Interactions of 4-nitroquinoline 1-oxide with four deoxyribonucleotides Article

Winkle, SA, Tinoco, I. (1978). Interactions of 4-nitroquinoline 1-oxide with four deoxyribonucleotides . BIOCHEMISTRY, 17(7), 1352-1356. 10.1021/bi00600a033

cited authors

  • Winkle, SA; Tinoco, I

authors

abstract

  • The interactions of 4-nitroquinoline 1-oxide (NQO) with the four 5'-deoxyribonucleotides were probed using absorption spectra of the charge transfer bands and 1H and 13C nuclear magnetic resonance (NMR) spectra of nucleotide-NQO mixtures. Spectral data yielded equilibrium constants (K(dpG:NQO) = 16 Mr-1, K(dpA:NQO) = 12 M-1, K(dpT:NQO) = K(dpC:NQO) = 4 M-1) which suggest the preference of NQO for the guanine residue in a DNA. This is in agreement with the data of Okano, T., et al. [(1969) Gann 60, 295], From 13C and 1H NMR data on nucleosides, a structure for the dpG:NQO complex is proposed. © 1978, American Chemical Society. All rights reserved.

publication date

  • January 1, 1978

published in

Digital Object Identifier (DOI)

start page

  • 1352

end page

  • 1356

volume

  • 17

issue

  • 7