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Bioorganic and Medicinal Chemistry Letters
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Overview
publication venue for
Polyheterocyclic peptidomimetics: Parallel solid phase synthesis of oligo cyclic guanidines and their inhibition activity against
Mycobacterium
tuberculosis DNA gyrase
. 93.
2023
Indolyl-α-keto-1,3,4-oxadiazoles: Synthesis, anti-cell proliferation activity, and inhibition of tubulin polymerization
. 37.
2021
Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase
. 30.
2020
Synthesis of dihydroimidazole tethered imidazolinethiones and their activity as novel antagonists of the nuclear retinoic acid receptor-related orphan receptors (RORs)
. 27:1608-1610.
2017
Design, synthesis and in vitro cytotoxicity studies of novel β-carbolinium bromides
. 27:1379-1384.
2017
Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment
. 26:3675-3678.
2016
Sequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities
. 26:3167-3171.
2016
Synthesis and antitubercular activity of 1,2,4-trisubstitued piperazines
. 26:2206-2209.
2016
2-(3′-Indolyl)-N-arylthiazole-4-carboxamides: Synthesis and evaluation of antibacterial and anticancer activities
. 25:4225-4231.
2015
Diversity oriented synthesis and IKK inhibition of aminobenzimidazole tethered quinazoline-2,4-diones, thioxoquinazolin-4-ones, benzodiazepine-2,3,5-triones, isoxazoles and isoxazolines
. 25:685-689.
2015
6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity
. 24:5238-5241.
2014
Synthesis and identification of α-cyano bis(indolyl)chalcones as novel anticancer agents
. 24:5170-5174.
2014
Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties
. 24:4743-4748.
2014
Substituted dithiazole piperazine benzamides as novel amyloid beta peptide reducing agents
. 24:4384-4388.
2014
Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin
. 24:4482-4485.
2014
Selective immunoproteasome inhibitors with non-peptide scaffolds identified from structure-based virtual screening
. 24:3614-3617.
2014
Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors
. 23:6663-6666.
2013
Antimalarial and cytotoxic activities of chiral triamines
. 23:4579-4582.
2013
Synthesis, receptor binding and activity of iso and azakainoids
. 23:1949-1952.
2013
S
-Adenosylhomocysteine hydrolase of the protozoan parasite
Trichomonas vaginalis
: Potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine
. 22:4203-4205.
2012
Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity
. 22:901-906.
2012
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases
. 21:7041-7044.
2011
Synthesis and in vitro evaluation of 7-methoxy-
N
-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties
. 21:6563-6566.
2011
Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors-implications for early Myasthenia gravis treatment
. 21:2505-2509.
2011
Preparation, in vitro screening and molecular modelling of symmetrical 4-
tert
-butylpyridinium cholinesterase inhibitors-Analogues of SAD-128
. 21:150-154.
2011
AdoHcy hydrolase of Trichomonas vaginalis: Studies of the effects of 5 '-modified adenosine analogues and related 6-N-cyclopropyl derivatives
. 20:7466-7468.
2010
Synthesis and in vitro evaluation of
N
-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease
. 20:6093-6095.
2010
On resin amino acid side chain attachment strategy for the head to tail synthesis of new glutamine containing gramicidin-S analogs and their antimicrobial activity
. 20:5701-5704.
2010
Parallel synthesis and anti-inflammatory activity of cyclic peptides cyclosquamosin D and Met-cherimolacyclopeptide B and their analogs
. 20:5653-5657.
2010
Small molecule functional analogs of peptides that inhibit λ site-specific recombination and bind Holliday junctions
. 20:4531-4534.
2010
Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications
. 20:1763-1766.
2010
Discovery and optimization of potent and selective functional antagonists of the human adenosine A
2B
receptor
. 19:5945-5949.
2009
Parallel synthesis of chiral pentaamines and pyrrolidine containing bis-heterocyclic libraries. Multiple scaffolds with multiple building blocks: A double diversity for the identification of new antitubercular compounds
. 19:5169-5175.
2009
Discovery of a novel protein kinase B inhibitor by structure-based virtual screening
. 19:4634-4638.
2009
Discovery and functional evaluation of diverse novel human CB
1
receptor ligands
. 19:4183-4190.
2009
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas
. 19:4241-4244.
2009
Antagonists of the human adenosine A
2A
receptor.: Part 1:: Discovery and synthesis of thieno[3,2-
d
] pyrimidine-4-methanone derivatives
. 18:2916-2919.
2008
Antagonists of the human adenosine A
2A
receptor.: Part 2:: Design and synthesis of 4-arylthieno[3,2-
d
]pyrimidine derivatives
. 18:2920-2923.
2008
Antagonists of the human adenosine A
2A
receptor.: Part 3:: Design and synthesis of pyrazolo[3,4-
d
]pyrimidines, pyrrolo[2,3-
d
] pyrimidines and 6-arylpurines
. 18:2924-2929.
2008
Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors
. 18:2990-2995.
2008
Discovery of a novel class of selective human CB
1
inverse agonists
. 18:1199-1206.
2008
Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
. 17:3172-3176.
2007
Novel selective human melanocortin-3 receptor ligands:: Use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold
. 17:2492-2498.
2007
Identification of non-furan containing A
2A
antagonists using database mining and molecular similarity approaches
. 16:5993-5997.
2006
Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
. 16:5673-5676.
2006
Pyrrolidine bis-cyclic guanidines with antimicrobial activity against drug-resistant Gram-positive pathogens identified from a mixture-based combinatorial library
. 16:5073-5079.
2006
Identification of potent and highly selective chiral tri-amine and tetra-amine μ opioid receptors ligands:: An example of lead optimization using mixture-based libraries
. 16:4331-4338.
2006
A versatile access to new macrocyclic oligoheterocycles (MOH)
. 16:3358-3361.
2006
SAR studies of 2-methoxyestradiol and development of its analogs as probes of anti-tumor mechanisms
. 16:3383-3387.
2006
Development of withaferin A analogs as probes of angiogenesis
. 16:2603-2607.
2006
A neural network based classification scheme for cytotoxicity predictions: Validation on 30,000 compounds
. 16:1037-1039.
2006
Synthesis of the novel series of bispyridinium compounds bearing (
E
)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase
. 16:622-627.
2006
Use of PROTACS as molecular probes of angiogenesis
. 15:2724-2727.
2005
Increased catalytic activity of protein disulfide isomerase using aromatic thiol based redox buffers
. 15:777-781.
2005
De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library
. 14:1947-1951.
2004
A neural network based prediction of octanol-water partition coefficients using atomic5 fragmental descriptors
. 14:851-853.
2004
Degradation of target protein in living cells by small-molecule proteolysis inducer
. 14:645-648.
2004
Opioid activity of 4-imidazolidinone positional analogues of Leu-enkephalin
. 12:3175-3178.
2002
Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: Insights into specificity and potency
. 9:3335-3340.
1999
Total synthesis of the potent proteasome inhibitor epoxomicin: A useful tool for understanding proteasome biology
. 9:2283-2288.
1999
Combinatorial chemistry: From peptides and peptidomimetics to small organic and heterocyclic compounds
. 8:2273-2278.
1998
The use of synthetic peptide combinatorial libraries for the determination of peptide ligands in radio-receptor assays: Opioid peptides
. 3:405-412.
1993
The function of S1′ subsite pocket of carboxypeptidase A
. 1:323-326.
1991
The structural feature of S1′ subsite of carboxypeptidase A
. 1:317-322.
1991
Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors
2006
Identifiers
International Standard Serial Number (ISSN)
0960-894X
Electronic International Standard Serial Number (EISSN)
1464-3405
