Equilibrium binding of spermine and histamine to salmon sperm DNA and poly(dGdC)
Article
WINKLE, SA, CROOKS, PA. (1988). Equilibrium binding of spermine and histamine to salmon sperm DNA and poly(dGdC)
. JOURNAL OF PHARMACY AND PHARMACOLOGY, 40(11), 809-811. 10.1111/j.2042-7158.1988.tb05179.x
WINKLE, SA, CROOKS, PA. (1988). Equilibrium binding of spermine and histamine to salmon sperm DNA and poly(dGdC)
. JOURNAL OF PHARMACY AND PHARMACOLOGY, 40(11), 809-811. 10.1111/j.2042-7158.1988.tb05179.x
Abstract— Studies using the solute‐enhanced phase partition technique demonstrate that the endogenous amines histamine and spermine bind to both salmon sperm DNA and poly(dGdC) in a markedly cooperative fashion. Both compounds exhibited DNA sequence‐dependence effects in their mode of binding. The linear aliphatic spermine molecule binds more strongly than histamine to both DNA types. 1988 Royal Pharmaceutical Society of Great Britain