucleosides: S-Adenosylhomocysteine analogues with the carbon-5 ' and sulfur atoms replaced by a vinyl or halovinyl unit. BIOORGANIC & MEDICINAL CHEMISTRY. 16:5424-5433.Full Text via DOI: 10.1016/j.bmc.2008.04.017 Web of Science: 000256052400007
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2008S-ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit. BIOORGANIC & MEDICINAL CHEMISTRY. 16:5090-5102.Full Text via DOI: 10.1016/j.bmc.2008.03.028 Web of Science: 000255605600026
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2007Deoxygenative [1,2]-hydride shift Rearrangements in nucleoside and sugar chemistry: Analogy with the [1,2]-electron shift in the deoxygenation of Ribonucleotides by ribonucleotide reductasesi. JOURNAL OF ORGANIC CHEMISTRY. 72:8216-8221.Full Text via DOI: 10.1021/jo071102b Web of Science: 000250344300007
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2007Novel S-ribosylhomocysteine analogues as potential inhibitors of luxS enzyme. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 26:1051-1055.Full Text via DOI: 10.1080/15257770701513190 Web of Science: 000251875400038
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2006An unexpected reaction of trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) with imidazoles. Formation of N-difluoromethylthioureas. ORGANIC LETTERS. 8:5549-5551.Full Text via DOI: 10.1021/ol062213k Web of Science: 000242046100033
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2006S-adenosylhomocysteine analogues with the carbon-5 ' and sulfur atoms replaced by a vinyl unit. ORGANIC LETTERS. 8:5093-5096.Full Text via DOI: 10.1021/ol062026m Web of Science: 000241381800028
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2006Antitrypanosomal activity of 5 '-deoxy-5 '-(iodomethylene)adenosine and related 6-N-cyclopropyladenosine analogues. JOURNAL OF MEDICINAL CHEMISTRY. 49:2096-2102.Full Text via DOI: 10.1021/jm0511379 Web of Science: 000236400100030
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2006Synthesis of the multisubstituted halogenated olefins via cross-coupling of dihaloalkenes with alkylzinc bromides. JOURNAL OF ORGANIC CHEMISTRY. 71:405-408.Full Text via DOI: 10.1021/jo051980e Web of Science: 000234438700062
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2005Pd‐Catalyzed Couplings of (α‐Fluoro)vinyl Tris(trimethylsilyl)germanes.Full Text via DOI: 10.1002/chin.200546172
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2005Application of Vinyl Tris(trimethylsilyl)germanes in Pd‐Catalyzed Couplings.Full Text via DOI: 10.1002/chin.200536180
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2005Pd-catalyzed couplings of (alpha-fluoro)vinyl tris(trimethylsilyl)germanes. TETRAHEDRON LETTERS. 46:5313-5316.Full Text via DOI: 10.1016/j.tetlet.2005.06.023 Web of Science: 000230685900015
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2005Structure of the nitrogen-centered radical formed during inactivation of E-coli ribonucleotide reductase by 2′-azido-2′-deoxyuridine-5′-diphosphate:: Trapping of the 3′-ketonucleotide. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 127:7729-7738.Full Text via DOI: 10.1021/ja043111x Web of Science: 000229447700025
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2005Are L-adenosine and its derivatives substrates for S-adenosyl-L-homocysteine hydrolase?. JOURNAL OF MEDICINAL CHEMISTRY. 48:3649-3653.Full Text via DOI: 10.1021/jm0490484 Web of Science: 000229129700023
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2005Application of vinyl tris(trimethylsilyl)germanes in Pd-catalyzed couplings. JOURNAL OF ORGANIC CHEMISTRY. 70:3281-3284.Full Text via DOI: 10.1021/jo047773g Web of Science: 000228367100049
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2005Reduction of ribonucleosides to 2'-deoxyribonucleosides.Full Text via DOI: 10.1002/0471142700.nc0111s21
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2004Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. INTERNATIONAL IMMUNOPHARMACOLOGY. 4:1645-1659.Full Text via DOI: 10.1016/j.intimp.2004.07.024 Web of Science: 000224478400008
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2004Stereoselective synthesis of sugar-modified enyne analogues of adenosine and uridine. Interaction with S-adenosyl-L-homocysteine hydrolase and antiviral and cytotoxic effects. JOURNAL OF MEDICINAL CHEMISTRY. 47:5251-5257.Full Text via DOI: 10.1021/jm040054+ Web of Science: 000224219200030
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2004Radical-mediated silyl- and germyldesulfonylation of vinyl and (alpha-fluoro)vinyl sulfones: Application of tris(trimethylsilyl)silanes and tris(trimethylsilyl)germanes in Pd-catalyzed couplings. ORGANIC LETTERS. 6:2047-2049.Full Text via DOI: 10.1021/ol049312n Web of Science: 000221868300042
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2004Theoretical and experimental study of the regioselectivity of Michael additions. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2004:313-322.Full Text via DOI: 10.1002/ejoc.200300523 Web of Science: 000188531600008
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2004Synthesis and cytotoxicity of 9-(2-deoxy-2-alkyldithio-beta-D-arabinofuranosyl)purine nucleosides which are stable precursors to potential mechanistic probes of ribonucleotide reductases. ORGANIC & BIOMOLECULAR CHEMISTRY. 2:120-126.Full Text via DOI: 10.1039/b311504f Web of Science: 000187398100020
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2003Open-chain carbocyclic analogs of adenosine with dihalovinyl unit as potential inhibitors of S-adenosyl-L-homocysteine hydrolase. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 22:1747-1755.Full Text via DOI: 10.1081/NCN-120023270 Web of Science: 000185439400002
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2003Stereocontrolled synthesis of diene and enyne sugar-modified nucleosides and their interaction with S-adenosyl-L-homocysteine hydrolase. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 22:783-785.Full Text via DOI: 10.1081/NCN-120022634 Web of Science: 000185439200054
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2002The beta-fluorine effect. Electronic versus steric effects in radical deoxygenations of fluorine-containing pentofuranose nucleosides. JOURNAL OF ORGANIC CHEMISTRY. 67:8794-8797.Full Text via DOI: 10.1021/jo020428b Web of Science: 000179736300011
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2002Sugar-modified conjugated diene analogues of adenosine and uridine: Synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects. JOURNAL OF MEDICINAL CHEMISTRY. 45:2651-2658.Full Text via DOI: 10.1021/jm020064f Web of Science: 000175957700033
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2002A bifunctional tRNA for in vitro selection. CHEMISTRY & BIOLOGY. 9:741-746.Full Text via DOI: 10.1016/S1074-5521(02)00161-8 Web of Science: 000176418100012
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2002Studies toward the synthesis of alpha-fluorinated phosphonates via tin-mediated cleavage of alpha-fluoro-alpha-(pyrimidin-2-ylsulfonyl)alkylphosphonates. Intramolecular cyclization of the alpha-phosphonyl radicals. JOURNAL OF ORGANIC CHEMISTRY. 67:3065-3071.Full Text via DOI: 10.1021/jo0111560 Web of Science: 000175323600046
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2002Stereodefined synthesis of O3 '-labeled uracil nucleosides. 3 '-[O-17]-2 '-azido-2 '-deoxyuridine 5 '-diphosphate as a probe for the mechanism of inactivation of ribonucleotide reductases. JOURNAL OF ORGANIC CHEMISTRY. 67:1816-1819.Full Text via DOI: 10.1021/jo010899i Web of Science: 000174489000013
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2002Studies on the rearrangement of ortho-nitro-benzylidenemalonates and their analogues to 2-aminobenzoate derivatives. CANADIAN JOURNAL OF CHEMISTRY. 80:192-199.Full Text via DOI: 10.1139/V02-010 Web of Science: 000174448300010
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2001Rhodium(I)-catalyzed regio- and stereoselective chloroesterification of furanose-derived terminal alkynes with ethyl chloroformate. JOURNAL OF CARBOHYDRATE CHEMISTRY. 20:71-79.Full Text via DOI: 10.1081/CAR-100102544 Web of Science: 000168937800006
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2000Mechanisms of inactivation of human S-adenosylhomocysteine hydrolase by 5 ',5 ',6 ',6 '-tetradehydro-6 '-deoxy-6 '-halohomoadenosines. BIOCHEMISTRY. 39:15234-15241.Full Text via DOI: 10.1021/bi0015055 Web of Science: 000165875300027
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2000Rearrangement of nitropyridylidenemalonate 1-oxides. A novel method for the synthesis of aminopyridine derivatives. TETRAHEDRON. 56:7667-7671.Full Text via DOI: 10.1016/S0040-4020(00)00693-1 Web of Science: 000089414100005
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2000Stannyl radical-mediated cleavage of pi-deficient heterocyclic sulfones. Synthesis of alpha-fluoro esters. JOURNAL OF ORGANIC CHEMISTRY. 65:4169-4174.Full Text via DOI: 10.1021/jo000342n Web of Science: 000087925800033
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2000Doubly homologated dihalovinyl and acetylene analogues of adenosine: Synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects. JOURNAL OF MEDICINAL CHEMISTRY. 43:1180-1186.Full Text via DOI: 10.1021/jm990486y Web of Science: 000086055900016
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1999Nucleic acid related compounds.: 108.: Biomimetic modeling of the abstraction of H3′ by ribonucleotide reductases.: 1,5-hydrogen atom transfer of H3 to aminyl and oxyl, but not thiyl, free radicals in homoribofuranose derivatives. TETRAHEDRON. 55:5705-5718.Full Text via DOI: 10.1016/S0040-4020(99)00238-0 Web of Science: 000079916700003
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1999Nucleic acid related compounds. 107. Efficient nitration of uracil base and nucleoside derivatives. JOURNAL OF ORGANIC CHEMISTRY. 64:2149-2151.Full Text via DOI: 10.1021/jo9822939 Web of Science: 000079320400063
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1999Biomimetic simulation of free radical-initiated cascade reactions postulated to occur at the active site of ribonucleotide reductases. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 121:1425-1433.Full Text via DOI: 10.1021/ja983449p Web of Science: 000078974400001
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1998Nucleic acid related compounds.: 105.: Synthesis of 2′,3′-didehydro-2′,3′-dideoxynucleosides from ribonucleoside cyclic 2′,3′-(sulfates or phosphates) or 2′,3′-dimesylates via reductive elimination with sodium naphthalenide. JOURNAL OF ORGANIC CHEMISTRY. 63:7375-7381.Full Text via DOI: 10.1021/jo981013m Web of Science: 000076550200040
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1998Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5′,5′,6′,6′-tetradehydro-6′-deoxy-6′-halohomoadenosine analogues (4′-haloacetylene analogues derived from adenosine). JOURNAL OF MEDICINAL CHEMISTRY. 41:3857-3864.Full Text via DOI: 10.1021/jm980163m Web of Science: 000076106400011
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1998Discovery of type II (covalent) inactivation of S-adenosyl-L-homocysteine hydrolase involving its "hydrolytic activity": Synthesis and evaluation of dihalohomovinyl nucleoside analogues derived from adenosine. JOURNAL OF MEDICINAL CHEMISTRY. 41:3078-3083.Full Text via DOI: 10.1021/jm9801410 Web of Science: 000075111400019
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1998A novel mechanism-based inhibitor (6′-bromo-5′,6′-didehydro-6′-deoxy-6′-fluorohomoadenosine) that covalently modifies human placental S-adenosylhomocysteine hydrolase. JOURNAL OF BIOLOGICAL CHEMISTRY. 273:18191-18197.Full Text via DOI: 10.1074/jbc.273.29.18191 Web of Science: 000074828500035
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1998What are the practical limits for detection of minor nucleoside reaction products with HPLC (UV detection), 1H NMR, and TLC (UV detection)?. NUCLEOSIDES & NUCLEOTIDES. 17:785-790.Full Text via DOI: 10.1080/07328319808004675 Web of Science: 000072726000007
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1998Nucleic acid related compounds.: 101.: S-adenosyl-L-homocysteine hydrolase does not hydrate (5′-fluoro)vinyl or (6′-halo)homovinyl analogues derived from 3′-deoxyadenosine or 3′-(chloro or fluoro)-3′-deoxyadenosine. JOURNAL OF ORGANIC CHEMISTRY. 63:1205-1211.Full Text via DOI: 10.1021/jo971741u Web of Science: 000072215400048
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1997The mechanism of inactivation of human placental S-adenosylhomocysteine hydrolase by (E)-4',5'didehydro-5'-methoxyadenosine and adenosine 5'-carboxaldehyde oxime. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 343:109-117.Full Text via DOI: 10.1006/abbi.1997.0159 Web of Science: A1997XH22000014
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1997Synthesis of sugar-modified 2,6-diaminopurine and guanine nucleosides from guanosine via transformations of 2-aminoadenosine and enzymatic deamination with adenosine deaminase. CANADIAN JOURNAL OF CHEMISTRY. 75:762-767.Full Text via DOI: 10.1139/v97-092 Web of Science: A1997XL70400023
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1997Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. JOURNAL OF MEDICINAL CHEMISTRY. 40:1608-1618.Full Text via DOI: 10.1021/jm960828p Web of Science: A1997XB65500007
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1997Efficient removal of sugar O-tosyl groups and heterocycle halogens from purine nucleosides with sodium naphthalenide. TETRAHEDRON. 53:6295-6302.Full Text via DOI: 10.1016/S0040-4020(97)00313-X Web of Science: A1997WX79900004
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1997Elimination of chlorine (radical) or tosylate (anion) from C2' of nucleoside C3' free radicals as model reactions postulated to occur at the active site of ribonucleotide reductases. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 119:3637-3638.Full Text via DOI: 10.1021/ja970171c Web of Science: A1997WU27200034
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1997Nucleic acid related compounds .94. Remarkably high stereoselective reductions of 2'- and 3'-ketonucleoside derivatives to give arabino, ribo, and xylofuranosyl nucleosides with hydrogen isotopes at C2' and C3'. TETRAHEDRON. 53:447-456.Full Text via DOI: 10.1016/S0040-4020(96)01035-6 Web of Science: A1997VZ74600006
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1996Nucleic acid related compounds .93. A solution for the historic problem of regioselective sugar-base coupling to produce 9-glycosylguanines or 7-glycosylguanines. JOURNAL OF ORGANIC CHEMISTRY. 61:9207-9212.Full Text via DOI: 10.1021/jo9617023 Web of Science: A1996WC12000023
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1996Nucleic acid related compounds .91. Biomimetic reactions are in harmony with loss of 2'-substituents as free radicals (not anions) during mechanism-based inactivation of ribonucleotide reductases. Differential interactions of azide, halogen, and alkylthio groups with tributylstannane and triphenylsilane. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 118:11341-11348.Full Text via DOI: 10.1021/ja962117m Web of Science: A1996VU99500001
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1996Biomimetic modeling of the decomposition of 2'-chloro-2'-deoxynucleotides by ribonucleotide reductases to give 3(2H)-furanones which can effect mechanism-based inactivation by Michael-type alkylation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 118:11317-11318.Full Text via DOI: 10.1021/ja962118e Web of Science: A1996VT46600051
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1996Inactivation of S-adenosyl-L-homocysteine hydrolase by amide and ester derivatives of adenosine-5'-carboxylic acid. JOURNAL OF MEDICINAL CHEMISTRY. 39:4162-4166.Full Text via DOI: 10.1021/jm960313y Web of Science: A1996VM04800006
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1996Stannyl radical-mediated cleavage of pi-deficient heterocyclic sulfones. Synthesis of alpha-fluoro esters and the first homonucleoside alpha-fluoromethylene phosphonate. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 118:2519-2520.Full Text via DOI: 10.1021/ja953513s Web of Science: A1996UA02900034
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1995NUCLEIC-ACID RELATED-COMPOUNDS .88. EFFICIENT CONVERSIONS OF RIBONUCLEOSIDES INTO THEIR 2',3'-ANHYDRO, 2'(AND 3')-DEOXY, 2',3'-DIDEHYDRO-2',3'-DIDEOXY, AND 2',3'-DIDEOXYNUCLEOSIDE ANALOGS. JOURNAL OF ORGANIC CHEMISTRY. 60:7902-7908.Full Text via DOI: 10.1021/jo00129a034 Web of Science: A1995TH61000034
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1995ChemInform Abstract: Nucleic Acid Related Compounds. Part 82. Conversions of Adenosine to Inosine 5′‐Thioether Derivatives with Aspergillus oryzae Adenosine Deaminase or Alkyl Nitrites. Substrate and Inhibitory Activities of Inosine 5′‐Thioether Derivatives with Purine Nucleoside Phosphorylase.Full Text via DOI: 10.1002/chin.199502185
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1995RATIONAL APPROACHES TO THE DESIGN OF MECHANISM-BASED INHIBITORS OF S-ADENOSYLHOMOCYSTEINE HYDROLASE. NUCLEOSIDES & NUCLEOTIDES. 14:439-447.Full Text via DOI: 10.1080/15257779508012403 Web of Science: A1995RB95600044
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1994NUCLEIC-ACID RELATED-COMPOUNDS .84. SYNTHESIS OF 6'-(E AND Z)-HALOHOMOVINYL DERIVATIVES OF ADENOSINE, INACTIVATION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE, AND CORRELATION OF ANTICANCER AND ANTIVIRAL POTENCIES WITH ENZYME-INHIBITION. JOURNAL OF MEDICINAL CHEMISTRY. 37:3579-3587.Full Text via DOI: 10.1021/jm00047a015 Web of Science: A1994PM60600015
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1994(E)-5',6'-DIDEHYDRO-6'-DEOXY-6'-FLUOROHOMOADENOSINE - A SUBSTRATE THAT MEASURES THE HYDROLYTIC ACTIVITY OF S-ADENOSYLHOMOCYSTEINE HYDROLASE. BIOCHEMISTRY. 33:12305-12311.Full Text via DOI: 10.1021/bi00206a038 Web of Science: A1994PL35800038
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1994ChemInform Abstract: Nucleic Acid Related Compounds. Part 80. Synthesis of 5′‐S‐(Alkyl and aryl)‐5′‐fluoro‐5′‐thioadenosines with Xenon Difluoride or ( Diethylamido)sulfur Trifluoride, Hydrolysis in Aqueous Buffer, and inhibition of S‐Adenosyl‐L‐homocysteine Hydrolase by Derived “ Adenosine 5′‐Aldehyde” Species.Full Text via DOI: 10.1002/chin.199426263
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1994MECHANISM OF INACTIVATION OF S-ADENOSYLHOMOCYSTEINE HYDROLASE BY (E)-5',6'-DIDEHYDRO-6'-DEOXY-6'-HALOHOMOADENOSINES. BIOCHEMISTRY. 33:3758-3765.Full Text via DOI: 10.1021/bi00178a036 Web of Science: A1994ND24800036
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1994NUCLEIC-ACID RELATED-COMPOUNDS .80. SYNTHESIS OF 5'-S-(ALKYL AND ARYL)-5'-FLUORO-5'-THIOADENOSINES WITH XENON DIFLUORIDE OR (DIETHYLAMIDO)SULFUR TRIFLUORIDE, HYDROLYSIS IN AQUEOUS BUFFER, AND INHIBITION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE BY DERIVED ADENOSINE 5'-ALDEHYDE SPECIES. JOURNAL OF ORGANIC CHEMISTRY. 59:544-555.Full Text via DOI: 10.1021/jo00082a010 Web of Science: A1994MX22600010
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1994NUCLEIC-ACID RELATED-COMPOUNDS .82. CONVERSIONS OF ADENOSINE TO INOSINE 5-BETA-THIOETHER DERIVATIVES WITH ASPERGILLUS-ORYZAE ADENOSINE-DEAMINASE OR ALKYL NITRATES - SUBSTRATE AND INHIBITORY ACTIVITIES OF INOSINE 5'-THIOETHER DERIVATIVES WITH PURINE NUCLEOSIDE PHOSPHORYLASE. NUCLEOSIDES & NUCLEOTIDES. 13:389-403.Full Text via DOI: 10.1080/15257779408013249 Web of Science: A1994NG42900024
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1993ChemInform Abstract: Nucleic Acid Related Compounds. Part 76. Synthesis of 5′(E‐ and Z)‐ Chloro‐4′,5′‐didehydro‐5′‐deoxyadenosines via Chlorination and Thermolysis of Adenosine 5′‐Sulfoxides. Mechanism‐Based Inhibition of S‐Adenosyl‐L‐homocysteine Hydrolase.Full Text via DOI: 10.1002/chin.199321232
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1993ADENOSINE-5'-CARBOXALDEHYDE - A POTENT INHIBITOR OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. JOURNAL OF MEDICINAL CHEMISTRY. 36:883-887.Full Text via DOI: 10.1021/jm00059a013 Web of Science: A1993KV70500013
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1993NUCLEIC-ACID RELATED-COMPOUNDS .78. STEREOCONTROLLED SYNTHESES OF 6'(E AND Z)-HALOVINYL ANALOGS FROM URIDINE-DERIVED VINYLSULFONES VIA VINYLTIN INTERMEDIATES. CANADIAN JOURNAL OF CHEMISTRY. 71:192-198.Full Text via DOI: 10.1139/v93-028 Web of Science: A1993KR85300008
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1993NUCLEIC-ACID RELATED-COMPOUNDS .76. SYNTHESIS OF 5'(E AND Z)-CHLORO-4',5'-DIDEHYDRO-5'-DEOXYADENOSINES VIA CHLORINATION AND THERMOLYSIS OF ADENOSINE 5'-SULFOXIDES - MECHANISM-BASED INHIBITION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. JOURNAL OF ORGANIC CHEMISTRY. 58:111-117.Full Text via DOI: 10.1021/jo00053a022 Web of Science: A1993KF75800022
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1992NUCLEIC ACID RELATED COMPOUNDS .73. FLUORINATION OF URIDINE 2'-THIOETHERS WITH XENON DIFLUORIDE OR (DIETHYLAMINO)SULFUR TRIFLUORIDE - SYNTHESIS OF STABLE 2'-[ALKYLSULFONYL]-2'-DEOXY-2'-FLUOROURIDINES OR 2'-[ARYLSULFONYL]-2'-DEOXY-2'-FLUOROURIDINES. JOURNAL OF ORGANIC CHEMISTRY. 57:2357-2364.Full Text via DOI: 10.1021/jo00034a031 Web of Science: A1992HN85800031
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1992NUCLEIC-ACID RELATED-COMPOUNDS .71. EFFICIENT GENERAL-SYNTHESIS OF PURINE (AMINO, AZIDO, AND TRIFLATE)-SUGAR NUCLEOSIDES. NUCLEOSIDES & NUCLEOTIDES. 11:821-834.Full Text via DOI: 10.1080/07328319208021743 Web of Science: A1992HU04300050
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1991NUCLEIC-ACID RELATED-COMPOUNDS .67. SYNTHESIS OF 5'-AMINO AND 5'-METHYLTHIO CHAIN-EXTENDED NUCLEOSIDES FROM URIDINE. CANADIAN JOURNAL OF CHEMISTRY. 69:2104-2111.Full Text via DOI: 10.1139/v91-303 Web of Science: A1991HF35600034
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1991NUCLEIC-ACID RELATED-COMPOUNDS .68. FLUORINATION AT C5' OF NUCLEOSIDE 5'-THIOETHERS WITH DAST/ANTIMONY(III) CHLORIDE OR XENON DIFLUORIDE TO GIVE 5'-S-ARYL-5'-FLUORO-5'-THIOURIDINES. JOURNAL OF ORGANIC CHEMISTRY. 56:6878-6884.Full Text via DOI: 10.1021/jo00024a033 Web of Science: A1991GR42800033
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1991NUCLEIC-ACID RELATED-COMPOUNDS .66. IMPROVED SYNTHESES OF 5'-CHLORO-5'-DEOXYNUCLEOSIDES AND 5'-S-ARYL(OR ALKYL)-5'-THIONUCLEOSIDES. CANADIAN JOURNAL OF CHEMISTRY. 69:1468-1474.Full Text via DOI: 10.1139/v91-217 Web of Science: A1991GH86100019
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1991NUCLEIC-ACID RELATED-COMPOUNDS .63. SYNTHESIS OF 5'-DEOXY-5'-METHYLENEADENOSINE AND RELATED WITTIG-EXTENDED NUCLEOSIDES. CANADIAN JOURNAL OF CHEMISTRY. 69:334-338.Full Text via DOI: 10.1139/v91-051 Web of Science: A1991FA87600024
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1988THE REARRANGEMENT OF ORTHO-NITROBENZYLIDENEMALONATE DERIVATIVES IN REACTIONS WITH AMINES - APPLICATIONS TO ORGANIC-SYNTHESIS. SYNTHESIS-STUTTGART. 111-118.Web of Science: A1988L854600006
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1988NUCLEIC-ACID RELATED-COMPOUNDS .54. FLUORINATION AT C5' OF NUCLEOSIDES - SYNTHESIS OF THE NEW CLASS OF 5'-FLUORO-5'-SARYL (ALKYL) THIONUCLEOSIDES FROM ADENOSINE. TETRAHEDRON LETTERS. 29:5729-5732.Full Text via DOI: 10.1016/S0040-4039(00)82174-7 Web of Science: A1988R097300009
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1986ANTIBIOTIC-Y - BIOSYNTHESIS BY FUSARIUM-AVENACEUM (CORDA EX FRIES) SACC, ISOLATION, AND SOME PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 51:743-745.Web of Science: A1986A781500014
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1983A convenient one-step synthesis of ethyl 2-[ n-(diethoxycarbonyl)(ethoxy)-methyl]amino-4-nitrobenzoate and analogues by rearrangement of 2,4-dinitrobenzylidenemalonates. SYNTHESIS-STUTTGART. 1983:654-659.Full Text via DOI: 10.1055/s-1983-30462
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Synthesis of homologated halovinyl derivatives from aristeromycin and their inhibition of human placental S-adenosyl-L-homocysteine hydrolase. NUCLEOSIDES & NUCLEOTIDES. 17:99-113.Full Text via DOI: 10.1080/07328319808005161 Web of Science: 000072594400010
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Book Chapter
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2023Transition metal-catalyzed C-H functionalization of nucleoside bases. 631-655.Full Text via DOI: 10.1002/9781119774167.ch15
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2018C-H bond functionalization strategies for modification of nucleosides. 197-246.Full Text via DOI: 10.1016/B978-0-12-811292-2.00007-6
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2018Chapter 7 CH Bond Functionalization Strategies for Modification of Nucleosides. 197-246.Full Text via DOI: 10.1016/b978-0-12-811292-2.00007-6
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Conference
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20194-N-alkyl gemcitabine analogues with NOTA chelators for 68-gallium labelling. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000478861203671
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2019Purine nucleosides with reactive beta-halovinyl, beta-aminovinyl and beta-keto sulfones at C8 and C2 positions. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000478861203685
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2018Purine nucleosides with reactive beta-halovinyl and beta-keto sulfones at C8 position. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000435539905154
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2018Synthesis of diphosphate ProTides for enhancement of cellular metabolism. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000435537701018
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20175-Azido-modified pyrimidine nucleosides: Chemistry and biology. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000430569105432
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20175-azidomethyl-2'-deoxyuridine triphosphate can be efficiently incorporated by a repair DNA polymerase. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000430568500835
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2017Clickable 4-N-alkanoyl and 4-N-alkylgemcitabine analogues with silicon-fluoride acceptors. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000430569104324
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2017Pyrimidine nucleosides with reactive beta-keto sulfonyl group at C5 position. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000430569105851
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2017Synthesis of 4-N-alkyl gemcitabine analog bearing beta-keto tosylate moiety suitable for 18F-labeling. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000430569105661
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2017Synthesis of amino derivatives of dehydroleucodine and dehydroparishin-B as potential anti-proliferative against breast cancer and B16 melanoma cells. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000430569104714
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20165-[1-Halo-2-(arylsulfonyl)vinyl] uracil nucleosides: New probes for cross-linking with amino acids. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000431905704564
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2016Electron-induced site specific formation and reactions of the aminyl radical in 2 '-azido-2 '-deoxycytidine and its 4 '-azidocytidine analogue. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000431905704683
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2016Reduction of sugar lactones to lactols with lithium triethylborohydride. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000431903801543
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2016ase-modified 7-deazapurine nucleosides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000431905704664
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2014Modeling inhibition of ribonucleotide reductase by 2-substituted hexofuranoses. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000348455201214
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2014Strain promoted click chemistry (SPAAC) of 8-azido purine and 5-azido pyrimidine nucleosides with cyclooctynes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000348457602457
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2014Synthesis and cytostatic evaluation of 4-N-alkanoyl and 4-N-alkyl gemcitabine analogs. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000348457602459
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2014Synthesis of 6-N-substituted 7-deazapurine nucleoside antibiotics: Potential nucleoside transport inhibitors. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000348457602415
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2014TBAF-promoted Pd-catalyzed direct arylation of 5-iodouracil nucleosides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000348457603228
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2013In vitro activity of nucleoside analogs on the veterinary protozoan parasite Tritrichomonas foetus. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324303602169
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2013Reductive desulfonylation of 2 '-(arylsulfonyl)-2 '-deoxy-2 '-fluorouridine derivatives with tetrakis(dimethylamino)ethylene. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324303603518
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2012Bromination at C-5 of pyrimidine and C-8 of purine nucleosides with 1,3-dibromo-5, 5-dimethylhydantoin. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324503202798
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2012Chemoselective transfer of allyl or phenyl group from allyl(phenyl)germanes in Pd-catalyzed reactions with aryl halides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324503202797
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2012Formation of the aminyl radical via one electron attachment to 2 '-azido-2 '-deoxyuridine and methyl 2-azido-2-deoxy-alpha-D-lyxofuranoside and subsequent reaction to sugar radical. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324475101120
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2012Inhibition of adenosylhomocysteine hydrolase of Trichomonas vaginalis with 9-(2-deoxy-2-fluoro-beta,D-arabinofuranosyl)adenine. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324503201806
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2012Novel 4-N-modified gemcitabine analogs. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324503201668
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2010Fluoride-promoted cross-coupling of chloro(mono-, di-, or triphenyl)germanes with aryl halides in "moist" toluene. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000208164705369
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2009Biomimetic simulation of reactions postulated to occur during inhibition of ribonucleotide reductases by 2 '-azido-2 '-deoxynucleotides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000207857804616
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2009Radical desulfonylation reactions in aqueous medium using tris(trimethylsilyl)silane and thiols. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000207857802300
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2009S-Adenosylhomocysteine vs. S-ribosylhomocysteinase (LuxS): Similarities and differences between two enzymes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 684-684.Web of Science: 000207857800610
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2008CARB 119-Aza analogs of the ribosylhomocysteine. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000271775101065
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2008CHED 657-Application of germyldesulfonylation reactions in nucleoside chemistry. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000271775102119
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2007CARB 102-S-Adenosylhomocysteine analogs with carbon-5' and sulfur atoms replaced by halovinyl unit. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 489-489.Web of Science: 000207722800414
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2007CARB 31-Synthesis of S-ribosylhomocysteine analogs modified at carbon-3. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 559-559.Web of Science: 000207722800484
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2007Pd-catalyzed reactions of triallyl(phenyl)germanes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000207722808215
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2006CARB 7-Synthesis of S-adenosylhomocysteine analogs via metathesis of 5'-deoxy-5'-methyleneadenosine analogs and homoallylglycine. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000207781602017
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20063-Deoxy analogues of S-ribosylhomocysteine: Targeting LuxS enzyme. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000238125901331
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2006Negishi coupling of dihaloalkenes with alkylzinc bromides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000238125907459
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2006Spirodifluorocyclopropyl carbohydrate analogs. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000238125900625
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2006Synthesis and antitrypanosomal activity of 6 '-(iodohomovinyl)adenosine and related 6-N-cyclopropyladenosine analogs. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000238125906561
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2005Tris(trimethylsilyl)silanes and germanes in Pd-catalyzed cross-couplings. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U3084-U3084.Web of Science: 000236797306134
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2005Application of tris(trimethylsilyl)germanes in organic synthesis.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U397-U397.Web of Science: 000228177702407
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2005Cross-coupling reactions of 1,1-dihalo-1-alkenes with alkylzinc bromides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U504-U504.Web of Science: 000235066602011
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2005Organogermanes in PD-catalyzed cross-coupling reactions.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U528-U528.Web of Science: 000235066602150
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2005S-adenosylhomocysteine and S-ribosylhomocysteine analogues with sulfur atom replaced by the vinyl unit. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U259-U259.Web of Science: 000228177701453
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2004Radical-mediated silyl- and germyldesulfonylation of vinyl sulfones: Synthesis of (alpha-fluoro)vinyl silanes and germanes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U130-U130.Web of Science: 000223655700671
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2004Synthesis of S-ribosyl-L-homocysteine analogues via trans-selective negishi coupling of sugar-derived dihaloalkenes.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U272-U273.Web of Science: 000223655601037
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2004Synthetic applications of vinyl tris(trimethylsilyl)silanes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U112-U112.Web of Science: 000223655700562
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2003Desulfonylation of pi-deficient heterocyclic sulfones.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U335-U335.Web of Science: 000187918001737
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2003Synthesis of S-adenosyl-L-homocysteine analogues with the sulfur atom replaced by "vinyl unit" via cross coupling reactions.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U253-U253.Web of Science: 000187917801084
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2002Ab initio study of abnormal Michael addition.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U166-U166.Web of Science: 000177422300845
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2002Intramolecular cyclization of the alpha-phosphonyl radicals. Synthesis of alpha-fluoro phosphonates. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U267-U267.Web of Science: 000176296701475
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2002Stereocontrolled synthesis of sugar-modified diene analogues of adenosine and uridine via stille coupling.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U100-U100.Web of Science: 000176296700460
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2001Application of pi-deficient heterocyclic sulfones towards synthesis of alpha-fluoro phosphonate esters.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U133-U133.Web of Science: 000168824701153
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2001Approach for clarification of the mechanism of inactivation of ribonucleotide reductases with 3 '[O-17]-labeled 2 '-azido-2 '-deoxynucleotides.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U169-U170.Web of Science: 000168824700828
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2001Synthesis of 9-(2-thio-beta-D-arabinofuranosyl)adenine 5 '-diphosphate as a valuable probe to study the mechanism of inhibition of ribonucleoside reductases.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U112-U113.Web of Science: 000168824800668
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2000Rhodium-catalyzed regio- and stereoselective chloroalkoxycarbonylation of sugar acetylenes with ethyl chloroformate.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U120-U120.Web of Science: 000166091200585
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2000Organotin hydride-catalyzed cleavage of pi-deficient heterocyclic sulfones.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U339-U339.Web of Science: 000087246101740
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1999Synthesis of alpha-fluoro carboxylate and phosphonate esters via stannyl radical-mediated cleavage of pi-deficient heterocyclic sulfones.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U280-U280.Web of Science: 000082033900788
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1999Synthesis of homologated dihalovinyl and acetylene analogs of adenosine as potential inhibitors of S-adenosyl-L-homocysteine hydrolase.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U207-U208.Web of Science: 000082033900570
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1999Synthesis of chain extended adenosine analogues from diacetone-D-glucose.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U433-U433.Web of Science: 000079148101283
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1999Design and biological evaluation of new mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase. NUCLEOSIDES & NUCLEOTIDES. 595-596.Full Text via DOI: 10.1080/15257779908041506 Web of Science: 000081357300022
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1994(E)-5',6'-DIDEHYDRO-6'-DEOXY-6'-FLUORO-HOMOADENOSINE (EDDFHA) - A SUBSTRATE THAT MEASURES THE HYDROLYTIC ACTIVITY OF S-ADENOSYL-L-HOMOCYSTEINE (ADOHCY) HYDROLASE. FASEB JOURNAL. A1412-A1412.Web of Science: A1994NH51601107
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1994SELECTED ASPECTS OF THE CHEMISTRY AND BIOCHEMISTRY OF SULFUR-CONTAINING NUCLEOSIDES. 71-88.Full Text via DOI: 10.1080/10426509408545341 Web of Science: A1994QX42600006
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1992SYNTHESIS AND ENZYME-INHIBITORY ACTIVITY OF NUCLEOSIDE ALPHA-HALO THIOETHERS. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 26-CARB.Web of Science: A1992HK16100815
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1992SYNTHESIS OF E AND Z 5'-DEOXY-5'-HALOMETHYLENE NUCLEOSIDES VIA VINYLTIN INTERMEDIATES. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 42-CARB.Web of Science: A1992HK16100831
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Letter
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1993NUCLEIC-ACID RELATED-COMPOUNDS .79. EFFICIENT CONVERSIONS OF THIOETHERS TO ALPHA-FLUORO THIOETHERS WITH DAST OR DAST ANTIMONY(III) CHLORIDE. JOURNAL OF ORGANIC CHEMISTRY. 3800-3801.Full Text via DOI: 10.1021/jo00067a009 Web of Science: A1993LV42400009
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Note
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2019Gas-Phase Synthesis of Triphenylene (C
18 H12 ). CHEMPHYSCHEM. 790.Full Text via DOI: 10.1002/cphc.201900200 -
1990ANTIMONY(III) CHLORIDE EXERTS POTENT CATALYSIS OF THE CONVERSION OF SULFOXIDES TO ALPHA-FLUORO THIOETHERS WITH (DIETHYLAMINO)SULFUR TRIFLUORIDE. JOURNAL OF ORGANIC CHEMISTRY. 4757-4760.Full Text via DOI: 10.1021/jo00302a052 Web of Science: A1990DP93900052
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1990C-13 CHEMICAL-SHIFT ASSIGNMENTS OF DERIVATIVES OF BENZOIC-ACID. 271-275.Full Text via DOI: 10.1002/mrc.1260280315 Web of Science: A1990CT87800014
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Other Scholarly Work
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2021Transition-Metal-Free Cross-Coupling of Aryl Halides with Arylstannanes (vol 81, pg 9422, 2016). JOURNAL OF ORGANIC CHEMISTRY. 7892-7892.Full Text via DOI: 10.1021/acs.joc.1c01067 Web of Science: 000661138500052
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2016Origanum majorana organic extract induces senescence and autophagic cell death in breast cancer cells through influencing mitochondrial metabolism. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2016-4061 Web of Science: 000389969803034
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2009FOREWORD: MORRIS J. ROBINS-TEACHER, MENTOR, SCIENTIST, COLLEAGUE, AND FRIEND. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 333-336.Full Text via DOI: 10.1080/15257770903143291 Web of Science: 000269443400001
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1997A novel mechanism-based inhibitor (6′-bromo-5′,6′-didehydro-deoxy-6′-fluorohomoadenosine) that covalently modifies human placental S-adenosylhomocysteine hydrolase. FASEB JOURNAL. A1020-A1020.Web of Science: 000073305601436
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1996
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Review
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2015Modification of Purine and Pyrimidine Nucleosides by Direct C-H Bond Activation. MOLECULES. 4874-4901.Full Text via DOI: 10.3390/molecules20034874 Web of Science: 000352472000044
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2006Ribonucleotide reductase inhibitors as anti-herpes agents. ANTIVIRAL RESEARCH. 122-126.Full Text via DOI: 10.1016/j.antiviral.2006.03.002 Web of Science: 000240381200007
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2001Targeting "Hydrolytic" Activity of the S-Adenosyl-L-Homocysteine Hydrolase. MINI-REVIEWS IN MEDICINAL CHEMISTRY. 307-316.Full Text via DOI: 10.2174/1389557013406918 Web of Science: 000208444800009
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1993SULFUR-SUGAR AND SELENO-SUGAR MODIFIED NUCLEOSIDES - SYNTHESIS, CHEMICAL-TRANSFORMATIONS AND BIOLOGICAL PROPERTIES. TETRAHEDRON. 9877-9936.Full Text via DOI: 10.1016/S0040-4020(01)80190-3 Web of Science: A1993ME21200001
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Works By Students
chaired theses and dissertations
- Wen, Zhiwei, Azido- and Triazolyl-modified Nucleoside/tide Analogues: Chemistry, Fluorescent Properties, and Anticancer Activities 2018
- Garoub, Mohannad, The Effect of Target-Specific Biomolecules in Breast Cancer 2017
- Suzol, Sk Md Sazzad Hossain, Novel nucleoside analogues with bases modified with (β-halo)vinyl sulfone or β-keto sulfone as probes to study RNA/DNA-Proteins interactions 2017
- Gonzalez-Espinoza, Cesar, Synthesis of Gemcitabine Analogues with Silicon-Fluoride Acceptors for 18F Labeling 2017
- Mudgal, Mukesh M, Insight Into the Inhibition of Ribonucleotide Reductases by 2'-chloro-2'-deoxynucleotides and 2'-azido-2'-deoxynucleotides: Biomimetic Studies with Model Substrates 2016
- Rayala, Ramanjaneyulu, Design and Synthesis of Novel Nucleoside Analogues: Oxidative and Reductive Approaches toward Synthesis of 2'-Fluoro Pyrimidine Nucleosides 2015
- Zayas, Jessica, Strain Promoted Click Chemistry of 8-Azidopurine and 5-Azidopyrimidine Nucleosides and Nucleotides with Cyclooctynes and Applications to Living Cell Imaging 2015
- Singh, Sandeep Kumar, A Case-Only Genome-wide Association Study of Gender- and Age-specific Risk Markers for Childhood Leukemia 2015
- Liang, Yong, Novel Approaches for the Synthesis of C-5 Modified Pyrimidine Nucleosides 2014
- Chbib, Christiane, Design and Synthesis of S-ribosylhomocysteine Analogues 2014
- Pulido, Jesse E, Design and Synthesis of 4-N-Alkanoyl and 4-N-Alkyl Gemcitabine Analogues Suitable for Positron Emission Tomography 2014
- Malladi, Venkata L, The 4-aza-S-ribosyl-L-homocysteine Derivatives and the Related Gamma-lactam and Azahemiacetal Analogs: Synthesis, Inhibition and Quorum Sensing Activity 2011
- Dang, Thao P., Biomimetic Modeling of the Nitrogen-centered Radical Postulated to occur during the Inhibition of Ribonucleotide Reductases by 2'-Azido-2'-deoxynucleotides. 2010
- Sacasa, Pablo R, Developing of Germyldesulonylation and Thiodesulfonylation Reactions for the Synthesis of Novel Nucleoside Analogues. Efficient Synthesis of Novel (α-Fluoro)vinyl Sulfides 2010
- Pitteloud, Jean-Philippe, New Organogermanium Substrates for Palladium-Catalyzed Cross-Coupling Reactions. Application of Organogermanes towards the Synthesis of Carbon-5 Modified Uridine Analogues 2010
- Andrei, Daniela, Synthesis of multisubstituted halo-olefins via Pd-catalyzed cross-coupling reactions : applications in nucleoside chemistry 2006
- Companioni, Dania, Targeting of ribonucleotide reductase with 2'-Disulfide analogs of adenosine. Electronic versus steric effects in radical deoxygenation of fluorine-containing nucleosides 2002
- Chowdhury, Saiful Mahmud, An approach for clarification of the mechanism of inactivation of ribonucleotide reductases with 3'<¹⁷O>-labeled 2'-azido-2'-deoxynucleotides 2001
advised honors theses
- VanDervort, Alana Ming-Amede, Anticancer activity of 4-N gemcitabine analogues 2012
Research
principal investigator on
- Bridge funding for Dr. Stanislaw Wnuk awarded by FIU Office of Research and Economic Deve 2016 - 2018
- Nucleoside and Carbohydrate-based Enzyme Inhibitors awarded by General Medical Sciences 2008 - 2014
investigator on
Contact
full name
- Stanislaw Wnuk
Identifiers
ORCID iD
- https://orcid.org/0000-0002-3111-3919 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in