Synthesis and identification of α-cyano bis(indolyl)chalcones as novel anticancer agents Article

Kumar, D, Maruthi Kumar, N, Tantak, MP et al. (2014). Synthesis and identification of α-cyano bis(indolyl)chalcones as novel anticancer agents . BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 24(22), 5170-5174. 10.1016/j.bmcl.2014.09.085

cited authors

  • Kumar, D; Maruthi Kumar, N; Tantak, MP; Ogura, M; Kusaka, E; Ito, T

authors

abstract

  • Microwave-assisted synthesis of 23 α-cyano bis(indolyl)chalcones (6a-w) and their in vitro anticancer activity against three human cancer cell lines have been discussed. Among the synthesized chalcones, compound 6n was found to be the most potent and selective against A549 lung cancer cell line (IC50 = 0.8 μM). In a preliminary mechanism of action studies some α-cyano bis(indolyl)chalcones were found to enhance tubulin polymerization suggesting these compounds could act as microtubule stabilizing agents.

publication date

  • November 15, 2014

published in

Digital Object Identifier (DOI)

start page

  • 5170

end page

  • 5174

volume

  • 24

issue

  • 22