Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17 beta-HSD10 modulators for Alzheimer's disease treatment Article

Hroch, Lukas, Benek, Ondrej, Guest, Patrick et al. (2016). Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17 beta-HSD10 modulators for Alzheimer's disease treatment . BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 26(15), 3675-3678. 10.1016/j.bmcl.2016.05.087

International Collaboration

cited authors

  • Hroch, Lukas; Benek, Ondrej; Guest, Patrick; Aitken, Laura; Soukup, Ondrej; Janockova, Jana; Musil, Karel; Dohnal, Vlastimil; Dolezal, Rafael; Kuca, Kamil; Smith, Terry K; Gunn-Moore, Frank; Musilek, Kamil

sustainable development goals

authors

publication date

  • August 1, 2016

keywords

  • 17 beta-Hydroxysteroid dehydrogenase type 10 (17 beta-HSD10)
  • 17-BETA-HYDROXYSTEROID-DEHYDROGENASE
  • A-BETA
  • AMYLOID-BETA PEPTIDE
  • Alzheimer's disease (AD)
  • Amyloid binding alcohol dehydrogenase (ABAD)
  • Amyloid-beta peptide (A beta)
  • Benzothiazole
  • Chemistry
  • Chemistry, Medicinal
  • Chemistry, Organic
  • IDENTIFICATION
  • INHIBITORS
  • Life Sciences & Biomedicine
  • MITOCHONDRIAL DYSFUNCTION
  • MODEL
  • Mitochondria
  • PERMEABILITY
  • PROGRESSION
  • Pharmacology & Pharmacy
  • Physical Sciences
  • RILUZOLE
  • Riluzole
  • Science & Technology

Digital Object Identifier (DOI)

publisher

  • PERGAMON-ELSEVIER SCIENCE LTD

start page

  • 3675

end page

  • 3678

volume

  • 26

issue

  • 15