Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis Article

Dempsey, Joseph L, Wang, Dongfang, Siginir, Gunseli et al. (2019). Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis . TOXICOLOGICAL SCIENCES, 168(1), 40-60. 10.1093/toxsci/kfy271

Open Access International Collaboration

cited authors

  • Dempsey, Joseph L; Wang, Dongfang; Siginir, Gunseli; Fei, Qiang; Raftery, Daniel; Gu, Haiwei; Cui, Julia Yue

sustainable development goals

authors

publication date

  • March 1, 2019

webpage

published in

keywords

  • 16S rDNA sequencing
  • BETA-GLUCURONIDASES
  • CAR
  • CONSTITUTIVE ANDROSTANE RECEPTOR
  • DRUG-PROCESSING GENES
  • GERM-FREE
  • GUT MICROBIOTA
  • INDUCED LIVER-INJURY
  • Life Sciences & Biomedicine
  • MOUSE-LIVER
  • ORPHAN NUCLEAR RECEPTOR
  • PREGNANE-X-RECEPTOR
  • PXR
  • SALT BIOTRANSFORMATIONS
  • Science & Technology
  • Toxicology
  • bile acid metabolism
  • gut microbiome
  • gut-liver axis
  • intestine
  • liver
  • liver metabolism
  • nuclear receptors

Digital Object Identifier (DOI)

publisher

  • OXFORD UNIV PRESS

start page

  • 40

end page

  • 60

volume

  • 168

issue

  • 1