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Winkle, Stephen
Positions
Associate Professor
,
Chemistry and Biochemistry
,
College of Arts, Sciences & Education
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Scholarly & Creative Works
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Scholarly & Creative Works
selected scholarly works & creative activities
Article
2014
Probing Sequence and Topological Specificity in the Binding of Tetra(Methylpyridyl)Porphines to DNAs
.
BIOPHYSICAL JOURNAL
. 106:275a.
Full Text via DOI:
10.1016/j.bpj.2013.11.1611
2013
Qualitative analysis of sequence specific binding of flavones to DNA using restriction endonuclease activity assays
.
BIOPOLYMERS
. 99:530-537.
Full Text via DOI:
10.1002/bip.22212
Web of Science:
000319416400005
1992
THE INTERFACE BETWEEN AN ALTERNATING CG MOTIF AND A RANDOM SEQUENCE MOTIF DISPLAYS ALTERED NUCLEASE ACTIVITY
.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
. 10:389-402.
Full Text via DOI:
10.1080/07391102.1992.10508654
Web of Science:
A1992JZ88800010
1992
LOCATING BINDING-SITES FOR THE CARCINOGEN N-ACETOXY-N-ACETYL-2-AMINOFLUORENE USING RESTRICTION ENZYME-INHIBITION ASSAYS
.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
. 10:83-96.
Full Text via DOI:
10.1080/07391102.1992.10508632
Web of Science:
A1992JL89900007
1992
RESTRICTION ENZYME MAPPING OF CARCINOGEN BINDING REGIONS ON PBR322
.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
. 10:73-82.
Full Text via DOI:
10.1080/07391102.1992.10508631
Web of Science:
A1992JL89900006
1992
USING LAMBDA EXONUCLEASE INHIBITION ASSAYS TO MAP CARCINOGEN BINDING-SITES
.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
. 10:63-72.
Full Text via DOI:
10.1080/07391102.1992.10508630
Web of Science:
A1992JL89900005
1991
ENHANCED REACTIVITY OF A B-Z JUNCTION FOR CLEAVAGE BY THE RESTRICTION ENZYME MBOI
.
BIOCHEMISTRY
. 30:10601-10606.
Full Text via DOI:
10.1021/bi00108a001
Web of Science:
A1991GN65800001
1990
ANOMALOUS GEL MIGRATION OF DNA OLIGOMERS CONTAINING MULTIPLE CONFORMATIONAL JUNCTIONS
.
BIOCHEMISTRY
. 29:6514-6521.
Full Text via DOI:
10.1021/bi00479a025
Web of Science:
A1990DN23200025
1990
Synthesis and characterization of deoxyguanosine–benzoquinone adducts
.
JOURNAL OF APPLIED TOXICOLOGY
. 10:47-54.
Full Text via DOI:
10.1002/jat.2550100109
1989
TEMPERATURE-DEPENDENT CD AND NMR-STUDIES ON A SYNTHETIC OLIGONUCLEOTIDE CONTAINING A B-Z JUNCTION AT HIGH SALT
.
BIOCHEMISTRY
. 28:720-725.
Full Text via DOI:
10.1021/bi00428a046
Web of Science:
A1989T049000046
1988
ChemInform Abstract: N‐Methyl‐N′‐oxonicotinium Ion: Synthesis and Stereochemistry.
Full Text via DOI:
10.1002/chin.198824355
1988
Equilibrium binding of spermine and histamine to salmon sperm DNA and poly(dGdC)
.
JOURNAL OF PHARMACY AND PHARMACOLOGY
. 40:809-811.
Full Text via DOI:
10.1111/j.2042-7158.1988.tb05179.x
1986
Mixed-mode hydrophobic ion exchange for the separation of oligonucleotides and DNA fragments using HPLC
.
ANALYTICAL BIOCHEMISTRY
. 154:570-577.
Full Text via DOI:
10.1016/0003-2697(86)90031-X
1986
Deoxyguanosine adducts formed from benzoquinone and hydroquinone.
Full Text via DOI:
10.1007/978-1-4684-5134-4_78
1985
13
C-NMR of ribosyl A-A-A, A-A-G, AND A-U-G Synthesis and Assignment
.
BIOPHYSICAL CHEMISTRY
. 23:129-138.
Full Text via DOI:
10.1016/0301-4622(85)80071-5
1982
On the cooperative and noncooperative binding of ethidium to DNA
.
NUCLEIC ACIDS RESEARCH
. 10:8211-8223.
Full Text via DOI:
10.1093/nar/10.24.8211
1982
The binding at high base pair/bound drug ratios of small molecules to DNA: Role of side chains in the cooperative binding of intercalators to DNA
.
BIOPHYSICAL JOURNAL
. 37.
1981
Equilibrium binding of carcinogens and antitumor antibiotics to DNA: Site selectivity, cooperativity, allosterism
.
NUCLEIC ACIDS RESEARCH
. 9:3175-3186.
Full Text via DOI:
10.1093/nar/9.13.3175
1981
Solute enhanced partition analysis-A novel method for measuring the binding of drugs to DNA
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
. 98:317-323.
Full Text via DOI:
10.1016/0006-291X(81)91905-7
1979
Interactions of 4-Nitroquinoline 1-Oxide with Deoxyribodinucleotides
.
BIOCHEMISTRY
. 18:3833-3839.
Full Text via DOI:
10.1021/bi00585a001
1978
Interactions of 4-nitroquinoline 1-oxide with four deoxyribonucleotides
.
BIOCHEMISTRY
. 17:1352-1356.
Full Text via DOI:
10.1021/bi00600a033
1976
Modification of fibrosarcomas and squamous cell carcinomas of mouse skin using various tissue extracts
.
NATURE
. 260:48-49.
Full Text via DOI:
10.1038/260048a0
Book
2012
Frontiers in Nucleic Acids
Conference
2020
Cooperativity and Competition in the Binding of Heterocyclic Diamidines and RNA Polymerases to phiX174 DNA
.
BIOPHYSICAL JOURNAL
. 222A-222A.
Web of Science:
000513023201361
2017
Effects of heterocyclic diamidine antiparastitic agent binding to DNA on restriction enzyme kinetics
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
.
Web of Science:
000430568500872
2015
Selectivity, cooperativity, and competition in the binding of heterocyclic diamidines to DNA
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
.
Web of Science:
000411183300420
2015
Sequence and topological specificity in the binding of tetra(N-methylpyridyl)porphines to DNAs
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
.
Web of Science:
000411183300421
2014
Probing Sequence and Topological Specificity in the Binding of Tetra(Methylpyridyl) Porphines to DNAs
.
BIOPHYSICAL JOURNAL
. 274A-274A.
Web of Science:
000337000401510
2013
Effects of DNA sequence and topology on the binding of heterocyclic diamidine anti-parasitic agents to DNA examined by restriction enzyme activity assays
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
.
Web of Science:
000323851302092
2012
Examining the roles of side chains in the sequence selectivity and in the cooperativity of the binding of anthraquinones to DNAs
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
.
Web of Science:
000324475100407
2009
Restriction enzyme activity studies of the binding of cisplatin to different DNA structures and sequences
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
. 519-519.
Web of Science:
000207857800473
2008
BIOL 243-RNA polymerase binds to specific nonpromoter DNA sequences
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
.
Web of Science:
000271775100603
2004
Using restriction enzyme activity assays to investigate the binding of T7 RNA polymerase to DNAs
.
BIOPHYSICAL JOURNAL
. 593A-593A.
Web of Science:
000187971203059
2002
AFLP analysis for the individualization of cannabis sativa.
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
. U67-U67.
Web of Science:
000176296700285
2002
The effects of alternate DNA structures on restriction enzyme and polymerase binding and activities with DNAs.
.
BIOPHYSICAL JOURNAL
. 463A-463A.
Web of Science:
000173252702273
2000
Binding of small molecules to the single strand DNA analog of a high affinity carcinogen binding site.
.
BIOPHYSICAL JOURNAL
. 305A-305A.
Web of Science:
000084779301783
1999
Effects of small molecule binding upon the activities of enzymes using a sequence possessing a (CG)(8) segment as a substrate.
.
BIOPHYSICAL JOURNAL
. A131-A131.
Web of Science:
000081085900764
1997
Probing high affinity carcinogen binding DNA sequences with porphyrin.
.
BIOPHYSICAL JOURNAL
. TH439-TH439.
Web of Science:
A1997WE74702417
1997
The conformation of (CG) DNA segments regulates RNA polymerase activity.
.
BIOPHYSICAL JOURNAL
. MP424-MP424.
Web of Science:
A1997WE74700559
1996
Molecular recognition of unusual DNA structures
.
BIOPHYSICAL JOURNAL
. TU207-TU207.
Web of Science:
A1996TZ68201727
1994
WHY CHEMICAL CARCINOGENS BIND SELECTIVELY TO CERTAIN SEQUENCES
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
. 327-ORGN.
Web of Science:
A1994MY95500404
1994
THE INTERACTIONS OF METAL-BOUND INTERCALATORS WITH DNA
.
BIOPHYSICAL JOURNAL
. A185-A185.
Web of Science:
A1994MU46201075
1994
WHY CHEMICAL CARCINOGENS BIND SELECTIVELY TO CERTAIN SEQUENCES
.
BIOPHYSICAL JOURNAL
. A231-A231.
Web of Science:
A1994MU46201347
1993
RESTRICTION ENZYMES HAVE ALTERED CLEAVAGE RATES AT SITES NEAR CERTAIN SEQUENCES
.
BIOPHYSICAL JOURNAL
. A280-A280.
Web of Science:
A1993KP51701604
1992
BINDING OF ANTIBIOTICS TO OLIGONUCLEOTIDES CONTAINING A B-Z JUNCTION
.
FASEB JOURNAL
. A363-A363.
Web of Science:
A1992GY44002077
1992
JUNCTIONS AFFECT THE SENSITIVITY OF DNAS TO REACTIONS WITH ENZYMES
.
FASEB JOURNAL
. A219-A219.
Web of Science:
A1992GY44001258
1992
SEQUENCE EFFECTS ON HELIX STABILITY AND EASE OF JUNCTION FORMATION IN SYNTHETIC DNA OLIGOMERS CONTAINING B-Z JUNCTIONS
.
FASEB JOURNAL
. A219-A219.
Web of Science:
A1992GY44001256
1991
DNA STRUCTURAL PECULIARITIES - CARCINOGEN BINDING-SITES AND B-Z JUNCTIONS
.
FASEB JOURNAL
. A809-A809.
Web of Science:
A1991FC20702545
1990
STRUCTURAL FEATURES OF HIGH-AFFINITY CARCINOGEN BINDING-SITES
.
BIOPHYSICAL JOURNAL
. A451-A451.
Web of Science:
A1990CN42801636
1990
STRUCTURAL STUDIES OF B-Z JUNCTIONS
.
BIOPHYSICAL JOURNAL
. A450-A450.
Web of Science:
A1990CN42801632
1989
H-1-NMR STUDY OF THE TEMPERATURE-DEPENDENCE OF THE CONFORMATION OF A FACE-TO-FACE BIPORPHYRIN
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
. 198-INOR.
Web of Science:
A1989DG64201713
Note
1991
A FURANOCOUMARIN FROM DORSTENIA-CONTRAJERVA
.
PHYTOCHEMISTRY
. 4196-4197.
Full Text via DOI:
10.1016/0031-9422(91)83504-E
Web of Science:
A1991GY73700084
Other Scholarly Work
2024
Effects of thymoquinone binding to DNA on DNA structure and activity
.
BIOPHYSICAL JOURNAL
. 81A-81A.
Web of Science:
001194120700386
2022
Sequence and topological specificity in the binding of thymoquinone to PHIX174RF DNA
.
BIOPHYSICAL JOURNAL
. 63-63.
Web of Science:
000759523000304
2018
Sequence Selectivity, Cooperativity and Competition in the Equilibrium Binding of Psoralens to DNA
.
BIOPHYSICAL JOURNAL
. 596A-596A.
Full Text via DOI:
10.1016/j.bpj.2017.11.3256
Web of Science:
000430563200735
2017
Binding of the Carcinogen 4-Nitroquinoline-1-Oxide to phiX174 DNA - Selectivity and Distortion
.
BIOPHYSICAL JOURNAL
. 213A-214A.
Full Text via DOI:
10.1016/j.bpj.2016.11.1179
Web of Science:
000402375600067
2011
Examining Flanking Sequence Specificity and Topological Specificity in the Binding of Various Molecular Types to DNAs Using Restriction Endonuclease Activity Assays
.
ACS SYMPOSIUM SERIES
. 167-180.
Web of Science:
000311058100010
1986
13C-NMR of ribosyl ApApA, ApApG and ApUpG.
.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
. 767-781.
Full Text via DOI:
10.1080/07391102.1986.10508460
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Winkle
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