Florida International University
Edit Your Profile
FIU Discovery
Toggle navigation
Browse
Home
People
Organizations
Scholarly & Creative Works
Research Facilities
Support
Edit Your Profile
Annamalai, Thirunavukkarasu
Positions
Research Assistant Professor
,
Chemistry and Biochemistry
,
College of Arts, Sciences & Education
athiruna@fiu.edu
Share this page
Twitter
Email
Copy link
Share
Scholarly & Creative Works
Research
Contact
View All
Scholarly & Creative Works
selected scholarly works & creative activities
Article
2024
Characterization and antimicrobial activity of endophytic fungi from medicinal plant Agave americana
.
LETTERS IN APPLIED MICROBIOLOGY
. 77.
Full Text via DOI:
10.1093/lambio/ovae025
Web of Science:
001184795600002
2023
Isolation and Characterization of Fungal Endophytes from
Petiveria alliacea
and Their Antimicrobial Activities in South Florida
Full Text via DOI:
10.3390/microbiolres14030100
Web of Science:
001073873800001
2023
The interaction between transport-segment DNA and topoisomerase IA-crystal structure of MtbTOP1 in complex with both G- and T-segments
.
NUCLEIC ACIDS RESEARCH
. 51:349-364.
Full Text via DOI:
10.1093/nar/gkac1205
Web of Science:
000905761600001
2022
Localization of Mycobacterium tuberculosis topoisomerase I C-terminal sequence motif required for inhibition by endogenous toxin MazF4
Full Text via DOI:
10.3389/fmicb.2022.1032320
Web of Science:
000899665400001
2022
Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives
.
CHEMMEDCHEM
. 17.
Full Text via DOI:
10.1002/cmdc.202200301
Web of Science:
000870041900001
2022
Proton Motive Force-Disrupting Antimycobacterial Guanylurea Polymer
Full Text via DOI:
10.1021/acs.biomac.2c00902
Web of Science:
000884681200001
2022
A Yeast-Based Screening System for Differential Identification of Poisons and Suppressors of Human Topoisomerase I
Full Text via DOI:
10.31083/j.fbl2703093
Web of Science:
000790056900022
2020
A diverse global fungal library for drug discovery
.
PEERJ
. 8.
Full Text via DOI:
10.7717/peerj.10392
Web of Science:
000593689800003
2020
Mechanistic insights from structure of
Mycobacterium smegmatis
topoisomerase I with ssDNA bound to both N- and C-terminal domains
.
NUCLEIC ACIDS RESEARCH
. 48:4448-4462.
Full Text via DOI:
10.1093/nar/gkaa201
Web of Science:
000569096800037
2020
Covalent Complex of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development
.
CHEMMEDCHEM
. 15:623-631.
Full Text via DOI:
10.1002/cmdc.201900721
Web of Science:
000520292700001
2020
Inhibition of base excision repair by natamycin suppresses prostate cancer cell proliferation
.
BIOCHIMIE
. 168:241-250.
Full Text via DOI:
10.1016/j.biochi.2019.11.008
Web of Science:
000503444300022
2019
Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound
.
PLOS ONE
. 14.
Full Text via DOI:
10.1371/journal.pone.0207733
Web of Science:
000459709100003
2018
Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site
.
NUCLEIC ACIDS RESEARCH
. 46:7296-7308.
Full Text via DOI:
10.1093/nar/gky492
Web of Science:
000444131400034
2018
Synthesis of Antimicrobial Poly(guanylurea)s
.
BIOCONJUGATE CHEMISTRY
. 29:1006-1009.
Full Text via DOI:
10.1021/acs.bioconjchem.8b00057
Web of Science:
000430641700020
2018
A Fluorescence-Based Assay for Identification of Bacterial Topoisomerase I Poisons
Full Text via DOI:
10.1007/978-1-4939-7459-7_18
Web of Science:
000686716600019
2017
Synthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors
.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
. 125:515-527.
Full Text via DOI:
10.1016/j.ejmech.2016.09.053
Web of Science:
000390496600040
2016
Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
. 60:4028-4036.
Full Text via DOI:
10.1128/AAC.00288-16
Web of Science:
000378094400020
2015
Antimicrobial Susceptibility and SOS-Dependent Increase in Mutation Frequency Are Impacted by
Escherichia coli
Topoisomerase I C-Terminal Point Mutation
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
. 59:6195-6202.
Full Text via DOI:
10.1128/AAC.00855-15
Web of Science:
000367591800041
2015
Inhibition of Zn(II) Binding Type IA Topoisomerases by Organomercury Compounds and Hg(II)
.
PLOS ONE
. 10.
Full Text via DOI:
10.1371/journal.pone.0120022
Web of Science:
000351987300103
2014
A surface plasmon resonance study of the intermolecular interaction between Escherichia coli topoisomerase I and pBAD/Thio supercoiled plasmid DNA
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
. 445:445-450.
Full Text via DOI:
10.1016/j.bbrc.2014.02.015
Web of Science:
000333228700031
2013
Synthesis and antibacterial evaluation of anziaic acid and its analogues as topoisomerase I inhibitors
.
MEDCHEMCOMM
. 4:1613-1618.
Full Text via DOI:
10.1039/c3md00238a
Web of Science:
000327461300011
2013
Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor
.
PLOS ONE
. 8.
Full Text via DOI:
10.1371/journal.pone.0060770
Web of Science:
000317898000064
2011
The Strictly Conserved Arg-321 Residue in the Active Site of
Escherichia coli
Topoisomerase I Plays a Critical Role in DNA Rejoining
Full Text via DOI:
10.1074/jbc.M111.229450
Web of Science:
000290785700040
2009
Hydroxyl Radicals Are Involved in Cell Killing by the Bacterial Topoisomerase I Cleavage Complex
.
JOURNAL OF BACTERIOLOGY
. 191:5315-5319.
Full Text via DOI:
10.1128/JB.00559-09
Web of Science:
000268386600032
2009
Analysis of DNA relaxation and cleavage activities of recombinant Mycobacterium tuberculosis DNA topoisomerase I from a new expression and purification protocol
Full Text via DOI:
10.1186/1471-2091-10-18
Web of Science:
000267522000001
2009
Role of proP and proU in betaine uptake by Yersinia enterocolitica under cold and osmotic stress conditions
.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
. 75:1471-1477.
Full Text via DOI:
10.1128/AEM.01644-08
2009
Asp-to-Asn Substitution at the First Position of the DxD TOPRIM Motif of Recombinant Bacterial Topoisomerase I Is Extremely Lethal to
E-coli
.
JOURNAL OF MOLECULAR BIOLOGY
. 385:558-567.
Full Text via DOI:
10.1016/j.jmb.2008.10.073
Web of Science:
000262916900018
2007
Inactivation of Listeria monocytogenes on Frankfurters by monocaprylin alone or in combination with acetic acid
.
JOURNAL OF FOOD PROTECTION
. 70:1594-1599.
Full Text via DOI:
10.4315/0362-028X-70.7.1594
2006
Inactivation of Escherichia coli O157:H7 in cattle drinking water by sodium caprylate
.
JOURNAL OF FOOD PROTECTION
. 69:2248-2252.
Full Text via DOI:
10.4315/0362-028X-69.9.2248
2005
Effect of erythorbate, storage and high-oxygen packaging on premature browning in ground beef
Full Text via DOI:
10.1016/j.meatsci.2004.08.008
2005
Expression of major cold shock proteins and genes by Yersinia enterocolitica in synthetic medium and foods
.
JOURNAL OF FOOD PROTECTION
. 68:2454-2458.
Full Text via DOI:
10.4315/0362-028X-68.11.2454
2005
In vitro inactivation of Salmonella enteritidis in autoclaved chicken cecal contents by caprylic acid
Full Text via DOI:
10.1093/japr/14.1.122
2004
Effect of muscle source on premature browning in ground beef
Full Text via DOI:
10.1016/j.meatsci.2004.04.012
2004
In vitro inactivation of Escherichia coli O157:H7 in bovine rumen fluid by caprylic acid
.
JOURNAL OF FOOD PROTECTION
. 67:884-888.
Full Text via DOI:
10.4315/0362-028X-67.5.884
2003
Detection of Penicillium expansum by polymerase chain reaction
Full Text via DOI:
10.1016/S0168-1605(03)00115-6
2003
Phenotypic and genotypic characterization of bovine mastitis isolates of Staphylococcus aureus for biofilm formation
Full Text via DOI:
10.1016/S0378-1135(02)00360-7
2003
Behavior of enteroaggregative Escherichia coli in bottled spring and mineral water
.
JOURNAL OF FOOD PROTECTION
. 66:497-500.
Full Text via DOI:
10.4315/0362-028X-66.3.497
2003
Heat inactivation of Escherichia coli O157:H7 in apple cider in the presence of glycerol monolaurate and a synthetic antimicrobial peptide, PR-26
Full Text via DOI:
10.1111/j.1745-4549.2003.tb00499.x
2001
Inactivation of Escherichia coli O157:H7 and Listeria monocytogenes by PR-26, a synthetic antibacterial peptide
.
JOURNAL OF FOOD PROTECTION
. 64:1929-1934.
Full Text via DOI:
10.4315/0362-028X-64.12.1929
Conference
2021
A DIVERSE GLOBAL FUNGAL LIBRARY FOR DRUG DISCOVERY
.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
. 204-204.
Web of Science:
000778105602327
2019
Structure-activity relationship studies of antimicrobial poly-(guanylurea) for overcoming drug resistance
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
.
Web of Science:
000525061505190
2008
Insertions in xanthene dehydrogenase genes suppress cell death due to stabilization of topoisomerase IA covalent complex
.
FASEB JOURNAL
.
Web of Science:
000208467800226
Other Scholarly Work
2023
Covalent Complex of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development (vol 15, pg 623, 2020)
.
CHEMMEDCHEM
.
Full Text via DOI:
10.1002/cmdc.202100427
Web of Science:
000663166200001
2015
Molecular Interaction between Escherichia Coli Topoisomerase I and pBAD/Thio Supercoiled Plasmid DNA
.
BIOPHYSICAL JOURNAL
. 398A-398A.
Full Text via DOI:
10.1016/j.bpj.2014.11.2181
Web of Science:
000362849400415
Preprint
A Yeast-Based Screening System for Differential Identification of Poison Inhibitors and Catalytic Inhibitors of Human Topoisomerase I
Full Text via DOI:
10.1101/2021.11.16.468530
Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound
Full Text via DOI:
10.1101/464990
Review
2021
Type IA Topoisomerases as Targets for Infectious Disease Treatments
Full Text via DOI:
10.3390/microorganisms9010086
Web of Science:
000610588900001
Research
co-principal investigator on
Grant
Collaboration for screening of Mycobacterium tuberculosis topoisomerase I inhibitors from DNA-Encoded Library at WuXi
awarded by
Global Alliance TB for Drug Development
2020 - 2021
investigator on
Structure, Mechanism and Interactions of Type IA Topoisomerases
awarded by
General Medical Sciences
2021 - 2026
Contact
full name
Thirunavukkarasu
Annamalai
visualizations
Co-author Network
Co-investigator Network
Map of Science
publication subject areas
Biochemistry & Molecular Biology
Biophysics
Chemistry
Microbiology
Pharmacology & Pharmacy
Science & Technology - Other Topics
Citation index-derived subject areas the researcher has published in