Metabolomics-based methods for early disease diagnostics Review

Gowda, GAN, Zhang, S, Gu, H et al. (2008). Metabolomics-based methods for early disease diagnostics . Expert Review of Molecular Diagnostics, 8(5), 617-633. 10.1586/14737159.8.5.617

cited authors

  • Gowda, GAN; Zhang, S; Gu, H; Asiago, V; Shanaiah, N; Raftery, D

abstract

  • The emerging field of metabolomics, in which a large number of small-molecule metabolites from body fluids or tissues are detected quantitatively in a single step, promises immense potential for early diagnosis, therapy monitoring and for understanding the pathogenesis of many diseases. Metabolomics methods are mostly focused on the information-rich analytical techniques of NMR spectroscopy and mass spectrometry (MS). Analysis of the data from these high-resolution methods using advanced chemometric approaches provides a powerful platform for translational and clinical research and diagnostic applications. In this review, the current trends and recent advances in NMR- and MS-based metabolomics are described with a focus on the development of advanced NMR and MS methods, improved multivariate statistical data analysis and recent applications in the area of cancer, diabetes, inborn errors of metabolism and cardiovascular diseases. © 2008 Expert Reviews Ltd.

authors

publication date

  • September 1, 2008

published in

Digital Object Identifier (DOI)

start page

  • 617

end page

  • 633

volume

  • 8

issue

  • 5