Wang, Xiaotang

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Wang, Xiaotang Graduate Faculty

Positions

Associate Professor, Chemistry and Biochemistry , College of Arts, Sciences & Education

wangx@fiu.edu

research interests

Structural and functional characterization of heme proteins containing thiolate axial ligand
Design and engineering of metalloproteins for asymmetric catalysis
Enzymatic synthesis of chiral synthons
NMR spectroscopic study of the active site structure of paramagnetic metalloproteins
The role of metal ions in cancer and neurodegenerative diseases

Patents issued

selected scholarly works & creative activities

Article
- 2024
  
  Hepatic Stellate Cell-Targeting Micelle Nanomedicine for Early Diagnosis and Treatment of Liver Fibrosis. ADVANCED HEALTHCARE MATERIALS. 13.
  Full Text via DOI: 10.1002/adhm.202303710 Web of Science: 001158935900001
- 2024
  
  miR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma
  Full Text via DOI: 10.1111/odi.14407 Web of Science: 000877529900001
- 2023
  
  Frizzled 6 mutation regulates reserpine-induced depression-like behavior and Wnt signaling pathway in mice. EUROPEAN JOURNAL OF PHARMACOLOGY. 957.
  Full Text via DOI: 10.1016/j.ejphar.2023.175996 Web of Science: 001068423300001
- 2023
  
  Screening and identification of miR-181a-5p in oral squamous cell carcinoma and functional verification in vivo and in vitro
  Full Text via DOI: 10.1186/s12885-023-10600-3 Web of Science: 000935937800001
- 2023
  
  Structure of the green heme isolated from allylbenzene-modified chloroperoxidase: A novel heme architecture implicating the mechanisms of CPO inactivation and epoxidation
  Full Text via DOI: 10.1016/j.csbj.2023.03.042 Web of Science: 001054127300001
- 2023
  
  iPSC-based model of Vogt-Koyanagi-Harada disease for phenotype recapitulation and drug screening
  Full Text via DOI: 10.1016/j.clim.2022.109205 Web of Science: 000906251900001
- 2022
  
  Anti-γ-aminobutyric acid-A receptor encephalitis with refractory seizures and cognitive impairment in a young woman: A case report. FRONTIERS IN NEUROLOGY. 13.
  Full Text via DOI: 10.3389/fneur.2022.954494 Web of Science: 000891736900001
- 2022
  
  The Application of the GP Model to Manage Controllable Risk Factors in Stroke Patients with Diabetes Can Effectively Improve the Prognosis and Reduce the Recurrence Rate (Retracted Article). EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2022.
  Full Text via DOI: 10.1155/2022/5413985 Web of Science: 000844628800038
- 2022
  
  LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 63.
  Full Text via DOI: 10.1167/iovs.63.8.25 Web of Science: 000865420100002
- 2022
  
  ThhspA1 is involved in lacA transcriptional regulation of Trametes hirsuta AH28-2 exposed to o-toluidine
  Full Text via DOI: 10.1016/j.fgb.2022.103716 Web of Science: 000821771000002
- 2021
  
  Selenium Exerts Protective Effects Against Fluoride-Induced Apoptosis and Oxidative Stress and Altered the Expression of Bcl-2/Caspase Family. BIOLOGICAL TRACE ELEMENT RESEARCH. 199:682-692.
  Full Text via DOI: 10.1007/s12011-020-02185-w Web of Science: 000544857100001
- 2021
  
  SYSTEMATIC SPORTS MEDICINE BASED ON THE CONCEPT OF REALIZING PHYSICAL FITNESS
  Full Text via DOI: 10.1590/1517-8692202127082021_0374 Web of Science: 000727052900019
- 2020
  
  DNA and RNA editing without sequence limitation using the flap endonuclease 1 guided by hairpin DNA probes. NUCLEIC ACIDS RESEARCH. 48.
  Full Text via DOI: 10.1093/nar/gkaa843 Web of Science: 000606018600003
- 2020
  
  Animal model and bioinformatics analyses suggest the TIMP1/MMP9 axis as a potential biomarker in oral squamous cell carcinoma. MOLECULAR CARCINOGENESIS. 59:1302-1316.
  Full Text via DOI: 10.1002/mc.23258 Web of Science: 000574164500006
- 2020
  
  Improving the thermostability of a GH97 dextran glucosidase by rational design. BIOTECHNOLOGY LETTERS. 42:2211-2221.
  Full Text via DOI: 10.1007/s10529-020-02928-8 Web of Science: 000537407400004
- 2020
  
  An unusual GH1 β-glucosidase from marine sediment with β-galactosidase and transglycosidation activities for superior galacto-oligosaccharide synthesis. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 104:4927-4943.
  Full Text via DOI: 10.1007/s00253-020-10578-z Web of Science: 000525476800001
- 2020
  
  An oroxylin A-loaded aggregation-induced emission active polymeric system greatly increased the antitumor efficacy against squamous cell carcinoma. JOURNAL OF MATERIALS CHEMISTRY B. 8:2040-2047.
  Full Text via DOI: 10.1039/c9tb01818b Web of Science: 000520502600018
- 2020
  
  MicroRNA-504 functions as a tumor suppressor in oral squamous cell carcinoma through inhibiting cell proliferation, migration and invasion by targeting CDK6
  Full Text via DOI: 10.1016/j.biocel.2019.105663 Web of Science: 000514011900001
- 2020
  
  Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3β-modulated mitochondrial binding of HKII. FREE RADICAL BIOLOGY AND MEDICINE. 146:119-129.
  Full Text via DOI: 10.1016/j.freeradbiomed.2019.10.413 Web of Science: 000504866900010
- 2019
  
  LZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells. CELL DEATH & DISEASE. 10.
  Full Text via DOI: 10.1038/s41419-019-1714-y Web of Science: 000472439500001
- 2019
  
  AmyZ1: a novel α-amylase from marine bacterium Pontibacillus sp. ZY with high activity toward raw starches. BIOTECHNOLOGY FOR BIOFUELS. 12.
  Full Text via DOI: 10.1186/s13068-019-1432-9 Web of Science: 000465384500002
- 2019
  
  Enhancing the catalytic performance of chloroperoxidase by co-immobilization with glucose oxidase on magnetic graphene oxide. BIOCHEMICAL ENGINEERING JOURNAL. 143:101-109.
  Full Text via DOI: 10.1016/j.bej.2018.12.013 Web of Science: 000460809900012
- 2018
  
  Comparing bevacizumab and ranibizumab for treatment of neovascular age-related macular degeneration: a meta-analysis of noninferiority randomized controlled trials
  Web of Science: 000451862900029
- 2017
  
  Capsaicin Protects Against Oxidative Insults and Alleviates Behavioral Deficits in Rats with 6-OHDA-Induced Parkinson's Disease via Activation of TRPV1. NEUROCHEMICAL RESEARCH. 42:3431-3438.
  Full Text via DOI: 10.1007/s11064-017-2388-4 Web of Science: 000415657000008
- 2017
  
  PLSCR1/IP3R1/Ca2+ axis contributes to differentiation of primary AML cells induced by wogonoside. CELL DEATH & DISEASE. 8.
  Full Text via DOI: 10.1038/cddis.2017.175 Web of Science: 000402195700031
- 2017
  
  Bioconversion of non-steroidal anti-inflammatory drugs diclofenac and naproxen by chloroperoxidase. BIOCHEMICAL ENGINEERING JOURNAL. 120:7-16.
  Full Text via DOI: 10.1016/j.bej.2016.12.018 Web of Science: 000395603900002
- 2017
  
  Pseudoruegeria marinistellae sp nov., isolated from an unidentified starfish in Sanya, China. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY. 110:187-194.
  Full Text via DOI: 10.1007/s10482-016-0789-z Web of Science: 000393743900002
- 2017
  
  Serum Growth Differentiation Factor 15 in Parkinson Disease
  Full Text via DOI: 10.1159/000477349 Web of Science: 000418304200003
- 2016
  
  Structures of PspAG97A α-glucoside hydrolase reveal a novel mechanism for chloride induced activation. JOURNAL OF STRUCTURAL BIOLOGY. 196:426-436.
  Full Text via DOI: 10.1016/j.jsb.2016.09.009 Web of Science: 000389295000015
- 2016
  
  PspAG97A: A Halophilic α-Glucoside Hydrolase with Wide Substrate Specificity from Glycoside Hydrolase Family 97. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY. 26:1933-1942.
  Full Text via DOI: 10.4014/jmb.1606.06047 Web of Science: 000388666200012
- 2016
  
  Lutimaribacter marinistellae sp nov., isolated from a starfish. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY. 66:3675-3680.
  Full Text via DOI: 10.1099/ijsem.0.001251 Web of Science: 000386871200068
- 2016
  
  Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. MOLECULAR CARCINOGENESIS. 55:1275-1289.
  Full Text via DOI: 10.1002/mc.22369 Web of Science: 000379788100006
- 2016
  
  Improve ethanol tolerance of β-glucosidase Bgl1A by semi-rational engineering for the hydrolysis of soybean isoflavone glycosides. JOURNAL OF BIOTECHNOLOGY. 227:64-71.
  Full Text via DOI: 10.1016/j.jbiotec.2016.04.022 Web of Science: 000375121800014
- 2016
  
  Spectroscopic and QM/MM investigations of Chloroperoxidase catalyzed degradation of orange G. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 596:1-9.
  Full Text via DOI: 10.1016/j.abb.2016.02.026 Web of Science: 000374626900001
- 2016
  
  A novel ethanol-tolerant laccase, Tvlac, from Trametes versicolor. BIOTECHNOLOGY LETTERS. 38:471-476.
  Full Text via DOI: 10.1007/s10529-015-1994-y Web of Science: 000371242700014
- 2016
  
  A cold-adapted and glucose-stimulated type II α-glucosidase from a deep-sea bacterium Pseudoalteromonas sp K8. BIOTECHNOLOGY LETTERS. 38:345-349.
  Full Text via DOI: 10.1007/s10529-015-1987-x Web of Science: 000370374300019
- 2015
  
  Genome sequence of a laccase producing fungus Trametes sp AH28-2. JOURNAL OF BIOTECHNOLOGY. 216:167-168.
  Full Text via DOI: 10.1016/j.jbiotec.2015.11.001 Web of Science: 000365769000026
- 2015
  
  A mechanism of glucose tolerance and stimulation of GH1 β-glucosidases. SCIENTIFIC REPORTS. 5.
  Full Text via DOI: 10.1038/srep17296 Web of Science: 000365387500001
- 2015
  
  Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
  Full Text via DOI: 10.1186/s13045-015-0137-1 Web of Science: 000353950000001
- 2015
  
  Identification of a laccase Glac15 from Ganoderma lucidum 77002 and its application in bioethanol production. BIOTECHNOLOGY FOR BIOFUELS. 8.
  Full Text via DOI: 10.1186/s13068-015-0235-x Web of Science: 000352940200001
- 2014
  
  Characterization of a Novel β-Glucosidase from Gongronella sp W5 and Its Application in the Hydrolysis of Soybean Isoflavone Glycosides. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 62:11688-11695.
  Full Text via DOI: 10.1021/jf502850z Web of Science: 000345883800010
- 2014
  
  Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells
  Full Text via DOI: 10.18632/oncotarget.2340 Web of Science: 000348030900018
- 2014
  
  Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα. INTERNATIONAL JOURNAL OF CANCER. 134:1195-1206.
  Full Text via DOI: 10.1002/ijc.28435 Web of Science: 000328246700019
- 2014
  
  Detection of Bursaphelenchus xylophilus infection in Pinus massoniana from hyperspectral data
  Full Text via DOI: 10.1163/15685411-00002846 Web of Science: 000345112700008
- 2013
  
  Paramagnetic Nuclear Magnetic Resonance Relaxation and Molecular Mechanics Studies of the Chloroperoxidase-Indole Complex: Insights into the Mechanism of Chloroperoxidase-Catalyzed Regioselective Oxidation of Indole. BIOCHEMISTRY. 52:3688-3701.
  Full Text via DOI: 10.1021/bi4002437 Web of Science: 000319795500011
- 2013
  
  Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells. BLOOD. 121:3682-3691.
  Full Text via DOI: 10.1182/blood-2012-11-466219 Web of Science: 000321870000021
- 2012
  
  Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells. BIOCHEMISTRY AND CELL BIOLOGY. 90:718-730.
  Full Text via DOI: 10.1139/O2012-030 Web of Science: 000311893500006
- 2012
  
  Beclin 1-mediated autophagy in hepatocellular carcinoma cells: Implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling. CELLULAR SIGNALLING. 24:1722-1732.
  Full Text via DOI: 10.1016/j.cellsig.2012.04.009 Web of Science: 000305712800028
- 2012
  
  The structures of three metabolites of the algal hepatotoxin okadaic acid produced by oxidation with human cytochrome P450. BIOORGANIC & MEDICINAL CHEMISTRY. 20:3742-3745.
  Full Text via DOI: 10.1016/j.bmc.2012.04.046 Web of Science: 000304486500007
- 2012
  
  HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. CELL DEATH AND DIFFERENTIATION. 19:284-294.
  Full Text via DOI: 10.1038/cdd.2011.95 Web of Science: 000299160600011
- 2010
  
  Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells. JOURNAL OF PHARMACY AND PHARMACOLOGY. 60:1459-1463.
  Full Text via DOI: 10.1211/jpp.60.11.0006
- 2009
  
  MAC related mitochondrial pathway in oroxylin A induces apoptosis in human hepatocellular carcinoma HepG2 cells. CANCER LETTERS. 284:198-207.
  Full Text via DOI: 10.1016/j.canlet.2009.04.021 Web of Science: 000270530700011
- 2009
  
  Isolation and characterization of cancer stem like cells in human glioblastoma cell lines. CANCER LETTERS. 279:13-21.
  Full Text via DOI: 10.1016/j.canlet.2009.01.016 Web of Science: 000266418100003
- 2009
  
  Speciation, formation, stability and analytical challenges of human arsenic metabolites. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY. 24:1397-1405.
  Full Text via DOI: 10.1039/b910943a Web of Science: 000270138800010
- 2008
  
  Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis. JOURNAL OF MOLECULAR MEDICINE-JMM. 86:1367-1377.
  Full Text via DOI: 10.1007/s00109-008-0398-z Web of Science: 000261180100007
- 2008
  
  Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H-22 transplanted mice. INTERNATIONAL IMMUNOPHARMACOLOGY. 8:1493-1502.
  Full Text via DOI: 10.1016/j.intimp.2008.05.013 Web of Science: 000260125800002
- 2008
  
  Oroxylin A induces G₂/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells. JOURNAL OF PHARMACY AND PHARMACOLOGY. 60:1459-1463.
  Full Text via DOI: 10.1211/jpp/60.11.0006 Web of Science: 000260921500006
- 2008
  
  Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells. BIOCHEMISTRY AND CELL BIOLOGY. 86:386-395.
  Full Text via DOI: 10.1139/O08-104 Web of Science: 000262711600004
- 2008
  
  Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells. MOLECULAR CANCER THERAPEUTICS. 7:3298-3305.
  Full Text via DOI: 10.1158/1535-7163.MCT-08-0212 Web of Science: 000260202000019
- 2008
  
  Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCδ phosphorylation. EUROPEAN JOURNAL OF PHARMACOLOGY. 591:7-12.
  Full Text via DOI: 10.1016/j.ejphar.2008.06.024 Web of Science: 000259162300002
- 2008
  
  Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells. LIFE SCIENCES. 83:103-109.
  Full Text via DOI: 10.1016/j.lfs.2008.05.003 Web of Science: 000257936100004
- 2008
  
  Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. LIFE SCIENCES. 82:956-963.
  Full Text via DOI: 10.1016/j.lfs.2008.02.013 Web of Science: 000255607600008
- 2008
  
  Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells. CANCER LETTERS. 262:223-231.
  Full Text via DOI: 10.1016/j.canlet.2007.12.002 Web of Science: 000254684200009
- 2008
  
  Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression
  Full Text via DOI: 10.1111/j.1349-7006.2008.00728.x Web of Science: 000254498800010
- 2008
  
  Inhibition of glioblastoma growth and angiogenesis by garnbogic acid: An in vitro and in vivo study. BIOCHEMICAL PHARMACOLOGY. 75:1083-1092.
  Full Text via DOI: 10.1016/j.bcp.2007.10.033 Web of Science: 000253614200010
- 2007
  
  Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1. CANCER LETTERS. 258:80-89.
  Full Text via DOI: 10.1016/j.canlet.2007.08.015 Web of Science: 000251407200010
- 2007
  
  High Output of a Trametes Laccase in Pichia pastoris and Characterization of Recombinant Enzymes
  Full Text via DOI: 10.1016/S1872-2075(07)60063-6
- 2007
  
  Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes. CANCER LETTERS. 256:259-266.
  Full Text via DOI: 10.1016/j.canlet.2007.06.014 Web of Science: 000250327100011
- 2007
  
  Wetland restoration response analysis using MODIS and groundwater data
  Full Text via DOI: 10.3390/s7091916 Web of Science: 000249723500017
- 2007
  
  Gambogic acid-induced G(2)/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells. CARCINOGENESIS. 28:632-638.
  Full Text via DOI: 10.1093/carcin/bgl168 Web of Science: 000245351100013
- 2007
  
  Large scale preparation of the mammalian high mobility group protein A2 for biophysical studies. PROTEIN AND PEPTIDE LETTERS. 14:87-91.
  Full Text via DOI: 10.2174/092986607779117281 Web of Science: 000245376700014
- 2006
  
  Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 351:521-527.
  Full Text via DOI: 10.1016/j.bbrc.2006.10.064 Web of Science: 000242119200033
- 2006
  
  Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells. CANCER CHEMOTHERAPY AND PHARMACOLOGY. 58:434-443.
  Full Text via DOI: 10.1007/s00280-005-0177-2 Web of Science: 000238740200003
- 2006
  
  Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. ANTI-CANCER DRUGS. 17:797-805.
  Full Text via DOI: 10.1097/01.cad.0000217431.64118.3f Web of Science: 000240257100007
- 2006
  
  The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 29:1132-1137.
  Full Text via DOI: 10.1248/bpb.29.1132 Web of Science: 000238470500010
- 2006
  
  Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells. LIFE SCIENCES. 78:1238-1245.
  Full Text via DOI: 10.1016/j.lfs.2005.06.046 Web of Science: 000235402000014
- 2005
  
  Potential energy surface and product branching ratios for the reaction of F(²P) with the methyl radical: An ab initio/RRKM study. CHEMICAL PHYSICS LETTERS. 406:60-74.
  Full Text via DOI: 10.1016/j.cplett.2005.02.081 Web of Science: 000228612200011
- 2004
  
  Crystallographic and NMR investigation of cobalt-substituted amicyanin. BIOCHEMISTRY. 43:9381-9389.
  Full Text via DOI: 10.1021/bi049635r
- 2004
  
  Proton NMR study of the heme environment in bacterial quinol oxidases. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 421:186-191.
  Full Text via DOI: 10.1016/j.abb.2003.11.016
- 2003
  
  Resonance Raman spectroscopy of cytochrome c peroxidase variants that mimic manganese peroxidase. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 8:699-706.
  Full Text via DOI: 10.1007/s00775-003-0460-9
- 2003
  
  Two-dimensional NMR study of the heme active site structure of chloroperoxidase. JOURNAL OF BIOLOGICAL CHEMISTRY. 278:7765-7774.
  Full Text via DOI: 10.1074/jbc.M209462200
- 2002
  
  Cyclic and hairpin peptide complexes of heme. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 124:12394-12395.
  Full Text via DOI: 10.1021/ja020912w
- 2002
  
  Unexpected SN2′-type addition-elimination reactions of 1-aryl-2,3-allenols with LiX. Synthesis and synthetic application of 1-aryl-3-halo-1,3-dienes. TETRAHEDRON LETTERS. 43:5723-5726.
  Full Text via DOI: 10.1016/S0040-4039(02)01207-8
- 2002
  
  Unexpected thermal rearrangement of n-alkoxycarbonyl imidazole acryl azides to imidazo[1,5-c]pyrimidinone or imidazo[4,5-c]pyridinone. TETRAHEDRON LETTERS. 43:5879-5881.
  Full Text via DOI: 10.1016/S0040-4039(02)01174-7
- 2002
  
  Redox properties of an engineered purple CuA azurin. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 404:158-162.
  Full Text via DOI: 10.1016/S0003-9861(02)00282-5
- 2001
  
  Designing a manganese peroxidase. ACS SYMPOSIUM SERIES. 785:487-500.
  Full Text via DOI: 10.1021/bk-2001-0785.ch031
- 2000
  
  Ligand replacement study at the His120 site of purple Cu(A) azurin. JOURNAL OF INORGANIC BIOCHEMISTRY. 78:89-95.
  Full Text via DOI: 10.1016/S0162-0134(99)00214-7
- 1999
  
  Replacement of the proximal heme thiolate ligand in chloroperoxidase with a histidine residue. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 96:12412-12417.
  Full Text via DOI: 10.1073/pnas.96.22.12412
- 1999
  
  Redesign of cytochrome c peroxidase into a manganese peroxidase: Role of tryptophans in peroxidase activity. BIOCHEMISTRY. 38:11425-11432.
  Full Text via DOI: 10.1021/bi990666+
- 1999
  
  Proton NMR investigation of the heme active site structure of an engineered cytochrome C peroxidase that mimics manganese peroxidase. BIOCHEMISTRY. 38:9146-9157.
  Full Text via DOI: 10.1021/bi990235r
- 1999
  
  Kinetics of copper incorporation into an engineered purple azurin. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 121:2947-2948.
  Full Text via DOI: 10.1021/ja982636k
- 1998
  
  Spectroscopic Characterization of an Engineered Purple CuA Center in Azurin. INORGANIC CHEMISTRY. 37:191-198.
  Full Text via DOI: 10.1021/ic971232a
- 1997
  
  A nuclear paramagnetic relaxation study of the interaction of the cyclopentanedione substrate with chloroperoxidase
  Full Text via DOI: 10.1016/S0167-4838(96)00216-6
- 1997
  
  Construction and characterization of a manganese-binding site in cytochrome c peroxidase: Towards a novel manganese peroxidase. CHEMISTRY & BIOLOGY. 4:215-221.
  Full Text via DOI: 10.1016/S1074-5521(97)90291-X
- 1992
  
  Proton Nuclear Overhauser Effect Study of the Heme Active Site Structure of Chloroperoxidase. BIOCHEMISTRY. 31:1651-1655.
  Full Text via DOI: 10.1021/bi00121a011
- A 3D localized surface plasmon resonance biosensor for the study of trivalent arsenic binding to the ArsA ATPase. BIOSENSORS & BIOELECTRONICS. 38:19-26.
  Full Text via DOI: 10.1016/j.bios.2012.04.026 Web of Science: 000308455700003
- Intravenous Recombinant Tissue-Type Plasminogen Activator Thrombolysis for Acute Central Retinal Artery Occlusion. JOURNAL OF CRANIOFACIAL SURGERY. 32:313-316.
  Full Text via DOI: 10.1097/SCS.0000000000007134 Web of Science: 000612955800124
- Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice
  Full Text via DOI: 10.1016/j.matbio.2015.12.001 Web of Science: 000378190700009
Conference
- 2023
  
  Assessment of the carrying capacity of distributed generation in distribution network considering soft open point. 151-159.
  Full Text via DOI: 10.1016/j.egyr.2022.12.120 Web of Science: 001057943700019
- 2018
  
  Effects of the pro-cys-pro tripeptide stretch on the structural and biochemical properties of chloroperoxidase. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000435537701001
- 2017
  
  Elucidating the role of the proximal ligand loop in chloroperoxidase catalysis. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000429525601346
- 2017
  
  Chloroperoxidase oxidative transformation of roxarsone. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000430569101264
- 2015
  
  Role of proximal thiolate ligand in chloroperoxidase catalysis. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000411183300569
- 2014
  
  Reactivity of chloroperoxidase, a promising bioengineering target, revealed through simulation. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000348455204612
- 2012
  
  Data-driven PoISAR Unsupervised Classification Based on Adaptive Model-based Decomposition. 2053-+.
  Web of Science: 000349102800459
- 2010
  
  Analytical challenges of human arsenic metabolites. 498-499.
  Web of Science: 000392030500196
- 2009
  
  Relative stability of iron-sulfur bond vs. iron-nitrogen bond in heme thiolate protein: Evidence from an engineered cytochrome P450cam with a novel heme iron ligand set. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000207862000778
- 2009
  
  Single amino acid switch turns P450cam from a monooxygenase to an efficient peroxidase. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000207857805748
- 2008
  
  INOR 523-Engineering P450 into P420 with catalytic activities. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000271775106503
- 2007
  
  Catalytic roles of Phe103 at the substrate-binding pocket of chloroperoxidase: Remote control of heme chemistry in heme-thiolate proteins. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000207593909599
- 2006
  
  INOR 1013-Structure of the green prosthetic group in chloroperoxidase following mechanism-based modification with terminal alkenes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000207781606676
- 2004
  
  Photochemical reaction of chrysene in acetonitrile/water. 249-256.
  Full Text via DOI: 10.1080/10406630490468243
Letter
- 2001
  
  Coupled oxidation of heme by myoglobin is mediated by exogenous peroxide. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 6945-6946.
  Full Text via DOI: 10.1021/ja015776u
- 1999
  
  The role of histidine ligands in the structure of purple Cu(A) azurin [23]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 7449-7450.
  Full Text via DOI: 10.1021/ja991304s
Other Scholarly Work
- 2020
  
  Erratum: Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells (Oncotarget (2014) 5 (8188-8201) DOI: 10.18632/oncotarget.2340). 300-301.
  Full Text via DOI: 10.18632/oncotarget.27373
- 2019
  
  Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells (vol 8, 41, 2015)
  Full Text via DOI: 10.1186/s13045-019-0792-8 Web of Science: 000510918500001
- 2010
  
  Structural Dynamics in Chloroperoxidase: A Photoacoustic Study. BIOPHYSICAL JOURNAL. 643A-643A.
  Full Text via DOI: 10.1016/j.bpj.2009.12.3523 Web of Science: 000208762006221
- 2009
  
  Dynamics And Energetics Associated With Ligand Photodissociation From Co Bound Chloroperoxidase. BIOPHYSICAL JOURNAL. 437A-437A.
  Full Text via DOI: 10.1016/j.bpj.2008.12.2242 Web of Science: 000426354000332
- 2004
  
  Erratum: Crystallographic and NMR investigation of cobalt-substituted amicyanin (Biochemistry (July 27, 2004) 43, 29 (9387-9389)). BIOCHEMISTRY. 11144.
  Full Text via DOI: 10.1021/bi040034+
Review
- 2023
  
  Risk of stroke in patients with diabetic retinopathy: A systematic review and meta-analysis. JOURNAL OF CLINICAL NEUROSCIENCE. 112-119.
  Full Text via DOI: 10.1016/j.jocn.2023.08.025 Web of Science: 001071269200001
- 2012
  
  Engineered Proteins: Redox Properties and Their Applications. ANTIOXIDANTS & REDOX SIGNALING. 1796-1822.
  Full Text via DOI: 10.1089/ars.2011.4001 Web of Science: 000310061100011

principal investigator on

Consortium Agreement on the Metabolism and Mechanism of the Anticancer Effects of Wogonin, Baicalein and their Derivatives awarded by China Pharmaceutical University 2016 - 2023
Structural Basis for the Chloroperoxidase-Catalyzed Enantioselective Transformations. awarded by National Science Foundation 2005 - 2010

co-principal investigator on

Grant
- Acquisition of an X-Ray/UV photoelectron spectroscopy setup for materials research and education. awarded by U.S. Army 2007 - 2009

full name

Xiaotang Wang

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