Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency.
Other Scholarly Work
Kim, KB, Myung, J, Sin, N et al. (1999). Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency.
. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 9(23), 3335-3340. 10.1016/s0960-894x(99)00612-5
Kim, KB, Myung, J, Sin, N et al. (1999). Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency.
. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 9(23), 3335-3340. 10.1016/s0960-894x(99)00612-5
While two structurally related epoxyketone-containing antitumor natural products, epoxomicin and eponemycin, share the proteasome as a common intracellular target, they differ in their antiproliferative activity, proteasome subunit binding specificity, and rates of proteasome inhibition. As a first step towards understanding such differences and developing novel proteasome subunit-specific inhibitors, we report here the synthesis and characterization of epoxomicin/dihydroeponemycin chimerae.
