FIU Discovery

Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults

Biomass smoke inhalation promotes neuroinflammatory and metabolomic temporal changes in the hippocampus of female mice

Effects of Increased Standing and Light-Intensity Physical Activity to Improve Postprandial Glucose in Sedentary Office Workers: Protocol for a Randomized Crossover Trial.

Increased cardiac PFK-2 protects against high-fat diet-induced cardiomyopathy and mediates beneficial systemic metabolic effects

Succinate based polymers drive immunometabolism in dendritic cells to generate cancer immunotherapy.  JOURNAL OF CONTROLLED RELEASE.  358:541-554.

Multi-omic assessment shows dysregulation of pulmonary and systemic immunity to e-cigarette exposure

SOX17 Deficiency Mediates Pulmonary Hypertension At the Crossroads of Sex, Metabolism, and Genetics.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.  207:1055-1069.

Hyperkalemic or Low Potassium Cardioplegia Protects against Reduction of Energy Metabolism by Oxidative Stress

The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma.  CANCER LETTERS.  549.

Association of food insecurity on gut microbiome and metabolome profiles in a diverse college-based sample.  SCIENTIFIC REPORTS.  12.

Ischemic Stroke and Dietary Vitamin B12 Deficiency in Old-Aged Females: Impaired Motor Function, Increased Ischemic Damage Size, and Changed Metabolite Profiles in Brain and Cecum Tissue

Identification of metabolic pathways underlying FGF1 and CHIR99021-mediated cardioprotection

Central Nervous System Metabolism in Autism, Epilepsy and Developmental Delays: A Cerebrospinal Fluid Analysis

Multiple Gastrointestinal Symptoms Are Associated With Chemotherapy-Induced Nausea in Patients With Breast Cancer.  CANCER NURSING.  45:181-189.

Metabolites Associated With Fatigue and Physical Activity in Childhood Cancer.  BIOLOGICAL RESEARCH FOR NURSING.  24:350-361.

A Metabolomic Aging Clock Using Human Cerebrospinal Fluid.  JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.  77:744-754.

Predictive Modeling of Alzheimer’s and Parkinson’s Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid

Microbiome and metabolome profiles of high screen time in a cohort of healthy college students.  SCIENTIFIC REPORTS.  12.

AAV8-Mediated Gene Therapy Rescues Retinal Degeneration Phenotype in a Tlcd3b Knockout Mouse Model.  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.  63.

Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice

Bile Acid Regulates the Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract by Controlling Host Defense System and Microbiota

Evaluation of potential metabolomic-based biomarkers of protein, carbohydrate and fat intakes using a controlled feeding study

Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial

The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis.  PLOS BIOLOGY.  19.

Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK

Metabolic Profiling of Neocortical Tissue Discriminates Alzheimer's Disease from Mild Cognitive Impairment, High Pathology Controls, and Normal Controls

Inhibition of glycolysis in the presence of antigen generates suppressive antigen-specific responses and restrains rheumatoid arthritis in mice.  BIOMATERIALS.  277.

A Metabolomic Analysis of the Sex-Dependent Hispanic Paradox

NAD(+) Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy

Early Breast Cancer Detection Using Untargeted and Targeted Metabolomics

Enhanced Detection of Short-Chain Fatty Acids Using Gas Chromatography Mass Spectrometry

Hypoxia promotes erythroid differentiation through the development of progenitors and proerythroblasts.  EXPERIMENTAL HEMATOLOGY.  97:32-+.

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism.  CELL REPORTS.  34.

A four-week high fat diet does not alter plasma glucose or metabolic physiology in wild-caught mourning doves (Zenaida macroura).  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY.  251.

Early Life Exposure to Environmental Contaminants (BDE-47, TBBPA, and BPS) Produced Persistent Alterations in Fecal Microbiome in Adult Male Mice.  TOXICOLOGICAL SCIENCES.  179:14-30.

Targeted serum metabolite profiling and sequential metabolite ratio analysis for colorectal cancer progression monitoring.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY.  407.

2,2 ',4,4 '-tetrabromodiphenyl ether (BDE-47) induces wide metabolic changes including attenuated mitochondrial function and enhanced glycolysis in PC12 cells.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.  201.

A four-week white bread diet does not alter plasma glucose concentrations, metabolic or vascular physiology in mourning doves, Zenaida macroura.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY.  247.

Comprehensive Isotopic Targeted Mass Spectrometry: Reliable Metabolic Flux Analysis with Broad Coverage.  ANALYTICAL CHEMISTRY.  92:11728-11738.

Gut Microbiome Critically Impacts PCB-induced Changes in Metabolic Fingerprints and the Hepatic Transcriptome in Mice.  TOXICOLOGICAL SCIENCES.  177:168-187.

Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism.  JOURNAL OF MATERIALS CHEMISTRY B.  8:5195-5203.

Triple Negative Breast Cancer Detection Using LC-MS/MS Lipidomic Profiling

Identifying Significant Metabolic Pathways Using Multi-Block Partial Least-Squares Analysis

Targeting the pregnane X receptor using microbial metabolite mimicry

Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment.  AGING CELL.  19.

Antibiotic-induced gut metabolome and microbiome alterations increase the susceptibility to Candida albicans colonization in the gastrointestinal tract.  FEMS MICROBIOLOGY ECOLOGY.  96.

Database-Assisted Globally Optimized Targeted Mass Spectrometry (dGOT-MS): Broad and Reliable Metabolomics Analysis with Enhanced Identification.  ANALYTICAL CHEMISTRY.  91:13737-13745.

Daily red wine vinegar ingestion for eight weeks improves glucose homeostasis and affects the metabolome but does not reduce adiposity in adults

Identification of major malate export systems in an engineered malate-producing Escherichia coli aided by substrate similarity search.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.  103:9001-9011.

Metabolomics Test Materials for Quality Control: A Study of a Urine Materials Suite

Influence of Storage Conditions and Preservatives on Metabolite Fingerprints in Urine

Plasma metabolomics profiles suggest beneficial effects of a low-glycemic load dietary pattern on inflammation and energy metabolism.  AMERICAN JOURNAL OF CLINICAL NUTRITION.  110:984-992.

Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study

Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates.  ANALYTICAL CHEMISTRY.  91:10413-10423.

Mass spectral similarity networking and gas-phase fragmentation reactions in the structural analysis of flavonoid glycoconjugates.  ANALYTICAL CHEMISTRY.  91:10458-10466.

Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome-Related Aqueous Metabolites in Mice

Coccidioidomycosis Detection Using Targeted Plasma and Urine Metabolic Profiling

Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G(0)/G(1) switch gene 2 (G0S2).  FASEB JOURNAL.  33:6655-6666.

Combining NMR and MS with Chemical Derivatization for Absolute Quantification with Reduced Matrix Effects.  ANALYTICAL CHEMISTRY.  91:4055-4062.

Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis.  TOXICOLOGICAL SCIENCES.  168:40-60.

Biodiversity and dynamics of cyanobacterial communities during blooms in temperate lake (Harsha Lake, Ohio, USA).  HARMFUL ALGAE.  82:9-18.

Metabolic profiling identifies phospholipids as potential serum biomarkers for schizophrenia.  PSYCHIATRY RESEARCH.  272:18-29.

Breast cancer detection using targeted plasma metabolomics.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES.  1105:26-37.

Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation

Glucose promotes cell growth by suppressing branched-chain amino acid degradation

Salivary metabolite profiling distinguishes patients with oral cavity squamous cell carcinoma from normal controls.  PLOS ONE.  13.

Chronic kidney disease attenuates the plasma metabolome response to insulin

PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice

Alterations of eicosanoids and related mediators in patients with schizophrenia.  JOURNAL OF PSYCHIATRIC RESEARCH.  102:168-178.

Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation.  PLOS ONE.  13.

Circulating bile acids in healthy adults respond differently to a dietary pattern characterized by whole grains, legumes and fruits and vegetables compared to a diet high in refined grains and added sugars: A randomized, controlled, crossover feeding study

Multiplatform Metabolomics Investigation of Antiadipogenic Effects on 3T3-L1 Adipocytes by a Potent Diarylheptanoid

Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  115:5462-5467.

A Metabolomics Study of BPTES Altered Metabolism in Human Breast Cancer Cell Lines

NMR-Guided Mass Spectrometry for Absolute Quantitation of Human Blood Metabolites.  ANALYTICAL CHEMISTRY.  90:2001-2009.

Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer

Metabolic Effects of Clenbuterol and Salbutamol on Pork Meat Studied Using Internal Extractive Electrospray Ionization Mass Spectrometry

Altered metabolite levels and correlations in patients with colorectal cancer and polyps detected using seemingly unrelated regression analysis

Development of a High-Performance Imaging-Aided Extractive Electrospray Ionization Sprayer

Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets

Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side.  JOURNAL OF BIOLOGICAL CHEMISTRY.  292:12895-12905.

Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett’s esophagus, and high-grade dysplasia/esophageal adenocarcinoma

Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury

Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  114:E717-E726.

Quantitative Method to Investigate the Balance between Metabolism and Proteome Biomass: Starting from Glycine.  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.  55:15646-15650.

Dereplication of natural products using GC-TOF mass spectrometry: Improved metabolite identification by spectral deconvolution ratio analysis

Metabolomics-identified metabolites associated with body mass index and prospective weight gain among Mexican American women

Combining NMR and LC/MS using backward variable elimination: Metabolomics analysis of colorectal cancer, polyps, and healthy controls.  ANALYTICAL CHEMISTRY.  88:7975-7983.

Use of metabolomics to trend recovery and therapy after injury in critically ill trauma patients.  JAMA SURGERY.  151.

EGFR signaling enhances aerobic glycolysis in triple-negative breast cancer cells to promote tumor growth and immune escape.  CANCER RESEARCH.  76:1284-1296.

Serum Tryptophan Metabolite Levels During Sleep in Patients With and Without Irritable Bowel Syndrome (IBS).  BIOLOGICAL RESEARCH FOR NURSING.  18:193-198.

Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina.  JOURNAL OF BIOLOGICAL CHEMISTRY.  291:4698-4710.

Identification of novel candidate plasma metabolite biomarkers for distinguishing serous ovarian carcinoma and benign serous ovarian tumors.  GYNECOLOGIC ONCOLOGY.  140:138-144.

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

Globally Optimized Targeted Mass Spectrometry: Reliable Metabolomics Analysis with Broad Coverage.  ANALYTICAL CHEMISTRY.  87:12355-12362.

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

Targeted plasma metabolome response to variations in dietary glycemic load in a randomized, controlled, crossover feeding trial in healthy adults

Direct analysis of micro area on tooth surface by surface desorption atmospheric pressure chemical ionization mass spectrometry

Exploring metabolic profile differences between colorectal polyp patients and controls using seemingly unrelated regression

Targeted metabolic profiling of wounds in diabetic and nondiabetic mice.  WOUND REPAIR AND REGENERATION.  23:423-434.

Metabolomics method to comprehensively analyze amino acids in different domains.  ANALYST.  140:2726-2734.

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

Aggression is associated with aerobic glycolysis in the honey bee brain¹

Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  112:424-429.

Quantitative detection of nitric oxide in exhaled human breath by extractive electrospray ionization mass spectrometry

Integrated plasma and urine metabolomics coupled with HPLC/QTOF-MS and chemometric analysis on potential biomarkers in liver injury and hepatoprotective effects of Er-Zhi-Wan.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY.  406:7367-7378.

Colorectal cancer detection using targeted serum metabolic profiling

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.  AGING CELL.  13:529-539.

Development of adjustable device for extractive electrospray ionization with improved performance

Global metabolic profiling using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

Statistical analysis and modeling of mass spectrometry-based metabolomics data

RAMSY: Ratio analysis of mass spectrometry to improve compound identification.  ANALYTICAL CHEMISTRY.  85:10771-10779.

¹⁵N-Cholamine - A smart isotope tag for combining NMR- and MS-based metabolite profiling.  ANALYTICAL CHEMISTRY.  85:8715-8721.

Direct characterization of bulk samples by internal extractive electrospray ionization mass spectrometry

Metabolomics study of Resina Draconis on myocardial ischemia rats using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry combined with pattern recognition methods and metabolic pathway analysis.  EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.  2013.

Facilitated diffusion of acetonitrile revealed by quantitative breath analysis using extractive electrospray ionization mass spectrometry

Direct detection of amino acids using extractive electrospray ionization tandem mass spectrometry

Targeted metabolic profiling of hepatocellular carcinoma and hepatitis C using LC-MS/MS.  ELECTROPHORESIS.  34:2910-2917.

Sensitive ionization of non-volatile analytes using protein solutions as spray liquid in desorption electrospray ionization mass spectrometry.  RAPID COMMUNICATIONS IN MASS SPECTROMETRY.  26:2770-2776.

Detection of trace levels of lead in aqueous liquids using extractive electrospray ionization tandem mass spectrometry.  TALANTA.  98:79-85.

Effect of first dimension phase selectivity in online comprehensive two dimensional liquid chromatography (LC×LC).  JOURNAL OF CHROMATOGRAPHY.  1218:6675-6687.

Direct detection of native proteins in biological matrices using extractive electrospray ionization mass spectrometry.  ANALYST.  136:3599-3601.

An experimental study of sampling time effects on the resolving power of on-line two-dimensional high performance liquid chromatography.  JOURNAL OF CHROMATOGRAPHY.  1218:2984-2994.

Principal component directed partial least squares analysis for combining nuclear magnetic resonance and mass spectrometry data in metabolomics: Application to the detection of breast cancer.  ANALYTICA CHIMICA ACTA.  686:57-63.

Peak capacity optimization in comprehensive two dimensional liquid chromatography: A practical approach.  JOURNAL OF CHROMATOGRAPHY.  1218:64-73.

Fast Quantitative Detection of Cocaine in Beverages Using Nanoextractive Electrospray Ionization Tandem Mass Spectrometry.  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY.  21:290-293.

Geometry-independent neutral desorption device for the sensitive EESI-MS detection of explosives on various surfaces.  ANALYST.  135:779-788.

Rapid analysis of aerosol drugs using nano extractive electrospray ionization tandem mass spectrometry.  ANALYST.  135:1259-1267.

¹H NMR metabolomics study of age profiling in children.  NMR IN BIOMEDICINE.  22:826-833.

Selective detection of diethylene glycol in toothpaste products using neutral desorption reactive extractive electrospray ionization tandem mass spectrometry.  ANALYTICAL CHEMISTRY.  81:8632-8638.

Desorption electrospray ionization tandem mass spectrometry for detection of 24 carcinogenic aromatic amines in textiles.  ANALYTICAL CHEMISTRY.  81:6070-6079.

Imaging melamine in Egg samples by surface desorption atmospheric pressure chemical ionization tandem mass spectrometry

¹H NMR study of the effects of sample contamination in the metabolomic analysis of mouse urine

Differentiation of maturity and quality of fruit using noninvasive extractive electrospray ionization quadrupole time-of-flight mass spectrometry.  ANALYTICAL CHEMISTRY.  79:1447-1455.

Monitoring diet effects via biofluids and their implications for metabolomics studies.  ANALYTICAL CHEMISTRY.  79:89-97.

Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY.  387:539-549.

Distinct Nausea Profiles Are Associated With Gastrointestinal Symptoms in Oncology Patients Receiving Chemotherapy.  CANCER NURSING.  46:92-102.

Increased Glycolysis Underlies FGF1 and CHIR99021 Mediated Cardioprotection

Metabolomics Analysis of Viral Therapeutics.  179-197.

Rapid and sensitive detection of chemical explosives using ambient mass spectrometry.  81-101.

Pretreatment serum metabolome predicts PFS in first-line trastuzumab-treated metastatic breast cancer.  CANCER RESEARCH.

EARLY LIFE EXPOSURE TO ENVIRONMENTAL CONTAMINANTS (BDE-47, TBBPA, AND BPS) PRODUCED PERSISTENT GUT DYSBIOSIS IN ADULT MALE MICE.  S70-S70.

Deciphering the Mechanisms of the Ontogeny of Host- and Gut Microbiome-Derived Bile Acids Using Multi-Omics Approach and Germ-Free Mice.  HEPATOLOGY. 145A-145A.

Xenobiotic-Sensing Nuclear Receptors Regulate Bile Acid Homeostasis in a Gut Microbiota-Dependent Manner.  HEPATOLOGY. 1056A-1057A.

Parenteral and enteral nutrition in surgical critical care: Plasma metabolomics demonstrates divergent effects on nitrogen, fatty-acid, ribonucleotide, and oxidative metabolism.  JOURNAL OF TRAUMA AND ACUTE CARE SURGERY. 704-713.

Targeted Metabolomics Reveals Plasma Biomarkers and Metabolic Alterations of the Aging Process in Healthy Young and Older Adults.  FASEB JOURNAL.

Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates (vol 91, pg 10413, 2019).  ANALYTICAL CHEMISTRY. 14780-14781.

Correction to: ¹⁵ N-cholamine - A smart isotope tag for combining NMR- and MS-based metabolite profiling (Analytical Chemistry (2013) 85:18 (8715-8721) DOI: 10.1021/ac401712a).  ANALYTICAL CHEMISTRY. 1211.

Increased Glycolysis Underlies FGF1 and CHIR99021 Mediated Cardioprotection

Recent review on selected xenobiotics and their impacts on gut microbiome and metabolome.  TRAC-TRENDS IN ANALYTICAL CHEMISTRY.

Metabolic profiling: Are we en route to better diagnostic tests for cancer?.  1207-1210.

Direct analysis of biological samples using extractive electrospray ionization mass spectrometry (EESI-MS).  ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2145-2153.

Nuclear magnetic resonance spectroscopy and mass spectrometry-based metabolomics for cancer diagnosis.  1933-1937.

Metabolomics-based methods for early disease diagnostics.  EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. 617-633.