FIU Discovery

Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults.  GeroScience.  45:3131-3146.

Biomass smoke inhalation promotes neuroinflammatory and metabolomic temporal changes in the hippocampus of female mice.  Journal of Neuroinflammation.  20.

Effects of Increased Standing and Light-Intensity Physical Activity to Improve Postprandial Glucose in Sedentary Office Workers: Protocol for a Randomized Crossover Trial..  JMIR Research Protocols.  12:e45133.

Increased cardiac PFK-2 protects against high-fat diet-induced cardiomyopathy and mediates beneficial systemic metabolic effects.  iScience.  26.

Succinate based polymers drive immunometabolism in dendritic cells to generate cancer immunotherapy.  Journal of Controlled Release.  358:541-554.

Multi-omic assessment shows dysregulation of pulmonary and systemic immunity to e-cigarette exposure.  Respiratory Research.  24.

Hyperkalemic or Low Potassium Cardioplegia Protects against Reduction of Energy Metabolism by Oxidative Stress.  Antioxidants.  12.

The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma.  Cancer Letters.  549.

Association of food insecurity on gut microbiome and metabolome profiles in a diverse college-based sample.  Scientific Reports.  12.

Ischemic Stroke and Dietary Vitamin B12 Deficiency in Old-Aged Females: Impaired Motor Function, Increased Ischemic Damage Size, and Changed Metabolite Profiles in Brain and Cecum Tissue.  Nutrients.  14.

Metabolites Associated With Fatigue and Physical Activity in Childhood Cancer.  Biological Research for Nursing.  24:350-361.

Identification of metabolic pathways underlying FGF1 and CHIR99021-mediated cardioprotection.  iScience.  25.

Central Nervous System Metabolism in Autism, Epilepsy and Developmental Delays: A Cerebrospinal Fluid Analysis.  Metabolites.  12.

Multiple Gastrointestinal Symptoms Are Associated With Chemotherapy-Induced Nausea in Patients With Breast Cancer.  Cancer Nursing.  45:181-189.

A Metabolomic Aging Clock Using Human Cerebrospinal Fluid.  The journals of gerontology. Series A, Biological sciences and medical sciences.  77:744-754.

Predictive Modeling of Alzheimer’s and Parkinson’s Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid.  Metabolites.  12.

Microbiome and metabolome profiles of high screen time in a cohort of healthy college students.  Scientific Reports.  12.

AAV8-Mediated Gene Therapy Rescues Retinal Degeneration Phenotype in a Tlcd3b Knockout Mouse Model.  Investigative Ophthalmology and Visual Science.  63.

Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice.  Acta Pharmaceutica Sinica B.  12:801-820.

Bile Acid Regulates the Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract by Controlling Host Defense System and Microbiota.  Journal of Fungi.  7.

Evaluation of potential metabolomic-based biomarkers of protein, carbohydrate and fat intakes using a controlled feeding study.  European Journal of Nutrition.  60:4207-4218.

Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial.  Nutrients.  13.

Inhibition of glycolysis in the presence of antigen generates suppressive antigen-specific responses and restrains rheumatoid arthritis in mice.  Biomaterials.  277.

The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis.  PLoS Biology.  19.

Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK.  Molecular Cell.  81:3803-+.

Metabolic Profiling of Neocortical Tissue Discriminates Alzheimer's Disease from Mild Cognitive Impairment, High Pathology Controls, and Normal Controls.  Journal of Proteome Research.  20:4303-4317.

A Metabolomic Analysis of the Sex-Dependent Hispanic Paradox.  Metabolites.  11.

NAD⁺ Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy.  Circulation. Heart Failure.  14.

Early Breast Cancer Detection Using Untargeted and Targeted Metabolomics.  Journal of Proteome Research.  20:3124-3133.

Enhanced Detection of Short-Chain Fatty Acids Using Gas Chromatography Mass Spectrometry.  Current Protocols.  1.

Hypoxia promotes erythroid differentiation through the development of progenitors and proerythroblasts.  Experimental Hematology.  97:32-+.

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism.  Cell Reports.  34.

A four-week high fat diet does not alter plasma glucose or metabolic physiology in wild-caught mourning doves (Zenaida macroura).  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.  251.

Early Life Exposure to Environmental Contaminants (BDE-47, TBBPA, and BPS) Produced Persistent Alterations in Fecal Microbiome in Adult Male Mice.  Toxicological Sciences.  179:14-30.

2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) induces wide metabolic changes including attenuated mitochondrial function and enhanced glycolysis in PC12 cells.  Ecotoxicology and Environmental Safety.  201.

A four-week white bread diet does not alter plasma glucose concentrations, metabolic or vascular physiology in mourning doves, Zenaida macroura.  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.  247.

Comprehensive Isotopic Targeted Mass Spectrometry: Reliable Metabolic Flux Analysis with Broad Coverage.  Analytical Chemistry.  92:11728-11738.

Gut Microbiome Critically Impacts PCB-induced Changes in Metabolic Fingerprints and the Hepatic Transcriptome in Mice.  Toxicological Sciences.  177:168-187.

Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism.  Journal of Materials Chemistry B.  8:5195-5203.

Triple Negative Breast Cancer Detection Using LC-MS/MS Lipidomic Profiling.  Journal of Proteome Research.  19:2367-2378.

Identifying Significant Metabolic Pathways Using Multi-Block Partial Least-Squares Analysis.  Journal of Proteome Research.  19:1965-1974.

Targeting the pregnane X receptor using microbial metabolite mimicry.  EMBO Molecular Medicine.  12.

Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment.  Aging Cell.  19.

Antibiotic-induced gut metabolome and microbiome alterations increase the susceptibility to Candida albicans colonization in the gastrointestinal tract.  FEMS Microbiology Ecology.  96.

Database-Assisted Globally Optimized Targeted Mass Spectrometry (dGOT-MS): Broad and Reliable Metabolomics Analysis with Enhanced Identification.  Analytical Chemistry.  91:13737-13745.

Daily red wine vinegar ingestion for eight weeks improves glucose homeostasis and affects the metabolome but does not reduce adiposity in adults.  Food and Function.  10:7343-7355.

Identification of major malate export systems in an engineered malate-producing Escherichia coli aided by substrate similarity search.  Applied Microbiology and Biotechnology.  103:9001-9011.

Metabolomics Test Materials for Quality Control: A Study of a Urine Materials Suite.  Metabolites.  9.

Influence of Storage Conditions and Preservatives on Metabolite Fingerprints in Urine.  Metabolites.  9.

Plasma metabolomics profiles suggest beneficial effects of a low-glycemic load dietary pattern on inflammation and energy metabolism.  American Journal of Clinical Nutrition.  110:984-992.

Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study.  Journal of Neurogastroenterology and Motility.  25:551-562.

Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates.  Analytical Chemistry.  91:10413-10423.

Mass spectral similarity networking and gas-phase fragmentation reactions in the structural analysis of flavonoid glycoconjugates.  Analytical Chemistry.  91:10458-10466.

Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome-Related Aqueous Metabolites in Mice.  Drug Metabolism And Disposition.  47:928-940.

Coccidioidomycosis Detection Using Targeted Plasma and Urine Metabolic Profiling.  Journal of Proteome Research.  18:2791-2802.

Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G₀/G₁ switch gene 2 (G0S2).  The FASEB Journal.  33:6655-6666.

Combining NMR and MS with Chemical Derivatization for Absolute Quantification with Reduced Matrix Effects.  Analytical Chemistry.  91:4055-4062.

Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis.  Toxicological Sciences.  168:40-60.

Biodiversity and dynamics of cyanobacterial communities during blooms in temperate lake (Harsha Lake, Ohio, USA).  Harmful Algae.  82:9-18.

Metabolic profiling identifies phospholipids as potential serum biomarkers for schizophrenia.  Psychiatry Research.  272:18-29.

Breast cancer detection using targeted plasma metabolomics.  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.  1105:26-37.

Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation.  Journal of Proteome Research.  18:331-340.

Glucose promotes cell growth by suppressing branched-chain amino acid degradation.  Nature Communications.  9.

Salivary metabolite profiling distinguishes patients with oral cavity squamous cell carcinoma from normal controls.  PLoS ONE.  13.

Chronic kidney disease attenuates the plasma metabolome response to insulin.  JCI insight.  3.

PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice.  Drug Metabolism And Disposition.  46:1226-1240.

Alterations of eicosanoids and related mediators in patients with schizophrenia.  Journal of Psychiatric Research.  102:168-178.

Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation.  PLoS ONE.  13.

Circulating bile acids in healthy adults respond differently to a dietary pattern characterized by whole grains, legumes and fruits and vegetables compared to a diet high in refined grains and added sugars: A randomized, controlled, crossover feeding study.  Metabolism: Clinical and Experimental.  83:197-204.

Multiplatform Metabolomics Investigation of Antiadipogenic Effects on 3T3-L1 Adipocytes by a Potent Diarylheptanoid.  Journal of Proteome Research.  17:2092-2101.

Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.  Proceedings of the National Academy of Sciences of the United States of America.  115:5462-5467.

A Metabolomics Study of BPTES Altered Metabolism in Human Breast Cancer Cell Lines.  Frontiers in Molecular Biosciences.  5.

NMR-Guided Mass Spectrometry for Absolute Quantitation of Human Blood Metabolites.  Analytical Chemistry.  90:2001-2009.

Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer.  Cell Reports.  22:624-637.

Metabolic Effects of Clenbuterol and Salbutamol on Pork Meat Studied Using Internal Extractive Electrospray Ionization Mass Spectrometry.  Scientific Reports.  7.

Altered metabolite levels and correlations in patients with colorectal cancer and polyps detected using seemingly unrelated regression analysis.  Metabolomics.  13.

Development of a High-Performance Imaging-Aided Extractive Electrospray Ionization Sprayer.  Journal of Chinese Mass Spectrometry Society.  38:671-677.

Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets.  Food and Function.  8:3209-3218.

Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side.  Journal of Biological Chemistry.  292:12895-12905.

Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett’s esophagus, and high-grade dysplasia/esophageal adenocarcinoma.  Metabolomics.  13.

Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury.  Cell Metabolism.  25:374-385.

Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish.  Proceedings of the National Academy of Sciences of the United States of America.  114:E717-E726.

Quantitative Method to Investigate the Balance between Metabolism and Proteome Biomass: Starting from Glycine.  Angewandte Chemie International Edition.  55:15646-15650.

Dereplication of natural products using GC-TOF mass spectrometry: Improved metabolite identification by spectral deconvolution ratio analysis.  Frontiers in Molecular Biosciences.  3.

Metabolomics-identified metabolites associated with body mass index and prospective weight gain among Mexican American women.  Obesity Science and Practice.  2:309-317.

Combining NMR and LC/MS using backward variable elimination: Metabolomics analysis of colorectal cancer, polyps, and healthy controls.  Analytical Chemistry.  88:7975-7983.

Use of metabolomics to trend recovery and therapy after injury in critically ill trauma patients.  JAMA Surgery.  151.

EGFR signaling enhances aerobic glycolysis in triple-negative breast cancer cells to promote tumor growth and immune escape.  Cancer Research.  76:1284-1296.

Serum Tryptophan Metabolite Levels During Sleep in Patients With and Without Irritable Bowel Syndrome (IBS).  Biological Research for Nursing.  18:193-198.

Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina.  Journal of Biological Chemistry.  291:4698-4710.

Identification of novel candidate plasma metabolite biomarkers for distinguishing serous ovarian carcinoma and benign serous ovarian tumors.  Gynecologic Oncology.  140:138-144.

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts.  Aging.  8:314-327.

Globally Optimized Targeted Mass Spectrometry: Reliable Metabolomics Analysis with Broad Coverage.  Analytical Chemistry.  87:12355-12362.

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.  Nature Cell Biology.  17:1523-1535.

Targeted serum metabolite profiling and sequential metabolite ratio analysis for colorectal cancer progression monitoring.  Analytical and Bioanalytical Chemistry.  407:7857-7863.

Targeted plasma metabolome response to variations in dietary glycemic load in a randomized, controlled, crossover feeding trial in healthy adults.  Food and Function.  6:2949-2956.

Direct analysis of micro area on tooth surface by surface desorption atmospheric pressure chemical ionization mass spectrometry.  Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities.  36:1067-1073.

Exploring metabolic profile differences between colorectal polyp patients and controls using seemingly unrelated regression.  Journal of Proteome Research.  14:2492-2499.

Targeted metabolic profiling of wounds in diabetic and nondiabetic mice.  Wound Repair and Regeneration.  23:423-434.

Metabolomics method to comprehensively analyze amino acids in different domains.  The Analyst.  140:2726-2734.

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis.  Cancer Cell.  27:271-285.

Aggression is associated with aerobic glycolysis in the honey bee brain1.  Genes, Brain and Behavior.  14:158-166.

Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy.  Proceedings of the National Academy of Sciences of the United States of America.  112:424-429.

Quantitative detection of nitric oxide in exhaled human breath by extractive electrospray ionization mass spectrometry.  Scientific Reports.  5.

Integrated plasma and urine metabolomics coupled with HPLC/QTOF-MS and chemometric analysis on potential biomarkers in liver injury and hepatoprotective effects of Er-Zhi-Wan.  Analytical and Bioanalytical Chemistry.  406:7367-7378.

Colorectal cancer detection using targeted serum metabolic profiling.  Journal of Proteome Research.  13:4120-4130.

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.  Aging Cell.  13:529-539.

Development of adjustable device for extractive electrospray ionization with improved performance.  Journal of Chinese Mass Spectrometry Society.  35:226-231.

Global metabolic profiling using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.  Methods in molecular biology (Clifton, N.J.).  1198:15-27.

Statistical analysis and modeling of mass spectrometry-based metabolomics data.  Methods in molecular biology (Clifton, N.J.).  1198:333-353.

RAMSY: Ratio analysis of mass spectrometry to improve compound identification.  Analytical Chemistry.  85:10771-10779.

15N-Cholamine - A smart isotope tag for combining NMR- and MS-based metabolite profiling.  Analytical Chemistry.  85:8715-8721.

Direct characterization of bulk samples by internal extractive electrospray ionization mass spectrometry.  Scientific Reports.  3.

Metabolomics study of Resina Draconis on myocardial ischemia rats using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry combined with pattern recognition methods and metabolic pathway analysis.  Evidence-Based Complementary and Alternative Medicine.  2013.

Facilitated diffusion of acetonitrile revealed by quantitative breath analysis using extractive electrospray ionization mass spectrometry.  Scientific Reports.  3.

Direct detection of amino acids using extractive electrospray ionization tandem mass spectrometry.  Chinese Journal of Analytical Chemistry.  41:523-528.

Targeted metabolic profiling of hepatocellular carcinoma and hepatitis C using LC-MS/MS.  Electrophoresis.  34:2910-2917.

Sensitive ionization of non-volatile analytes using protein solutions as spray liquid in desorption electrospray ionization mass spectrometry.  Rapid Communications in Mass Spectrometry.  26:2770-2776.

Detection of trace levels of lead in aqueous liquids using extractive electrospray ionization tandem mass spectrometry.  Talanta.  98:79-85.

Effect of first dimension phase selectivity in online comprehensive two dimensional liquid chromatography (LC×LC).  Journal of Chromatography A.  1218:6675-6687.

Direct detection of native proteins in biological matrices using extractive electrospray ionization mass spectrometry.  The Analyst.  136:3599-3601.

An experimental study of sampling time effects on the resolving power of on-line two-dimensional high performance liquid chromatography.  Journal of Chromatography A.  1218:2984-2994.

Principal component directed partial least squares analysis for combining nuclear magnetic resonance and mass spectrometry data in metabolomics: Application to the detection of breast cancer.  Analytica Chimica Acta.  686:57-63.

Peak capacity optimization in comprehensive two dimensional liquid chromatography: A practical approach.  Journal of Chromatography A.  1218:64-73.

Fast Quantitative Detection of Cocaine in Beverages Using Nanoextractive Electrospray Ionization Tandem Mass Spectrometry.  Journal of the American Society for Mass Spectrometry.  21:290-293.

Geometry-independent neutral desorption device for the sensitive EESI-MS detection of explosives on various surfaces.  The Analyst.  135:779-788.

Rapid analysis of aerosol drugs using nano extractive electrospray ionization tandem mass spectrometry.  The Analyst.  135:1259-1267.

1H NMR metabolomics study of age profiling in children.  NMR in Biomedicine.  22:826-833.

Selective detection of diethylene glycol in toothpaste products using neutral desorption reactive extractive electrospray ionization tandem mass spectrometry.  Analytical Chemistry.  81:8632-8638.

Desorption electrospray ionization tandem mass spectrometry for detection of 24 carcinogenic aromatic amines in textiles.  Analytical Chemistry.  81:6070-6079.

Imaging melamine in Egg samples by surface desorption atmospheric pressure chemical ionization tandem mass spectrometry.  Chinese Journal of Analytical Chemistry.  37:315-318.

1H NMR study of the effects of sample contamination in the metabolomic analysis of mouse urine.  Journal of Pharmaceutical and Biomedical Analysis.  45:134-140.

Differentiation of maturity and quality of fruit using noninvasive extractive electrospray ionization quadrupole time-of-flight mass spectrometry.  Analytical Chemistry.  79:1447-1455.

Monitoring diet effects via biofluids and their implications for metabolomics studies.  Analytical Chemistry.  79:89-97.

Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism.  Analytical and Bioanalytical Chemistry.  387:539-549.

Distinct Nausea Profiles Are Associated With Gastrointestinal Symptoms in Oncology Patients Receiving Chemotherapy.  Cancer Nursing.  46:92-102.

Increased Glycolysis Underlies FGF1 and CHIR99021 Mediated Cardioprotection

Metabolomics Analysis of Viral Therapeutics.  179-197.

Rapid and sensitive detection of chemical explosives using ambient mass spectrometry.  81-101.

Pretreatment serum metabolome predicts PFS in first-line trastuzumab-treated metastatic breast cancer.  Cancer Research.

EARLY LIFE EXPOSURE TO ENVIRONMENTAL CONTAMINANTS (BDE-47, TBBPA, AND BPS) PRODUCED PERSISTENT GUT DYSBIOSIS IN ADULT MALE MICE.  Drug Metabolism and Pharmacokinetics. S70-S70.

Deciphering the Mechanisms of the Ontogeny of Host- and Gut Microbiome-Derived Bile Acids Using Multi-Omics Approach and Germ-Free Mice.  Hepatology. 145A-145A.

Xenobiotic-Sensing Nuclear Receptors Regulate Bile Acid Homeostasis in a Gut Microbiota-Dependent Manner.  Hepatology. 1056A-1057A.

Parenteral and enteral nutrition in surgical critical care: Plasma metabolomics demonstrates divergent effects on nitrogen, fatty-acid, ribonucleotide, and oxidative metabolism.  Journal of Trauma and Acute Care Surgery. 704-713.

Targeted Metabolomics Reveals Plasma Biomarkers and Metabolic Alterations of the Aging Process in Healthy Young and Older Adults.  The FASEB Journal.

Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates (vol 91, pg 10413, 2019).  Analytical Chemistry. 14780-14781.

Correction to: 15 N-cholamine - A smart isotope tag for combining NMR- and MS-based metabolite profiling (Analytical Chemistry (2013) 85:18 (8715-8721) DOI: 10.1021/ac401712a).  Analytical Chemistry. 1211.

Increased Glycolysis Underlies FGF1 and CHIR99021 Mediated Cardioprotection

Recent review on selected xenobiotics and their impacts on gut microbiome and metabolome.  TrAC. Trends in analytical chemistry.

Metabolic profiling: Are we en route to better diagnostic tests for cancer?.  Future Oncology. 1207-1210.

Direct analysis of biological samples using extractive electrospray ionization mass spectrometry (EESI-MS).  Analytical and Bioanalytical Chemistry. 2145-2153.

Nuclear magnetic resonance spectroscopy and mass spectrometry-based metabolomics for cancer diagnosis.  Chinese Journal of Analytical Chemistry. 1933-1937.

Metabolomics-based methods for early disease diagnostics.  Expert Review of Molecular Diagnostics. 617-633.