Annamalai, Thirunavukkarasu
- Research Assistant Professor, Chemistry and Biochemistry , College of Arts, Sciences & Education
Scholarly & Creative Works
selected scholarly works & creative activities
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Article
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2024Characterization and antimicrobial activity of endophytic fungi from medicinal plant Agave americana. LETTERS IN APPLIED MICROBIOLOGY. 77.Full Text via DOI: 10.1093/lambio/ovae025 Web of Science: 001184795600002
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2023The interaction between transport-segment DNA and topoisomerase IA-crystal structure of MtbTOP1 in complex with both G- and T-segments. NUCLEIC ACIDS RESEARCH. 51:349-364.Full Text via DOI: 10.1093/nar/gkac1205 Web of Science: 000905761600001
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2022Proton Motive Force-Disrupting Antimycobacterial Guanylurea PolymerFull Text via DOI: 10.1021/acs.biomac.2c00902 Web of Science: 000884681200001
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2022Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives. CHEMMEDCHEM. 17.Full Text via DOI: 10.1002/cmdc.202200301 Web of Science: 000870041900001
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2022A Yeast-Based Screening System for Differential Identification of Poisons and Suppressors of Human Topoisomerase IFull Text via DOI: 10.31083/j.fbl2703093 Web of Science: 000790056900022
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2020A diverse global fungal library for drug discovery. PEERJ. 8.Full Text via DOI: 10.7717/peerj.10392 Web of Science: 000593689800003
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2020Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains. NUCLEIC ACIDS RESEARCH. 48:4448-4462.Full Text via DOI: 10.1093/nar/gkaa201 Web of Science: 000569096800037
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2020Covalent Complex of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development. CHEMMEDCHEM. 15:623-631.Full Text via DOI: 10.1002/cmdc.201900721 Web of Science: 000520292700001
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2020Inhibition of base excision repair by natamycin suppresses prostate cancer cell proliferation. BIOCHIMIE. 168:241-250.Full Text via DOI: 10.1016/j.biochi.2019.11.008 Web of Science: 000503444300022
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2019Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound. PLOS ONE. 14.Full Text via DOI: 10.1371/journal.pone.0207733 Web of Science: 000459709100003
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2018Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site. NUCLEIC ACIDS RESEARCH. 46:7296-7308.Full Text via DOI: 10.1093/nar/gky492 Web of Science: 000444131400034
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2018Synthesis of Antimicrobial Poly(guanylurea)s. BIOCONJUGATE CHEMISTRY. 29:1006-1009.Full Text via DOI: 10.1021/acs.bioconjchem.8b00057 Web of Science: 000430641700020
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2018A Fluorescence-Based Assay for Identification of Bacterial Topoisomerase I PoisonsFull Text via DOI: 10.1007/978-1-4939-7459-7_18 Web of Science: 000686716600019
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2017Synthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 125:515-527.Full Text via DOI: 10.1016/j.ejmech.2016.09.053 Web of Science: 000390496600040
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2016Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 60:4028-4036.Full Text via DOI: 10.1128/AAC.00288-16 Web of Science: 000378094400020
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2015Antimicrobial Susceptibility and SOS-Dependent Increase in Mutation Frequency Are Impacted by Escherichia coli Topoisomerase I C-Terminal Point Mutation. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 59:6195-6202.Full Text via DOI: 10.1128/AAC.00855-15 Web of Science: 000367591800041
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2015Inhibition of Zn(II) Binding Type IA Topoisomerases by Organomercury Compounds and Hg(II). PLOS ONE. 10.Full Text via DOI: 10.1371/journal.pone.0120022 Web of Science: 000351987300103
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2014A surface plasmon resonance study of the intermolecular interaction between Escherichia coli topoisomerase I and pBAD/Thio supercoiled plasmid DNA. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 445:445-450.Full Text via DOI: 10.1016/j.bbrc.2014.02.015 Web of Science: 000333228700031
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2013Synthesis and antibacterial evaluation of anziaic acid and its analogues as topoisomerase I inhibitors. MEDCHEMCOMM. 4:1613-1618.Full Text via DOI: 10.1039/c3md00238a Web of Science: 000327461300011
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2013Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor. PLOS ONE. 8.Full Text via DOI: 10.1371/journal.pone.0060770 Web of Science: 000317898000064
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2009Hydroxyl Radicals Are Involved in Cell Killing by the Bacterial Topoisomerase I Cleavage Complex. JOURNAL OF BACTERIOLOGY. 191:5315-5319.Full Text via DOI: 10.1128/JB.00559-09 Web of Science: 000268386600032
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2009Role of proP and proU in betaine uptake by Yersinia enterocolitica under cold and osmotic stress conditions. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 75:1471-1477.Full Text via DOI: 10.1128/AEM.01644-08
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2009Asp-to-Asn Substitution at the First Position of the DxD TOPRIM Motif of Recombinant Bacterial Topoisomerase I Is Extremely Lethal to E-coli. JOURNAL OF MOLECULAR BIOLOGY. 385:558-567.Full Text via DOI: 10.1016/j.jmb.2008.10.073 Web of Science: 000262916900018
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2007Inactivation of Listeria monocytogenes on Frankfurters by monocaprylin alone or in combination with acetic acid. JOURNAL OF FOOD PROTECTION. 70:1594-1599.Full Text via DOI: 10.4315/0362-028X-70.7.1594
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2006Inactivation of Escherichia coli O157:H7 in cattle drinking water by sodium caprylate. JOURNAL OF FOOD PROTECTION. 69:2248-2252.Full Text via DOI: 10.4315/0362-028X-69.9.2248
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2005Expression of major cold shock proteins and genes by Yersinia enterocolitica in synthetic medium and foods. JOURNAL OF FOOD PROTECTION. 68:2454-2458.Full Text via DOI: 10.4315/0362-028X-68.11.2454
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2004Effect of muscle source on premature browning in ground beefFull Text via DOI: 10.1016/j.meatsci.2004.04.012
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2004In vitro inactivation of Escherichia coli O157:H7 in bovine rumen fluid by caprylic acid. JOURNAL OF FOOD PROTECTION. 67:884-888.Full Text via DOI: 10.4315/0362-028X-67.5.884
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2003Detection of Penicillium expansum by polymerase chain reactionFull Text via DOI: 10.1016/S0168-1605(03)00115-6
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2003Behavior of enteroaggregative Escherichia coli in bottled spring and mineral water. JOURNAL OF FOOD PROTECTION. 66:497-500.Full Text via DOI: 10.4315/0362-028X-66.3.497
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2001Inactivation of Escherichia coli O157:H7 and Listeria monocytogenes by PR-26, a synthetic antibacterial peptide. JOURNAL OF FOOD PROTECTION. 64:1929-1934.Full Text via DOI: 10.4315/0362-028X-64.12.1929
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Conference
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2021A DIVERSE GLOBAL FUNGAL LIBRARY FOR DRUG DISCOVERY. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 204-204.Web of Science: 000778105602327
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2019Structure-activity relationship studies of antimicrobial poly-(guanylurea) for overcoming drug resistance. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000525061505190
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2008
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Other Scholarly Work
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2023Covalent Complex of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development (vol 15, pg 623, 2020). CHEMMEDCHEM.Full Text via DOI: 10.1002/cmdc.202100427 Web of Science: 000663166200001
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2015Molecular Interaction between Escherichia Coli Topoisomerase I and pBAD/Thio Supercoiled Plasmid DNA. BIOPHYSICAL JOURNAL. 398A-398A.Full Text via DOI: 10.1016/j.bpj.2014.11.2181 Web of Science: 000362849400415
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Preprint
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Review
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2021Type IA Topoisomerases as Targets for Infectious Disease TreatmentsFull Text via DOI: 10.3390/microorganisms9010086 Web of Science: 000610588900001
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Research
co-principal investigator on
investigator on
- Structure, Mechanism and Interactions of Type IA Topoisomerases awarded by General Medical Sciences 2021 - 2026
Contact
full name
- Thirunavukkarasu Annamalai
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publication subject areas
Citation index-derived subject areas the researcher has published in