FIU Discovery

Article

• 2022

  Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function.  JOURNAL OF MEDICINAL CHEMISTRY.  65:15391-15415.

  Full Text via DOI: 10.1021/acs.jmedchem.2c01350
• 2022

  Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics

  Full Text via DOI: 10.3390/ijms23179623 Web of Science: 000852521300001
• 2021

  Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome.  JOURNAL OF MEDICINAL CHEMISTRY.  64:15593-15607.

  Full Text via DOI: 10.1021/acs.jmedchem.1c00419
• 2021

  Indolyl-α-keto-1,3,4-oxadiazoles: Synthesis, anti-cell proliferation activity, and inhibition of tubulin polymerization.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  37.

  Full Text via DOI: 10.1016/j.bmcl.2021.127842
• 2020

  NMK-BH2, a novel microtubule-depolymerising bis (indolyl)-hydrazide-hydrazone, induces apoptotic and autophagic cell death in cervical cancer cells by binding to tubulin at colchicine – site

  Full Text via DOI: 10.1016/j.bbamcr.2020.118762
• 2017

  A facile and microwave-assisted rapid synthesis of 2-arylamino-4-(3′-indolyl)-thiazoles as apoptosis inducing cytotoxic agents.  ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY.  17:442-455.

  Full Text via DOI: 10.2174/1871520616666160622095406
• 2017

  Design and synthesis of bis(indolyl)ketohydrazide-hydrazones: Identification of potent and selective novel tubulin inhibitors.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.  136:184-194.

  Full Text via DOI: 10.1016/j.ejmech.2017.04.078
• 2017

  Design, synthesis and in vitro cytotoxicity studies of novel β-carbolinium bromides.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  27:1379-1384.

  Full Text via DOI: 10.1016/j.bmcl.2017.02.010
• 2017

  Metal-free regioselective formation of C-N and C-O bonds with the utilization of diaryliodonium salts in water: Facile synthesis of: N-Arylquinolones and aryloxyquinolines.  ORGANIC & BIOMOLECULAR CHEMISTRY.  15:4956-4961.

  Full Text via DOI: 10.1039/c7ob00940b
• 2017

  Synthesis, evaluation and molecular modelling studies of 2-(carbazol-3-yl)-2-oxoacetamide analogues as a new class of potential pancreatic lipase inhibitors.  BIOORGANIC & MEDICINAL CHEMISTRY.  25:609-620.

  Full Text via DOI: 10.1016/j.bmc.2016.11.031
• 2016

  Cu–Catalyzed Expeditious Synthesis of N-Benzylaminoheter-ocycles Using N-Tosylhydrazones and Aminoheteroarenes

  Full Text via DOI: 10.1002/slct.201601734
• 2016

  Sequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  26:3167-3171.

  Full Text via DOI: 10.1016/j.bmcl.2016.04.080
• 2016

  ChemInform Abstract: Microwave‐Assisted Metal‐ and Ligand‐Free O‐Arylation of Quinolones Using Diaryliodonium Salts: An Easy and Rapid Synthesis of Aryloxyquinolines.

  Full Text via DOI: 10.1002/chin.201628187
• 2016

  Development of Novel Bis(indolyl)-hydrazide-Hydrazone Derivatives as Potent Microtubule-Targeting Cytotoxic Agents against A549 Lung Cancer Cells.  BIOCHEMISTRY.  55:3020-3035.

  Full Text via DOI: 10.1021/acs.biochem.5b01127
• 2016

  Synthesis and anticancer activity study of indolyl hydrazide-hydrazones

  Full Text via DOI: 10.1007/s00044-016-1522-1
• 2016

  One-pot synthesis and in-vitro anticancer evaluation of 5-(2′-indolyl)thiazoles

  Full Text via DOI: 10.1038/srep23401
• 2016

  Microwave-Assisted Metal- and Ligand-Free O-Arylation of Quinolones Using Diaryliodonium Salts: An Easy and Rapid Synthesis of Aryloxyquinolines.  SYNLETT.  27:604-610.

  Full Text via DOI: 10.1055/s-0035-1560367
• 2016

  Synthesis and biological evaluation of novel carbazolyl glyoxamides as anticancer and antibacterial agents

  Full Text via DOI: 10.1039/c5ra27175d
• 2015

  2-(3′-Indolyl)-N-arylthiazole-4-carboxamides: Synthesis and evaluation of antibacterial and anticancer activities.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  25:4225-4231.

  Full Text via DOI: 10.1016/j.bmcl.2015.07.105
• 2015

  Synthesis of meso-(4′-cyanophenyl) porphyrins: efficient photocytotoxicity against A549 cancer cells and their DNA interactions

  Full Text via DOI: 10.1039/c5ra03075g
• 2014

  Synthesis and identification of α-cyano bis(indolyl)chalcones as novel anticancer agents.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  24:5170-5174.

  Full Text via DOI: 10.1016/j.bmcl.2014.09.085
• 2014

  ChemInform Abstract: Synthesis and Biological Evaluation of 2‐Arylamino‐5‐(3′‐indolyl)‐1,3,4‐oxadiazoles as Potent Cytotoxic Agents.

  Full Text via DOI: 10.1002/chin.201404137
• 2013

  NMK-TD-100, a Novel Microtubule Modulating Agent, Blocks Mitosis and Induces Apoptosis in HeLa Cells by Binding to Tubulin

  Full Text via DOI: 10.1371/journal.pone.0076286
• 2013

  Synthesis and biological evaluation of 2-arylamino-5- (3′-Indolyl)-1,3,4-oxadiazoles as potent cytotoxic agents.  CHEMMEDCHEM.  8:1468-1474.

  Full Text via DOI: 10.1002/cmdc.201300221